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6. Early‐season mass‐flowering crop cover dilutes wild bee abundance and species richness in temperate regions: A quantitative synthesis

Author

Riggi, L. G. A., primary, Raderschall, C. A., additional, Fijen, T. P. M., additional, Scheper, J., additional, Smith, H. G., additional, Kleijn, D., additional, Holzschuh, A., additional, Aguilera, G., additional, Badenhausser, I., additional, Bänsch, S., additional, Beyer, N., additional, Blitzer, E. J., additional, Bommarco, R., additional, Danforth, B., additional, González‐Varo, J. P., additional, Grab, H., additional, Le Provost, G., additional, Poveda, K., additional, Potts, S. G., additional, Rundlöf, M., additional, Steffan‐Dewenter, I., additional, Tscharntke, T., additional, Vilà, M., additional, Westphal, C., additional, Berggren, Å., additional, and Lundin, O., additional

Published
2023
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9. Early‐season mass‐flowering crop cover dilutes wild bee abundance and species richness in temperate regions: A quantitative synthesis.

Author

Riggi, L. G. A., Raderschall, C. A., Fijen, T. P. M., Scheper, J., Smith, H. G., Kleijn, D., Holzschuh, A., Aguilera, G., Badenhausser, I., Bänsch, S., Beyer, N., Blitzer, E. J., Bommarco, R., Danforth, B., González‐Varo, J. P., Grab, H., Le Provost, G., Poveda, K., Potts, S. G., and Rundlöf, M.

Subjects
SPECIES diversity, BEES, AGRICULTURAL resources, POLLINATORS, FLOWERING time, BEEKEEPING
Abstract

Pollinators benefit from increasing floral resources in agricultural landscapes, which could be an underexplored co‐benefit of mass‐flowering crop cultivation. However, the impacts of mass‐flowering crops on pollinator communities are complex and appear to be context‐dependent, mediated by factors such as crop flowering time and the availability of other flower resources in the landscape. A synthesis of research is needed to develop management recommendations for effective pollinator conservation in agroecosystems.By combining 22 datasets from 13 publications conducted in nine temperate countries (20 European, 2 North American), we investigated if mass‐flowering crop flowering time (early or late season), bloom state (during or after crop flowering) and extent of non‐crop habitat cover in the landscape moderated the effect of mass‐flowering crop cover on wild pollinator abundance and species richness in mass‐flowering crop and non‐crop habitats.During bloom, wild bee abundance and richness are negatively related to mass‐flowering crop cover. Dilution effects were predominant in crop habitats and early in the season, except for bumblebees, which declined with mass‐flowering crop cover irrespective of habitat or season. Late in the season and in non‐crop habitats, several of these negative relationships were either absent or reversed. Late‐season mass‐flowering crop cover is positively related to honeybee abundance in crop habitats and to other bee abundance in non‐crop habitats. These results indicate that crop‐adapted species, like honeybees, move to forage and concentrate on late‐season mass‐flowering crops at a time when flower availability in the landscape is limited, potentially alleviating competition for flower resources in non‐crop habitats. We found no evidence of pollinators moving from mass‐flowering crop to non‐crop habitats after crop bloom.Synthesis and applications: Our results confirm that increasing early‐season mass‐flowering crop cover dilutes wild pollinators in crop habitats during bloom. We find that dilution effects were absent late in the season. While mass‐flowering crop cultivation alone is unlikely to be sufficient for maintaining pollinators, as part of carefully designed diverse crop rotations or mixtures combined with the preservation of permanent non‐crop habitats, it might provide valuable supplementary food resources for pollinators in temperate agroecosystems, particularly later in the season when alternative flower resources are scarce. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Meta-analysis reveals that pollinator functional diversity and abundance enhance crop pollination and yield

Author

Woodcock, B. A., Garratt, M. P. D., Powney, G. D., Shaw, R. F., Osborne, J. L., Soroka, J., Lindström, S. A. M., Stanley, D., Ouvrard, P., Edwards, M. E., Jauker, F., McCracken, M. E., Zou, Y., Potts, S. G., Rundlöf, M., Noriega, J. A., Greenop, A., Smith, H. G., Bommarco, R., van der Werf, W., Stout, J. C., Steffan-Dewenter, I., Morandin, L., Bullock, J. M., and Pywell, R. F.

Published
2019
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11. Early-season mass-flowering crop cover dilutes wild bee abundance and species richness in temperate regions: A quantitative synthesis

Author

Universidad de Sevilla. Departamento de Biología Vegetal y Ecología, Deutsche Forschungsgemeinschaft / German Research Foundation (DFG), Riggi, Lea G. A., Raderschall, C. A., Fijen, T. P. M., Scheper, J., Smith, H. G., Kleijn, David, Vilà, Montserrat, Lundin, O., Universidad de Sevilla. Departamento de Biología Vegetal y Ecología, Deutsche Forschungsgemeinschaft / German Research Foundation (DFG), Riggi, Lea G. A., Raderschall, C. A., Fijen, T. P. M., Scheper, J., Smith, H. G., Kleijn, David, Vilà, Montserrat, and Lundin, O.

Abstract

1. Pollinators benefit from increasing floral resources in agricultural landscapes, which could be an underexplored co-benefit of mass-flowering crop cultivation. However, the impacts of mass-flowering crops on pollinator communities are complex and appear to be context-dependent, mediated by factors such as crop flowering time and the availability of other flower resources in the landscape. A synthesis of research is needed to develop management recommendations for effective pollinator conservation in agroecosystems. 2. By combining 22 datasets from 13 publications conducted in nine temperate countries (20 European, 2 North American), we investigated if mass-flowering crop flowering time (early or late season), bloom state (during or after crop flowering) and extent of non-crop habitat cover in the landscape moderated the effect of mass-flowering crop cover on wild pollinator abundance and species richness in mass-flowering crop and non-crop habitats. 3. During bloom, wild bee abundance and richness are negatively related to mass-flowering crop cover. Dilution effects were predominant in crop habitats and early in the season, except for bumblebees, which declined with mass-flowering crop cover irrespective of habitat or season. Late in the season and in non-crop habitats, several of these negative relationships were either absent or reversed. Late-season mass-flowering crop cover is positively related to honeybee abundance in crop habitats and to other bee abundance in non-crop habitats. These results indicate that crop-adapted species, like honeybees, move to forage and concentrate on late-season mass-flowering crops at a time when flower availability in the landscape is limited, potentially alleviating competition for flower resources in non-crop habitats. We found no evidence of pollinators moving from mass-flowering crop to non-crop habitats after crop bloom. 4. Synthesis and applications: Our results confirm that increasing early-season mass-flowering crop cov

Published
2023

12. Differences in adjuvant chemotherapy and oncological outcomes according to margin status in patients with stage III colon cancer

Author

Smith, H. G., Skovgaards, D. M., Bui, N. H., Chiranth, D., Qvortrup, C., Schlesinger, N. H., Smith, H. G., Skovgaards, D. M., Bui, N. H., Chiranth, D., Qvortrup, C., and Schlesinger, N. H.

Abstract

Background: Microscopically positive margins to lymph node metastases (R1LNM) are associated with poorer oncological outcomes in patients with Stage 3 colon cancer. These poorer outcomes were seen despite a greater proportion of these patients receiving adjuvant chemotherapy when compared to those with microscopically negative (R0) margins. We sought to determine if differences in the type or duration of adjuvant chemotherapy could account for the differences in outcomes seen between patients with R0 and R1LNM margins. Methods: A multicentre retrospective study including patients undergoing surgery for Stage 3 colon cancer between 2016–2019 at specialist centres. Patients were stratified according to margins status (R0 vs R1LNM). Type/duration of chemotherapy and oncological outcomes were compared between groups. Results: 718 patients were included, of whom 100 had R1LNM margins (13.1%). Patients with R1LNM margins had significantly poorer 3-year distant metastases-free (R0 78.2% (95% CI 74.5–81.3) versus R1LNM 58.8% (95% CI 47.2–68.6), p < 0.001) and disease specific survival (R0 88.3% (95% CI 85.2–90.9) versus R1LNM 78.5% (95% CI 68.0–85.8), p < 0.001) when compared to those with R0 margins. No differences were noted in the proportion of patients who completed long-course chemotherapy or were treated with oxaliplatin-based combinations between the R1LNM and R0 groups. Differences in outcomes between R0 and R1LNM groups persisted even when only those patients who completed long-course chemotherapy were compared. Discussion: Differences in adjuvant chemotherapy do not appear to account for the poorer oncological outcomes seen in patients with R1LNM margins after surgery for Stage 3 colon cancer. This suggests that adjuvant chemotherapy may be less effective in this patient group. Further studies to elucidate a potential biological basis for this difference are warranted.

