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948 results on '"Smith, Ian E."'

1. Longitudinal monitoring of circulating tumor DNA to detect relapse early and predict outcome in early breast cancer

Author

Garcia-Murillas, Isaac, Cutts, Rosalind J., Walsh-Crestani, Giselle, Phillips, Edward, Hrebien, Sarah, Dunne, Kathryn, Sidhu, Kally, Daber, Robert, Hubert, Benjamin, Graybill, Chiharu, DeFord, Peter M., Wooten, David J., Zhao, Jianhua, Ellsworth, Rachel E., Johnston, Stephen R. D., Ring, Alistair, Russell, Simon, Evans, Abigail, Skene, Anthony, Wheatley, Duncan, Smith, Ian E., Korn, W. Michael, and Turner, Nicholas C.

Published
2024
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2. HER2-enriched subtype and novel molecular subgroups drive aromatase inhibitor resistance and an increased risk of relapse in early ER+/HER2+ breast cancer

Author

Evans, Abigail, Ball, Adrian, Johri, Akhil, Nejim, Ali, Jones, Alison, Corder, Allan, Thorne, Amanda, Anand, Ambika, Chakrabarti, Amitabha, Robinson, Anne, Skene, Anthony, Modi, Anupam, Patel, Ashraf, Kothari, Ashutosh, McFall, Brendan, Mortimer, Caroline, Lee, Caroline, Chan, Charlie, Abson, Charlotte, Holcombe, Christopher, Hinton, Christopher, Hollywood, Ciaran, Murphy, Claire, Crowley, Clare, Harding-Mackean, Claudia, Griffith, Clive, Lewanski, Conrad, Rea, Daniel, Hwang, David, Crawford, Derek, Thekkinkattil, Dinesh, Ferguson, Douglas, Adamson, Douglas, Wheatley, Duncan, Ravichandran, Duraisamy, Babu, Ed, Hyett, Elaine, Ashkanani, Fawzia, Hoar, Fiona, Kenny, Frances, Dyke, Gary, Sparrow, Geoffrey, Gilbert, Cunnick, Giles, Algurafi, Hafiz, Sweetland, Helen, Prof, Highes-Davies, Hamed, Hisham, Smith, Ian, Laidlaw, Ian, Khattak, Ilyas, Newby, Jacqueline, Rees-Lee, Jacqueline, Kokan, Jalal, Barrett, Jane, Naik, Jay Dolatrai, Vaidya, Jayant, Forrest, Jennifer, Parmar, Jitendra, Adams, Jocelyn, Fox, John, Roberts, Jonathan, Dawson, Jonathan, Doughty, Julie, Donnelly, Jull, Dunn, Kathleen, Chin, Kian, Horgan, Kieran, Thakur, Kislaya, Barthelmes, Ludger, Wyld, Lynda, Bhattacharyya, Madhumita, Hadaki, Maher, Kishore, Makam, Ornstein, Marcus, Bramley, Maria, Bews-Hair, Maria, Parton, Marina, Sibbering, Mark, Kissin, Mark, Churn, Mark, Hogg, Martin, Quigley, Mary, Hatton, Matthew, Winter, Matthew, Adelekan, Matthew, Shere, Michael, Carr, Michael, Williams, Michael, Absar, Mohammed, Sharif, Muhammad, Kelleher, Muireann, Walji, Nawaz, Williams, Nicholas, Gallegos, Nicholas, Bundred, Nigel, Hatcher, Olivia, Crellin, Perric, Crane, Peter, Donnelly, Peter, Kneeshaw, Peter, Walker, Philip, Sinha, Prakash, Bhaskar, Pudhupalayam, Soulsby, Racheal, Todd, Radha, Vidya, Raghavan, Mehra, Rakesh, Prasad, Ramachandran, Cutress, Ramsay, Sharma, Ravi, Roylance, Rebecca, Goranova, Rebecca, Salman, Reem Ramzi, Bonom, Riccardo, Johnson, Richard, Sutton, Richard, Linforth, Rick, Coleman, Rob, Grieve, Robert, Leonard, Robert, Reichert, Robert, Kennedy, Robert, Agarwal, Roshan, Allerton, Rozenn, Burcombe, Russell, Davis, Ruth, Narayanan, Sankaran, Chandrasekharan, Sankaran, Vesty, Sarah, Seetharam, Seema, Ledwidge, Serena, Iqbal, Shabana, Wahee, Shamaela, Silva, Shobha, Pain, Simon, Holt, Simon, Thomson, Simon, Smith, Simon, Ellenbogen, Simon, Laws, Siobhan, Chan, Stephen, Johnston, Stephen, Holt, Steve, Thrush, Steven, McIntosh, Stuart, Chatterjee, Sumohan, Cleator, Susan, Usman, Tamoor, Johnson, Tayo, Kovacs, Tibor, Irvine, Tracey, Barthkur, Urmila, Pope, Vanessa, Brown, Victoria Alexandra, Muralikrishna, Vummiti, Samra, Walid, Maxwell, William, Winters, Zoe, Bergamino, Milana A., López-Knowles, Elena, Morani, Gabriele, Tovey, Holly, Kilburn, Lucy, Schuster, Eugene F., Alataki, Anastasia, Hills, Margaret, Xiao, Hui, Holcombe, Chris, Robertson, John F., Smith, Ian E., Bliss, Judith M., Dowsett, Mitch, and Cheang, Maggie C.U.

