318 results on '"Smith, L.A."'
Search Results
2. Chytrid fungi cell-free supernatants have differential effects on Xenopus laevis skin epithelial-like cell lines
- Author
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Todd, L.A., Reinert, L.K., Wu J, M., Morningstar, B.E.E., Rollins-Smith, L.A., and Katzenback, B.A.
- Published
- 2023
- Full Text
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3. Separate and combined effects of advanced age and obesity on mammary adipose inflammation, immunosuppression and tumor progression in mouse models of triple negative breast cancer
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Smith L.A., Rainey M.A., Rezeli E.T., McDonell S.B., Bowers L.W., Hursting S.D., Cozzo A.J., Montgomery S.A., Coleman M.F., Sheth N., Carson M.S., Glenny E.M., and Craven D.M.
- Abstract
Introduction: Advanced age and obesity are independent risk and progression factors for triple negative breast cancer (TNBC), which presents significant public health concerns for the aging population and its increasing burden of obesity. Due to parallels between advanced age- and obesityrelated biology, particularly adipose inflammation, we hypothesized that advanced age and obesity each accelerate mammary tumor growth through convergent, and likely interactive, mechanisms. Methods: To test this hypothesis, we orthotopically transplanted murine syngeneic TNBC cells into the mammary glands of young normoweight control (7 months), young diet-induced obese (DIO), aged normoweight control (17 months), and aged DIO female C57BL/6J mice. Results: Here we report accelerated tumor growth in aged control and young DIO mice, compared with young controls. Transcriptional analyses revealed, with a few exceptions, overlapping patterns of mammary tumor inflammation and tumor immunosuppression in aged control mice and young DIO mice, relative to young controls. Moreover, aged control and young DIO tumors, compared with young controls, had reduced abundance ofcytotoxic CD8 T cells. Finally, DIO in advanced age exacerbated mammary tumor growth, inflammation and tumor immunosuppression. Discussion: These findings demonstrate commonalities in the mechanisms driving TNBC in aged and obese mice, relative to young normoweight controls. Moreover, we found that advanced age and DIO interact to accelerate mammary tumor progression. Given the US population is getting older and more obese, age- and obesity-related biological differences will need to be considered when developing mechanism-based strategies for preventing or controlling breast cancer.
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- 2023
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4. Overcoming uncertainty and barriers to adoption of Blue‐Green Infrastructure for urban flood risk management
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Thorne, C.R., Lawson, E.C., Ozawa, C., Hamlin, S.L., and Smith, L.A.
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- 2018
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5. Pasifika adolescents' recommendations for increasing access to oral health care
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Smith, L.A
- Published
- 2019
6. High prevalence of paratuberculosis in rabbits is associated with difficulties in controlling the disease in cattle
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Shaughnessy, L.J., Smith, L.A., Evans, J., Anderson, D., Caldow, G., Marion, G., Low, J.C., and Hutchings, M.R.
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- 2013
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7. 133P Neoadjuvant pembrolizumab plus lenvatinib in resectable stage III melanoma patients (pts) (NeoPele): Analysis of the peripheral immune profile correlated to pathological response
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Pires da Silva, I., Conway, J.W., Smith, L.A., Ramanathan, A., Adegoke, N.A., Rawson, R., Grover, P., Maher, N., Braden, J., Gonzalez, M., Palendira, U., Menzies, A.M., Scolyer, R.A., and Long, G.V.
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- 2024
- Full Text
- View/download PDF
8. 72MO Concurrent BRAF targeted therapy (TT) with dabrafenib and trametinib and anti-PD-1 agent pembrolizumab (PD1) increased B cell signalling and inflammatory pathways more effectively than when given sequentially or with anti-PD-1 alone
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Braden, J., Conway, J.W., Ramanathan, A., Smith, L.A., Menzies, A.M., Carlino, M.S., Au-Yeung, G., Rawson, R., Shannon, K.F., Pennington, T.E., Ch'ng, S., Saw, R.P.M., Spillane, A.J., Gyokri, D., Howle, J., Wilmott, J., Scolyer, R.A., Long, G.V., and Pires da Silva, I.
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- 2024
- Full Text
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9. Pilot trial of sunitinib therapy in patients with von Hippel–Lindau disease
- Author
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Jonasch, E., McCutcheon, I.E., Waguespack, S.G., Wen, S., Davis, D.W., Smith, L.A., Tannir, N.M., Gombos, D.S., Fuller, G.N., and Matin, S.F.
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- 2011
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10. Viral Carcinogenesis
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Smith, A.J., primary and Smith, L.A., additional
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- 2016
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11. A critical evaluation of sampling methods used for assessing microorganisms on surfaces
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Verran, J., J.Redfern, Smith, L.A., and Whitehead, K.A.
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- 2010
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12. An in vivo pharmacological evaluation of pardoprunox (SLV308) — A novel combined dopamine D 2/D 3 receptor partial agonist and 5-HT 1A receptor agonist with efficacy in experimental models of Parkinson's disease
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Jones, C.A., Johnston, L.C., Jackson, M.J., Smith, L.A., van Scharrenburg, G., Rose, S., Jenner, P.G., and McCreary, A.C.
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- 2010
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13. Valproate for the treatment of acute bipolar depression: Systematic review and meta-analysis
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Smith, L.A., Cornelius, V.R., Azorin, J.M., Perugi, G., Vieta, E., Young, A.H., and Bowden, C.L.
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- 2010
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14. Continuous rotigotine administration reduces dyskinesia resulting from pulsatile treatment with rotigotine or l-DOPA in MPTP-treated common marmosets
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Stockwell, K.A., Scheller, D.K.A., Smith, L.A., Rose, S., Iravani, M.M., Jackson, M.J., and Jenner, P.
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- 2010
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15. Effects of group composition on the grazing behaviour of herbivores
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Smith, L.A., Wells, K.L., Marion, G., Swain, D.L., and Hutchings, M.R.
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- 2010
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16. The effect of grazing management on livestock exposure to parasites via the faecal–oral route
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Smith, L.A., Marion, G., Swain, D.L., White, P.C.L., and Hutchings, M.R.
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- 2009
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17. Continuous administration of rotigotine to MPTP-treated common marmosets enhances anti-parkinsonian activity and reduces dyskinesia induction
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Stockwell, K.A., Scheller, D., Rose, S., Jackson, M.J., Tayarani-Binazir, K., Iravani, M.M., Smith, L.A., Olanow, C.W., and Jenner, P.
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- 2009
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18. DATA ASSIMILATION AND PREDICTABILITY | Predictability and Chaos
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Smith, L.A., primary
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- 2015
- Full Text
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19. ICD risk stratification post MI: are we meeting guidelines?
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Adhya, S., Smith, L.A., Zhao, T., Bannister, C., and Kamdar, R.H.
- Published
- 2011
20. Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: The COVIDSurg mortality score.