Published
2023

13. Management and short-term outcomes of patients with small bowel obstruction in Denmark:a multicentre prospective cohort study

Author

Olausson, M., Aerenlund, M. P., Azzam, M., Bjerke, T., Burcharth, J. F.H., Dibbern, C. B., Jensen, T. K., Jordhøj, J. Q., Lolle, I., Ngo-Stuyt, L., Nielsen, E.Ø., Nielsen, L. B. J., Skovsen, A. P., Tolver, M. A., Smith, H. G., Olausson, M., Aerenlund, M. P., Azzam, M., Bjerke, T., Burcharth, J. F.H., Dibbern, C. B., Jensen, T. K., Jordhøj, J. Q., Lolle, I., Ngo-Stuyt, L., Nielsen, E.Ø., Nielsen, L. B. J., Skovsen, A. P., Tolver, M. A., and Smith, H. G.

Abstract

Aims: The optimal management of small bowel obstruction (SBO) remains a matter of debate and treatment varies internationally. In Denmark, a more surgically aggressive strategy has traditionally been used, but to what extent patient outcomes differ from international reports is unknown. This study aimed to describe the current management and outcomes of patients admitted with SBO in Denmark. Methods: This was a prospective cohort study conducted at six acute hospitals in Denmark over a 4-month period. Patients aged ≥ 18 years with a clinical or radiological diagnosis of SBO were eligible. Primary outcomes were 30 day morbidity and mortality rates. Results: 316 patients were included during the study period. The median age was 72 years and 56% were female. Diagnosis was made by computed tomography (CT) in 313 patients (99.1%), with the remaining three diagnosed clinically. Non-operative management was the initial strategy in 152 patients (48.1%) and successful in 119 (78.3%). Urgent surgery was performed in the remaining 164 (51.9%), with a laparoscopic approach used in 84 patients (51.2%). The entire cohort had a 30 day mortality rate of 7.3% and a 30 day morbidity rate of 17.1%. Conclusions: The management of SBO in Denmark differs markedly to previous international reports, with an almost ubiquitous use of CT for diagnosis and a high proportion of patients undergoing urgent surgery. Despite higher rates of surgery, patient outcomes are broadly similar to reports of more conservative strategies, perhaps due to a reduction in delayed operations. Trial registration: Trial registration number: NCT04750811. Trial registration date: 11/02/2021.

Published
2023

15. Management and short-term outcomes of patients with small bowel obstruction in Denmark: a multicentre prospective cohort study

Author

Olausson, M., primary, Aerenlund, M. P., additional, Azzam, M., additional, Bjerke, T., additional, Burcharth, J. F. H., additional, Dibbern, C. B., additional, Jensen, T. K., additional, Jordhøj, J. Q., additional, Lolle, I., additional, Ngo-Stuyt, L., additional, Nielsen, E. Ø., additional, Nielsen, L. B. J., additional, Skovsen, A. P., additional, Tolver, M. A., additional, and Smith, H. G., additional

Published
2022
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17. Differences in adjuvant chemotherapy and oncological outcomes according to margin status in patients with stage III colon cancer.

Author

Smith, H. G, Skovgaards, D. M., Bui, N. H., Chiranth, D., Qvortrup, C., and Schlesinger, N. H.

Subjects
*COLON tumors, *ADJUVANT chemotherapy, *RESEARCH, *CONFIDENCE intervals, *CANCER chemotherapy, *METASTASIS, *LYMPH nodes, *TREATMENT duration, *RETROSPECTIVE studies, *TREATMENT effectiveness, *TUMOR classification, *SURGICAL margin, *DESCRIPTIVE statistics, *STATISTICAL sampling, *OXALIPLATIN, *DATA analysis software
Abstract

Microscopically positive margins to lymph node metastases (R1LNM) are associated with poorer oncological outcomes in patients with Stage 3 colon cancer. These poorer outcomes were seen despite a greater proportion of these patients receiving adjuvant chemotherapy when compared to those with microscopically negative (R0) margins. We sought to determine if differences in the type or duration of adjuvant chemotherapy could account for the differences in outcomes seen between patients with R0 and R1LNM margins. A multicentre retrospective study including patients undergoing surgery for Stage 3 colon cancer between 2016–2019 at specialist centres. Patients were stratified according to margins status (R0 vs R1LNM). Type/duration of chemotherapy and oncological outcomes were compared between groups. 718 patients were included, of whom 100 had R1LNM margins (13.1%). Patients with R1LNM margins had significantly poorer 3-year distant metastases-free (R0 78.2% (95% CI 74.5–81.3) versus R1LNM 58.8% (95% CI 47.2–68.6), p < 0.001) and disease specific survival (R0 88.3% (95% CI 85.2–90.9) versus R1LNM 78.5% (95% CI 68.0–85.8), p < 0.001) when compared to those with R0 margins. No differences were noted in the proportion of patients who completed long-course chemotherapy or were treated with oxaliplatin-based combinations between the R1LNM and R0 groups. Differences in outcomes between R0 and R1LNM groups persisted even when only those patients who completed long-course chemotherapy were compared. Differences in adjuvant chemotherapy do not appear to account for the poorer oncological outcomes seen in patients with R1LNM margins after surgery for Stage 3 colon cancer. This suggests that adjuvant chemotherapy may be less effective in this patient group. Further studies to elucidate a potential biological basis for this difference are warranted. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Logo and artificial intelligence

Author

Smith, H. G. .

Subjects
ComputingMilieux_COMPUTERSANDEDUCATION, ComputerApplications_COMPUTERSINOTHERSYSTEMS
Abstract

This thesis was scanned from the print manuscript for digital preservation and is copyright the author. Researchers can access this thesis by asking their local university, institution or public library to make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.

Published
2022
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29. Histopathological risk factors for lymph node metastases in T1 colorectal cancer:meta-analysis

Author

Ebbehøj, A. L., Jørgensen, L. N., Krarup, P. M., Smith, H. G., Ebbehøj, A. L., Jørgensen, L. N., Krarup, P. M., and Smith, H. G.

Abstract

BACKGROUND: National screening programmes increase the proportion of T1 colorectal cancers. Local excision may be possible, but the risk of lymph node metastases (LNMs) could jeopardize long-term outcomes. The aim of the present study was to review the association between histopathological findings and LNMs in T1 colorectal cancer. METHODS: A systematic literature search was conducted using PubMed,Embase, and Cochrane online databases. Studies investigating the association between one or more histopathological factors and LNMs in patients who underwent resection for T1 colorectal cancer were included. RESULTS: Sixteen observational studies were included in the meta-analysis, including a total of 10 181 patients, of whom 1 307 had LNMs. Lymphovascular invasion (odds ratio (OR) 7.42; P < 0.001), tumour budding (OR 4.00; P < 0.001), depth of submucosal invasion, whether measured as at least 1000 µm (OR 3.53; P < 0.001) or Sm2-3 (OR 2.12; P = 0.020), high tumour grade (OR 3.75; P < 0.001), polypoid growth pattern (OR 1.59; P = 0.040), and rectal location of tumour (OR 1.36; P = 0.003) were associated with LNMs. CONCLUSION: Distinct histopathological factors associated with nodal metastases in T1 colorectal cancer can aid selection of patients for local excision or major excisional surgery.

