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1. Heterogeneous melting near the Thwaites Glacier grounding line

Author

Schmidt, BE, Washam, P, Davis, PED, Nicholls, KW, Holland, DM, Lawrence, JD, Riverman, KL, Smith, JA, Spears, A, Dichek, DJG, Mullen, AD, Clyne, E, Yeager, B, Anker, P, Meister, MR, Hurwitz, BC, Quartini, ES, Bryson, FE, Basinski-Ferris, A, Thomas, C, Wake, J, Vaughan, DG, Anandakrishnan, S, Rignot, E, Paden, J, and Makinson, K

Subjects
Earth Sciences, Oceanography, Physical Geography and Environmental Geoscience, Geology, Climate Action, General Science & Technology
Abstract

Thwaites Glacier represents 15% of the ice discharge from the West Antarctic Ice Sheet and influences a wider catchment1-3. Because it is grounded below sea level4,5, Thwaites Glacier is thought to be susceptible to runaway retreat triggered at the grounding line (GL) at which the glacier reaches the ocean6,7. Recent ice-flow acceleration2,8 and retreat of the ice front8-10 and GL11,12 indicate that ice loss will continue. The relative impacts of mechanisms underlying recent retreat are however uncertain. Here we show sustained GL retreat from at least 2011 to 2020 and resolve mechanisms of ice-shelf melt at the submetre scale. Our conclusions are based on observations of the Thwaites Eastern Ice Shelf (TEIS) from an underwater vehicle, extending from the GL to 3 km oceanward and from the ice-ocean interface to the sea floor. These observations show a rough ice base above a sea floor sloping upward towards the GL and an ocean cavity in which the warmest water exceeds 2 °C above freezing. Data closest to the ice base show that enhanced melting occurs along sloped surfaces that initiate near the GL and evolve into steep-sided terraces. This pronounced melting along steep ice faces, including in crevasses, produces stratification that suppresses melt along flat interfaces. These data imply that slope-dependent melting sculpts the ice base and acts as an important response to ocean warming.

Published
2023

2. Analysis of Nurse and Patient Preferences for Pre-Filled Pen Devices for Self-Injection of Highly Purified Human Menopausal Gonadotropin (HP-hMG, MENOPUR®)

Author

De Mesmaeker G, Calles B, and Smith JA

Subjects
fertility, ovarian stimulation, patient preference, assisted reproductive technology, gonadotropin-injection pen, Medicine (General), R5-920
Abstract

Guy De Mesmaeker,1,* Brigitte Calles,2,* Judith A Smith3,* 1Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium; 2Ferring Pharmaceuticals, Gentilly, France; 3CARE Fertility Group, Nottingham, UK*These authors contributed equally to this workCorrespondence: Judith A Smith, CARE Fertility Nottingham, John Webster House, 6 Lawrence Drive, Nottingham Business Park, Nottingham, NG8 6PZ, UK, Tel + 44 0 115 852 8100, Email judith.smith@carefertility.comPurpose: This study aimed to identify the most important attributes for a gonadotropin pen as perceived by assisted reproductive technology (ART) patients and fertility nurses, and to examine how well a prototype HP-hMG (MENOPUR®) pen reflects these preferences.Patients and Methods: This market research study incorporated a two-part survey with respondents (N=221) from Poland, Spain and the UK. Respondents included patients (n=141) who consulted a fertility specialist in the previous 2 years, and fertility nurses (n=80) who assisted in at least 75 ART cycles/year. Patients were divided into two subgroups depending on their experience with ART (experienced and naïve). Key attributes for an injection pen, as perceived by patients and nurses, were assessed via an online survey and ranked by their relative importance using Anchored Maximum Difference Scaling. After performing a dummy injection, respondents compared the attributes of an unbranded prototype pen against the key attributes identified.Results: Across all survey respondents, the ability to correct the dialed dose was considered to be the most important product attribute of a gonadotropin pen. Confidence in the patient’s ability to inject correctly at home was also identified as a key attribute, considered by both nurses and naïve patients as extremely high. When considering the prototype pen device, almost all study respondents reported a positive experience (99%) with 72% rating it as “very good”. The prototype pen was perceived to possess the key attributes considered important for a gonadotropin pen by patients and nurses, including correcting the dose, the ability to self-inject safely and correctly, ease of preparation and use, and an injection which appeared to be as painless as possible.Conclusion: The prototype pen was found to perform well across all key attributes, especially those considered most important in gonadotropin pens, suggesting that it is a user-friendly option for patients undergoing ART.Graphical Abstract: Keywords: fertility, ovarian stimulation, patient preference, assisted reproductive technology, gonadotropin-injection pen