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Bravo L., Nepogodiev D., Glasbey J.C., Li E., Simoes J.F.F., Kamarajah S.K., Picciochi M., Abbott T.E.F., Ademuyiwa A.O., Arnaud A.P., Agarwal A., Brar A., Elhadi M., Mazingi D., Cardoso V.R., Lawday S., Sayyed R., Omar O.M., de la Madina A.R., Slater L., Venn M.L., Gkoutos G., Bhangu A., Karwath A., Siaw-Acheampong K., Argus L., Chaudhry D., Dawson B.E., Gujjuri R.R., Jones C.S., Khatri C., Keatley J.M., Mann H., Marson E.J., Mclean K.A., Taylor E.H., Tiwari A., Trout I.M., Wilkin R.J.W., Dajti I., Gjata A., Boccalatte L., Modolo M.M., Cox D., Pockney P., Townend P., Aigner F., Kronberger I., Hossain K., VanRamshorst G., Lawani I., Ataide G., Baiocchi G., Buarque I., Gohar M., Slavchev M., Martin J., Olivos M., Calvache J., Rivera C.J.P., Hadzibegovic A.D., Kopjar T., Mihanovic J., Klat J., Novysedlak R., Christensen P., El-Hussuna A., Batista S., Lincango E., Emile S.H., Mengesha M.G., Hailu S., Tamiru H., Kauppila J., Laukkarinen J., Albertsmeiers M., Lederhuber H., Loffler M., Tabiri S., Metallidis S., Tsoulfas G., Lorena M.A., Grecinos G., Mersich T., Wettstein D., Ghosh D., Kembuan G., Brouk P., Khosravi M., Mozafari M., Adil A., Mohan H.M., Zmora O., Fiore M., Gallo G., Pata F., Pellino G., Satoi S., Ayasra F., Chaar M., Fakhradiyev I.R., Jamal M., Gulla A., Roslani A., Martinez L., De La Medina A.R., Outani O., Jonker P., Kruijff S., Noltes M., Steinkamp P., van der Plas W., Osinaike B., Seyiolajide J., Williams E., Pejkova S., Augestad K.M., Soreide K., Al Balushi Z., Qureshi A., Daraghmeh M.A.M., Abukhalaf S., Cukier M., Gomez H., Shu S., Vasquez X., Parreno-Sacdalan M.D., Major P., Azevedo J., Cunha M., Santos I., Zarour A., Bonci E.-A., Negoi I., Efetov S., Litvin A., Ntirenganya F., Al Ameer E., Radenkovic D., Xiang F.K.H., Hoe C.M., Yong J.N.C., Moore R., Nhlabathi N., Colino R.B., Bravo A.M., Minaya-Bravo A., Jayarajah U., Wickramasinghe D., Elmujtaba M., Jebril W., Rutegard M., Sund M., Isik A., Leventoglu S., Benson R., Caruna E., Chakrabortee S., Demetriades A., Desai A., Drake T.D., Edwards J.G., Evans J.P., Ford S., Fotopoulou C., Griffiths E., Hutchinson P., Jenkinson M.D., Khan T., Knight S., Kolias A., Leung E., McKay S., Norman L., Ots R., Raghavan V., Roberts K., Schache A., Shaw R., Shaw K., Smart N., Stewart G., Sundar S., Vimalchandran D., Wright N., Alshryda S., Alser O., Breen K., Ganly I., Kaafarani H., Kendall B., Mashbari H., Al Naggar H., Valenzuela J.I., Boccalatte L.A., Gemelli N.A., Smith D.E., Dudi-Venkata N.N., Kroon H.M., Sammour T., Roberts M., Mitchell D., Lah K., Pearce A., Morton A., Dawson A.C., Drane A., Sharpin C., Nataraja R.M., Pacilli M., Cox D.R.A., Muralidharan V., Riddiough G.E., Clarke E.M., Jamel W., Qin K.R., Cope D., Egoroff N., Lott N., Putnis S., De Robles S., Ang Z., Mitteregger M., Uranitsch S., Stiegler M., Seitinger G., Lumenta D.B., Nischwitz S.P., Richtig E., Pau M., Srekl-Filzmaier P., Eibinger N., Michelitsch B., Fediuk M., Papinutti A., Seidel G., Kahn J., Cohnert T.U., Messner F., Ofner D., Presl J., Varga M., Weitzendorfer M., Emmanuel K., Binder A.D., Zimmermann M., Holawe S., Nkenke E., Grimm C., Kranawetter M., Rahman Mitul A., Islam N., Karim S., Komen N., Ang E., De Praetere H., Tollens T., Schols G., Smets C., Haenen L., Quintens J., Van Belle K., Van Ramshorst G.H., Pattyn P., Desender L., Martens T., Van de Putte D., Lerut P., Grimonprez A., Janssen M., De Smul G., Wallaert P., Van den Eynde J., Oosterlinck W., Van den Eynde R., Sermon A., Boeckxstaens A., Cordonnier A., De Coster J., Jaekers J., Politis C., Miserez M., Duchateau N., De Gheldere C., Flamey N., Christiano A., Guidi B., Minussi A.L., Castro S., Okoba W., Maldonado F.H.R., Oliveira P., Baldasso T., Santos L., Gomes G.M.A., Buarque I.L., Pol-Fachin L., Bezerra T.S., Barros A.V., da Silva A.M.R., Leite A.L.S., Silvestre D.W.A., Ferro C.C., Araujo M.S., Lopes L.M., Damasceno P.D., Araujo D.H.S., Laporte G., Salem M.C., Guimaraes-Filho M.A.C., Nacif L., Flumignan R.L.G., Nakano L.C.U., Kuramoto D.A.B., Aidar A.L.S., Pereda M.R., Correia R.M., Santos B.C., Carvalho A.A., Amorim J.E., Guedes Neto H.J., Areias L.L., Sousa A.F., Flumignan C.D.Q., Lustre W.G., Moreno D.H., Barros N., Baptista-Silva J.C.C., Matos L.L., Kowaski L.P., Kulcsar M.A.V., Nunes K.S., Teixeira M.F., Nunes R.L., Ijichi T.R., Kim N.J., Marreiro A., Muller B., Barakat Awada J., Kowalski L.P., Vartanian J.G., Makdissi F.B., Aguiar S., Marques N., Carvalho G.B., Marques T.M.D.M., Abdallah E.A., Zurstrassen C.E., Gross J.L., Zequi S.C., Goncalves B.T., Santos S.S., Duprat J.P., Coimbra F.J.F., Cicco R., Takeda F., Cecconello I., Ribeiro U., Gatti A., Oliva R., Nardi C., Atanasov B., Belev N., Dell A., Bigam D., Dajani K., Al Riyami S., Cheng D., Yang H., Fayad A., Carrier F.M., Amzallag E., Desroches J., Ruel M., Caminsky N.G., Boutros M., Moon J., Wong E.G., Vanounou T., Pelletier J., Wong S., Girsowicz E., Bayne J., Obrand D., Gill H., Steinmetz O., MacKenzie K., Lukaszewski M., Jamjoum G., Richebe P., Verdonck O., Discepola S., Godin N., Idrissi M., Briatico D., Sharma S., Talwar G., Bailey K., Lecluyse V., Cote G., Demyttenaere S., Garfinkle R., Kouyoumdjian A., Dumitra S., Khwaja K., Luo L., Berry G., Liberman A.S., Schmid S., Spicer J., Al Farsi M., Abou-Khalil J., Couture E., Mohammadi S., Tremblay H., Gagne N., Bergeron A., Turgeon A.F., Costerousse O., Bellemare D., Babin C., Blier C., Wood M.L., Persad A., Groot G., Pham H., D'Aragon F., Carbonneau E., Bouchard M., Masse M., Pesant F., Heroux J., Karanicolas P., Hallet J., Nadler A., Nathens A., Ko M., Mayson K., Kidane B., Srinathan S., Escudero M.I., Reyes J.T., Ramirez Nieto P., Sepulveda R., Bolbaran A., Molero A., Ruiz I., Reyes G.P., Salas R., Suazo C., Munoz R., Grasset E., Inzunza M., Besser N., Irarrazaval M.J., Jarry C., Bellolio F., Romero Manqui C.A., Ruiz Esquide M., Fuentes T., Campos J., Perez Rivera C.J., Cabrera P.A., Pinilla R.E., Guevara O., Jimenez Ramirez L.J., Velasquez Cuasquen B.G., Herrera Mora D.R., Bonilla A., Diaz S., Manrique E., Facundo H., Velez Bernal J.L., Angel J., Garcia M., Guzman L., Lehmann C., Cervera S., Trujillo Sanchez L.M., Guevara R., Valbuena D., Suarez L., Jimenez G., Velandia A., Vargas J., Espinosa J., Rey S., Mendoza Quevedo J., Calvache J.A., Orozco-Chamorro C.M., Sanchez-Gomez T.A., Rojas-Tejada D.A., Bakmaz B., Rakvin I., Sulen N., Andabaka T., Luksic I., Mamic M., Martinek L., Skrovina M., Zatecky J., Peteja M., Kristensen H.O., Mekhael M., Westh L., Smith H., Haugstvedt A.F., Jonsson M.L., Crespo A., Rodriguez-Abreu J., Tactuk N., Diaz-Delgado P.J., Rivas R., Sarmiento-Bobadilla J.A., Ashoush F., Samir Abdelaal A., Qatora M.S., Elsayed Hewalla M.E., Metwalli M., Atta R., Abdelmajeed A., Abosamak N.E., Sabry A., Shehata S., Sallam I., Amira G., Sherief M., Sherif A., Salem H., Hamdy R., Aboulkassem H., Ghaly G., Sherif G., Morsi A., Abdelrahman A., Omnia A., Tawheed A., El Kassas M., Omar W., Abdelsamed A., Seleim A., Azzam A.Y., ElFiky M., Nabil A., Ibraheem M., ElDeeb M., Fawzy M., Hamed H., Emile S., Elfallal A., Elfeki H., Shalaby M., Sakr A., Alrahawy M., Atif H., Soltan H., Sayed A.K., Salah A., Atiya