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8. Intelligence and UN peacekeeping

Author

Smith, Hugh

Subjects
PEACEKEEPING - United Nations, UNITED NATIONS, INTELLIGENCE - United Nations
Abstract

bibliog

Published
1994

10. Why a Trump presidency won’t necessarily be as bad as you think for sustainable investing

Author

Smith, Hugh and Mba

Subjects
Inflation (Finance)
Abstract

The Inflation Reduction Act may be harder to repeal than its opponents think, Last month, the Climate Group, an international non-profit, hosted a week of meetings in partnership with the United Nations, bringing together figures from business, government, civil society and the climate [...]

Published
2024

11. Eight stocks that could offer a pleasant earning season surprise

Author

Smith, Hugh and Mba

Subjects
London Stock Exchange Group PLC -- Securities, Stocks, Securities industry, Securities industry, Company securities
Abstract

We are looking for companies positioned to surprise the market with upcoming earnings reports, What we are looking for A company that could be ready to surprise the market (in a good way) with its upcoming earnings report. We are right in the middle [...]

Published
2024

12. 4 Canadian copper firms worth watching for potential takeover

Author

Smith, Hugh and Mba

Subjects
Market trend/market analysis, Company acquisition/merger, Natural language interfaces -- Forecasts and trends, Copper industry -- Forecasts and trends -- Mergers, acquisitions and divestments, Computational linguistics -- Forecasts and trends, Language processing -- Forecasts and trends, Price gouging -- Forecasts and trends, London Stock Exchange Group PLC -- Mergers, acquisitions and divestments -- Forecasts and trends
Abstract

We are looking for copper miners worth watching in the green transition, What we are looking for A Canadian copper miner that could be a takeover target. Metal prices are highly cyclical, and it’s a cycle closely watched by investment bankers, because [...]

Published
2024

19. Introduction

Author

Smith, Hugh, Roberts, Hazel, de Grandpre, Marcel, and Harris, Robin, S.

Published
1981

23. Sources

Author

Smith, Hugh, Roberts, Hazel, de Grandpre, Marcel, and Harris, Robin, S.

Published
1981

24. Forward/avant-Propos

Author

Smith, Hugh, Roberts, Hazel, de Grandpre, Marcel, and Harris, Robin, S.

Published
1981

25. Contents

Author

Smith, Hugh, Roberts, Hazel, de Grandpre, Marcel, and Harris, Robin, S.

Published
1981

28. 10 Alberta

Author

Smith, Hugh, Roberts, Hazel, de Grandpre, Marcel, and Harris, Robin, S.

Published
1981

30. Front Matter

Author

Smith, Hugh, Roberts, Hazel, de Grandpre, Marcel, and Harris, Robin, S.

Published
1981

31. 6 Quebec/Québec

Author

Smith, Hugh, Roberts, Hazel, de Grandpre, Marcel, and Harris, Robin, S.

Published
1981

32. 9 Saskatchewan

Author

Smith, Hugh, Roberts, Hazel, de Grandpre, Marcel, and Harris, Robin, S.

Published
1981

33. 8 Manitoba

Author

Smith, Hugh, Roberts, Hazel, de Grandpre, Marcel, and Harris, Robin, S.

Published
1981

34. 7 Ontario

Author

Smith, Hugh, Roberts, Hazel, de Grandpre, Marcel, and Harris, Robin, S.

Published
1981

37. 1 General/Généralités

Author

Smith, Hugh, Roberts, Hazel, de Grandpre, Marcel, and Harris, Robin, S.

Published
1981

46. Developing a Diagnostic Multivariable Prediction Model for Urinary Tract Cancer in Patients Referred with Haematuria: Results from the IDENTIFY Collaborative Study