Published
2021

31. Abstracts of presentations on plant protection issues at the fifth international Mango Symposium Abstracts of presentations on plant protection issues at the Xth international congress of Virology: September 1–6, 1996 Dan Panorama Hotel, Tel Aviv, Israel August 11-16, 1996 Binyanei haoma, Jerusalem, Israel

Author

Peña, J. E., Wysoki, M., Singh, Gajendra, Boscán de M., Nancy, Godoy, Freddy J., Obligado, A., Rossetto, C. J., Ribeiro, I. J. A., Gallo, P. B., Soares, N. B., Sabino, J. C., Martins, A. L. M., Bortoletto, N., Ploetz, R. C., Benscher, D., Vázquez, Aimé, Colls, A., Nagel, Julianne, Schaffer, B., Pinkas, Y., Maymon, M., Freeman, S., Bostros Bastawros, Mikhail, Gosbee, M. J., Johnson, G. I., Joyce, D. C., Irwin, J. A. G., Saaiman, W. C., Prusky, D., Falik, E., Kobiler, I., Fuchs, Y., Zauberman, G., Pesis, E., Ackerman, M., Roth, I., Weksler, A., Yekutiely, O., Waisblum, A., Keinan, A., Ofek, G., Reved, R., Barak, R., Bel, P., Artes, L., Visarathanonth, N., Xu, Z., Ponce de León, L., Muñoz, C., Pérez, L., Diaz de León, F., Kerbel, C., Esparza, S., Bósquez, E., Trinidad, M., Coates, L. M., Cooke, A. W., Dean, J. R., Lucia Duarte, Ana, Alberto Otto, Paulo, Malavasi, Aldo, Lizado, M. C. C., Bautista, M. L., Artes, L. A., Bacalangco, N. S., Farungsang, U., Farungsang, N., Waskar, D. P., Masalkar, S. D., Gaikwad, R. S., Damame, S. V., Bally, Ian S. E., O’Hare, Tim J., Holmes, Rowland J., Atabekov, J. G., Fauquet, Claude M., Tomori, O., Nuss, D. L., Ahlquist, P., Díez, J., Ishikawa, M., Janda, M., Price, B. D., Restrepo-Hartwig, M., Bol, J. F., van Rossum, C. M. A., Garcia, M. L., van der Vossen, E. A. G., Reusken, Chantal B. E. M., Canto, T. R., Gal-On, A., Palukaitis, P., Roossinck, M. J., Flasinski, S., Restrepo-Hartwig, Maria A., Ahlquist, Paul, Smirnyagina, Ekaterina, Lin, Na-Sheng, Nagy, Peter D., Figlerowicz, Marek, Bujarski, Jozef J., Proll, D. F., Guyatt, K. J., Davidson, A. D., Kim, Kook-Hyung, Miller, Eric, Hemenway, Cynthia, Havelda, Z., Dalmay, T., Burgyán, J., Kearney, C. M., Thomson, M., Roland, K. E., Dawson, W. O., Bao, Y., Carter, S. A., Nelson, R. S., Derrick, P. M., Shun Ding, Xin, Eskarous, J. K., Sarkar, S., El-Shamy, M., Chen, J., Sako, N., Yuichiro, W., Ohshima, K., Okada, Y., Felden, Brice, Kuznetsov, Yuri G., Malkin, Alexander J., Greenwood, Aaron, McPherson, Alexander, Ivanov, K. I., Dorokhov, Y. L., Kim, C. H., Sálanki, Katalin, Carrére, Isabelle, Jacquemond, Mireille, Tepfer, Mark, Balazs, Ervin, Sanz, A. I., Serra, M. T., García-Luque, I., Revers, F., Candresse, T., LeGall, O., Souche, S., Lot, H., Dunez, J., Cecchini, E., Milner, J., Al-Kaff, N., Covey, S., Gong, Z., Geri, C., Covey, S. N., Richert-Pöggeler, K. R., Shepherd, R. J., Casper, R., Meiri, Eti, Raccah, B., Gera, A., Singer, S., Allam, E. K., El Afifi, Soheir I., Abo El Nasr, M. A., Abd El Ghaffar, M. H., Elisabeth Johansen, I., Keller, K. E., Hampton, R. O., SÕrensen, Karina, Bishnoi, S. S., Rishi, Narayan, Gumedzoe, M. Y. D., Atissime, K., Yedibahoma, S., Wellink, Joan, Verver, Jan, Bertens, Peter, van Lent, Jan, Goldbach, Rob W., van Kammen, Ab, Lekkerkerker, Annemarie, Taylor, K. M., Spall, V. E., Lomonossoff, G. P., Yu. Morozov, S., Solovyev, A. G., Zelenina, D. A., Savenkov, E. I., Grdzelishvili, V. Z., Morozov, S. Y., Jansen, K. A. J., Wolfs, C. J. A. M., Lohuis, H., Verduin, B. J. M., Stein-Margolina, V. A., Hsu, Y. H., Chang, B. Y., Lin, N. S., Pilartz, Marcel, Jeske, Holger, Verchot, Jeanmarie, Baulcombe, David C., English, David J., Müller, E., Baulcombe, D. C., Malcuit, Isabelle, Kavanagh, Tony, Valkonen, J. P. T., Puurand, Ü., Merits, A., Rabinstein, F., Sorri, O., Saarma, M., Liao, Y. C., Vaquero-Martin, C., Monecke, M., Rohde, W., Prüfer, D., Fischer, R., Antignus, Y., Lachman, O., Pearlsman, M., Cohen, S., Qiu, W. P., Moyer, J. W., Feldhoff, A., Kikkert, M., Kormelink, R., Krczal, G., Peters, D., Szittya, György, Burgyán, József, Wvpijewski, K., Paduch-Cichal, E., Rezler, A., Skrzeczkowska, S., Augustyniak, J., Nemchinov, L., Maiss, E., Hadidi, A., Wittner, Anita, Palkovics, László, Balázs, Ervin, Crescenzi, A., Piazzolla, P., Kheyr-Pour, A., Dafalla, G. A., Lecoq, H., Gronenborn, B., Bauer, U., Laux, I., Hajimorad, M. R., Ding, X. S., Flasinski, Stanislaw, Cassidy, Pour G., Dugdale, B., Beetham, P. R., Harding, R. M., Dale, J. L., Qiu, G., Shaw, J. G., Molnár, A., Más, P., Balsalobre, J. M., Sánchez-Pina, M. A., Pallás, V., Rahontei, J., López, L., Lázara, J. J., Barón, M., Owens, R. A., Steger, G., Hu, Y., Fels, A., Hammond, R. W., Riesner, D., Schröder, A. R. W., Góra, A., Pawlowicz, J., Kierzek, A., Zagorski, W., Baumstark, T., Schiebel, W., Schiebel, R., Axmann, A., Haas, B., Sänger, H. L., Xicai, Yang, Yin, Yie, Feng, Zhu, Yule, Liu, Liangyi, Kang, Po, Tien, Poliyka, H., Staub, U., Wagner, M., Gross, H. J., Sano, Teruo, Ishiguro, Akiro, Fayos, J., Garro, R., Bellés, J. M., Conejero, V., Bonfiglioli, R. G., Webb, D. R., Symons, R. H., El-Dougdoug, K. A., Abo-Zeid, A. A., Ambrós, S., Hernandez, C., Desvignes, J. C. C., Flores, R., d’Aquilio, M., Lisa, V., Boccardo, G., Vera, A., Daròs, J. A., Henkel, J., Spieker, R., Higgins, C., Turley, R., Chamberlain, D., Bateson, M., Dale, J., d’Aquino, L., Ragozzino, A., Henderson, J., Bateson, M. F., Chaleeprom, W., Gibbs, A. J., Graichen, K., Rabenstein, F., Schliephake, E., Smith, H. G., Stevens, M., Sadowy, E., Hulanicka, D., Wegener, B., Martin, M. T., Wetzel, T., Cook, G., Kasdorf, G. G. F., Pietersen, G., Braithwaite, Kathryn S., Gambley, Cherie F., Smith, Grant R., Druka, Arnis, Villegas, Lucille, Dahal, Ganesh, Hull, Roger, Senchugova, N. A., Büchen-Osmond, C., Dallwitz, M. J., Blaine, L. D., Naik, P. S., Sonone, A. B., Kolaskar, A. S., Sgro, J. Y., Palmenberg, A. C., Leclerc, Denis, Hohn, Thomas, Moriones, E., Batlle, A., Luis, M., Alvarez, J., Bernal, J. J., Alonso, J. L., Spak, J., Kubelkova, D., Kuo, T. T., Gachechiladze, K. K., Adamia, R. S., Balardshishvili, N. S., Chanishvili, T. G., Krüger, D. H., Nagy, Tibor, Élö, Péter, Papp, Péter, Orosz, László, Licis, N., Berzins, V., Sariol-Carbelo, Carlos A., RodrCarlos, C. M., Janzen, D., Ward, Colin W., Scott, S. W., Shiel, P. J., Berger, P. H., Aleman, M. E., Beachy, R. N., Fauquet, C. M., Salm, S. N., Rybicki, E. P., Rey, M. E. C., Briddon, R. W., Harper, G., Druka, A., Phillips, S., Brunt, A. A., Hull, R., Hay, Jo, Dasgupta, Indranil, Zaifeng, Fan, Meehan, Brian M., Todd, Daniel, Bunk, Hans-Jörk, Grieco, F., Martelli, G. P., Saldarelli, P., Minafra, A., Morag, A., Mumcuoglu, M., Baybikov, T., Schlesinger, M., Zakay-Rones, Z., Shohat, B., Shohat, M., Miller, M., Shaklay, M., Kalvatchev, Z., Walder, R., Garzaro, D., Barrios, M., Karagöz, Ali, Kuru, Avni, Karim, M. R., Johnson, A. J., Takida, S., Thompson, M. C., Omer, H. M. K., Omer, O. L. M., Biyiti, L., Amvam, R. H., Lamaty, G., Bouchet, P., Xu, J., Hefferon, K. L., Abou Haidar, M. G., and Meng, A. X. X.