A., Wassim K., Abbas A.M., Abd Elazeem H.A.S., Abd-Elkariem A.Y., Abd-Elkarem M.M., Alaa S., Ali A.K., Ashraf M., Ayman A., Azizeldine M.G., Elkhayat H., Emad Mashhour A., Gaber M., Hamza H.M., Hawal I., Hetta H.F., Elghazaly S.M., Mohammed M.M., Monib F.A., Nageh M.A., Saad A., Saad M.M., Shahine M., Yousof E.A., Youssef A., Esmail E., Khalaf M., Eldaly A., Ghoneim A., Hawila A., Badr H., Elhalaby I., Abdel-Bari M., Elbahnasawy M., Hamada M.K., Morsy M.S., Hammad M., Essa M., Fayed M.T., Elzoghby M., Rady M., Hamad O., Salman S., Sarsik S., Abd-Elsalam S., Gamal Badr S., El-Masry Y., Moahmmed M.M.H., Wolde A., Mengesha M., Nida S., Workneh M., Ahmed M.Y., Fisseha T., Kassa D., Zeleke H., Admasu A., Laeke T., Tirsit A., Gessesse M., Addissie A., Bekele D., Kauppila J.H., Sarjanoja E., Testelin S., Dakpe S., Devauchelle B., Bettoni J., Lavagen N., Schmitt F., Lemee J.M., Boucher S., Breheret R., Kun-Darbois J.D., Kahn A., Gueutier A., Bigot P., Borraccino B., Lakkis Z., Doussot A., Heyd B., Manfredelli S., Mathieu P., Paquette B., Turco C., Barrabe A., Louvrier A., Moszkowicz D., Giovinazzo D., Bretagnol F., Police A., Charre L., Volpin E., Braham H., El Arbi N., Villefranque V., Bendjemar L., Girard E., Abba J., Trilling B., Chebaro A., Lecolle K., Truant S., El Amrani M., Zerbib P., Pruvot F.R., Mathieu D., Surmei E., Mattei L., Christou N., Ballouhey Q., Ferrero P., Coste Mazeau P., Tricard J., Barrat B., Taibi A., Usseglio J., Laloze J., Salle H., Fourcade L., Duchalais E., Regenet N., Rigaud J., Waast D., Denis W., Malard O., Buffenoir K., Espitalier F., Ferron C., Varenne Y., Crenn V., De Vergie S., Cristini J., Samarut E., Tzedakis S., Bouche P.A., Gaujoux S., Kantor E., Gossot D., Seguin-Givelet A., Fuks D., Grigoroiu M., Sanchez Salas R., Cathelineau X., Macek P., Barbe Y., Rozet F., Barret E., Mombet A., Cathala N., Brian E., Zadegan F., Conso C., Blanc T., Broch A., Sarnacki S., Ali L., Bonnard A., Peycelon M., Hervieux E., Clermidi P., Maisonneuve E., Aubry E., Thomin A., Langlais T., Passot G., Glehen O., Cotte E., Lifante J.C., De Simone B., Chouillard E., Violas P., Bergeat D., Merdrignac A., Scalabre A., Perotto L.O., Le Roy B., Haddad E., Vermersch S., Ezanno A.C., Barbier O., Vigouroux F., Malgras B., Aime A., Seeliger B., Mutter D., Philouze G., Pessaux P., Germain A., Chanty H., Ayav A., Kassir R., Von Theobald P., Sauvat F., O'Connor J., Mayombo Idiata M., O'Connor Z., Tchoba S., Modabber A., Winnand P., Holzle F., Sommer B., Shiban E., Wolf S., Anthuber M., Sommer F., Kaemmerer D., Schreiber T., Kamphues C., Lauscher J.C., Schineis C., Loch F.N., Beyer K., Nasser S., Sehouli J., Hohn P., Braumann C., Reinkemeier F., Uhl W., Weitz J., Bork U., Welsch T., Praetorius C., Korn S., Distler M., Fluegen G., Knoefel W.T., Vay C., Golcher H., Grutzmann R., Binder J., Meister P., Gallinat A., Paul A., Schnitzbauer A.A., Thoenissen P., El Youzouri H., Schreckenbach T., Nguyen T.A., Eberbach H., Bayer J., Erdle B., Sandkamp R., Nitschke C., Izbicki J., Uzunoglu F.G., Koenig D., Gosau M., Bottcher A., Heuer A., Klatte T.O., Priemel M., Betz C.S., Burg S., Mockelmann N., Busch C.J., Bewarder J., Zeller N., Smeets R., Thole S., Vollkommer T., Speth U., Stangenberg M., Hakami I., Boeker C., Mall J., Schardey H.M., von Ahnen T., von Ahnen M., Brunner U., Tapking C., Kneser U., Hirche C., Jung M., Kowalewski K.F., Kienle P., Reissfelder C., Seyfried S., Herrle F., Hardt J., Galata C., Birgin E., Rahbari N., Vassos N., Stoleriu M.G., Hatz R., Albertsmeier M., Borner N., Lampert C., Werner J., Kuehlmann B., Prantl L., Brunner S.M., Schlitt H.J., Brennfleck F., Pfister K., Oikonomou K., Reinhard T., Nowak K., Ronellenfitsch U., Kleeff J., Delank K.S., Michalski C.W., Szabo G., Widyaningsih R., Stavrou G.A., Bschorer R., Mielke J., Peschel T., Konigsrainer A., Quante M., Loffler M.W., Yurttas C., Doerner J., Seiberth R., Bouchagier K., Klimopoulos S., Paspaliari D., Stylianidis G., Syllaios A., Baili E., Schizas D., Liakakos T., Charalabopoulos A., Zografos C., Spartalis E., Manatakis D.K., Tasis N., Antonopoulou M.I., Xenaki S., Xynos E., Chrysos E., Athanasakis E., Tsiaousis J., Lostoridis E., Tourountzi P., Tzovaras G., Tepetes K., Zacharoulis D., Baloyiannis I., Perivoliotis K., Hajiioannou J., Korais C., Gkrinia E., Skoulakis C.E., Saratziotis A., Koukoura O., Symeonidis D., Diamantis A., Christou C.D., Tooulias A., Papadopoulos V., Anthoulakis C., Grimbizis G., Zouzoulas D., Tsolakidis D., Tatsis D., Christidis P., Loutzidou L., Ioannidis O., Astreidis I., Antoniou A., Antoniadis K., Vachtsevanos K., Paraskevopoulos K., Kalaitsidou I., Alexoudi V., Stavroglou A., Mantevas A., Michailidou D., Grivas T., Deligiannidis D., Politis S., Barrios Duarte A., Portilla A.L., Lowey M.J., Recinos G., Lopez Muralles I., Siguantay M.A., Estrada E.E., Aguilera-Arevalo M.L., Cojulun J.M., Echeverria-Davila G., Marin C., Icaza de Marin G.C., Kok S.Y., Joeng H.K.M., Chan L.L., Lim D., Novak Z., Echim T., Susztak N., Banky B., Pajan H., Islam A.A., Rahim F., Safari H., Brouki Milan P., Tizmaghz A., Rezaei Tavirani M., Ahmed A., Hussein R., Fleming C., O'Brien S., Kayyal M.Y., Daly A., Killeen S., Corrigan M., De Marchi J., Hill A., Farrell T., Davis N.F., Kearney D., Nelson T., Maguire P.J., Barry C., Farrell R., Smith L.A., Mehigan B.J., McCormick P., Larkin J.O., Fahey B.A., Rogers A., Donlon N., O'Sullivan H., Nugent T., Reynolds J.V., Donohue C., Shokuhi P., Ravi N., Fitzgerald C., Lennon P., Timon C., Kinsella J., Smith J., Boyle T., Alazawi D., Connolly E., Butt W., Croghan S.M., Manecksha R.P., Fearon N., Winter D., Heneghan H., Maguire D., Gallagher T., Conlon K., Kennedy N., Martin S., Kennelly R., Hanly A., Ng K.C., Fagan J., Geary E., Cullinane C., Carrington E., Geraghty J., McDermott E., Pritchard R., McPartland D., Boland M., Stafford A., Geoghegan J., Elliott J.A., Ridgway P.F., Gillis A.E., Bass G.A., Neary P.C., O'Riordan J.M., Kavanagh D.O., Reynolds I.S., Joyce D.P., Boyle E., Egan B., Whelan M., Elkady R., Tierney S., Connelly T.M., Earley H., Umair M., O'Connell C., Thomas A.Z., Rice D., Madden A., Bashir Y., Creavin B., Cullivan O., Owens P., Canas-Martinez A., Murphy C., Pickett L., Murphy B., Mastrosimone A., Beddy D., Arumugasamy M., Allen M., Aremu M., McCarthy C., O'Connor C., O'Connor D.B., Kent E., Malone F., Geary M., McKevitt K.L., Lowery A.J., Ryan E.J., Aherne T.M., Fowler A., Hassanin A., Hogan A.M., Collins C.G., Finnegan L., Carroll P.A., Kerin M.J., Walsh S.R., Nally D., Peirce C., Coffey J.C., Cunningham R.M., Tormey S., Hardy N.P., Neary P.M., Muallem-Kalmovich L., Kugler N., Lavy R., Horesh N., Vergari R., Mochet S., Barmasse R., Usai A., Morelli L., Picciariello A., Papagni V., Altomare D.F., Colledan M., Zambelli M.F., Tornese S., Camillo A., Rausa E., Bianco F., 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S., Markaryan D., Kazachenko E., Yanishev A., Abelevich A., Bazaev A., Kokobelyan A., Zarubenko P., Zakharenko A., Novikova A., Kim G., Shmatov D., Stoliarov M., Kamenskikh M., Nambi G., Almulhim A.S., Madkhali T., Alzouhir A., Alissa A., Alameer E., Badedi M., Alnami A.Q., Darraj H., Alkhuzaie A., Khadwardi F., Abualjadayel M., Tashkandi