Published
2022
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5. Ultra-sensitive ctDNA mutation tracking to identify molecular residual disease and predict relapse in patients with early breast cancer.

Author

Garcia-Murillas, Isaac, primary, Cutts, Ros, additional, Abbott, Charles, additional, Boyle, Sean Michael, additional, Pugh, Jason, additional, Chen, Richard, additional, Dunne, Kathryn, additional, Bunce, Catey, additional, Johnston, Stephen R. D., additional, Ring, Alistair E., additional, Russell, Simon, additional, Evans, Abigail A, additional, Skene, Anthony, additional, Wheatley, Duncan, additional, Smith, Ian E, additional, and Turner, Nicholas C., additional

Published
2024
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6. Molecular profiling after short-term preoperative endocrine therapy to identify oestrogen receptor positive (ER+)/HER2+ early breast tumours with favourable prognosis.

Author

Bergamino Sirvén, Milana, primary, Lopez-Knowles, Elena, additional, Zhu, Xixuan, additional, Tovey, Holly, additional, Xiao, Hui, additional, Kilburn, Lucy, additional, Alataki, Anastasia, additional, Holcombe, Chris, additional, Skene, Anthony, additional, Smith, Ian E., additional, Robertson, John Forsyth Russell, additional, Bliss, Judith, additional, Schuster, Eugene F., additional, Dowsett, Mitchell, additional, and Cheang, Maggie Chon U, additional

Published
2024
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7. Impact of the menstrual cycle on commercial prognostic gene signatures in oestrogen receptor-positive primary breast cancer

Author

Haynes, Ben P., Schuster, Gene, Buus, Richard, Alataki, Anastasia, Ginsburg, Ophira, Quang, Le Hong, Han, Pham Thi, Khoa, Pham Hong, Van Dinh, Nguyen, Van To, Ta, Clemons, Mark, Holcombe, Chris, Osborne, Caroline, Evans, Abigail, Skene, Anthony, Sibbering, Mark, Rogers, Clare, Laws, Siobhan, Noor, Lubna, Cheang, Maggie Chon U., Cleator, Susan J., Smith, Ian E., and Dowsett, Mitch

Published
2021
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8. Updated results from the international phase III ALTTO trial (BIG 2-06/Alliance N063D)

Author

Hilbers, Florentine, El-Abed, Sarra, Balta, Vasiliki, Schurmans, Celine, Rosa, Daniela D., Saini, Kamal, Filho, Otto Metzger, McConnell, Robin, Paterson, Vicki, Campbell, Christine, McFadden, Eleanor, Paterson, Emma, Kassab, Garrick, Moreno-Aspitia, Alvaro, Holmes, Eileen M., Jackisch, Christian, de Azambuja, Evandro, Boyle, Frances, Hillman, David W., Korde, Larissa, Fumagalli, Debora, Izquierdo, Miguel A., McCullough, Ann E., Wolff, Antonio C., Pritchard, Kathleen I., Untch, Michael, Guillaume, Sébastien, Ewer, Michael S., Shao, Zhimin, Sim, Sung Hoon, Aziz, Zeba, Demetriou, Georgia, Mehta, Ajay O., Andersson, Michael, Toi, Masakazu, Lang, Istvan, Xu, Binghe, Smith, Ian E., Barrios, Carlos H., Baselga, Jose, Gelber, Richard D., and Piccart-Gebhart, Martine