Published
1997
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37. Mortality and pulmonary complications in patients undergoing surgery with perioperative sars-cov-2 infection: An international cohort study

Author

Almaadany, F. S., Samadov, E., Namazov, I., Jafarova, S., Ramshorst, G. H. V., Pattyn, P., Desender, L., Gheldere, C. A. D., Duchateau, N., Mihanovic, J., Sulen, N., Andabaka, T., Rakvin, I., Bakmaz, B., Smith, H. G., Jonsson, M. L., Kassas, M. E., Tawheed, A., Shehata, S., Ashoush, F. M., Abdelaal, A. S., Elfiky, M. M. A., Emile, S. H., Elfallal, A. H., Elfeki, H., Shalaby, M., Alrahawy, M. M., Sallam, I., Amira, G., Sherief, A., Sherief, M., Lakkis, Z., Doussot, A., Turco, C., Heyd, B., Mathieu, P., Chebaro, A., Lecolle, K., Zerbib, P., Truant, S., Saudemont, A., Pruvot, F. -R., Arnaud, A. P., Bergeat, D., Merdrignac, A., Scalabre, A., Roy, B. L., Perotto, O., Tzedakis, S., Gaujoux, S., Dousset, B., Moszkowicz, D., Bretagnol, F., Hervieux, E., Maisonneuve, E., Clermidi, P., Aubry, E., Thomin, A., Seguin-Givelet, A., Zadegan, F., Conso, C., Ollat, D., Kamphues, C., Lauscher, J. C., Schineis, C., Schnitzbauer, A. A., Thoenissen, P., Youzouri, H. E., Schreckenbach, T., Nguyen, T. A., Modabber, A., Holzle, F., Winnand, P., Konigsrainer, A., Quante, M., Yurttas, C., Loffler, M. W., Klimopoulos, S., Tzovaras, G., Baloyiannis, I., Perivoliotis, K., Lostoridis, E., Tourountzi, P., Marchi, J. A. D., Farrell, T., Davis, N. F., Kearney, D., Larkin, J. O., Mohan, H. M., Mehigan, B. J., Fahey, B. A., Barry, C. P., Elliott, J. A., Bass, G. A., Connelly, T. M., Kavanagh, D. O., Elkady, R., Neary, P. C., Ridgway, P. F., Joyce, D. P., Tierney, S., Boyle, E., Egan, B., Lowery, A. J., Collins, C. G., Hogan, A., Mckevitt, K. L., Ryan, E. J., Fowler, A. L., Aherne, T. M., Nizami, K., Walsh, S., Zmora, O., Kugler, N., Falco, G., Ruiz, C. C., Mele, S., Annessi, V., Ferrari, G., Montella, M. T., Mariani, N. M., Ceretti, A. P., Lomiento, D., Taglietti, L., Giudice, R. D., Compagnoni, B., Dester, S., Granieri, S., Cotsoglou, C., Campagnaro, T., Turri, G., Guglielmi, A., Ruzzenente, A., Pedrazzani, C., Salvia, R., Paiella, S., Nobile, S., Marino, M. V., Mirabella, A., Vaccarella, G., Francone, E., Gentilli, S., Nikaj, H., Morelli, L., Franco, G. D., Palmeri, M., Tartaglia, D., Coccolini, F., Chiarugi, M., Anania, G., Chiozza, M., Urbani, A., Podda, M., Pisanu, A., Porcu, A., Perra, T., Fancellu, A., Familiari, P., D'Andrea, G., Bambina, F., Fiore, M., Macchi, A., Citterio, D., Mosca, A., Martinelli, F., Rolli, L., Guaglio, M., Comini, L. V., Capizzi, V., Mazzaferro, V., Cozza, V., Gordini, L., Lombardi, Celestino Pio, Simone, V. D., Marzi, F., Marra, A. A., Baldini, E., Conti, L., Ribolla, M., Isolani, S. M., Capelli, P., Spinelli, A., Carvello, M., Candido, F. D., Kurihara, H., Marrano, E., Torzilli, G., Castoro, C., Roit, A. D., Mercante, G., Spriano, G., Gaino, F., De Virgilio, A., Bonavina, L., Asti, E., Feo, C. V., Fabbri, N., Righini, E., Di Saverio, S., Scorza, A., Iovino, D., Carcano, G., Baldi, C., Sampietro, G. M., Corbellini, C., Cellerino, P., Zappa, M. A., Ardito, A., Galfrascoli, E., Iacob, G., Zanini, N. C., Palini, G., Garulli, G., Ballabio, M., Bisagni, P., Pizzini, P., Gagliano, A., Armao, T., Longhi, M., Madonini, M., Luraghi, M., Galimberti, L., Romano, S., Bastazza, M., Trotta, F., Gipponi, M., Malabarba, S., Centinaio, G., Mochet, S., Usai, A., Grivon, M., Barmasse, R., Sagnotta, A. S., Marino, L. M. P., Galleano, R., Malerba, M., Baldo, S., Ligure, P., Casati, M., Abate, E., Laface, L., Brianza, C., Lizzi, V., Vovola, F., Arminio, A., Vergari, R., Rausa, E., Bianco, F., Lucianetti, A., Guaitoli, E., Pinotti, E., Carissimi, F., Montuori, M., Baronio, G., Campanelli, M., Sica, G. S., Siragusa, L. S., Lapolla, P., Mingoli, A., Toma, G. D., Fiori, E., Torre, F. L., Sapienza, P., Brachini, G., Cirillo, B., Iannone, I., Zambon, M., Chiappini, A., Meneghini, S., Fonsi, G. B., Cicerchia, P. M., Bruzzaniti, P., Santoro, A., Bartolomeo, A. D., Sasia, D., Gattolin, A., Rottoli, M., Ravaioli, M., Schiavina, R., Solli, P., Frio, F., Neri, J., Poggioli, G., Belvedere, A., Pezzuto, A. P., Parlanti, D., Violante, T., Tonini, V., Cervellera, M., Sartarelli, L., Giacometti, M., Zonta, S., Ferrara, F., Stella, M. M., Gobatti, D., Costanzi, A., Confalonieri, M., Colletti, G., Frattaruolo, C., Mari, G. M., Monteleone, M., Candiani, M., Bonavina, G., Valsecchi, L., Ottolina, J., Mortini, P., Gagliardi, F., Piloni, M., Medone, M., Carlucci, M., Negri, G., Bandiera, A., Nardi, P. D., Elmore, U., Sileri, P., Lisi, G., Carlini, M., Spoletini, D., Giuffrida, M. C., Borghi, F., Rosato, F., Puppo, A., D'Agruma, M., Marano, A., Testa, V., Peluso, C., Barra, F., Ferrero, S., Gustavino, C., Gallo, G., Sammarco, G., Trompetto, M., Vescio, G., Fontana, T., Al-Masri, M., Chaar, M. K. A., Al-Najjar, H., Maadany, F. S. A., Nasef, E., Elkhafeefi, F., Eljareh, M., Bouhuwaish, A. E. M., Taher, A. S. A., Yousuf, F. B., Morgom, M. M., Salamah, A. A., Salama, H. A., Bulugma, M. R., Alvarez, M. R., Gisbertz, S. S., Borgstein, A. B. J., Henegouwen, M. I. V. B., Leclercq, W. K. G., Uittenbogaart, M., Kruijff, S., De