Published
2023

3. Correction: Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

Author

Liang, J, Le, TH, Velez Edwards, DR, Tayo, BO, Gaulton, KJ, Smith, JA, Lu, Y, Jensen, RA, Chen, G, Yanek, LR, Schwander, K, Tajuddin, SM, Sofer, T, Kim, W, Kayima, J, McKenzie, CA, Fox, E, Nalls, MA, Young, JH, Sun, YV, Lane, JM, Cechova, S, Zhou, J, Tang, H, Fornage, M, Musani, SK, Wang, H, Lee, J, Adeyemo, A, Dreisbach, AW, Forrester, T, Chu, P-L, Cappola, A, Evans, MK, Morrison, AC, Martin, LW, Wiggins, KL, Hui, Q, Zhao, W, Jackson, RD, Ware, EB, Faul, JD, Reiner, AP, Bray, M, Denny, JC, Mosley, TH, Palmas, W, Guo, X, Papanicolaou, GJ, Penman, AD, Polak, JF, Rice, K, Taylor, KD, Boerwinkle, E, Bottinger, EP, Liu, K, Risch, N, Hunt, SC, Kooperberg, C, Zonderman, AB, Laurie, CC, Becker, DM, Cai, J, Loos, RJF, Psaty, BM, Weir, DR, Kardia, SLR, Arnett, DK, Won, S, Edwards, TL, Redline, S, Cooper, RS, Rao, DC, Rotter, JI, Rotimi, C, Levy, D, Chakravarti, A, Zhu, X, and Franceschini, N

Abstract

[This corrects the article DOI: 10.1371/journal.pgen.1006728.].

Published
2018

4. GWAS for executive function and processing speed suggests involvement of the CADM2 gene

Author

Ibrahim-Verbaas, CA, Bressler, J, Debette, S, Schuur, M, Smith, AV, Bis, JC, Davies, G, Trompet, S, Smith, JA, Wolf, C, Chibnik, LB, Liu, Y, Vitart, V, Kirin, M, Petrovic, K, Polasek, O, Zgaga, L, Fawns-Ritchie, C, Hoffmann, P, Karjalainen, J, Lahti, J, Llewellyn, DJ, Schmidt, CO, Mather, KA, Chouraki, V, Sun, Q, Resnick, SM, Rose, LM, Oldmeadow, C, Stewart, M, Smith, BH, Gudnason, V, Yang, Q, Mirza, SS, Jukema, JW, deJager, PL, Harris, TB, Liewald, DC, Amin, N, Coker, LH, Stegle, O, Lopez, OL, Schmidt, R, Teumer, A, Ford, I, Karbalai, N, Becker, JT, Jonsdottir, MK, Au, R, Fehrmann, RSN, Herms, S, Nalls, M, Zhao, W, Turner, ST, Yaffe, K, Lohman, K, van Swieten, JC, Kardia, SLR, Knopman, DS, Meeks, WM, Heiss, G, Holliday, EG, Schofield, PW, Tanaka, T, Stott, DJ, Wang, J, Ridker, P, Gow, AJ, Pattie, A, Starr, JM, Hocking, LJ, Armstrong, NJ, McLachlan, S, Shulman, JM, Pilling, LC, Eiriksdottir, G, Scott, RJ, Kochan, NA, Palotie, A, Hsieh, Y-C, Eriksson, JG, Penman, A, Gottesman, RF, Oostra, BA, Yu, L, DeStefano, AL, Beiser, A, Garcia, M, Rotter, JI, Nöthen, MM, Hofman, A, Slagboom, PE, Westendorp, RGJ, Buckley, BM, Wolf, PA, Uitterlinden, AG, Psaty, BM, Grabe, HJ, Bandinelli, S, and Chasman, DI

Subjects
Biological Psychology, Clinical and Health Psychology, Psychology, Human Genome, Neurosciences, Genetics, Clinical Research, Aging, Aetiology, 2.1 Biological and endogenous factors, Aged, Aged, 80 and over, Cell Adhesion Molecules, Cognition, Cohort Studies, Executive Function, Female, Genetic Association Studies, Genetic Variation, Genome-Wide Association Study, Genomics, Humans, Introns, Male, Middle Aged, Neuropsychological Tests, Polymorphism, Single Nucleotide, White People, gamma-Aminobutyric Acid, Generation Scotland, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information processing speed in non-demented older adults from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium. Neuropsychological testing was available for 5429-32,070 subjects of European ancestry aged 45 years or older, free of dementia and clinical stroke at the time of cognitive testing from 20 cohorts in the discovery phase. We analyzed performance on the Trail Making Test parts A and B, the Letter Digit Substitution Test (LDST), the Digit Symbol Substitution Task (DSST), semantic and phonemic fluency tests, and the Stroop Color and Word Test. Replication was sought in 1311-21860 subjects from 20 independent cohorts. A significant association was observed in the discovery cohorts for the single-nucleotide polymorphism (SNP) rs17518584 (discovery P-value=3.12 × 10(-8)) and in the joint discovery and replication meta-analysis (P-value=3.28 × 10(-9) after adjustment for age, gender and education) in an intron of the gene cell adhesion molecule 2 (CADM2) for performance on the LDST/DSST. Rs17518584 is located about 170 kb upstream of the transcription start site of the major transcript for the CADM2 gene, but is within an intron of a variant transcript that includes an alternative first exon. The variant is associated with expression of CADM2 in the cingulate cortex (P-value=4 × 10(-4)). The protein encoded by CADM2 is involved in glutamate signaling (P-value=7.22 × 10(-15)), gamma-aminobutyric acid (GABA) transport (P-value=1.36 × 10(-11)) and neuron cell-cell adhesion (P-value=1.48 × 10(-13)). Our findings suggest that genetic variation in the CADM2 gene is associated with individual differences in information processing speed.

