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10. The effects of marijuana extract and ∆9-tetrahydrocannabinol on luteal function in the rhesus monkey**Supported in part by National Institute on Drug Abuse grant DAO-R012063.††Presented at the Thirty-Eighth Annual Meeting of The American Fertility Society, March 20 to 24, 1982, Las Vegas, Nevada.

Author

Almirez, Ramona G., Smith, Carol Grace, and Asch, Ricardo H.

Abstract

The effects of marijuana extract (ME) and ∆9-tetrahydrocannabinol (THC) on corpus luteum function were studied in the rhesus monkey by the use of in vivo and in vitro techniques.

Published
1983
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11. Effect of Tetrahydrocannabinol on the Hypothalamic-Pituitary Axis in the Ovariectomized Rhesus Monkey**Supported by National Institute on Drug Abuse Grant 1-R01-DA1346-02.

Author

Smith, Carol Grace, Besch, Norma F., Smith, Roy G., and Besch, Paige K.

Abstract

Single doses of ∆9-tetrahydrocannabinol (THC) (5.0, 2.5, 1.25, or 0.625mg/kg) can decrease the levels of both luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the ovariectomized rhesus monkey. The inhibition of gonadotropins (50% to 88%) lasts for 6 to 24 hours depending upon the dose of THC. There are no great differences in the responses of the two gonadotropins to THC. The inhibition of gonadotropin levels by THC appears to be at the level of the hypothalamus, since both LH and FSH are released from the pituitary gland in response to LH-releasing factor in the presence of THC.

Published
1979
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