W., Farsi A., Malibary N., Trabulsi N., Farsi S., Said Bayazeed A., Nasser M., Siddiqui M.S., Al Awwad S., Alshahrani M., Alsharif F., Fahmi M.W., Gudal A., Alasmari A., Alqahtani S., Majrashi S., Mashat A., Al Raddadi R., Alharbi A., Nasser Y., Hamayel H., Alhojaili A., Aljohani R., Sogair O., Alfarhan O., Alzahrani A., Alzomaili B., Azab M.A., Alotaibi M., Maashi A., Zowgar A., Alsakkaf M., Alnemary M., Khayat S., Felmban S., Almhmadi A., Alqannas M., Cortes Guiral D., Alyami M., Elawad A., Alhefdhi A., Alresaini F., Kurdi W., Tulbah M., Aldakheel M., Alsahan N., Koussayer S., Elsheikh H., Al-Qattan M., Alshanafey S., Rafique A., Mahabbat N., Saeed B., Al-Kharashi E., Alsowaina K., Arab N., Aljaber F., Al Hasan I., Alghamdi A., Badahdah F., Alghuliga A., Abdulfattah F., Alanazi F., Albaqami F., Alsuhaibani A., AlFakhri A., Alqasem S., Alajaji N., Nouh T., Bin Nasser A., Alowais J., Alburakan A., Alamri O., Albdah A., Alawi K., Alshalhoub M., ElSanhoury K., Almofarreh A., Ibrahim S., Elshafie H., Osman I., Guzman T., Mutair H., Siddiqui A., Chowdhury S., Alghamdi R., Almutrafi S., Alfaifi J., D'Souza J., Alshitwi A., Alkreedees N., Alramadhan M., Alshehri M., Alobaysi S., Alshahrani A., Alshehri A., Alrashed M., Altahan T., Alsabahi T., Alhossaini R., Sbaih M., Alalawi Y., Alnwijy K., Al Ayed A., Ghedan S., Alharthi R., Awad S., Sharara M., Abdelrhman S., Althobaiti W., Srbinovic L., Perovic M., Mikovic Z., Nikolic B., Vasiljevic M., Pazin V., Mandic Markovic V., Dimitrijevic D., Zecevic N., Gregoric P., Micic D., Loncar Z., Doklestic K., Ivancevic N., Djukic V., Stojakov D., Ilic R., Savic P., Pijanovic N., Milanovic M., Radosavljevic M., Dejanovic T., Kostic M., Paskas J., Bojic S., Stevanovic P., Djuric M., Kadija M., Tulic G., Glisovic Jovanovic I., Lieske B., Kayombo E., Kruger I., De Kock M., Malan A., Ferreira C., Du Preez H., Mulder W., Noel C., Le Grange S., Lusawana O., Kies C., Steyn E., Janson J., Buitendag J.J.P., Chu K., Mihalik M., Nel R., Naidoo S., Kloppers C., Nel D., Jonas E., Pickard H., Bernon M., Almgla N., Rayamajhi S., Mugla W., Carapinha C., Hyman G.Y., Fourtounas M., Sanchez Mozo A., Aguado Lopez H., Zarate Pinedo A., Jimenez Toscano M., Alonso de la Fuente N., Mancebo G., Cecchini L., Munarriz M., Cazador Labat M., Lopez Campillo A., Martorell P., Espinosa C.A., Caja Vivancos P., Villalabeitia Ateca I., Prieto Calvo M., Marin H., Martin Playa P., Gainza A., Aragon Achig E.J., Rodriguez Fraga A., Melchor Corcostegui I., Mallabiabarrena Ormaechea G., Garcia Gutierrez J.J., Barbier L., Pesantez Peralta M.A., Jimenez Jimenez M., Municio Martin J.A., Gomez Suarez J., Garcia Opere G., Pascua Gomez L.A., Onate Aguirre M., Fernandez-Colorado A., De la Rosa-Estadella M., Gasulla-Rodriguez A., Serrano-Martin M., Peig-Font A., Junca-Marti S., Juarez-Pomes M., Garrido-Ondono S., Blasco-Torres L., Molina-Corbacho M., Maldonado-Sotoca Y., Gasset-Teixidor A., Blasco-Moreu J., Gomez Fernandez L., Cayetano Paniagua L., Izquierdo O., Ventura D., Castellanos J., Ballester Vazquez E., Sanchez Lopez A., Balague Ponz C., Targarona Soler E.M., Sanchez Cabus S., Molina Santos V., Gonzalez Lopez J.A., Medrano Caviedes R., Moral Duarte A., Espin-Basany E., Blanco-Colino R., Turrado-Rodriguez V., Lacy A.M., de Lacy F.B., Morales X., Carreras-Castaner A., Torner P., Jornet-Gibert M., Balaguer-Castro M., Renau-Cerrillo M., Camacho-Carrasco P., Vives-Barq... [Ovid has truncated this field to avoid Excel character limitations], Bravo L., Nepogodiev D., Glasbey J.C., Li E., Simoes J.F.F., Kamarajah S.K., Picciochi M., Abbott T.E.F., Ademuyiwa A.O., Arnaud A.P., Agarwal A., Brar A., Elhadi M., Mazingi D., Cardoso V.R., Lawday S., Sayyed R., Omar O.M., de la Madina A.R., Slater L., Venn M.L., Gkoutos G., Bhangu A., Karwath A., Siaw-Acheampong K., Argus L., Chaudhry D., Dawson B.E., Gujjuri R.R., Jones C.S., Khatri C., Keatley J.M., Mann H., Marson E.J., Mclean K.A., Taylor E.H., Tiwari A., Trout I.M., Wilkin R.J.W., Dajti I., Gjata A., Boccalatte L., Modolo M.M., Cox D., Pockney P., Townend P., Aigner F., Kronberger I., Hossain K., VanRamshorst G., Lawani I., Ataide G., Baiocchi G., Buarque I., Gohar M., Slavchev M., Martin J., Olivos M., Calvache J., Rivera C.J.P., Hadzibegovic A.D., Kopjar T., Mihanovic J., Klat J., Novysedlak R., Christensen P., El-Hussuna A., Batista S., Lincango E., Emile S.H., Mengesha M.G., Hailu S., Tamiru H., Kauppila J., Laukkarinen J., Albertsmeiers M., Lederhuber H., Loffler M., Tabiri S., Metallidis S., Tsoulfas G., Lorena M.A., Grecinos G., Mersich T., Wettstein D., Ghosh D., Kembuan G., Brouk P., Khosravi M., Mozafari M., Adil A., Mohan H.M., Zmora O., Fiore M., Gallo G., Pata F., Pellino G., Satoi S., Ayasra F., Chaar M., Fakhradiyev I.R., Jamal M., Gulla A., Roslani A., Martinez L., De La Medina A.R., Outani O., Jonker P., Kruijff S., Noltes M., Steinkamp P., van der Plas W., Osinaike B., Seyiolajide J., Williams E., Pejkova S., Augestad K.M., Soreide K., Al Balushi Z., Qureshi A., Daraghmeh M.A.M., Abukhalaf S., Cukier M., Gomez H., Shu S., Vasquez X., Parreno-Sacdalan M.D., Major P., Azevedo J., Cunha M., Santos I., Zarour A., Bonci E.-A., Negoi I., Efetov S., Litvin A., Ntirenganya F., Al Ameer E., Radenkovic D., Xiang F.K.H., Hoe C.M., Yong J.N.C., Moore R., Nhlabathi N., Colino R.B., Bravo A.M., Minaya-Bravo A., Jayarajah U., Wickramasinghe D., Elmujtaba M., Jebril W., Rutegard M., Sund M., Isik A., Leventoglu S., Benson R., Caruna E., Chakrabortee S., Demetriades A., Desai A., Drake T.D., Edwards J.G., Evans J.P., Ford S., Fotopoulou C., Griffiths E., Hutchinson P., Jenkinson M.D., Khan T., Knight S., Kolias A., Leung E., McKay S., Norman L., Ots R., Raghavan V., Roberts K., Schache A., Shaw R., Shaw K., Smart N., Stewart G., Sundar S., Vimalchandran D., Wright N., Alshryda S., Alser O., Breen K., Ganly I., Kaafarani H., Kendall B., Mashbari H., Al Naggar H., Valenzuela J.I., Boccalatte L.A., Gemelli N.A., Smith D.E., Dudi-Venkata N.N., Kroon H.M., Sammour T., Roberts M., Mitchell D., Lah K., Pearce A., Morton A., Dawson A.C., Drane A., Sharpin C., Nataraja R.M., Pacilli M., Cox D.R.A., Muralidharan V., Riddiough G.E., Clarke E.M., Jamel W., Qin K.R., Cope D., Egoroff N., Lott N., Putnis S., De Robles S., Ang Z., Mitteregger M., Uranitsch S., Stiegler M., Seitinger G., Lumenta D.B., Nischwitz S.P., Richtig E., Pau M., Srekl-Filzmaier P., Eibinger N., Michelitsch B., Fediuk M., Papinutti A., Seidel G., Kahn J., Cohnert T.U., Messner F., Ofner D., Presl J., Varga M., Weitzendorfer M., Emmanuel K., Binder A.D., Zimmermann M., Holawe S., Nkenke E., Grimm C., Kranawetter M., Rahman Mitul A., Islam N., Karim S., Komen N., Ang E., De Praetere H., Tollens T., Schols G., Smets C., Haenen L., Quintens J., Van Belle K., Van Ramshorst G.H., Pattyn P., Desender L., Martens T., Van de Putte D., Lerut P., Grimonprez A., Janssen M., De Smul G., Wallaert P., Van den Eynde J., Oosterlinck W., Van den Eynde R., Sermon A., Boeckxstaens A., Cordonnier A., De Coster J., Jaekers J., Politis C., Miserez M., Duchateau N., De Gheldere C., Flamey N., Christiano A., Guidi B., Minussi A.L., Castro S., Okoba W., Maldonado F.H.R., Oliveira P., Baldasso T., Santos L., Gomes