Vries, J. -P. P. M., Van Der Plas, W. Y., Steinkamp, P. J., Jonker, P. K. C., Konsten, J., Van Heinsbergen, M., Anwer, M., Santos-Sousa, H., Cavaleiro, S., Leite-Moreira, A. M., Pereira, A., Pereira-Neves, A., Faria, C. S., Monteiro, J. M., Nogueiro, J., Sampaio-Alves, M., Maia, M. M., Vieira, P., Lazaro, A., Martins, R., Oliveira, A., Costa, M., Almeida, A. C., Serralheiro, P. A., Teles, T., Borges, F., Lima, M. J., Costa, P. M., Henriques, S., Vivas, A. A., Vega, V. A., Navarro-Sanchez, A., Lozano, S. M., Fernandez-Pacheco, B. C., Bernal-Sprekelsen, J. C., Perez, C. M., Bauset, J. C. C., Rodriguez, V. T., Morales, X., Gracia, I., Pujol-Muncunill, R., De Lacy, F. B., Muguerza, J. M., Dziakova, J., Pueblo, C. S. D., Avellana, R. B., Catalan, V., Picazo, S., Fernandez, A. G., Romera, J. L., Galocha, J. L. G., Rojo, M., Torres, A. J., Rivas, A. M., Camarero, E., Saez, C., Antonanzas, L. L., De Andres-Asenjo, B., De Heredia, J. B., Fernandez, A. V., Trujillo-Diaz, J., Ruiz-Soriano, M., Minaya-Bravo, A., Mendez, C. S. M., Galvan-Perez, A., Robin-Valle, A., Gonzalez-Gonzalez, E., Calcerrada-Alises, E., Garcia-Urena, M. A., Carrasco, M., Gimenez, C., Medina, E., Fernandez, A. J., Ruiz-Marin, M., Estaire-Gomez, M., Martinez-Depaz, F., Sanchez-Pelaez, D., Jimenez-Higuera, E., Martinez-Pinedo, C., Picon-Rodriguez, R., Fernandez-Camunas, A., Padilla-Valverde, D., Rey-Valcarcel, C., Perez-Diaz, M. D., Fernandez-Martinez, M., Martin-Roman, L., Gomez, M. F., Rio-Gomez, J., Tousidonis, M., Alonso-Ortuno, P., Ayuso-Herrera, E., Martin-Albo, L., Aragon-Chamizo, J., Lowy-Benoliel, A., Quintana-Villamandos, B., Sanchez-Perez, C., Mateo-Sierra, O., Corral, J., Caballero, A., Zarate, A., Diez-Alonso, M. M., Mendoza-Moreno, F., Mansilla, C. V., Ruiz-Grande, F., Hernandez-Juara, P., Blazquez-Martin, A., Montesinos, C. S., Diaz, C. J. G., Guariglia, C. A., Fructuoso, L. S., Osorio, A. L., Font, R. F., Ormazabal, P. C., Mora-Guzman, I., Gonzalez, J. S., Perez, D. D., Samaniego, M. G., Jara, P. G., Garcia, M. H., Ruiz, M. L., Fernandez, B. D., Delgado, M. G. -C., Poza, A. A., Mallen, V. D., Gracia-Roche, C., Martinez-German, A., Santero-Ramirez, M. -P., Matute-Najarro, M. -S., De Miguel-Ardevines, M. -C., Sanchez-Fuentes, M. -N., Saudi-Moro, S., Gascon-Ferrer, I., Herrero-Lopez, M., Delgado-Oliver, E., Sanchez-Rubio, M., Cantalejo-Diaz, M., Perez-Sanchez, L. E., Diaz-Garcia, A., Ramos, D., Barranquero, A. G., Ocana, J., Nunez, J., Cerro, C., Tejero-Pintor, F. J., Perez-Saborido, B., Marcos-Santos, P., Choolani-Bhojwani, E., Acebes-Garcia, F., Bueno-Canones, A. D., Pacheco-Sanchez, D., Cuadrado, M. B., Senent-Boza, A., Benitez-Linero, I., Ramallo-Solis, I., Sanchez-Arteaga, A., Melero-Cortes, L., Fernandez-Marin, R., Duran-Munoz-Cruzado, V. M., Gomez-Rosado, J. -C., Toro, M. D. D., Valdes-Hernandez, J., Reguera-Rosal, J., Capitan-Morales, L. -C., Oliva-Mompean, F., Sancho-Muriel, J., Cholewa, H., Flor, B., Landaluce-Olavarria, A., Miguel, M. G. -D., Cruzado, L. F. -G., Jimeno, J., Toledo, E., Pascual, A., Carrillo, M., Morales, D., Gomez, M., Rodriguez-Sanjuan, J. C., Aguilar, J., Baeza, M., Rey-Biel, J., Pingarron-Martin, L., Escartin, J., Laina, J. L. B., Pevidal, A. N., Enjuto, D. T., Ramos-Bonilla, A., Perez-Gonzalez, M., Diaz-Pena, P., Garces-Garcia, R., Salas, M. M. D., Cagigal-Ortega, E. P., Ali, O. M., Arigoni, M., Mongelli, F., Bernasconi, M., Giuseppe, M. D., Adamina, M., Peros, G., Aytac, E., Aliyeva, Z., Kara, Y., Bozkurt, M. A., Kocatas, A., Altintoprak, F., Gonullu, E., Mantoglu, B., Yildiz, A., Davies, R. J., Ashcroft, J., Baker, O. J., Byrne, M. H. V., Coughlin, P. A., Durst, A. Z. E., Georgiades, F., Habeeb, A., Hudson, V. E., Kolias, A., Luke, L., Mitrasinovic, S., Mohan, M., Murphy, S. H., Ngu, A. W. T., O'Neill, J. R., Ramzi, J., Rooney, S. M., Singh, A. A., Waseem, S., Wong, K., Lunevicius, R., Sheel, A. R. G., Jones, R. P., Nunes, Q. M., Hughes, J. L., Haq, I., Misra, N., Baig, M. M., Sundhu, M., Rossborough, C., Skelly, B. L., Neely, D. T. A., Angelou, D., Mccanny, A., Pachl, M. J., Martin, B., Sundar, S., Leung, E. Y., Vashisht, R., Bakri, N. A. C., Jiao, L. R., Nazarian, S., Warren, O. J., Kontovounisios, C., Grove, T., Vimalachandran, D., Manu, N., Eardley, N. J., Krishnan, E., Serevina, O. L., Martin, E., Povey, M. G., Jones, A. P., Smith, C., Mannan, S., Ayeni, F. A., Houston, R., Tustin, H., Rogers, L. J., Minto, G., Marchbank, A., Miller, D., Ho, B., Gohil, K., Labib, P. L., Emslie, K. M., Clough, E. C. S., Enemosah, I., Perkins, C., Rela, M., Panahi, P., Baker, M. P., Holme, T. J., Abbott, S. J., Bence, M. N., Razik, A., Osagie-Clouard, L., Holbrook, C. M., Kufeji, D., Chong, C., Hammond, J. S., Moir, J. A. G., Mcpherson, I., Booth, K., Patel, P. K., Kler, A., Handa, S., Kaushal, M. V., Redfern, J., Morgan, R., Maw, A., Gala, T., Abdelkarim, M., Asqalan, A., Ibrahim, S., Venkatesan, G. S., Caruana, E. J., Mohammad, A., Acharya, M., Rathinam, S., Nakas, A., Higgs, S., Brown, O. D., Boal, M., Dean, H., Stanger, S., Abdalaziz, H., Sayasneh, A., Najdy, M., Nath, R., Gautam, M., Fehervari, M., Spalding, D. R., Pai, M., Naumann, D. N., Kalkat, M., Syed, A., Alam, R., Tayeh, S., Chase, T. J. G., Ayorinde, J. O., Cuming, T., Ghanbari, A., Loubani, M., Aboelkassem-Ibrahim, A., Cao, H., Ross, E., Totty, J., Wilkins, A., Hitchman, L., Dixon, J. R., Dunning, J., Viswanath, Y. K. S., Lester, M. J. S., Bond-Smith, G., Lami, M., Tebala, G. D., Tucker, S. C., Shaw, A. V., Winter, S. C., Cernei, C., Qureshi, A., Belcher, E., Wallwork, K., Stavroulias, D., Di Chiara, F., Dare, O., Jeyaretna, D. S., Ganau, M., Chidambaram, S., Sravanam, S., Sinha, S., Smillie, R., Shah, K., Shankar, S., Dunstan, M., Beak, P., Gerogiannis, I., Jones, G. P., Gardner, A., Tripathi, S. S., Boddy, A. P., Hossain, T., Ashmore, C., Annamalai, S., Irvine, E., Kourdouli, A., Kirmani, B. H., Shackcloth, M. J., Harky, A., Stylianides, N. A., Abdalla, M. O., Newton, K., Bajomo, O. M., Rizvi, S., Darko, E., Saad, A. R., Li, Z., Motter, D., Hurt, L., Egan, R., Harries, R., Youssef, M. M. G., Evans, L., Chrastek, D., Kouritas, V., Shah, J., Anthoney, J., Amjad, R., Harrison, J., Mabrouk, I., Hebblethwaite, B., Emmerson, O., Bosch, K. D., Kalidindi, V., Bashkirova, V., Edwards, J. G., Rao, J. N., Hopkinson, D. N., Chetty, G., Forlani, S., Guha, S., Sherif, M., Giblin, A. -V., Lye, G., Whitehall, E., Blundell, C. M., Ward, A., Tadross, D., Wells, F., Majkowski, L., Townshend, D. N., Mills, S. J., Seymour, K., Shenfine, A., Mclarty, N., Kashora, F., Lewis, S. E., Ubhi, H. K., Exley, R., Singh, A., Basgaran, A., Bartsch, A. -M., Okechukwu, V., Basha, A., Barmpagianni, C., Gallagher, P., Khan, U., Maqsood, A., Shah, P., Saxena, S., Sahnan, K., Siddique, M. H., Leo, C. A., Zafar, N., Rollett, R. A., Collins, M. L., Tamimy, M. S., Riyat, H., Neil-Dwyer, J., Wen, J., Burnside, N., Weaver, H., Hawari, M., Addae-Boateng, E., Duffy, J. P., Dean, B. J. F., Luney, C. R., Sarveswaran, J., Patil, S., Ravindran, S., Scott, L., Michel, M., Toh, S., Ahmed, Y., Vijay, V., Shakir, T., Hasan, R., Tansey, R., Alanbuki, A., Patel, M., Shabana, A., Paisley, S., Khan, J. S., Griffiths, E. A., Kisiel, A. P., Kamal, M., Cato, L. D., Parente, A., Kulkarni, R., Saeed, S. A., Mak, J., Liew, I., Al-Sukaini, A., Saxena, D., Mediratta, S., Ali, I. A. M., Smith, A., Fell, A., English, C., Kristinsson, S., Goatly, G., Halkias, C., Evans, J., Glen, P., Al-Azzawi, M., Aitken, E., Mukherjee, S., Singh, S., English, W., Vulliamy, P., Karam, E., Chui, K., Mansuri, A., Sivayoganathan, S., Aaraj, M. A., El-Ali, A., Chowdhury, A. H., Worku, D., Hampton, M., Manson, J., Findlay, L., Majkowska, A., Brixton, G., Potter, R., De Souza, A. C., Rochon, M., Cannoletta, M., Bhalla, A., Daliya, P., Chia, Z., Pollok, J. M., Raptis, D. A., Davidson, B. R., Fusai, G. K., Xyda, S. E., Soggiu, F., Machairas, N., Bosanquet, D. C., Tang, A. M., Beamish, A. J., Nassa, H., Price, C., Williams, G., Magowan, D., Solari, F., Davies, E. J., Ryska, O., Hawkin, P., Raymond, T., Baron, R. D., Szatmary, P., Gahunia, S., Thomas, A. J., Dunne, D. F. J., Nita, G. E., Sochorova, D., Sivaprakasam, R., Venn, M. L., Ledesma, F. S. J., Thaha, M. A., Sullivan, T. B. B., Parry, J. T., Baumber, R., Archer, J. E., Odeh, A., Stewart, R., Ullah, R., Armstrong, L., Jones, M., Aljanadi, F., Moawad, N., Gregg, A., Jeganathan, R., Ferguson, H. J. M., Ramcharan, S., Yershov, D., Hopkins, J. C., Doe, M. J., Ambler, G. K., Lostis, E., Lawday, S., Babu, B. H., Liyanage, A. S. D., Weerasinghe, C. K., Blake, I., Sanders, J., Bueser, T., Curtis, M., Oo, A. Y., Abbott, T. E. F., Anwar, S., Sohrabi, C., Williams, K. J., Chung, E. A., Hagger, R., Karim, A., Hainsworth, A. J., Flatman, M., Hing, C. B., Trompeter, A., Lo, T., Wade, R. G., Bourke, G., Burke, J. R., Young, A. L., Wall, J. J. S., Johnstone, J. R., Peckham-Cooper, A., Elkadi, H. H., Kowal, M. R., Pompili, C., Ho, M. W. S., Kinross, J., Ibrahim, M. A. H., Abuown, A., Denning, M., Erridge, S., Yalamanchili, S., Martin, G., Hall, C., Hall, J. R. W., Baldwin, A. J., Gammeri, E., West, R., Wormald, J. C. R., Catton, A. B., Kudsk-Iversen, S., Kouris, S. M., Nugent, M., Lin, D. J., Kang, C., Scurrah, R. J., Rajgor, A. D., Steel, B., Day, A., Belgaumkar, A. P., Oyewole, B., Gilbert, C., Dass, D., Ford, D., Duff, S., Khan, A., Asaad, P., Brown, B. C., Jenkinson, M. D., Zakaria, R., Elmoslemany, T., Parmar, C., Mccluney, S. J., Shah, S., Kalavrezos, N., Sinha, D., Schilling, C., Tewari, N., Dunne, N. J. M., Carlos, W. J., Gill, C. K., Godbole, C., Dickson, K. E., Khajuria, A., Connolly