Published
2021
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10. Trends and Variation in Issuance of High-Cost Narcolepsy Drugs by NHS England Organisations and Regions from 2019-2022

Author

van Someren, Frederick, primary, Wiedemann, Milan, additional, Warren-Gash, Charlotte, additional, Mistry, Hema, additional, Miller, Michelle A., additional, Leschziner, Guy, additional, Nolte, Ellen, additional, Belot, Aurélien, additional, Smith, Ian E., additional, Quinnell, Timothy, additional, Eriksson, Sofia H., additional, and Strongman, Helen, additional

Published
2024
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11. Noninvasive Detection of HER2 Amplification with Plasma DNA Digital PCR

Author

Gevensleben, Heidrun, Garcia-Murillas, Isaac, Graeser, Monika K, Schiavon, Gaia, Osin, Peter, Parton, Marina, Smith, Ian E, Ashworth, Alan, and Turner, Nicholas C

Subjects
Breast Cancer, Genetics, Cancer, Detection, screening and diagnosis, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, 4.1 Discovery and preclinical testing of markers and technologies, Adult, Aged, Aged, 80 and over, Breast Neoplasms, Chromosomes, Human, Pair 17, DNA Copy Number Variations, DNA, Neoplasm, Female, Humans, Middle Aged, Neoplasm Metastasis, Peptide Elongation Factors, Polymerase Chain Reaction, Receptor, ErbB-2, Ribonucleoprotein, U5 Small Nuclear, Receptor, erbB-2, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Digital PCR is a highly accurate method of determining DNA concentration. We adapted digital PCR to determine the presence of oncogenic amplification through noninvasive analysis of circulating free plasma DNA and exemplify this approach by developing a plasma DNA digital PCR assay for HER2 copy number. The reference gene for copy number assessment was assessed experimentally and bioinformatically. Chromosome 17 pericentromeric probes were shown to be suboptimal, and EFTUD2 at chromosome position 17q21.31 was selected for analysis. Digital PCR assay parameters were determined on plasma samples from a development cohort of 65 patients and assessed in an independent validation cohort of plasma samples from 58 patients with metastatic breast cancer. The sequential probability ratio test was used to assign the plasma DNA digital PCR test as being HER2-positive or -negative in the validation cohort. In the development cohort, the HER2:EFTUD2 plasma DNA copy number ratio had a receiver operator area under the curve (AUC) = 0.92 [95% confidence interval (CI), 0.86-0.99, P = 0.0003]. In the independent validation cohort, 64% (7 of 11) of patients with HER2-amplified cancers were classified as plasma digital PCR HER2-positive and 94% (44 of 47) of patients with HER2-nonamplified cancers were classified as digital PCR HER2-negative, with a positive and negative predictive value of 70% and 92%, respectively. Analysis of plasma DNA with digital PCR has the potential to screen for the acquisition of HER2 amplification in metastatic breast cancer. This approach could potentially be adapted to the analysis of any locus amplified in cancer.

Published
2013

12. Rapid Application Evolution and Integration Through Document Metamorphosis

Author

Aoki, Paul M., Smith, Ian E., and Thornton, James D.

Subjects
Computer Science - Databases, H.2.3, D.2.11, K.6.3
Abstract

The Harland document management system implements a data model in which document (object) structure can be altered by mixin-style multiple inheritance at any time. This kind of structural fluidity has long been supported by knowledge-base management systems, but its use has primarily been in support of reasoning and inference. In this paper, we report our experiences building and supporting several non-trivial applications on top of this data model. Based on these experiences, we argue that structural fluidity is convenient for data-intensive applications other than knowledge-base management. Specifically, we suggest that this flexible data model is a natural fit for the decoupled programming methodology that arises naturally when using enterprise component frameworks.