G.M.A., Buarque I.L., Pol-Fachin L., Bezerra T.S., Barros A.V., da Silva A.M.R., Leite A.L.S., Silvestre D.W.A., Ferro C.C., Araujo M.S., Lopes L.M., Damasceno P.D., Araujo D.H.S., Laporte G., Salem M.C., 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Steinmetz O., MacKenzie K., Lukaszewski M., Jamjoum G., Richebe P., Verdonck O., Discepola S., Godin N., Idrissi M., Briatico D., Sharma S., Talwar G., Bailey K., Lecluyse V., Cote G., Demyttenaere S., Garfinkle R., Kouyoumdjian A., Dumitra S., Khwaja K., Luo L., Berry G., Liberman A.S., Schmid S., Spicer J., Al Farsi M., Abou-Khalil J., Couture E., Mohammadi S., Tremblay H., Gagne N., Bergeron A., Turgeon A.F., Costerousse O., Bellemare D., Babin C., Blier C., Wood M.L., Persad A., Groot G., Pham H., D'Aragon F., Carbonneau E., Bouchard M., Masse M., Pesant F., Heroux J., Karanicolas P., Hallet J., Nadler A., Nathens A., Ko M., Mayson K., Kidane B., Srinathan S., Escudero M.I., Reyes J.T., Ramirez Nieto P., Sepulveda R., Bolbaran A., Molero A., Ruiz I., Reyes G.P., Salas R., Suazo C., Munoz R., Grasset E., Inzunza M., Besser N., Irarrazaval M.J., Jarry C., Bellolio F., Romero Manqui C.A., Ruiz Esquide M., Fuentes T., Campos J., Perez Rivera C.J., Cabrera P.A., Pinilla R.E., Guevara O., Jimenez Ramirez L.J., Velasquez Cuasquen B.G., Herrera Mora D.R., Bonilla A., Diaz S., Manrique E., Facundo H., Velez Bernal J.L., Angel J., Garcia M., Guzman L., Lehmann C., Cervera S., Trujillo Sanchez L.M., Guevara R., Valbuena D., Suarez L., Jimenez G., Velandia A., Vargas J., Espinosa J., Rey S., Mendoza Quevedo J., Calvache J.A., Orozco-Chamorro C.M., Sanchez-Gomez T.A., Rojas-Tejada D.A., Bakmaz B., Rakvin I., Sulen N., Andabaka T., Luksic I., Mamic M., Martinek L., Skrovina M., Zatecky J., Peteja M., Kristensen H.O., Mekhael M., Westh L., Smith H., Haugstvedt A.F., Jonsson M.L., Crespo A., Rodriguez-Abreu J., Tactuk N., Diaz-Delgado P.J., Rivas R., Sarmiento-Bobadilla J.A., Ashoush F., Samir Abdelaal A., Qatora M.S., Elsayed Hewalla M.E., Metwalli M., Atta R., Abdelmajeed A., Abosamak N.E., Sabry A., Shehata S., Sallam I., Amira G., Sherief M., Sherif A., Salem H., Hamdy R., Aboulkassem H., Ghaly G., Sherif G., Morsi A., Abdelrahman A., Omnia A., Tawheed A., El Kassas M., 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Kauppila J.H., Sarjanoja E., Testelin S., Dakpe S., Devauchelle B., Bettoni J., Lavagen N., Schmitt F., Lemee J.M., Boucher S., Breheret R., Kun-Darbois J.D., Kahn A., Gueutier A., Bigot P., Borraccino B., Lakkis Z., Doussot A., Heyd B., Manfredelli S., Mathieu P., Paquette B., Turco C., Barrabe A., Louvrier A., Moszkowicz D., Giovinazzo D., Bretagnol F., Police A., Charre L., Volpin E., Braham H., El Arbi N., Villefranque V., Bendjemar L., Girard E., Abba J., Trilling B., Chebaro A., Lecolle K., Truant S., El Amrani M., Zerbib P., Pruvot F.R., Mathieu D., Surmei E., Mattei L., Christou N., Ballouhey Q., Ferrero P., Coste Mazeau P., Tricard J., Barrat B., Taibi A., Usseglio J., Laloze J., Salle H., Fourcade L., Duchalais E., Regenet N., Rigaud J., Waast D., Denis W., Malard O., Buffenoir K., Espitalier F., Ferron C., Varenne Y., Crenn V., De Vergie S., Cristini J., Samarut E., Tzedakis S., Bouche P.A., Gaujoux S., Kantor E., Gossot D., Seguin-Givelet A., Fuks D., Grigoroiu M., Sanchez Salas R., Cathelineau X., Macek P., Barbe Y., Rozet F., Barret E., Mombet A., Cathala N., Brian E., Zadegan F., Conso C., Blanc T., Broch A., Sarnacki S., Ali L., Bonnard A., Peycelon M., Hervieux E., Clermidi P., Maisonneuve E., Aubry E., Thomin A., Langlais T., Passot G., Glehen O., Cotte E., Lifante J.C., De Simone B., Chouillard E., Violas P., Bergeat D., Merdrignac A., Scalabre A., Perotto L.O., Le Roy B., Haddad E., Vermersch S., Ezanno A.C., Barbier O., Vigouroux F., Malgras B., Aime A., Seeliger B., Mutter D., Philouze G., Pessaux P., Germain A., Chanty H., Ayav A., Kassir R., Von Theobald P., Sauvat F., O'Connor J., Mayombo Idiata M., O'Connor Z., Tchoba S., Modabber A., Winnand P., Holzle F., Sommer B., Shiban E., Wolf S., Anthuber M., Sommer F., Kaemmerer D., Schreiber T., Kamphues C., Lauscher J.C., Schineis C., Loch F.N., Beyer K., Nasser S., Sehouli J., Hohn P., Braumann C., Reinkemeier F., Uhl W., Weitz J., Bork U., Welsch T., Praetorius C., Korn S., Distler M., Fluegen G., Knoefel W.T., Vay C., Golcher H., Grutzmann R., Binder J., Meister P., Gallinat A., Paul A., Schnitzbauer A.A., Thoenissen P., El Youzouri H., Schreckenbach T., Nguyen T.A., Eberbach H., Bayer J., Erdle B., Sandkamp R., Nitschke C., Izbicki J., Uzunoglu F.G., Koenig D., Gosau M., Bottcher A., Heuer A., Klatte T.O., Priemel M., Betz C.S., Burg S., Mockelmann N., Busch C.J., Bewarder J., Zeller N., Smeets R., Thole S., Vollkommer T., Speth U., Stangenberg M., Hakami I., Boeker C., Mall J., Schardey H.M., von Ahnen T., von Ahnen M., Brunner U., Tapking C., Kneser U., Hirche C., Jung M., Kowalewski K.F., Kienle P., Reissfelder C., Seyfried S., Herrle F., Hardt J., Galata C., Birgin E., Rahbari N., Vassos N., Stoleriu M.G., Hatz R., Albertsmeier M., Borner N., Lampert C., Werner J., Kuehlmann B., Prantl L., Brunner S.M., Schlitt H.J., Brennfleck F., Pfister K., Oikonomou K., Reinhard T., Nowak K., Ronellenfitsch U., Kleeff J., Delank K.S., Michalski C.W., Szabo G., Widyaningsih R., Stavrou G.A., Bschorer R., Mielke J., Peschel T., Konigsrainer A., Quante M., Loffler M.W., Yurttas C., Doerner J., Seiberth R., Bouchagier K., Klimopoulos S., Paspaliari D., Stylianidis G., Syllaios A., Baili E., Schizas D., Liakakos T., Charalabopoulos A., Zografos C., Spartalis E., Manatakis D.K., Tasis N., Antonopoulou M.I., Xenaki S., Xynos E., Chrysos E., Athanasakis E., Tsiaousis J., Lostoridis E., Tourountzi P., Tzovaras G., Tepetes K., Zacharoulis D., Baloyiannis I., Perivoliotis K., Hajiioannou J., Korais C., Gkrinia E., Skoulakis C.E., Saratziotis A., Koukoura O., Symeonidis D., Diamantis A., Christou C.D., Tooulias A., Papadopoulos V., Anthoulakis C., Grimbizis G., Zouzoulas D., Tsolakidis D., Tatsis D., Christidis P., Loutzidou L., Ioannidis O., Astreidis I., Antoniou A., Antoniadis K., Vachtsevanos K., Paraskevopoulos K., Kalaitsidou I., Alexoudi V., Stavroglou A., Mantevas A., Michailidou D., Grivas T., Deligiannidis D., Politis S., Barrios Duarte A., Portilla A.L., Lowey M.J., Recinos G., Lopez Muralles I., Siguantay M.A., Estrada E.E., Aguilera-Arevalo M.L., Cojulun J.M., Echeverria-Davila G., Marin C., Icaza de Marin G.C., Kok S.Y., Joeng H.K.M., Chan L.L., Lim D., Novak Z., Echim T., Susztak N., Banky B., Pajan H., Islam A.A., Rahim F., Safari H., Brouki Milan P., Tizmaghz A., Rezaei Tavirani M., Ahmed A., Hussein R., Fleming C., O'Brien S., Kayyal M.Y., Daly A., Killeen S., Corrigan M., De Marchi J., Hill A., Farrell T., Davis N.F., Kearney D., Nelson T., Maguire P.J., Barry C., Farrell R., Smith L.A., Mehigan B.J., McCormick P., Larkin J.O., Fahey B.A., Rogers A., Donlon N., O'Sullivan H., Nugent T., Reynolds J.V., Donohue C., Shokuhi P., Ravi N., Fitzgerald C., Lennon P., Timon C., Kinsella J., Smith J., Boyle T., Alazawi D., Connolly E., Butt W., Croghan S.M., Manecksha R.P., Fearon N., Winter D., Heneghan H., Maguire D., Gallagher T., Conlon K., Kennedy