, H., Naredla, P., Sarma, D. R., Robertson, S., Morris, C., Richards, T., Torkington, J., Williams, M., Shinkwin, M., Jayaraju, U., Singh, R. P., Aftab, R., Warwick, D., Khalefa, M. A., Hossain, F. S., Osman, K., Andreani, S. M., Bath, M. F., Sahni, A., Judkins, N., Springford, L. R., Wadley, M. S., Tyler, J., Wild, L., Wall, R., Jenner, E., Chamberlain, S., Thrush, J., Brain, J., Townsend, C., Stringer, S., Breckles, L., Flindall, I., Phenix, G., Thomas, K., Young, R., Macdonald, L., Green, S., Miu, V., Sheridan, K., Onos, L., Monson, J. R. T., Drake, F. T., Haqqani, M. H., Cooper, Z., Salim, A., Hirji, S. A., Brown, A. K., Chung, C., Hansen, L., Okafor, B. U., Roxo, V. I., Rice, H. E., Hwang, E. S., Blazer, D. G., Hall, B. J., Olson, S. A., Nehra, D., Cuschieri, J., Davidson, G. H., Walters, A. M., Nygaard, R. M., Colonna, E. T., Endorf, F. W., Meagher, A. D., Kinnaman, G., Mckenzie, K., Fretwell, K. R., Chan, J., Nugent, W. C., Chen, D., Stevens, K. A., Etchill, E. W., Jenny, H. E., Dehal, A., Kaafarani, H. M., Breen, K. A., Bankhead-Kendall, B. K., Alser, O., Mashbari, H. N., Velmahos, G. C., Chang, G., Dehart, D., Ourieff, J., Merola, S., Volpe, A., Podolsky, D., Coleman, N. L., Callahan, M., Brathwaite, C. E. M., Liu, H. H., Petrone, P., Baltazar, G., Hakmi, H., Sohail, A. H., Hazelton, J. P., Ssentongo, A. E., Ssentongo, P., Jamil, T., Al-Embideen, S., Seegert, S., Torquati, A., Bhama, A. R., Biffl, W. L., Schaffer, K. B., Marsh, C. L., Philp, M. M., Ross, H., Santora, T., Pathak, A., Sewards, J. M., Pontari, M., Engel, J. L., Giorgakis, E., Bhavaraju, A. V., Kalkwarf, K. J., Roberts, M., Robertson, R., Callcut, R. A., Canova, M. E., Suri, A., Velopulos, C. G., Carmichael, H., Mcintyre, R. C., Wright, F. L., Urban, S., Martin, R. C. G., Bhutiani, N., Diaz, J. J., Abdou, H., O'Meara, L. B., Richmond, M., Almasri, M., Marwan, H., Mehdi, M. Q., Kulkarni, G., Ban, V. S., Aoun, S. G., Batjer, H. H., Bhangu, A., Migliore, M., Lombardi C. P. (ORCID:0000-0001-8910-6693), Almaadany, F. S., Samadov, E., Namazov, I., Jafarova, S., Ramshorst, G. H. V., Pattyn, P., Desender, L., Gheldere, C. A. D., Duchateau, N., Mihanovic, J., Sulen, N., Andabaka, T., Rakvin, I., Bakmaz, B., Smith, H. G., Jonsson, M. L., Kassas, M. E., Tawheed, A., Shehata, S., Ashoush, F. M., Abdelaal, A. S., Elfiky, M. M. A., Emile, S. H., Elfallal, A. H., Elfeki, H., Shalaby, M., Alrahawy, M. M., Sallam, I., Amira, G., Sherief, A., Sherief, M., Lakkis, Z., Doussot, A., Turco, C., Heyd, B., Mathieu, P., Chebaro, A., Lecolle, K., Zerbib, P., Truant, S., Saudemont, A., Pruvot, F. -R., Arnaud, A. P., Bergeat, D., Merdrignac, A., Scalabre, A., Roy, B. L., Perotto, O., Tzedakis, S., Gaujoux, S., Dousset, B., Moszkowicz, D., Bretagnol, F., Hervieux, E., Maisonneuve, E., Clermidi, P., Aubry, E., Thomin, A., Seguin-Givelet, A., Zadegan, F., Conso, C., Ollat, D., Kamphues, C., Lauscher, J. C., Schineis, C., Schnitzbauer, A. A., Thoenissen, P., Youzouri, H. E., Schreckenbach, T., Nguyen, T. 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P., Aftab, R., Warwick, D., Khalefa, M. A., Hossain, F. S., Osman, K., Andreani, S. M., Bath, M. F., Sahni, A., Judkins, N., Springford, L. R., Wadley, M. S., Tyler, J., Wild, L., Wall, R., Jenner, E., Chamberlain, S., Thrush, J., Brain, J., Townsend, C., Stringer, S., Breckles, L., Flindall, I., Phenix, G., Thomas, K., Young, R., Macdonald, L., Green, S., Miu, V., Sheridan, K., Onos, L., Monson, J. R. T., Drake, F. T., Haqqani, M. H., Cooper, Z., Salim, A., Hirji, S. A., Brown, A. K., Chung, C., Hansen, L., Okafor, B. U., Roxo, V. I., Rice, H. E., Hwang, E. S., Blazer, D. G., Hall, B. J., Olson, S. A., Nehra, D., Cuschieri, J., Davidson, G. H., Walters, A. M., Nygaard, R. M., Colonna, E. T., Endorf, F. W., Meagher, A. D., Kinnaman, G., Mckenzie, K., Fretwell, K. R., Chan, J., Nugent, W. C., Chen, D., Stevens, K. A., Etchill, E. W., Jenny, H. E., Dehal, A., Kaafarani, H. M., Breen, K. A., Bankhead-Kendall, B. K., Alser, O., Mashbari, H. N., Velmahos, G. C., Chang, G., Dehart, D., Ourieff, J., Merola, S., Volpe, A., Podolsky, D., Coleman, N. L., Callahan, M., Brathwaite, C. E. M., Liu, H. H., Petrone, P., Baltazar, G., Hakmi, H., Sohail, A. H., Hazelton, J. P., Ssentongo, A. E., Ssentongo, P., Jamil, T., Al-Embideen, S., Seegert, S., Torquati, A., Bhama, A. R., Biffl, W. L., Schaffer, K. B., Marsh, C. L., Philp, M. M., Ross, H., Santora, T., Pathak, A., Sewards, J. M., Pontari, M., Engel, J. L., Giorgakis, E., Bhavaraju, A. V., Kalkwarf, K. J., Roberts, M., Robertson, R., Callcut, R. A., Canova, M. E., Suri, A., Velopulos, C. G., Carmichael, H., Mcintyre, R. C., Wright, F. L., Urban, S., Martin, R. C. G., Bhutiani, N., Diaz, J. J., Abdou, H., O'Meara, L. B., Richmond, M., Almasri, M., Marwan, H., Mehdi, M. Q., Kulkarni, G., Ban, V. S., Aoun, S. G., Batjer, H. H., Bhangu, A., Migliore, M., and Lombardi C. P. (ORCID:0000-0001-8910-6693)

