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14 results on '"Smith, Alexander C.W."'

6. Synaptic Microtubule-Associated Protein EB3 and SRC Phosphorylation Mediate Structural and Behavioral Adaptations During Withdrawal From Cocaine Self-Administration

Author

Calipari, Erin S., primary, Godino, Arthur, additional, Salery, Marine, additional, Damez-Werno, Diane M., additional, Cahill, Michael E., additional, Werner, Craig T., additional, Gancarz, Amy M., additional, Peck, Emily G., additional, Jlayer, Zahra, additional, Rabkin, Jacqui, additional, Landry, Joseph A., additional, Smith, Alexander C.W., additional, Defilippi, Paola, additional, Kenny, Paul J., additional, Hurd, Yasmin L., additional, Neve, Rachael L., additional, Dietz, David M., additional, and Nestler, Eric J., additional

Published
2019
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9. Transient synaptic potentiation in nucleus accumbens shell during refraining from cocaine seeking.

Author

Roberts‐Wolfe, Douglas J., Heinsbroek, Jasper A., Spencer, Sade M., Bobadilla, Ana Clara, Smith, Alexander C.W., Gipson, Cassandra D., Kalivas, Peter W., and Roberts-Wolfe, Douglas J

Subjects
NUCLEUS accumbens, GLUTAMATE receptors, METHYL aspartate receptors, AMPA receptors, COCAINE, GLUTAMIC acid metabolism, ASPARTIC acid metabolism, NEURAL transmission, NEURONS, BASAL ganglia, HETEROCYCLIC compounds, NEUROPLASTICITY, CELL receptors, REINFORCEMENT (Psychology), RATS, MEDIUM spiny neurons, RESEARCH funding, DOPAMINE uptake inhibitors, COMPULSIVE behavior, ANIMALS, PROMPTS (Psychology), MICE, MEMBRANE potential
Abstract

Repeated exposure to drug-associated cues without reward (extinction) leads to refraining from drug seeking in rodents. We determined if refraining is associated with transient synaptic plasticity (t-SP) in nucleus accumbens shell (NAshell), akin to the t-SP measured in the NAcore during cue-induced reinstatement of drug seeking. Using whole cell patch electrophysiology, we found that medium spiny neurons (MSNs) in NAshell expressed increased ratio of AMPA to NMDA glutamate receptor currents during refraining, which normalized to baseline levels by the end of the 2-hour extinction session. Unlike t-SP observed in NAcore during reinstated drug seeking, neither dendrite spine head enlargement nor activation of matrix metalloproteases (MMP2/9) accompanied the increased AMPA:NMDA in NAshell during refraining. Refraining was also not associated with changes in paired pulse ratio, NMDA receptor current decay time, or AMPA receptor rectification index in NAshell MSNs. Our preliminary data in transgenic mice suggest that t-SP may increase D2-MSN inputs relative to D1-MSN inputs. [ABSTRACT FROM AUTHOR]

Published
2020
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11. Accumbens nNOS Interneurons Regulate Cocaine Relapse

Author

Smith, Alexander C.W., primary, Scofield, Michael D., additional, Heinsbroek, Jasper A., additional, Gipson, Cassandra D., additional, Neuhofer, Daniela, additional, Roberts-Wolfe, Doug J., additional, Spencer, Sade, additional, Garcia-Keller, Constanza, additional, Stankeviciute, Neringa M., additional, Smith, Rachel J., additional, Allen, Nicholas P., additional, Lorang, Melissa R., additional, Griffin, William C., additional, Boger, Heather A., additional, and Kalivas, Peter W., additional

Published
2017
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12. Accumbens nNOS Interneurons Regulate Cocaine Relapse

Author

Smith, Alexander C.W., primary, Scofield, Michael D., additional, Heinsbroek, Jasper A., additional, Gipson, Cassandra D., additional, Neuhofer, Daniela, additional, Roberts-Wolfe, Doug J., additional, Spencer, Sade, additional, Garcia-Keller, Constanza, additional, Stankeviciute, Neringa M., additional, Smith, Rachel J., additional, Allen, Nicholas P., additional, Lorang, Melissa R., additional, Griffin, William C., additional, Boger, Heather A., additional, and Kalivas, Peter W., additional

Published
2016
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