N., Martin S., Kennelly R., Hanly A., Ng K.C., Fagan J., Geary E., Cullinane C., Carrington E., Geraghty J., McDermott E., Pritchard R., McPartland D., Boland M., Stafford A., Geoghegan J., Elliott J.A., Ridgway P.F., Gillis A.E., Bass G.A., Neary P.C., O'Riordan J.M., Kavanagh D.O., Reynolds I.S., Joyce D.P., Boyle E., Egan B., Whelan M., Elkady R., Tierney S., Connelly T.M., Earley H., Umair M., O'Connell C., Thomas A.Z., Rice D., Madden A., Bashir Y., Creavin B., Cullivan O., Owens P., Canas-Martinez A., Murphy C., Pickett L., Murphy B., Mastrosimone A., Beddy D., Arumugasamy M., Allen M., Aremu M., McCarthy C., O'Connor C., O'Connor D.B., Kent E., Malone F., Geary M., McKevitt K.L., Lowery A.J., Ryan E.J., Aherne T.M., Fowler A., Hassanin A., Hogan A.M., Collins C.G., Finnegan L., Carroll P.A., Kerin M.J., Walsh S.R., Nally D., Peirce C., Coffey J.C., Cunningham R.M., Tormey S., Hardy N.P., Neary P.M., Muallem-Kalmovich L., Kugler N., Lavy R., Horesh N., Vergari R., Mochet S., Barmasse R., Usai A., Morelli L., Picciariello A., Papagni V., Altomare D.F., Colledan M., Zambelli M.F., Tornese S., Camillo A., Rausa E., Bianco F., Lucianetti A., Prucher G.M., Baietti A.M., Ruggiero F., Maremonti P., Neri F., Ricci S., Biasini M., Zarabini A.G., Belvedere A., Bernante P., Bertoglio P., Boussedra S., Brunocilla E., Cipriani R., Cisternino G., De Crescenzo E., De Iaco P., Della Gatta A.N., Dondi G., Frio F., Jovine E., Mineo Bianchi F., Neri J., Parlanti D., Perrone A.M., Pezzuto A.P., Pignatti M., Pilu G., Pinto V., Poggioli G., Ravaioli M., Rottoli M., Schiavina R., Serenari M., Serra M., Solli P., Taffurelli M., Tanzanu M., Tesei M., Violante T., Zanotti S., Tonini V., Sartarelli L., Cervellera M., Gori A., Armatura G., Scotton G., Patauner S., Frena A., Podda M., Pisanu A., Esposito G., Frongia F., Abate E., Laface L., Casati M., Schiavo M., Casiraghi T., Sammarco G., Vescio G., Fulginiti S., Scorcia V., Giannaccare G., Carnevali A., Giuffrida M.C., Marano A., Palagi S., Di Maria Grimaldi S., Testa V., Peluso C., Borghi F., Simonato A., Puppo A., D'Agruma M., Chiarpenello R., Pellegrino L., Maione F., Cianflocca D., Pruiti Ciarello V., Giraudo G., Gelarda E., Dalmasso E., Abrate A., Daniele A., Ciriello V., Rosato F., Garnero A., Leotta L., Giacometti M., Zonta S., Lomiento D., Taglietti L., Dester S., Compagnoni B., Viotti F., Cazzaniga R., Del Giudice R., Mazzotti F., Pasini F., Ugolini G., Fabbri N., Feo C.V., Righini E., Gennari S., Chiozza M., Anania G., Urbani A., Koleva Radica M., Carcoforo P., Portinari M., Sibilla M., Anastasi A., Bartalucci B., Bellacci A., Canonico G., Capezzuoli L., Di Martino C., Ipponi P., Linari C., Montelatici M., Nelli T., Spagni G., Tirloni L., Vitali A., Agostini C., Alemanno G., Bartolini I., Bergamini C., Bruscino A., Checcucci C., De Vincenti R., Di Bella A., Fambrini M., Fortuna L., Maltinti G., Muiesan P., Petraglia F., Prosperi P., Ringressi M.N., Risaliti M., Sorbi F., Taddei A., Lizzi V., Vovola F., Arminio A., Cotoia A., Sarni A.L., Familiari P., D'Andrea G., Picotti V., 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S.H., De Vries J.P.P.M., Steinkamp P.J., Jonker P.K.C., Van der Plas W.Y., Bierman W., Janssen Y., Franken J., Oosterling S., Boerma E.G., Schweitzer D., Keulen M.H.F., Ketting S., Wegdam J.A., de Vries Reilingh T.S., Schipper E., Teeuwen P.H.E., Hendriks E.R., Van Geloven A.A.W., Emous M., Poelstra R., Teunissen M., Gerritsen S.L., Boerma D., De Reuver P.R., Thunnissen F., Vermeulen B.A.M., Groen A., Van Ginhoven T.M., Vietor C.L., van der Oest M.J.W., Vriens P.W.H.E., Houwen T., Heisterkamp J., van Petersen A.S., van der Meij W., Stevens C.T., Pronk A., Bakker W.J., Richir M.C., Vriens M.R., Filipe M.D., Uittenbogaart M., Leclercq W.K.G., Sijmons J.M.L., Vancoillie P.J., Konsten J., Van Heinsbergen M., Dekker N.A.M., den Boer F.C., Akinmade A., Adeyeye A., Enoch E., Fayose S., Okunlola A.I., Adeniyi A.A., Adeyemo O.T., Adebara I.O., Bakare A., Babalola O.F., Abiyere O.H., Banjo O.O., Olori S., Akaba O.G., Agida E.T., Abdullahi I.H., Egbuchulem I.K., Olulana D., Lawal T.A., Ogundoyin 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Martin J.A., Gomez Suarez J., Garcia Opere G., Pascua Gomez L.A., Onate Aguirre M., Fernandez-Colorado A., De la Rosa-Estadella M., Gasulla-Rodriguez A., Serrano-Martin M., Peig-Font A., Junca-Marti S., Juarez-Pomes M., Garrido-Ondono S., Blasco-Torres L., Molina-Corbacho M., Maldonado-Sotoca Y., Gasset-Teixidor A., Blasco-Moreu J., Gomez Fernandez L., Cayetano Paniagua L., Izquierdo O., Ventura D., Castellanos J., Ballester Vazquez E., Sanchez Lopez A., Balague Ponz C., Targarona Soler E.M., Sanchez Cabus S., Molina Santos V., Gonzalez Lopez J.A., Medrano Caviedes R., Moral Duarte A., Espin-Basany E., Blanco-Colino R., Turrado-Rodriguez V., Lacy A.M., de Lacy F.B., Morales X., Carreras-Castaner A., Torner P., Jornet-Gibert M., Balaguer-Castro M., Renau-Cerrillo M., Camacho-Carrasco P., and Vives-Barq... [Ovid has truncated this field to avoid Excel character limitations]
- Published
- 2021
21. Genetic diversity among botulinum neurotoxin-producing clostridial strains
- Author
-
Hill, K.K., Smith, T.J., Helma, C.H., Ticknor, L.O., Foley, B.T., Svensson, R.T., Brown, J.L., Johnson, E.A., Smith, L.A., Okinaka, R.T., Jackson, P.J., and Marks, J.D.
- Subjects
Biological diversity -- Research ,Botulinum toxin -- Research ,Clostridium botulinum -- Research ,Genetic polymorphisms -- Research ,Biological sciences - Abstract
Clostridium botulinum is a taxonomic designation for many diverse anaerobic spore-forming rod-shaped bacteria that have the common property of producing botulinum neurotoxins (BoNTs). The BoNTs are exoneurotoxins that can cause severe paralysis and death in humans and other animal species. A collection of 174 C. botulinum strains was examined by amplified fragment length polymorphism (AFLP) analysis and by sequencing of the 16S rRNA gene and BoNT genes to examine the genetic diversity within this species. This collection contained representatives of each of the seven different serotypes of botulinum neurotoxins (BoNT/A to BoNT/G). Analysis of the16S rRNA gene sequences confirmed previous identifications of at least four distinct genomic backgrounds (groups I to IV), each of which has independently acquired one or more BoNT genes through horizontal gene transfer. AFLP analysis provided higher resolution and could be used to further subdivide the four groups into subgroups. Sequencing of the BoNT genes from multiple strains of serotypes A, B, and E confirmed significant sequence variation within each serotype. Four distinct lineages within each of the BoNT A and B serotypes and five distinct lineages of serotype E strains were identified. The nucleotide sequences of the seven toxin genes of the serotypes were compared and showed various degrees of interrelatedness and recombination, as was previously noted for the nontoxic nonhemagglutinin gene, which is linked to the BoNT gene. These analyses contribute to the understanding of the evolution and phylogeny within this species and assist in the development of improved diagnostics and therapeutics for the treatment of botulism.