Published
2016

6. Prolonged survival in patients >= 60 years with first relapsed/refractory acute myeloid leukemia treated with vosaroxin plus cytarabine vs placebo plus cytarabine: Results from the phase 3 VALOR study

Author

Krug, U, Ravandi, F, Ritchie, EK, Sayar, H, Lancet, JE, Craig, MD, Vey, N, Strickland, SA, Schiller, GJ, Jabbour, E, Erba, HP, Pigneux, A, Horst, H-A, Recher, C, Klimek, VM, Cortes, J, Roboz, GJ, Craig, AR, Fox, JA, Ward, R, Smith, JA, Acton, G, Mehta, C, Kantarjian, HM, and Stuart, RK

Published
2015

7. Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).

Author

Davies, G, Armstrong, N, Bis, JC, Bressler, J, Chouraki, V, Giddaluru, S, Hofer, E, Ibrahim-Verbaas, CA, Kirin, M, Lahti, J, van der Lee, SJ, Le Hellard, S, Liu, T, Marioni, RE, Oldmeadow, C, Postmus, I, Smith, AV, Smith, JA, Thalamuthu, A, Thomson, R, Vitart, V, Wang, J, Yu, L, Zgaga, L, Zhao, W, Boxall, R, Harris, SE, Hill, WD, Liewald, DC, Luciano, M, Adams, H, Ames, D, Amin, N, Amouyel, P, Assareh, AA, Au, R, Becker, JT, Beiser, A, Berr, C, Bertram, L, Boerwinkle, E, Buckley, BM, Campbell, H, Corley, J, De Jager, PL, Dufouil, C, Eriksson, JG, Espeseth, T, Faul, JD, Ford, I, Generation Scotland, Gottesman, RF, Griswold, ME, Gudnason, V, Harris, TB, Heiss, G, Hofman, A, Holliday, EG, Huffman, J, Kardia, SLR, Kochan, N, Knopman, DS, Kwok, JB, Lambert, J-C, Lee, T, Li, G, Li, S-C, Loitfelder, M, Lopez, OL, Lundervold, AJ, Lundqvist, A, Mather, KA, Mirza, SS, Nyberg, L, Oostra, BA, Palotie, A, Papenberg, G, Pattie, A, Petrovic, K, Polasek, O, Psaty, BM, Redmond, P, Reppermund, S, Rotter, JI, Schmidt, H, Schuur, M, Schofield, PW, Scott, RJ, Steen, VM, Stott, DJ, van Swieten, JC, Taylor, KD, Trollor, J, Trompet, S, Uitterlinden, AG, Weinstein, G, Widen, E, Windham, BG, Jukema, JW, and Wright, AF

Subjects
Generation Scotland, Humans, Genetic Predisposition to Disease, HMGN1 Protein, Cohort Studies, Cognition, Cognition Disorders, Neuropsychological Tests, Phenotype, Polymorphism, Single Nucleotide, Aged, Aged, 80 and over, Middle Aged, Scotland, Female, Male, Atherosclerosis, Genome-Wide Association Study, and over, Polymorphism, Single Nucleotide, Psychiatry, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences
Abstract

General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait in middle-aged and older adults. We conducted a meta-analysis of genome-wide association studies of 31 cohorts (N=53,949) in which the participants had undertaken multiple, diverse cognitive tests. A general cognitive function phenotype was tested for, and created in each cohort by principal component analysis. We report 13 genome-wide significant single-nucleotide polymorphism (SNP) associations in three genomic regions, 6q16.1, 14q12 and 19q13.32 (best SNP and closest gene, respectively: rs10457441, P=3.93 × 10(-9), MIR2113; rs17522122, P=2.55 × 10(-8), AKAP6; rs10119, P=5.67 × 10(-9), APOE/TOMM40). We report one gene-based significant association with the HMGN1 gene located on chromosome 21 (P=1 × 10(-6)). These genes have previously been associated with neuropsychiatric phenotypes. Meta-analysis results are consistent with a polygenic model of inheritance. To estimate SNP-based heritability, the genome-wide complex trait analysis procedure was applied to two large cohorts, the Atherosclerosis Risk in Communities Study (N=6617) and the Health and Retirement Study (N=5976). The proportion of phenotypic variation accounted for by all genotyped common SNPs was 29% (s.e.=5%) and 28% (s.e.=7%), respectively. Using polygenic prediction analysis, ~1.2% of the variance in general cognitive function was predicted in the Generation Scotland cohort (N=5487; P=1.5 × 10(-17)). In hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with Alzheimer's disease: TOMM40, APOE, ABCG1 and MEF2C.