Abstract

Background The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (740%) had emergency surgery and 280 (248%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (261%) patients. 30-day mortality was 238% (268 of 1128). Pulmonary complications occurred in 577 (512%) of 1128 patients; 30-day mortality in these patients was 380% (219 of 577), accounting for 817% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 175 [95% CI 128-240], p<00001), age 70 years or older versus younger than 70 years (230 [165-322], p<00001), American Society of Anesthesiologists grades 3-5 versus grades 1-2 (235 [157-353], p<00001), malignant versus benign or obstetric diagnosis (155 [101-239], p=0046), emergency versus elective surgery (167 [106-263], p=0026), and major versus minor surgery (152 [101-231], p=0047). Interpretation Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal

Published
2020

39. OX40 and 4-1BB delineate distinct immune profiles in sarcoma.

Author

Melake, M. J., Smith, H. G., Mansfield, D., Davies, E., Dillon, M. T., Wilkins, A. C., Patin, E. C., Pedersen, M., Buus, R., Melcher, A. A., Thway, K., Miah, A. B., Zaidi, S. H., Hayes, A. J., Fenton, T. R., Harrington, K. J., and McLaughlin, M.

Subjects
*SARCOMA, *IMMUNOTHERAPY, *TERTIARY structure, *GENE expression, *LIPOSARCOMA, *TUMOR microenvironment
Abstract

Systemic relapse after radiotherapy and surgery is the major cause of disease-related mortality in sarcoma patients. Combining radiotherapy and immunotherapy is under investigation as a means to improve response rates. However, the immune contexture of sarcoma is understudied. Here, we use a retrospective cohort of sarcoma patients, treated with neoadjuvant radiotherapy, and TCGA data. We explore therapeutic targets of relevance to sarcoma, using genomics and multispectral immunohistochemistry to provide insights into the tumor immune microenvironment across sarcoma subtypes. Differential gene expression between radioresponsive myxoid liposarcoma (MLPS) and more radioresistant undifferentiated pleomorphic sarcoma (UPS) indicated UPS contained higher transcript levels of a number of immunotherapy targets (CD73/NT5E, CD39/ENTPD1, CD25/IL2RA, and 4-1BB/TNFRSF9). We focused on 4-1BB/TNFRSF9 and other costimulatory molecules. In TCGA data, 4-1BB correlated to an inflamed and exhausted phenotype. OX40/TNFRSF4 and 4-1BB/TNFRSF9 were highly expressed in sarcoma subtypes versus other cancers. Despite OX40 and 4-1BB being described as Treg markers, we identified that they delineate distinct tumor immune profiles. This was true for sarcoma and other cancers. While only a limited number of samples could be analyzed, spatial analysis of OX40 expression identified two diverse phenotypes of OX40+ Tregs, one associated with and one independent of tertiary lymphoid structures (TLSs). Patient stratification is of intense interest for immunotherapies. We provide data supporting the viewpoint that a cohort of sarcoma patients, appropriately selected, are promising candidates for immunotherapies. Spatial profiling of OX40+ Tregs, in relation to TLSs, could be an additional metric to improve future patient stratification. [ABSTRACT FROM AUTHOR]

Published
2022
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43. Grasslands-more important for ecosystem services than you might think

Author

Bengtsson, J., Bullock, J. M., Egoh, B., Everson, C., Everson, T., O'Connor, T., O'Farrell, P. J., Smith, H. G., Lindborg, Regina, Bengtsson, J., Bullock, J. M., Egoh, B., Everson, C., Everson, T., O'Connor, T., O'Farrell, P. J., Smith, H. G., and Lindborg, Regina

Abstract

Extensively managed grasslands are recognized globally for their high biodiversity and their social and cultural values. However, their capacity to deliver multiple ecosystem services (ES) as parts of agricultural systems is surprisingly understudied compared to other production systems. We undertook a comprehensive overview of ES provided by natural and semi-natural grasslands, using southern Africa (SA) and northwest Europe as case studies, respectively. We show that these grasslands can supply additional non-agricultural services, such as water supply and flow regulation, carbon storage, erosion control, climate mitigation, pollination, and cultural ES. While demand for ecosystems services seems to balance supply in natural grasslands of SA, the smaller areas of semi-natural grasslands in Europe appear to not meet the demand for many services. We identified three bundles of related ES from grasslands: water ES including fodder production, cultural ES connected to livestock production, and population-based regulating services (e.g., pollination and biological control), which also linked to biodiversity. Greenhouse gas emission mitigation seemed unrelated to the three bundles. The similarities among the bundles in SA and northwestern Europe suggest that there are generalities in ES relations among natural and semi-natural grassland areas. We assessed trade-offs and synergies among services in relation to management practices and found that although some trade-offs are inevitable, appropriate management may create synergies and avoid trade-offs among many services. We argue that ecosystem service and food security research and policy should give higher priority to how grasslands can be managed for fodder and meat production alongside other ES. By integrating grass-lands into agricultural production systems and land-use decisions locally and regionally, their potential to contribute to functional landscapes and to food security and sustainable livelihoods can be grea

Published
2019
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44. Meta-analysis reveals that pollinator functional diversity and abundance enhance crop pollination and yield

Author

Natural Environment Research Council (UK), Biotechnology and Biological Sciences Research Council (UK), Scottish Government, Irish Government, Woodcock, Ben A., Garratt, M.P.D., Powney, G.D., Shaw, R.F., Osborne, J.L., Soroka, J., Lindström, S.A.M., Stanley, D., Ouvrard, P., Edwards, M.E., Jauker, F., McCracken, M.E., Zou, Y., Potts, S.G., Rundlöf, M., Noriega, José Antonio, Greenop, A., Smith, H. G., Bommarco, R., Van der Werf, W., Stout, J.C., Steffan-Dewenter, I., Morandin, L., Bullock, J.M., Pywell, Richard F., Natural Environment Research Council (UK), Biotechnology and Biological Sciences Research Council (UK), Scottish Government, Irish Government, Woodcock, Ben A., Garratt, M.P.D., Powney, G.D., Shaw, R.F., Osborne, J.L., Soroka, J., Lindström, S.A.M., Stanley, D., Ouvrard, P., Edwards, M.E., Jauker, F., McCracken, M.E., Zou, Y., Potts, S.G., Rundlöf, M., Noriega, José Antonio, Greenop, A., Smith, H. G., Bommarco, R., Van der Werf, W., Stout, J.C., Steffan-Dewenter, I., Morandin, L., Bullock, J.M., and Pywell, Richard F.

Abstract

How insects promote crop pollination remains poorly understood in terms of the contribution of functional trait differences between species. We used meta-analyses to test for correlations between community abundance, species richness and functional trait metrics with oilseed rape yield, a globally important crop. While overall abundance is consistently important in predicting yield, functional divergence between species traits also showed a positive correlation. This result supports the complementarity hypothesis that pollination function is maintained by non-overlapping trait distributions. In artificially constructed communities (mesocosms), species richness is positively correlated with yield, although this effect is not seen under field conditions. As traits of the dominant species do not predict yield above that attributed to the effect of abundance alone, we find no evidence in support of the mass ratio hypothesis. Management practices increasing not just pollinator abundance, but also functional divergence, could benefit oilseed rape agriculture.

Published
2019

45. A global synthesis reveals biodiversity-mediated benefits for crop production

Author

Dainese, M., Martin, E. A., Aizen, Marcelo A., Albrecht, M., Bartomeus, I., Bommarco, R., Carvalheiro, L. G., Chaplin-Kramer, R., Gagic, V., Garibaldi, Lucas A., Ghazoul, J., Grab, H., Jonsson, M., Karp, D. S., Kennedy, Cristina M., Kleijn, D., Kremen, C., Landis, D. A., Letourneau, D. K., Marini, Lorenzo, Poveda, K., Rader, R., Smith, H. G., Tscharntke, T., Andersson, G. K. S., Badenhausser, I., Baensch, S., Bezerra, A. D. M., Bianchi, F. J. J. A., Boreux, V., Bretagnolle, V., Caballero-López, Berta, Cavigliasso, P., Cetkovic, Aleksandar, Chacoff, Natacha P., Classen, A., Cusser, S., Da Silva E Silva, F. D., Arjen De Groot, G., Dudenhöffer, J. H., Ekroos, J., Fijen, T., Franck, P., Freitas, B. M., Garratt, M. P. D., Gratton, C., Hipólito, J., Holzschuh, A., Hunt, L., Zaragoza-Trello, C., Dainese, M., Martin, E. A., Aizen, Marcelo A., Albrecht, M., Bartomeus, I., Bommarco, R., Carvalheiro, L. G., Chaplin-Kramer, R., Gagic, V., Garibaldi, Lucas A., Ghazoul, J., Grab, H., Jonsson, M., Karp, D. S., Kennedy, Cristina M., Kleijn, D., Kremen, C., Landis, D. A., Letourneau, D. K., Marini, Lorenzo, Poveda, K., Rader, R., Smith, H. G., Tscharntke, T., Andersson, G. K. S., Badenhausser, I., Baensch, S., Bezerra, A. D. M., Bianchi, F. J. J. A., Boreux, V., Bretagnolle, V., Caballero-López, Berta, Cavigliasso, P., Cetkovic, Aleksandar, Chacoff, Natacha P., Classen, A., Cusser, S., Da Silva E Silva, F. D., Arjen De Groot, G., Dudenhöffer, J. H., Ekroos, J., Fijen, T., Franck, P., Freitas, B. M., Garratt, M. P. D., Gratton, C., Hipólito, J., Holzschuh, A., Hunt, L., and Zaragoza-Trello, C.

Abstract

Human land use threatens global biodiversity and compromises multiple ecosystem functions critical to food production. Whether crop yield-related ecosystem services can be maintained by a few dominant species or rely on high richness remains unclear. Using a global database from 89 studies (with 1475 locations), we partition the relative importance of species richness, abundance, and dominance for pollination; biological pest control; and final yields in the context of ongoing land-use change. Pollinator and enemy richness directly supported ecosystem services in addition to and independent of abundance and dominance. Up to 50% of the negative effects of landscape simplification on ecosystem services was due to richness losses of service-providing organisms, with negative consequences for crop yields. Maintaining the biodiversity of ecosystem service providers is therefore vital to sustain the flow of key agroecosystem benefits to society.

Published
2019

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