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2. Causal analysis of plasma IL-8 on carotid intima media thickness, a measure of subclinical atherosclerosis

Author

Velásquez, Ilais Moreno, Malarstig, Anders, Baldassarre, Damiano, Borne, Yan, de Faire, Ulf, Engström, Gunnar, Eriksson, Per, Giral, Philippe, Humphries, Steve E., Kurl, Sudhir, Leander, Karin, Lind, Lars, Lindén, Anders, Orsini, Nicola, Pirro, Matteo, Silveira, Angela, Smit, Andries J., Tremoli, Elena, Veglia, Fabrizio, Strawbridge, Rona J., and Gigante, Bruna

Published
2023
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5. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.

Author

Franceschini, Nora, Giambartolomei, Claudia, de Vries, Paul S, Finan, Chris, Bis, Joshua C, Huntley, Rachael P, Lovering, Ruth C, Tajuddin, Salman M, Winkler, Thomas W, Graff, Misa, Kavousi, Maryam, Dale, Caroline, Smith, Albert V, Hofer, Edith, van Leeuwen, Elisabeth M, Nolte, Ilja M, Lu, Lingyi, Scholz, Markus, Sargurupremraj, Muralidharan, Pitkänen, Niina, Franzén, Oscar, Joshi, Peter K, Noordam, Raymond, Marioni, Riccardo E, Hwang, Shih-Jen, Musani, Solomon K, Schminke, Ulf, Palmas, Walter, Isaacs, Aaron, Correa, Adolfo, Zonderman, Alan B, Hofman, Albert, Teumer, Alexander, Cox, Amanda J, Uitterlinden, André G, Wong, Andrew, Smit, Andries J, Newman, Anne B, Britton, Annie, Ruusalepp, Arno, Sennblad, Bengt, Hedblad, Bo, Pasaniuc, Bogdan, Penninx, Brenda W, Langefeld, Carl D, Wassel, Christina L, Tzourio, Christophe, Fava, Cristiano, Baldassarre, Damiano, O'Leary, Daniel H, Teupser, Daniel, Kuh, Diana, Tremoli, Elena, Mannarino, Elmo, Grossi, Enzo, Boerwinkle, Eric, Schadt, Eric E, Ingelsson, Erik, Veglia, Fabrizio, Rivadeneira, Fernando, Beutner, Frank, Chauhan, Ganesh, Heiss, Gerardo, Snieder, Harold, Campbell, Harry, Völzke, Henry, Markus, Hugh S, Deary, Ian J, Jukema, J Wouter, de Graaf, Jacqueline, Price, Jacqueline, Pott, Janne, Hopewell, Jemma C, Liang, Jingjing, Thiery, Joachim, Engmann, Jorgen, Gertow, Karl, Rice, Kenneth, Taylor, Kent D, Dhana, Klodian, Kiemeney, Lambertus ALM, Lind, Lars, Raffield, Laura M, Launer, Lenore J, Holdt, Lesca M, Dörr, Marcus, Dichgans, Martin, Traylor, Matthew, Sitzer, Matthias, Kumari, Meena, Kivimaki, Mika, Nalls, Mike A, Melander, Olle, Raitakari, Olli, Franco, Oscar H, Rueda-Ochoa, Oscar L, Roussos, Panos, Whincup, Peter H, Amouyel, Philippe, and Giral, Philippe

Subjects
MEGASTROKE Consortium, Humans, Coronary Disease, Genetic Predisposition to Disease, Amino Acid Oxidoreductases, Protein-Lysine 6-Oxidase, Risk Factors, Lod Score, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Genome-Wide Association Study, Plaque, Atherosclerotic, Carotid Intima-Media Thickness, ADAMTS9 Protein, Plaque, Atherosclerotic, Polymorphism, Single Nucleotide
Abstract

Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans.

Published
2018

7. Association between skin autofluorescence and coronary calcification in the general population.

Author

Boersma, Henderikus E., Xia, Congying, van der Klauw, Melanie M., Vonder, Marleen, Oudkerk, Matthijs, van der Harst, Pim, Jan Pelgrim, Gert, Wolffenbuttel, Bruce H. R., Smit, Andries J., and Vliegenthart, Rozemarijn

Subjects
CORONARY artery calcification, ADVANCED glycation end-products, CARDIOVASCULAR diseases risk factors, COMPUTED tomography, CARDIOVASCULAR diseases
Abstract

Objective: To address the relationship between tissue accumulation of advanced glycation end-products, assessed by skin autofluorescence (SAF), and subclinical atherosclerosis quantified with coronary artery calcium score (CACS) in the general Dutch population. Methods: A total of 3,839 participants of the LifeLines Cohort Study without diabetes or cardiovascular disease were included in this cross-sectional evaluation. They underwent SAF measurement and cardiac computed tomography to measure CACS. Associations between SAF and CACS was assessed using regression models. Participants at elevated risk for cardiovascular disease were selected by either CACS≥100, or SAF value in the top 15%; overlap and cardiovascular risk profile of these participants were compared. Results: In univariate analysis, every 1 arbitrary unit (AU) increase in SAF resulted in an odds ratio of 2.91 (95% confidence interval 2.44–3.48, p<0.001) for coronary calcification. After adjustment for cardiovascular risk factors, there was still 20% higher odds of coronary calcification with 1 AU increase in SAF, but significance was lost. In total, 1025 (27%) participants either had high SAF and/or high CACS, of these 441 (12%) had only high SAF, 450 (12%) had only high CACS and 134 (3%) participants had high SAF and high CACS. Conclusion: In a population-based Dutch cohort, SAF was associated with the degree of coronary calcification. This association was largely explained by classical cardiovascular risk factors. Limited overlap was found in subgroups with high SAF or high CACS, indicating that SAF and CACS may have complementary role in identifying individuals at elevated cardiovascular risk. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Sex-specific predictors of PCSK9 levels in a European population: The IMPROVE study