Published
2015

9. Unilateral nevoid telangiectasia syndrome (UNTS) associated with chronic Hepatitis C virus and positive immunoreactivity for VEGF

Author

Smith, JA, Kamangar, F, Prakash, N, Fung, MA, Konia, T, and Fazel, N

Abstract

Unilateral Nevoid Telangectasia Syndrome (UNTS) is characterized by superficial telangiectasias in a unilateral distribution. Vascular endothelial growth factor (VEGF) may play a role in the pathogenesis of UNTS in patients with underlying hepatic disease.  We report a case of a patient with UNTS accompanied by chronic hepatitis C virus infection, with a normal serum estrogen profile and strong positive immunohistochemical staining of lesional skin with VEGF.

Published
2014

10. Genetics of coronary artery calcification among African Americans, a meta-analysis

Author

Wojczynski, MK, Li, M, Bielak, LF, Kerr, KF, Reiner, AP, Wong, ND, Yanek, LR, Qu, L, White, CC, Lange, LA, Ferguson, JF, He, J, Young, T, Mosley, TH, Smith, JA, Kral, BG, Guo, X, Wong, Q, Ganesh, SK, Heckbert, SR, Griswold, ME, O'Leary, DH, Budoff, M, Carr, JJ, Taylor, HA, Bluemke, DA, Demissie, S, Hwang, SJ, Paltoo, DN, Polak, JF, Psaty, BM, Becker, DM, Province, MA, Post, WS, O'Donnell, CJ, Wilson, JG, Harris, TB, Kavousi, M, Cupples, LA, Rotter, JI, Fornage, M, Becker, LC, Peyser, PA, Borecki, IB, and Reilly, MP

Abstract

Background: Coronary heart disease (CHD) is the major cause of death in the United States. Coronary artery calcification (CAC) scores are independent predictors of CHD. African Americans (AA) have higher rates of CHD but are less well-studied in genomic studies. We assembled the largest AA data resource currently available with measured CAC to identify associated genetic variants.Methods: We analyzed log transformed CAC quantity (ln(CAC + 1)), for association with ~2.5 million single nucleotide polymorphisms (SNPs) and performed an inverse-variance weighted meta-analysis on results for 5,823 AA from 8 studies. Heritability was calculated using family studies. The most significant SNPs among AAs were evaluated in European Ancestry (EA) CAC data; conversely, the significance of published SNPs for CAC/CHD in EA was queried within our AA meta-analysis.Results: Heritability of CAC was lower in AA (~30%) than previously reported for EA (~50%). No SNP reached genome wide significance (p < 5E-08). Of 67 SNPs with p < 1E-05 in AA there was no evidence of association in EA CAC data. Four SNPs in regions previously implicated in CAC/CHD (at 9p21 and PHACTR1) in EA reached nominal significance for CAC in AA, with concordant direction. Among AA, rs16905644 (p = 4.08E-05) had the strongest association in the 9p21 region.Conclusions: While we observed substantial heritability for CAC in AA, we failed to identify loci for CAC at genome-wide significant levels despite having adequate power to detect alleles with moderate to large effects. Although suggestive signals in AA were apparent at 9p21 and additional CAC and CAD EA loci, overall the data suggest that even larger samples and an ethnic specific focus will be required for GWAS discoveries for CAC in AA populations. © 2013 Wojczynski et al.; licensee BioMed Central Ltd.

Published
2013

11. Controlling anisotropic properties by manipulating the orientation of chiral small molecules

Author

Wade, J, Salerno, F, Kilbride, RC, Kim, DK, Schmidt, JA, Smith, JA, LeBlanc, LM, Wolpert, EH, Adeleke, AA, Johnson, ER, Nelson, J, Mori, T, Jelfs, KE, Heutz, S, and Fuchter, MJ

Subjects
General Chemical Engineering, Anisotropy, Electrons, General Chemistry
Abstract

Chiral π-conjugated molecules bring new functionality to technological applications and represent an exciting, rapidly expanding area of research. Their functional properties, such as the absorption and emission of circularly polarized light or the transport of spin-polarized electrons, are highly anisotropic. As a result, the orientation of chiral molecules critically determines the functionality and efficiency of chiral devices. Here we present a strategy to control the orientation of a small chiral molecule (2,2'-dicyano[6]helicene) by the use of organic and inorganic templating layers. Such templating layers can either force 2,2'-dicyano[6]helicene to adopt a face-on orientation and self-assemble into upright supramolecular columns oriented with their helical axis perpendicular to the substrate, or an edge-on orientation with parallel-lying supramolecular columns. Through such control, we show that low- and high-energy chiroptical responses can be independently 'turned on' or 'turned off'. The templating methodologies described here provide a simple way to engineer orientational control and, by association, anisotropic functional properties of chiral molecular systems for a range of emerging technologies.