Published
2001

14. Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2

Author

Mares, Alina, Miah, Afjal H., Smith, Ian E. D., Rackham, Mark, Thawani, Aditya R., Cryan, Jenni, Haile, Pamela A., Votta, Bartholomew J., Beal, Allison M., Capriotti, Carol, Reilly, Michael A., Fisher, Don T., Zinn, Nico, Bantscheff, Marcus, MacDonald, Thomas T., Vossenkamper, Anna, Dace, Phoebe, Churcher, Ian, Benowitz, Andrew B., Watt, Gillian, Denyer, Jane, Scott-Stevens, Paul, and Harling, John D.

Published
2020
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15. Evidence-based guidelines for managing patients with primary ER+ HER2− breast cancer deferred from surgery due to the COVID-19 pandemic

Author

Dowsett, Mitch, Ellis, Matthew J., Dixon, J. Michael, Gluz, Oleg, Robertson, John, Kates, Ronald, Suman, Vera J., Turnbull, Arran K., Nitz, Ulrike, Christgen, Matthias, Kreipe, Hans, Kuemmel, Sherko, Bliss, Judith M., Barry, Peter, Johnston, Stephen R., Jacobs, Samuel A., Ma, Cynthia X., Smith, Ian E., and Harbeck, Nadia

Published
2020
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16. Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial

Author

Tutt, Andrew, Tovey, Holly, Cheang, Maggie Chon U., Kernaghan, Sarah, Kilburn, Lucy, Gazinska, Patrycja, Owen, Julie, Abraham, Jacinta, Barrett, Sophie, Barrett-Lee, Peter, Brown, Robert, Chan, Stephen, Dowsett, Mitchell, Flanagan, James M, Fox, Lisa, Grigoriadis, Anita, Gutin, Alexander, Harper-Wynne, Catherine, Hatton, Matthew Q., Hoadley, Katherine A., Parikh, Jyoti, Parker, Peter, Perou, Charles M., Roylance, Rebecca, Shah, Vandna, Shaw, Adam, Smith, Ian E., Timms, Kirsten M., Wardley, Andrew M., Wilson, Gregory, Gillett, Cheryl, Lanchbury, Jerry S., Ashworth, Alan, Rahman, Nazneen, Harries, Mark, Ellis, Paul, Pinder, Sarah E., and Bliss, Judith M.

Published
2018
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20. Menstrual cycle associated changes in hormone-related gene expression in oestrogen receptor positive breast cancer

Author

Haynes, Ben P., Ginsburg, Ophira, Gao, Qiong, Folkerd, Elizabeth, Afentakis, Maria, Buus, Richard, Quang, Le Hong, Thi Han, Pham, Khoa, Pham Hong, Dinh, Nguyen Van, To, Ta Van, Clemons, Mark, Holcombe, Chris, Osborne, Caroline, Evans, Abigail, Skene, Anthony, Sibbering, Mark, Rogers, Clare, Laws, Siobhan, Noor, Lubna, Smith, Ian E., and Dowsett, Mitch

Published
2019
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21. Supplementary Figure from Impact of Duration of Neoadjuvant Aromatase Inhibitors on Molecular Expression Profiles in Estrogen Receptor–positive Breast Cancers

Author

Bergamino, Milana A., primary, Morani, Gabriele, primary, Parker, Joel, primary, Schuster, Eugene F., primary, Leal, Mariana F., primary, López-Knowles, Elena, primary, Tovey, Holly, primary, Bliss, Judith M., primary, Robertson, John F.R., primary, Smith, Ian E., primary, Dowsett, Mitch, primary, and Cheang, Maggie C.U., primary

Published
2023
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23. Supplementary methods from Early Enrichment of ESR1 Mutations and the Impact on Gene Expression in Presurgical Primary Breast Cancer Treated with Aromatase Inhibitors

Author

Leal, Mariana Ferreira, primary, Haynes, Ben P., primary, Schuster, Eugene, primary, Yeo, Belinda, primary, Afentakis, Maria, primary, Zabaglo, Lila, primary, Martins, Vera, primary, Buus, Richard, primary, Dodson, Andrew, primary, Cheang, Maggie C.U., primary, Smith, Ian E., primary, Martin, Lesley-Ann, primary, and Dowsett, Mitch, primary

Published
2023
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24. Supplementary Data from Impact of Duration of Neoadjuvant Aromatase Inhibitors on Molecular Expression Profiles in Estrogen Receptor–positive Breast Cancers