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- 2007
22. Fine and Domain-level Epitope Mapping of Botulinum Neurotoxin Type A Neutralizing Antibodies by Yeast Surface Display
- Author
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Levy, R., Forsyth, C.M., LaPorte, S.L., Geren, I.N., Smith, L.A., and Marks, J.D.
- Published
- 2007
- Full Text
- View/download PDF
23. Antiparkinsonian and neuroprotective effects of modafinil in the mptp-treated common marmoset
- Author
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Jenner, P., Zeng, B.-Y., Smith, L.A., Pearce, R.K.B., Tel, B., Chancharme, L., and Moachon, G.
- Published
- 2000
- Full Text
- View/download PDF
24. Potent neutralization of botulinum neurotoxin by recombinant oligoclonal antibody
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Nowakowski, A., Wang, C., Powers, D.B., Amersdorfer, P., Smith, T.J., Montgomery, V.A., Sheridan, R., Blake, R., Smith, L.A., and Marks, J.D.
- Subjects
Immunotherapy -- Physiological aspects ,Botulinum toxin ,Botulism -- Causes of ,Bioterrorism -- Prevention ,Science and technology - Abstract
The botulinum neurotoxins (BoNTs) cause the paralytic human disease botulism and are one of the highest-risk threat agents for bioterrorism. To generate a pharmaceutical to prevent or treat botulism, monoclonal antibodies (mAbs) were generated by phage display and evaluated for neutralization of BoNT serotype A (BoNT/A) in vivo. Although no single mAb significantly neutralized toxin, a combination of three mAbs (oligoclonal Ab) neutralized 450,000 50% lethal doses of BoNT/A, a potency 90 times greater than human hyperimmune globulin. The potency of oligoclonal Ab was primarily due to a large increase in functional Ab binding affinity. The results indicate that the potency of the polyclonal humoral immune response can be deconvoluted to a few mAbs binding nonoverlapping epitopes, providing a route to drugs for preventing and treating botulism and diseases caused by other pathogens and biologic threat agents. monoclonal antibody | immunotherapy | antibody engineering | vaccine | phage display
- Published
- 2002
25. Response re: ‘Neutralizing human monoclonal antibodies binding multiple serotypes of botulinum neurotoxinʼ by Garcia-Rodriguez et al., PEDS, 2011;24: 321–331.
- Author
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Garcia-Rodriguez, C., Geren, I.N., Lou, J., Conrad, F., Forsyth, C., Wen, W., Chakraborti, S., Zao, H., Manzanarez, G., Smith, T.J., Brown, J., Tepp, W.H., Liu, N., Wijesuriya, S., Tomic, M.T., Johnson, E.A., Smith, L.A., and Marks, J.D.
- Published
- 2011
- Full Text
- View/download PDF
26. Neutralizing human monoclonal antibodies binding multiple serotypes of botulinum neurotoxin
- Author
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Garcia-Rodriguez, C., Geren, I.N., Lou, J., Conrad, F., Forsyth, C., Wen, W., Chakraborti, S., Zao, H., Manzanarez, G., Smith, T.J., Brown, J., Tepp, W.H., Liu, N., Wijesuriya, S., Tomic, M.T., Johnson, E.A., Smith, L.A., and Marks, J.D.
- Published
- 2011
- Full Text
- View/download PDF
27. Affinity maturation of human botulinum neurotoxin antibodies by light chain shuffling via yeast mating
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Lou, J., Geren, I., Garcia-Rodriguez, C., Forsyth, C.M., Wen, W., Knopp, K., Brown, J., Smith, T., Smith, L.A., and Marks, J.D.
- Published
- 2010
- Full Text
- View/download PDF
28. Molecular Evolution of Antibody Affinity for Sensitive Detection of Botulinum Neurotoxin Type A
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Razai, A., Garcia-Rodriguez, C., Lou, J., Geren, I.N., Forsyth, C.M., Robles, Y., Tsai, R., Smith, T.J., Smith, L.A., Siegel, R.W., Feldhaus, M., and Marks, J.D.
- Published
- 2005
- Full Text
- View/download PDF
29. Predictability and Chaos
- Author
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Smith, L.A., primary
- Published
- 2003
- Full Text
- View/download PDF
30. Crystallisation of sodium dodecyl sulphate from aqueous solution: phase identification, crystal morphology, surface chemistry and kinetic interface roughening
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Smith, L.A., Duncan, A., Thomson, G.B., Roberts, K.J., Machin, D., and McLeod, G.
- Published
- 2004
- Full Text
- View/download PDF
31. Nano-fibrous scaffolds for tissue engineering
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Smith, L.A. and Ma, P.X.
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- 2004
- Full Text
- View/download PDF
32. Comparison of a Mechanistic Model for Nucleate Boiling with Experimental Spatio-Temporal Data
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Golobič, I., Pavlovič, E., Von Hardenberg, J., Berry, M., Nelson, R.A., Kenning, D.B.R., and Smith, L.A.
- Published
- 2004
- Full Text
- View/download PDF
33. Identification of nucleation site interactions
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von Hardenberg, Jost, Kenning, David B.R., Xing, Huijuan, and Smith, L.A.
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- 2004
- Full Text
- View/download PDF
34. Using medium-range weather forcasts to improve the value of wind energy production
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Roulston, M.S., Kaplan, D.T., Hardenberg, J., and Smith, L.A.
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- 2003
- Full Text
- View/download PDF
35. Expression, purification, and efficacy of the type A botulinum neurotoxin catalytic domain fused to two translocation domain variants
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Jensen, M.J., Smith, T.J., Ahmed, S.A., and Smith, L.A.
- Published
- 2003
- Full Text
- View/download PDF
36. Children's Rights in their Oral Health Care: How responsive are oral health professionals to children’s rights
- Author
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Smith, L.A., Tumilty, E., Foster Page, L., Thomson, W.M., and Gibson, B.J.
- Abstract
© 2018 by Koninklijke Brill NV, Leiden, The Netherlands. Research on children's rights in oral health care is lacking, and this study aims to partially fill this gap. In 2015, we conducted research in one region of New Zealand using video methods to explore the rights of 22 children during a specific oral health treatment, the placement of stainless steel crowns. Our findings show that many children did not receive a professional standard of care, there were gaps in the delivery and standard of care, and there were numerous examples of children's rights' violations. At the same time, however, some of the children's dental practitioners' actions may have been acceptable practice within the profession if children's rights have not yet fully been embedded into the practice of oral health care workers. We conclude with a discussion of the implications of our findings and suggestions for a more rights based standard of oral health care.
- Published
- 2018
37. Kell hydrometallurgical extraction of precious and base metals from flotation concentrates: piloting, engineering, and implementation advances
- Author
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Liddell K.S., Adams M.D., Muller B., Smith L.A., Liddell K.S., Adams M.D., Muller B., and Smith L.A.
- Abstract
The Kell process is cyanide-free, and eliminates emissions of sulphur dioxide, arsenic trioxide, and other toxic species often emitted by smelters and roasters. It comprises four sequential steps: aqueous pressure oxidation, atmospheric leaching, heat treatment, and atmospheric oxidative leaching. Tests on a range of concentrates, including PGMs, refractory gold-silver, copper-gold, and polymetallic concentrates have given extraction efficiencies of over 95%. When compared with smelter-refining, Kell shows economic benefits (capex 18-33% of smelting, opex 51-66%, electricity consumption 13-46%) and environmental benefits (greenhouse gas emissions 57-61% of smelting, acidification 5-27%, human toxicity 37-62%, and freshwater ecotoxicity 43-55% of smelting). Synergies for Kell plants alongside smelter-refineries include utilisation of recovered acid from sulphur abatement systems and excess capacity in precious metal refineries. Kell is unconstrained by concentrate grade and impurities, allowing the co-location of Kell plants for treatment of non-smeltable concentrates alongside existing smelters. Kell has been demonstrated in a nine-week integrated pilot campaign at a 110 000 t/a plant treating a UG2-Merensky concentrate at the Pilanesberg platinum mine in South Africa. A centralised PGM concentrate processing plant using the Kell process is also being planning in Zimbabwe., The Kell process is cyanide-free, and eliminates emissions of sulphur dioxide, arsenic trioxide, and other toxic species often emitted by smelters and roasters. It comprises four sequential steps: aqueous pressure oxidation, atmospheric leaching, heat treatment, and atmospheric oxidative leaching. Tests on a range of concentrates, including PGMs, refractory gold-silver, copper-gold, and polymetallic concentrates have given extraction efficiencies of over 95%. When compared with smelter-refining, Kell shows economic benefits (capex 18-33% of smelting, opex 51-66%, electricity consumption 13-46%) and environmental benefits (greenhouse gas emissions 57-61% of smelting, acidification 5-27%, human toxicity 37-62%, and freshwater ecotoxicity 43-55% of smelting). Synergies for Kell plants alongside smelter-refineries include utilisation of recovered acid from sulphur abatement systems and excess capacity in precious metal refineries. Kell is unconstrained by concentrate grade and impurities, allowing the co-location of Kell plants for treatment of non-smeltable concentrates alongside existing smelters. Kell has been demonstrated in a nine-week integrated pilot campaign at a 110 000 t/a plant treating a UG2-Merensky concentrate at the Pilanesberg platinum mine in South Africa. A centralised PGM concentrate processing plant using the Kell process is also being planning in Zimbabwe.