Published
2022

12. Open-circuit and short-circuit loss management in wide-gap perovskite p-i-n solar cells

Author

Caprioglio, P, Smith, JA, Oliver, RDJ, Dasgupta, A, Choudhary, S, Farrar, MD, Ramadan, AJ, Lin, Y-H, Christoforo, MG, Ball, JM, Diekmann, J, Thiesbrummel, J, Zaininger, K-A, Shen, X, Johnston, MB, Neher, D, Stolterfoht, M, and Snaith, HJ

Subjects
Multidisciplinary, General Physics and Astronomy, General Chemistry, General Biochemistry, Genetics and Molecular Biology
Abstract

In this work, we couple theoretical and experimental approaches to understand and reduce the losses of wide bandgap Br-rich perovskite pin devices at open-circuit voltage (VOC) and short-circuit current (JSC) conditions. A mismatch between the internal quasi-Fermi level splitting (QFLS) and the external VOC is detrimental for these devices. We demonstrate that modifying the perovskite top-surface with guanidinium-Br and imidazolium-Br forms a low-dimensional perovskite phase at the n-interface, suppressing the QFLS-VOC mismatch, and boosting the VOC. Concurrently, the use of an ionic interlayer or a self-assembled monolayer at the p-interface reduces the inferred field screening induced by mobile ions at JSC, promoting charge extraction and raising the JSC. The combination of the n- and p-type optimizations allows us to approach the thermodynamic potential of the perovskite absorber layer, resulting in 1 cm2 devices with performance parameters of VOCs up to 1.29 V, fill factors above 80% and JSCs up to 17 mA/cm2, in addition to a thermal stability T80 lifetime of more than 3500 h at 85 °C.

Published
2023

13. Enhancing health and independent living for veterans with disabilities by leveraging community-based resources

Author

Hale-Gallardo J, Jia H, Delisle T, Levy CE, Osorio V, Smith JA, and Hannold EM

Subjects
independent living, veterans, disabilities, community, Medicine (General), R5-920
Abstract

Jennifer Hale-Gallardo,1 Huanguang Jia,1 Tony Delisle,2 Charles E Levy,1,3–5 Valentina Osorio,1 Jennifer A Smith,1 Elizabeth M Hannold,1,† 1Center of Innovation on Disability and Rehabilitation Research, North Florida/South Georgia Veterans Health System, 2Center for Independent Living of North Central Florida, 3Physical Medicine and Rehabilitation Service, North Florida/South Georgia Veterans Health Service, 4The Department of Occupational Therapy, College of Public Health and Health Professions, 5The Center for the Arts in Medicine, College of the Arts, University of Florida, Gainesville, FL, USA †Elizabeth M Hannold passed away on September 28, 2015. Abstract: The number of US veterans with disabilities has increased in recent years as service members have returned home with extensive injuries and veterans from previous wars acquire functional limitations as a consequence of aging with chronic diseases. Veterans with severe disabilities need assistance and support to maintain independence at home and to avoid institutionalization. The US Department of Veterans Affairs (VA) strives to network with community organizations to achieve the best possible outcomes for veterans. Key community resources in the US for individuals with disabilities are Centers for Independent Living (CILs) that provide a wide range of services, promoting independent living and well-being for people across disabilities. The widespread availability and services of CILs nationwide suggest their potential as a community-based resource for veterans, particularly for those with limited access to VA care. In this article, we discuss long-term needs of veterans with disabilities, efforts to address veterans’ rehabilitation needs at the VA and opportunities for leveraging the strengths of community-based organizations for veterans. More research is warranted to investigate CIL services and potential for CIL–VA partnerships. Keywords: rehabilitation, community engagement, community reintegration, functional limitations

Published
2017

15. Proactive breast cancer risk assessment in primary care: a review based on the principles of screening.

Author

Usher-Smith, JA, Hindmarch, S, French, DP, Tischkowitz, M, Moorthie, S, Walter, FM, Dennison, RA, Stutzin Donoso, F, Archer, S, Taylor, L, Emery, J, Morris, S, Easton, DF, Antoniou, AC, Usher-Smith, JA, Hindmarch, S, French, DP, Tischkowitz, M, Moorthie, S, Walter, FM, Dennison, RA, Stutzin Donoso, F, Archer, S, Taylor, L, Emery, J, Morris, S, Easton, DF, and Antoniou, AC

Abstract

In the UK, the National Institute for Health and Care Excellence (NICE) recommends that women at moderate or high risk of breast cancer be offered risk-reducing medication and enhanced breast screening/surveillance. In June 2022, NICE withdrew a statement recommending assessment of risk in primary care only when women present with concerns. This shift to the proactive assessment of risk substantially changes the role of primary care, in effect paving the way for a primary care-based screening programme to identify those at moderate or high risk of breast cancer. In this article, we review the literature surrounding proactive breast cancer risk assessment within primary care against the consolidated framework for screening. We find that risk assessment for women under 50 years currently satisfies many of the standard principles for screening. Most notably, there are large numbers of women at moderate or high risk currently unidentified, risk models exist that can identify those women with reasonable accuracy, and management options offer the opportunity to reduce breast cancer incidence and mortality in that group. However, there remain a number of uncertainties and research gaps, particularly around the programme/system requirements, that need to be addressed before these benefits can be realised.