Author

Bergamino, Milana A., primary, Morani, Gabriele, primary, Parker, Joel, primary, Schuster, Eugene F., primary, Leal, Mariana F., primary, López-Knowles, Elena, primary, Tovey, Holly, primary, Bliss, Judith M., primary, Robertson, John F.R., primary, Smith, Ian E., primary, Dowsett, Mitch, primary, and Cheang, Maggie C.U., primary

Published
2023
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26. Supplementary Data from A Marker of Homologous Recombination Predicts Pathologic Complete Response to Neoadjuvant Chemotherapy in Primary Breast Cancer

Author

Graeser, Monika, primary, McCarthy, Afshan, primary, Lord, Christopher J., primary, Savage, Kay, primary, Hills, Margaret, primary, Salter, Janine, primary, Orr, Nicholas, primary, Parton, Marina, primary, Smith, Ian E., primary, Reis-Filho, Jorge S., primary, Dowsett, Mitch, primary, Ashworth, Alan, primary, and Turner, Nicholas C., primary

Published
2023
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28. Supplementary Figures from Early Enrichment of ESR1 Mutations and the Impact on Gene Expression in Presurgical Primary Breast Cancer Treated with Aromatase Inhibitors

Author

Leal, Mariana Ferreira, primary, Haynes, Ben P., primary, Schuster, Eugene, primary, Yeo, Belinda, primary, Afentakis, Maria, primary, Zabaglo, Lila, primary, Martins, Vera, primary, Buus, Richard, primary, Dodson, Andrew, primary, Cheang, Maggie C.U., primary, Smith, Ian E., primary, Martin, Lesley-Ann, primary, and Dowsett, Mitch, primary

Published
2023
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35. Data from A Marker of Homologous Recombination Predicts Pathologic Complete Response to Neoadjuvant Chemotherapy in Primary Breast Cancer

Author

Graeser, Monika, primary, McCarthy, Afshan, primary, Lord, Christopher J., primary, Savage, Kay, primary, Hills, Margaret, primary, Salter, Janine, primary, Orr, Nicholas, primary, Parton, Marina, primary, Smith, Ian E., primary, Reis-Filho, Jorge S., primary, Dowsett, Mitch, primary, Ashworth, Alan, primary, and Turner, Nicholas C., primary

Published
2023
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40. Supplementary Tables from Early Enrichment of ESR1 Mutations and the Impact on Gene Expression in Presurgical Primary Breast Cancer Treated with Aromatase Inhibitors

Author

Leal, Mariana Ferreira, primary, Haynes, Ben P., primary, Schuster, Eugene, primary, Yeo, Belinda, primary, Afentakis, Maria, primary, Zabaglo, Lila, primary, Martins, Vera, primary, Buus, Richard, primary, Dodson, Andrew, primary, Cheang, Maggie C.U., primary, Smith, Ian E., primary, Martin, Lesley-Ann, primary, and Dowsett, Mitch, primary

Published
2023
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48. SUPPLEMENTARY FIGURE AND TABLE LEGENDS from Early Enrichment of ESR1 Mutations and the Impact on Gene Expression in Presurgical Primary Breast Cancer Treated with Aromatase Inhibitors

Author

Leal, Mariana Ferreira, primary, Haynes, Ben P., primary, Schuster, Eugene, primary, Yeo, Belinda, primary, Afentakis, Maria, primary, Zabaglo, Lila, primary, Martins, Vera, primary, Buus, Richard, primary, Dodson, Andrew, primary, Cheang, Maggie C.U., primary, Smith, Ian E., primary, Martin, Lesley-Ann, primary, and Dowsett, Mitch, primary

Published
2023
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50. Health related quality of life of women in TEACH, a randomised placebo controlled adjuvant trial of lapatinib in early stage Human Epidermal Growth Factor Receptor (HER2) overexpressing breast cancer

Author

Boyle, Frances M., Smith, Ian E., O’Shaughnessy, Joyce, Ejlertsen, Bent, Buzdar, Aman U., Fumoleau, Pierre, Gradishar, William, Martin, Miguel, Moy, Beverly, Piccart-Gebhart, Martine, Pritchard, Kathleen I., Lindquist, Deborah, Amonkar, Mayur, Huang, Yingjie, Rappold, Erica, Williams, Lisa S., Wang-Silvanto, Jing, Kaneko, Tomomi, Finkelstein, Dianne M., and Goss, Paul E.

Published
2015
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