Author

Chaudry, Aasem, Sharma, Abhishek, Bennett, Adam, Ahmad, Adnan, Abroaf, Ahmed, Suliman, Ahmed Musa, Lloyd, Aimee, McKay, Alastair, Wong, Albert, Silva, Alberto, Schneider, Alexandre, MacKay, Alison, Knight, Allen, Grigorakis, Alkiviadis, Bdesha, Amar, Nagle, Amy, Cebola, Ana, Dhanasekaran, Ananda Kumar, Kondža, Andraž, Barcelos, André, Galosi, Andrea Benedetto, Ebur, Andrea, Minervini, Andrea, Russell, Andrew, Webb, Andrew, de Jalón, Ángel García, Desai, Ankit, Czech, Anna Katarzyna, Mainwaring, Anna, Adimonye, Anthony, Das, Arighno, Figueiredo, Arnaldo, Villers, Arnauld, Leminski, Artur, Chippagiri, Arvinda, Lal, Asim Ahmed, Yıldırım, Asıf, Voulgaris, Athanasios Marios, Uzan, Audrey, Oo, Aye Moh Moh, Younis, Ayman, Zelhof, Bachar, Mukhtar, Bashir, Ayres, Ben, Challacombe, Ben, Sherwood, Benedict, Ristau, Benjamin, Lai, Billy, Nellensteijn, Brechtje, Schreiter, Brielle, Trombetta, Carlo, Dowling, Catherine, Hobbs, Catherine, Benitez, Cayo Augusto Estigarribia, Lebacle, Cédric, Ho, Cherrie Wing Yin, Ng, Chi-Fai, Mount, Chloe, Lam, Chon Meng, Blick, Chris, Brown, Christian, Gallegos, Christopher, Higgs, Claire, Browne, Clíodhna, McCann, Conor, Plaza Alonso, Cristina, Beder, Daniel, Cohen, Daniel, Gordon, Daniel, Wilby, Daniel, Gordon, Danny, Hrouda, David, Lau, David Hua Wu, Karsza, Dávid, Mak, David, Martin-Way, David, Suthaharan, Denula, Patel, Dhruv, Carrion, Diego M, Nyanhongo, Donald, Bass, Edward, Mains, Edward, Chau, Edwin, Canelon Castillo, Elba, Day, Elizabeth, Desouky, Elsayed, Gaines, Emily, Papworth, Emma, Yuruk, Emrah, Kilic, Enes, Dinneen, Eoin, Palagonia, Erika, Xylinas, Evanguelos, Khawaja, Faizan, Cimarra, Fernando, Bardet, Florian, Kum, Francesca, Peters, Francesca, Kovács, Gábor, Tanasescu, Geroge, Hellawell, Giles, Tasso, Giovanni, Lam, Gitte, La Montagna, Giuseppe, Pizzuto, Giuseppe, Lenart, Gordan, MacLennan, Graeme, Özgür, Günal, Bi, Hai, Lyons, Hannah, Warren, Hannah, Ahmed, Hashim, Simpson, Helen, Burden, Helena, Gresty, Helena, Rios Pita, Hernado, Clarke, Holly, Serag, Hosam, Kynaston, Howard, Crawford-Smith, Hugh, Mostafid, Hugh, Otaola-Arca, Hugo, Koo, Hui Fen, Ibrahim, Ibrahim, Ouzaid, Idir, Puche-Sanz, Ignacio, Tomašković, Igor, Tinay, Ilker, Sahibzada, Iqbal, Thangasamy, Isaac, Cadena, Iván Revelo, Irani, Jacques, Udzik, Jakub, Brittain, James, Catto, James, Green, James, Tweedle, James, Hernando, Jamie Borrego, Leask, Jamie, Kalsi, Jas, Frankel, Jason, Toniolo, Jason, Raman, Jay D., Courcier, Jean, Kumaradeevan, Jeevan, Clark, Jennifer, Jones, Jennifer, Teoh, Jeremy Yuen-Chun, Iacovou, John, Kelly, John, Selph, John P., Aning, Jonathan, Deeks, Jon, Cobley, Jonathan, Olivier, Jonathan, Maw, Jonny, Herranz-Yagüe, José Antonio, Nolazco, Jose Ignacio, Cózar-Olmo, Jose Manuel, Bagley, Joseph, Jelski, Joseph, Norris, Joseph, Testa, Joseph, Meeks, Joshua, Hernandez, Juan, Vásquez, Juan Luis, Randhawa, Karen, Dhera, Karishma, Gronostaj, Katarzyna, Houlton, Kathleen, Lehman, Kathleen, Gillams, Kathryn, Adasonla, Kelvin, Brown, Kevin, Murtagh, Kevin, Mistry, Kiki, Davenport, Kim, Kitamura, Kosuke, Derbyshire, Laura, Clarke, Laurence, Morton, Lawrie, Martinez, Levin, Goldsmith, Louise, Paramore, Louise, Cormier, Luc, Dell'Atti, Lucio, Simmons, Lucy, Martinez-Piñeiro, Luis, Rico, Luis, Chan, Luke, Forster, Luke, Ma, Lulin, Moore, Madeline, Gallego, Maria