Published
2023

16. Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy.

Author

Smith, JA, Tso, JY, Clark, MR, Cole, MS, and Bluestone, JA

Subjects
Lymph Nodes, T-Lymphocytes, Animals, Mice, Inbred BALB C, Mice, Inbred DBA, Mice, Phosphotyrosine, Receptors, Antigen, T-Cell, Antibodies, Monoclonal, Immunosuppression, Lymphocyte Activation, Signal Transduction, Receptor Aggregation, Clonal Anergy, Phosphorylation, ZAP-70 Protein-Tyrosine Kinase, Protein-Tyrosine Kinases, CD3 Complex, Antibodies, Monoclonal, Inbred BALB C, Inbred DBA, Receptors, Antigen, T-Cell, Medical and Health Sciences, Immunology
Abstract

Anti-CD3 monoclonal antibodies (mAbs) are potent immunosuppressive agents used in clinical transplantation. However, the activation-related adverse side effects associated with these mAbs have prompted the development of less toxic nonmitogenic anti-CD3 mAb therapies. At present, the functional and biochemical consequences of T cell exposure to nonmitogenic anti-CD3 is unclear. In this study, we have examined the early signaling events triggered by a nonmitogenic anti-CD3 mAb. Like the mitogenic anti-CD3 mAb, nonnmitogenic anti-CD3 triggered changes in the T cell receptor (TCR) complex, including zeta chain tyrosine phosphorylation and ZAP-70 association. However, unlike the mitogenic anti-CD3 stimulation, nonmitogenic anti-CD3 was ineffective at inducing the highly phosphorylated form of zeta (p23) and tyrosine phosphorylation of the associated ZAP-70 tyrosine kinase. This proximal signaling deficiency correlated with minimal phospholipase Cgamma-1 phosphorylation and failure to mobilize detectable Ca2+. Not only did biochemical signals delivered by nonmitogenic anti-CD3 resemble altered peptide ligand signaling, but exposure of Th1 clones to nonmitogenic anti-CD3 also resulted in functional anergy. Finally, a bispecific anti-CD3 X anti-CD4 F(ab)'2 reconstituted early signal transduction events and induced proliferation, suggesting that defective association of lck with the TCR complex may underlie the observed signaling differences between the mitogenic and nonmitogenic anti-CD3.

Published
1997

20. Seed banks, community dynamics and species persistence in 5 Tasmanian temporary wetlands

Author

Smith, JA

Subjects
Biogeography and phylogeography
Abstract

Water regime has been found to be the most important factor in determining vegetation patterns in wetlands. The present study investigates the short and long-term persistence of plant communities within 5 temporary Tasmanian lentic wetlands and- resistance and resilience of wetland communities to dry periods. Within each wetland an aquatic herbaceous and sedge-dominated zone were sampled seasonally between February, 1997 and November, 1998, to test difference between and within wetlands, and their relations to water depth. Four glasshouse experiments using sediments taken from 9 permanent quadrats per vegetation type per wetland (zone) were used to determine temporal and spatial differences in seed banks in relation to season, vegetation type, depth, germination treatment and water regime. The relationship between the seed bank and extant vegetation was investigated. A functional group classification generated similar groups to Brock and Casanova (1997). These were: a) submerged; b) amphibious fluctuation responder; c) amphibious fluctuation tolerator-emergent; d) amphibious fluctuation tolerator-saturated/mudflat; and e) terrestrial. The vegetation communities within the 5 temporary wetlands proved not resistant to changes in water level. Large differences in percentage cover were associated with hydrological changes over the 2 year period. However, the communities were able to resurrect relatively quickly after both short and long term dry periods. The seed bank experiments indicated that Tasmanian temporary wetlands have speciesrich persistent seed banks, and, therefore, the potential for future regeneration. In general, species in the seed bank could be related to species found in the extant vegetation. However, at any given time, species can be found in the seed bank and not present in the extant vegetation, or vice versa. Both seed banks and vegetative regeneration were important mechanisms for species persistence in the vegetation communities of the 5 wetlands.