- Published
- 2019
38. An examination of the solution phase and nucleation properties of sodium, potassium and rubidium dodecyl sulphates
- Author
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Smith, L.A, Roberts, K.J, Machin, D, and McLeod, G
- Published
- 2001
- Full Text
- View/download PDF
39. Determination of the crystal structure of anhydrous sodium dodecyl sulphate using a combination of synchrotron radiation powder diffraction and molecular modelling techniques
- Author
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Smith, L.A., Hammond, R.B., Roberts, K.J., Machin, D., and McLeod, G.
- Published
- 2000
- Full Text
- View/download PDF
40. Evidence for a vesicle-mediated maintenance of store-operated calcium channels in a human embryonic kidney cell line
- Author
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Alderton, J.M., Ahmed, S.A., Smith, L.A., and Steinhardt, R.A.
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- 2000
- Full Text
- View/download PDF
41. PSY170 - IMPACT OF MULTIPLE INDICATIONS ON PRICE AND ACCESS OF DRUGS FOR AUTOIMMUNE DISEASES
- Author
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Ohanjanyan, A., primary, Edathodu, A., additional, Mukku, S.R., additional, Samuel, J., additional, and Smith, L.A., additional
- Published
- 2018
- Full Text
- View/download PDF
42. PMD159 - ASSESSMENT OF THE MARKET ACCESS POTENTIAL OF A NOVEL MEDICAL DEVICE AND APP COMBINATION FOR AN ORPHAN DISEASE
- Author
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Smith, L.A., primary, Mukku, S.R., additional, Ohanjanyan, A., additional, and Awasthi, P., additional
- Published
- 2018
- Full Text
- View/download PDF
43. PUK28 - ASSESSMENT OF CHALLENGES ASSOCIATED WITH DRUG INNOVATION IN ORPHAN RENAL DISEASE
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Maram, V., primary, Edathodu, A., additional, Ohanjanyan, A., additional, Ganesh, S., additional, and Smith, L.A., additional
- Published
- 2018
- Full Text
- View/download PDF
44. PSY145 - IMPACT OF BIOSIMILAR ENTRY ON PRICE AND UPTAKE OF BRANDED BIOLOGICS FOR THE TREATMENT OF AUTOIMMUNE DISEASES
- Author
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Ohanjanyan, A., primary, Edathodu, A., additional, Mukku, S.R., additional, Samuel, J., additional, and Smith, L.A., additional
- Published
- 2018
- Full Text
- View/download PDF
45. Chapter Four - Viral Carcinogenesis
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Smith, A.J. and Smith, L.A.
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- 2016
- Full Text
- View/download PDF
46. De Novo Pathogenic Variants in CACNA1E Cause Developmental and Epileptic Encephalopathy with Contractures, Macrocephaly, and Dyskinesias
- Author
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Helbig, K.L., Lauerer, R.J., Bahr, J.C., Souza, I.A., Myers, C.T., Uysal, B., Schwarz, N., Gandini, M.A., Huang, S., Keren, B., Mignot, C., Afenjar, A., Villemeur, T. Billette de, Heron, D., Nava, C., Valence, S., Buratti, J., Fagerberg, C.R., Soerensen, K.P., Kibaek, M., Kamsteeg, E.J., Koolen, D.A., Gunning, B., Schelhaas, H.J., Kruer, M.C., Fox, J., Bakhtiari, S., Jarrar, R., Padilla-Lopez, S., Lindstrom, K., Jin, S.C., Zeng, X., Bilguvar, K., Papavasileiou, A., Xin, Q., Zhu, C., Boysen, K., Vairo, F., Lanpher, B.C., Klee, E.W., Tillema, J.M., Payne, E.T., Cousin, M.A., Kruisselbrink, T.M., Wick, M.J., Baker, J., Haan, E., Smith, N., Corbett, M.A., MacLennan, A.H., Gecz, J., Biskup, S., Goldmann, E., Rodan, L.H., Kichula, E., Segal, E., Jackson, K.E., Asamoah, A., Dimmock, D., McCarrier, J., Botto, L.D., Filloux, F., Tvrdik, T., Cascino, G.D., Klingerman, S., Neumann, C., Wang, R., Jacobsen, J.C., Nolan, M.A., Snell, R.G., Lehnert, K., Sadleir, L.G., Anderlid, B.M., Kvarnung, M., Guerrini, R., Friez, M.J., Lyons, M.J., Leonhard, J., Kringlen, G., Casas, K., Achkar, C.M. El, Smith, L.A., Rotenberg, A., Poduri, A., Sanchis-Juan, A., Carss, K.J., Rankin, J., Zeman, A., Raymond, F.L., Blyth, M., Kerr, B., Ruiz, K., Urquhart, J., Hughes, I., Banka, S., Hedrich, U.B.S., Scheffer, I.E., Helbig, I., Zamponi, G.W., Lerche, H., et al., Helbig, K.L., Lauerer, R.J., Bahr, J.C., Souza, I.A., Myers, C.T., Uysal, B., Schwarz, N., Gandini, M.A., Huang, S., Keren, B., Mignot, C., Afenjar, A., Villemeur, T. Billette de, Heron, D., Nava, C., Valence, S., Buratti, J., Fagerberg, C.R., Soerensen, K.P., Kibaek, M., Kamsteeg, E.J., Koolen, D.A., Gunning, B., Schelhaas, H.J., Kruer, M.C., Fox, J., Bakhtiari, S., Jarrar, R., Padilla-Lopez, S., Lindstrom, K., Jin, S.C., Zeng, X., Bilguvar, K., Papavasileiou, A., Xin, Q., Zhu, C., Boysen, K., Vairo, F., Lanpher, B.C., Klee, E.W., Tillema, J.M., Payne, E.T., Cousin, M.A., Kruisselbrink, T.M., Wick, M.J., Baker, J., Haan, E., Smith, N., Corbett, M.A., MacLennan, A.H., Gecz, J., Biskup, S., Goldmann, E., Rodan, L.H., Kichula, E., Segal, E., Jackson, K.E., Asamoah, A., Dimmock, D., McCarrier, J., Botto, L.D., Filloux, F., Tvrdik, T., Cascino, G.D., Klingerman, S., Neumann, C., Wang, R., Jacobsen, J.C., Nolan, M.A., Snell, R.G., Lehnert, K., Sadleir, L.G., Anderlid, B.M., Kvarnung, M., Guerrini, R., Friez, M.J., Lyons, M.J., Leonhard, J., Kringlen, G., Casas, K., Achkar, C.M. El, Smith, L.A., Rotenberg, A., Poduri, A., Sanchis-Juan, A., Carss, K.J., Rankin, J., Zeman, A., Raymond, F.L., Blyth, M., Kerr, B., Ruiz, K., Urquhart, J., Hughes, I., Banka, S., Hedrich, U.B.S., Scheffer, I.E., Helbig, I., Zamponi, G.W., and Lerche, H., et al.
- Abstract
Item does not contain fulltext, Developmental and epileptic encephalopathies (DEEs) are severe neurodevelopmental disorders often beginning in infancy or early childhood that are characterized by intractable seizures, abundant epileptiform activity on EEG, and developmental impairment or regression. CACNA1E is highly expressed in the central nervous system and encodes the alpha1-subunit of the voltage-gated CaV2.3 channel, which conducts high voltage-activated R-type calcium currents that initiate synaptic transmission. Using next-generation sequencing techniques, we identified de novo CACNA1E variants in 30 individuals with DEE, characterized by refractory infantile-onset seizures, severe hypotonia, and profound developmental impairment, often with congenital contractures, macrocephaly, hyperkinetic movement disorders, and early death. Most of the 14, partially recurring, variants cluster within the cytoplasmic ends of all four S6 segments, which form the presumed CaV2.3 channel activation gate. Functional analysis of several S6 variants revealed consistent gain-of-function effects comprising facilitated voltage-dependent activation and slowed inactivation. Another variant located in the domain II S4-S5 linker results in facilitated activation and increased current density. Five participants achieved seizure freedom on the anti-epileptic drug topiramate, which blocks R-type calcium channels. We establish pathogenic variants in CACNA1E as a cause of DEEs and suggest facilitated R-type calcium currents as a disease mechanism for human epilepsy and developmental disorders.
- Published
- 2018
47. Selection and Mating Considering Expected Inbreeding of Future Progeny
- Author
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VanRaden, P.M. and Smith, L.A.
- Published
- 1999
- Full Text
- View/download PDF
48. Mathematical Representations of Correlations Among Yield Traits and Somatic Cell Score on Test Day
- Author
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Norman, H.D., Vanraden, P.M., Wright, J.R., and Smith, L.A.
- Published
- 1999
- Full Text
- View/download PDF
49. Productivity of strawberry plants growing under dry and wet conditions in subtropical Queensland
- Author
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Menzel, C.M., primary, Smith, L.A., additional, and Moisander, J.A., additional
- Published
- 2017
- Full Text
- View/download PDF
50. Validation of multigroup neutron cross sections and calculational methods for the advanced neutron source against the FOEHN critical experiments measurements
- Author
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Smith, L.A., primary, Gallmeier, F.X., additional, and Gehin, J.C., additional
- Published
- 1995
- Full Text
- View/download PDF
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