Camacho, Freire, Maria José, Emberton, Mark, Feneley, Mark, Antón-Juanilla, Marta, Rivero, Marta Viridiana Muñoz, Pirša, Matea, Tallè, Matteo, Crockett, Matthew, Liew, Matthew, Trail, Matthew, Peters, Max, Cooper, Meghan, Kulkarni, Meghana, Ager, Michael, He, Ming, Li, Mo, Omran Breish, Mohamed, Tarin, Mohamed, Aldiwani, Mohammed, Matanhelia, Mudit, Pasha, Muhammad, Akalın, Mustafa Kaan, Abdullah, Nasreen, Hale, Nathan, Gadiyar, Neha, Kocher, Neil, Bullock, Nicholas, Campain, Nicholas, Pavan, Nicola, Al-Ibraheem, Nihad, Bhatt, Nikita, Bedi, Nishant, Shrotri, Nitin, Lobo, Niyati, Balderas, Olga, Kouli, Omar, Capoun, Otakar, Oteo Manjavacas, Pablo, Gontero, Paolo, Mariappan, Paramananthan, Marchiñena, Patricio Garcia, Erotocritou, Paul, Sweeney, Paul, Planelles, Paula, Acher, Peter, Black, Peter C., Osei-Bonsu, Peter K, Østergren, Peter, Smith, Peter, Willemse, Peter-Paul Michiel, Chlosta, Piotr L., Ul Ain, Qurrat, Barratt, Rachel, Esler, Rachel, Khalid, Raihan, Hsu, Ray, Stamirowski, Remigiusz, Mangat, Reshma, Cruz, Ricardo, Ellis, Ricky, Adams, Robert, Hessell, Robert, Oomen, Robert J.A., McConkey, Robert, Ritchie, Robert, Jarimba, Roberto, Chahal, Rohit, Andres, Rosado Mario, Hawkins, Rosalyn, David, Rotimi, Manecksha, Rustom P., Agrawal, Sachin, Hamid, Syed Sami, Deem, Samuel, Goonewardene, Sanchia, Swami, Satchi Kuchibhotla, Hori, Satoshi, Khan, Shahid, Mohammud Inder, Shakeel, Sangaralingam, Shanthi, Marathe, Shekhar, Raveenthiran, Sheliyan, Horie, Shigeo, Sengupta, Shomik, Parson, Sian, Parker, Sidney, Hawlina, Simon, Williams, Simon, Mazzoli, Simone, Grzegorz Kata, Slawomir, Pinheiro Lopes, Sofia, Ramos, Sónia, Rai, Sonpreet, Rintoul-Hoad, Sophie, O'Meara, Sorcha, Morris, Steve, Turner, Stacey, Venturini, Stefano, Almpanis, Stephanos, Joniau, Steven, Jain, Sunjay, Mallett, Susan, Nikles, Sven, Shahzad, Yan, Sylvia, Lee, Taeweon, Uçar, Taha, Drake, Tamsin, Toma, Tarq, Cabañuz Plo, Teresa, Bonnin, Thierry, Muilwijk, Tim, Wollin, Tim, Chu, Timothy Shun Man, Appanna, Timson, Brophy, Tom, Ellul, Tom, Austin, Tomas, Smrkolj, Tomaž, Rowe, Tracey, Sukhu, Troy, Patel, Trushar, Garg, Tullika, Çaşkurlu, Turhan, Bele, Uros, Haroon, Usman, Crespo-Atín, Víctor, Parejo Cortes, Victor, Capapé Poves, Victoria, Gnanapragasam, Vincent, Gauhar, Vineet, During, Vinnie, Kumar, Vivek, Fiala, Vojtech, Mahmalji, Wasim, Lam, Wayne, Fung Chin, Yew, Filtekin, Yigit, Chyn Phan, Yih, Ibrahim, Youssed, Glaser, Zachary A, Abiddin, Zainal Adwin, Qin, Zijian, Zotter, Zsuzsanna, Zainuddin, Zulkifli, Khadhouri, Sinan, Gallagher, Kevin M., MacKenzie, Kenneth R., Shah, Taimur T., Gao, Chuanyu, Moore, Sacha, Zimmermann, Eleanor F., Edison, Eric, Jefferies, Matthew, Nambiar, Arjun, Anbarasan, Thineskrishna, Mannas, Miles P., Marra, Giancarlo, Gómez Rivas, Juan, Marcq, Gautier, Assmus, Mark A., Claps, Francesco, Boltri, Matteo, Burnhope, Tara, Nkwam, Nkwam, Boxall, Nicholas E., Downey, Alison P., Sukhu, Troy A., Chin, Yew-Fung, Green, James S.A., Goulao, Beatriz, Nielsen, Matthew, McGrath, John S., and Kasivisvanathan, Veeru