Published
2023
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21. Validation and Meaningful Change Thresholds for an Objective Cough Frequency Measurement in Chronic Cough

Author

Smith, Jaclyn, Schelfhout, J, Nguyen, AM, Birring, SS, Bacci, ED, Vernon, M, Muccino, DR, La, Rosa C, and Smith, JA

Subjects
Pulmonary and Respiratory Medicine, Clinically meaningful change, Patient-reported outcomes, Cough, ROC Curve, Objective cough frequency, Chronic cough, Cough monitoring, Humans, Patient Reported Outcome Measures, Plastic Surgery Procedures, Pain Measurement, Cough severity
Abstract

Purpose Objective cough frequency is used to assess efficacy of chronic cough (CC) treatments. The objective of this study was to explore the relationship between objective cough frequency and cough-specific patient-reported outcomes (PROs) and estimate a clinically meaningful change threshold (MCT) for objective cough frequency. Methods Data collected in a phase 2b study in participants with refractory or unexplained CC were used to investigate the relationship between 24-h cough frequency (measured using an ambulatory cough monitor) and cough-specific PROs (i.e., cough severity visual analog scale, cough severity diary, Leicester Cough Questionnaire). Convergent validity was assessed using Spearman ρ. An MCT for 24-h cough frequency was estimated using the patient global impression of change (PGIC) scale as an anchor. Results Correlations between 24-h cough frequency and cough-specific PROs at baseline, Week 4, and Week 12 were significant (P ρ = 0.30–0.58). Participants categorized as very much improved/much improved (i.e., PGIC of 1 or 2) or minimally improved (i.e., PGIC of 3) had mean 24-h cough frequency reductions of 55% and 30%, respectively. Receiver operating characteristic curve analysis suggested that a 24-h cough frequency reduction of 38% optimizes sensitivity and specificity for predicting a PGIC score of 1–3. Conclusion Objective 24-h cough frequency is significantly associated with cough-specific PROs, but cough frequency and PROs most likely capture distinct aspects of CC. A ≥ 30% reduction in 24-h cough frequency is a reasonable MCT to define treatment response in CC clinical trials.

Published
2022

22. Synergistic Surface Modification of Tin-Lead Perovskite Solar Cells

Author

Hu, S, Zhao, P, Nakano, K, Oliver, RDJ, Pascual, J, Smith, JA, Yamada, T, Truong, MA, Murdey, R, Shioya, N, Hasegawa, T, Ehara, M, Johnston, MB, Tajima, K, Kanemitsu, Y, Snaith, HJ, and Wakamiya, A

Subjects
Mechanics of Materials, Mechanical Engineering, General Materials Science
Abstract

Interfaces in thin-film photovoltaics play a pivotal role in determining device efficiency and longevity. Herein, we study the top surface treatment of mixed tin-lead (∼1.26 eV) halide perovskite films for p-i-n solar cells. We are able to promote charge extraction by treating the perovskite surface with piperazine. This compound reacts with the organic cations at the perovskite surface, modifying the surface structure and tuning the interfacial energy level alignment. In addition, the combined treatment with C60 pyrrolidine tris-acid (CPTA) reduces hysteresis and leads to efficiencies up to 22.7%, with open-circuit voltage values reaching 0.90 V, ∼92% of the radiative limit for the band gap of this material. The modified cells also show superior stability, with unencapsulated cells retaining 96% of their initial efficiency after >2000 hours of storage in N2 and encapsulated cells retaining 90% efficiency after >450 hours of storage in air. Intriguingly, CPTA preferentially binds to Sn2+ sites at film surface over Pb2+ due to the energetically favoured exposure of the former, according to first-principles calculations. This work provides new insights into the surface chemistry of perovskite films in terms of their structural, electronic, and defect characteristics and we use this knowledge to fabricate state-of-the-art solar cells.

Published
2022

23. Contribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke

Author

Jaworek, T, Xu, H, Gaynor, BJ, Cole, JW, Rannikmae, K, Stanne, TM, Tomppo, L, Abedi, V, Amouyel, P, Armstrong, ND, Attia, J, Bell, S, Benavente, OR, Boncoraglio, GB, Butterworth, A, Cervical Artery Dissections and Ischemic Stroke Patients (CADSIP) Consortium, Carcel-Marquez, J, Chen, Z, Chong, M, Cruchaga, C, Cushman, M, Danesh, J, Debette, S, Duggan, DJ, Durda, JP, Engstrom, G, Enzinger, C, Faul, JD, Fecteau, NS, Fernandez-Cadenas, I, Gieger, C, Giese, A-K, Grewal, RP, Grittner, U, Havulinna, AS, Heitsch, L, Hochberg, MC, Holliday, E, Hu, J, Ilinca, A, INVENT Consortium, Irvin, MR, Jackson, RD, Jacob, MA, Janssen, RR, Jimenez-Conde, J, Johnson, JA, Kamatani, Y, Kardia, SL, Koido, M, Kubo, M, Lange, L, Lee, J-M, Lemmens, R, Levi, CR, Li, J, Li, L, Lin, K, Lopez, H, Luke, S, Maguire, J, McArdle, PF, McDonough, CW, Meschia, JF, Metso, T, Muller-Nurasyid, M, O'Connor, TD, O'Donnell, M, Peddareddygari, LR, Pera, J, Perry, JA, Peters, A, Putaala, J, Ray, D, Rexrode, K, Ribases, M, Rosand, J, Rothwell, PM, Rundek, T, Ryan, KA, Sacco, RL, Salomaa, V, Sanchez-Mora, C, Schmidt, R, Sharma, P, Slowik, A, Smith, JA, Smith, NL, Wassertheil-Smoller, S, Soederholm, M, Stine, OC, Strbian, D, Sudlow, CL, Tatlisumak, T, Terao, C, Thijs, V, Torres-Aguila, NP, Tregouet, D-A, Tuladhar, AM, Veldink, JH, Walters, RG, Weir, DR, Woo, D, Worrall, BB, Hong, CC, Ross, O, Zand, R, Leeuw, F-ED, Lindgren, AG, Pare, G, Anderson, CD, Markus, HS, Jern, C, Malik, R, Dichgans, M, Mitchell, BD, Kittner, SJ, and Early Onset Stroke Genetics Consortium of the International Stroke Genetics Consortium (ISGC)

Subjects
Neurology & Neurosurgery, 1103 Clinical Sciences, 1109 Neurosciences, 1702 Cognitive Sciences
Abstract

BACKGROUND AND OBJECTIVES: Current genome-wide association studies of ischemic stroke have focused primarily on late onset disease. As a complement to these studies, we sought to identifythe contribution of common genetic variants to risk of early onset ischemic stroke. METHODS: We performed a meta-analysis of genome-wide association studies of early onset stroke (EOS), ages 18-59, using individual level data or summary statistics in 16,730 cases and 599,237 non-stroke controls obtained across 48 different studies. We further compared effect sizes at associated loci between EOS and late onset stroke (LOS) and compared polygenic risk scores for venous thromboembolism between EOS and LOS. RESULTS: We observed genome-wide significant associations of EOS with two variants in ABO, a known stroke locus. These variants tag blood subgroups O1 and A1, and the effect sizes of both variants were significantly larger in EOS compared to LOS. The odds ratio (OR) for rs529565, tagging O1, 0.88 (95% CI: 0.85-0.91) in EOS vs 0.96 (95% CI: 0.92-1.00) in LOS, and the OR for rs635634, tagging A1, was 1.16 (1.11-1.21) for EOS vs 1.05 (0.99-1.11) in LOS; p-values for interaction = 0.001 and 0.005, respectively. Using polygenic risk scores, we observed that greater genetic risk for venous thromboembolism, another prothrombotic condition, was more strongly associated with EOS compared to LOS (p=0.008). DISCUSSION: The ABO locus, genetically predicted blood group A, and higher genetic propensity for venous thrombosis are more strongly associated with EOS than with LOS, supporting a stronger role of prothrombotic factors in EOS.

Published
2022

24. SIXTEEN Shelter from the storm

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

25. FOURTEEN Centering racial justice in the US emergency response framework

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

26. FIFTEEN Affordable housing in America

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

27. PART V Housing insecurity

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

28. Afterword

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

29. SEVENTEEN Social problems in the age of culture wars

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

30. PART VI Looking forward

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

31. Cover

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

32. Title Page, Copyright

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

33. President's welcome

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

34. Table of Contents

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

35. ONE From blame to criminalization

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

36. PART I Crime, law, and policy

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

37. Editorial introduction

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

38. Notes on contributors

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

39. About the Society for the Study of Social Problems

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

40. SEVEN Inequality in the experiential core

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

41. TWO Curbing pretextual traffic stops to reduce racial profiling

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

42. FIVE News media and the crime coverage problem

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

43. FOUR Immigration enforcement

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

44. SIX Caught in the crossfire

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

45. THREE Pay to talk

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

46. PART II Education

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

47. TEN Reproductive health in crisis

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

48. PART IV Health and healthcare

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

49. PART III Food insecurity

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

50. TWELVE Gender-affirming healthcare for transgender and gender minority youth

Author

Smith, Jason A., Nair, Manjusha, Muschert, Glenn W., Lane, David C., Dillaway, Heather, Budd, Kristen M., Bernstein, Mary, Johnson, Dana, Samara, Tony, Joseph, Tiffany, Sullivan, Teresa A., Ingel, Sydney, Webb, Sophie, Brubaker, Sarah Jane, Rose, Raquel, Ghandnoosh, Nazgol, Harrison, Monique, Van Natta, Meredith, Berezin, McKenzie, Redditt, Lindsay, Hannon, Lance, Burke, Kristen, Kerstetter, Katie, Kimpel, Jeanne, Carlisle, Hayley, Gonzalez, Gabriela, Windsor, Elroi, Bonner, Drew, Anderson, Charity, Cordes, Brooke, Silver, Blake R., Gwathney, Ashley N., and Rondini, Ashley C.

Published
2024

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