Published
2022
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48. Dynamic structures of rare conformations involved in amyloid formation

Author

Smith, Hugh Ian, Radford, S. E., and Breeze, A. L.

Subjects
570
Abstract

In work described in this thesis the conformational landscape of a recently identified ß2m variant, D76N, was examined with NMR and state of the art molecular dynamics simulations. The D76N ß2m variant was recently identified as the first naturally occurring amyloidogenic variant of ß2m, a 99 residue, seven stranded Ig domain protein. The D76N variant of ß2m causes a hereditary, late onset and fatal systemic amyloid disease. Affected individuals are heterozygous for the D76N mutation and thus also express wild-type (WT) ß2m in the serum. Co-aggregation of D76N and WT ß2m is not observed in vivo, and D76N amyloidosis follows a distinctive disease progression from the WT ß2m associated disease, Dialysis-Related Amyloidosis, which occurs in patients undergoing long-term haemodialysis. This work aims to understand the mechanism by which the single amino acid substitution, D76N, results in a dramatically more aggregation-prone protein while maintaining the same overall native structure as WT ß2m. In this work, the structure, stability and dynamics of the D76N variant are studied with NMR spectroscopy and a range of complementary biophysical techniques. The folding intermediates of D76N and WT ß2m are also probed with real-time NMR and circular dichroism spectroscopy, revealing structural, dynamic and kinetic insights into the folding intermediates present within the D76N and WT ß2m folding pathways and their roles in aggregation. The study of the folding intermediates demonstrated that the IT -state, which is a known precursor for ß2m aggregation, is not responsible for the rapid aggregation of the D76N variant. Instead, a low-populated state, unique to D76N, in equilibrium with the native state must be responsible for D76N aggregation, consistent with the different disease progression associated with D76N. The NMR and data-guided molecular dynamics simulations presented in this thesis reveal the effects of the D76N substitution on the conformational landscape of the D76N variant and detail the structures of the low-populated states in equilibrium with the native state. Additionally, saturation mutagenesis of position 76 in D76N, carried out with a split-ßlactamase assay have demonstrated the exquisite specificity for an aspartate residue at position 76 in the ß2m structural ensemble.

Published
2018

49. 1980s: Expanding the Practice

Author

Holmes, David R., Jr., Smith, Hugh C., Vlietstra, Ronald E., Holmes Jr., David R., editor, Frye, Robert L., editor, Friedman, Paul A., editor, Hagler, Donald J, editor, Munger, Thomas M., editor, and Ritman, Erik L., editor

Published
2021
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50. 1970s: Growth and Innovation

Author

Smith, Hugh C., Holmes, David R., Jr., Vlietstra, Ronald E., Holmes Jr., David R., editor, Frye, Robert L., editor, Friedman, Paul A., editor, Hagler, Donald J, editor, Munger, Thomas M., editor, and Ritman, Erik L., editor

Published
2021
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