Author

Ferri, Nicola, Ruscica, Massimiliano, Coggi, Daniela, Bonomi, Alice, Amato, Mauro, Frigerio, Beatrice, Sansaro, Daniela, Ravani, Alessio, Veglia, Fabrizio, Capra, Nicolò, Lupo, Maria G., Macchi, Chiara, Castelnuovo, Samuela, Savonen, Kai, Silveira, Angela, Kurl, Sudhir, Giral, Philippe, Pirro, Matteo, Strawbridge, Rona J., Gigante, Bruna, Smit, Andries J., Tremoli, Elena, Colombo, Gualtiero I., and Baldassarre, Damiano

Published
2020
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11. The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals

Author

Strawbridge, Rona J., Johnston, Keira J. A., Bailey, Mark E. S., Baldassarre, Damiano, Cullen, Breda, Eriksson, Per, deFaire, Ulf, Ferguson, Amy, Gigante, Bruna, Giral, Philippe, Graham, Nicholas, Hamsten, Anders, Humphries, Steve E., Kurl, Sudhir, Lyall, Donald M., Lyall, Laura M., Pell, Jill P., Pirro, Matteo, Savonen, Kai, Smit, Andries J., Tremoli, Elena, Tomainen, Tomi-Pekka, Veglia, Fabrizio, Ward, Joey, Sennblad, Bengt, and Smith, Daniel J.

Published
2021
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13. Association of lifelong occupation and educational level with subclinical atherosclerosis in different European regions. Results from the IMPROVE study

Author

Tedesco, Calogero C., Veglia, Fabrizio, de Faire, Ulf, Kurl, Sudhir, Smit, Andries J., Rauramaa, Rainer, Giral, Philippe, Amato, Mauro, Bonomi, Alice, Ravani, Alessio, Frigerio, Beatrice, Castelnuovo, Samuela, Sansaro, Daniela, Mannarino, Elmo, Humphries, Steve E., Hamsten, Anders, Tremoli, Elena, and Baldassarre, Damiano

Published
2018
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15. Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation

Author

Strawbridge, Rona J., Silveira, Angela, Hoed, Marcel den, Gustafsson, Stefan, Luan, Jian'an, Rybin, Denis, Dupuis, Josée, Li-Gao, Ruifang, Kavousi, Maryam, Dehghan, Abbas, Haljas, Kadri, Lahti, Jari, Gådin, Jesper R., Bäcklund, Alexandra, de Faire, Ulf, Gertow, Karl, Giral, Phillipe, Goel, Anuj, Humphries, Steve E., Kurl, Sudhir, Langenberg, Claudia, Lannfelt, Lars L., Lind, Lars, Lindgren, Cecilia C.M., Mannarino, Elmo, Mook-Kanamori, Dennis O., Morris, Andrew P., de Mutsert, Renée, Rauramaa, Rainer, Saliba-Gustafsson, Peter, Sennblad, Bengt, Smit, Andries J., Syvänen, Ann-Christine, Tremoli, Elena, Veglia, Fabrizio, Zethelius, Björn, Björck, Hanna M., Eriksson, Johan G., Hofman, Albert, Franco, Oscar H., Watkins, Hugh, Jukema, J. Wouter, Florez, Jose C., Wareham, Nicholas J., Meigs, James B., Ingelsson, Erik, Baldassarre, Damiano, and Hamsten, Anders

Published
2017
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16. The soluble receptor for advanced glycation end products is potentially predictive of pulmonary arterial hypertension in systemic sclerosis

Author

Atzeni, Isabella M., primary, Al-Adwi, Yehya, additional, Doornbos-van der Meer, Berber, additional, Roozendaal, Caroline, additional, Stel, Alja, additional, van Goor, Harry, additional, Gan, C. Tji, additional, Dickinson, Michael, additional, Timens, Wim, additional, Smit, Andries J., additional, Westra, Johanna, additional, and Mulder, Douwe J., additional

Published
2023
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17. Induced ischemia-reperfusion and oxidative stress in patients with systemic sclerosis lead to increased release of High-Mobility Group Box-1 which potentially activate skin fibroblast to produce interferon-γ Induced Protein-10: a translational study

Author

Al-Adwi, Yehya, primary, Atzeni, Isabella M., additional, Doornbos-van der Meer, Berber, additional, Abdulle, Amel E., additional, van Roon, Anniek M., additional, Stel, Alja, additional, van Goor, Harry, additional, Smit, Andries J., additional, Westra, Johanna, additional, and Mulder, Douwe J., additional

Published
2023
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18. Carotid plaque-thickness and common carotid IMT show additive value in cardiovascular risk prediction and reclassification

Author

Amato, Mauro, Veglia, Fabrizio, de Faire, Ulf, Giral, Philippe, Rauramaa, Rainer, Smit, Andries J., Kurl, Sudhir, Ravani, Alessio, Frigerio, Beatrice, Sansaro, Daniela, Bonomi, Alice, Tedesco, Calogero C., Castelnuovo, Samuela, Mannarino, Elmo, Humphries, Steve E., Hamsten, Anders, Tremoli, Elena, and Baldassarre, Damiano

Published
2017
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19. Association between the tissue accumulation of advanced glycation end products and exercise capacity in cardiac rehabilitation patients

Author

Kunimoto, Mitsuhiro, Shimada, Kazunori, Yokoyama, Miho, Matsubara, Tomomi, Aikawa, Tatsuro, Ouchi, Shohei, Shimizu, Megumi, Fukao, Kosuke, Miyazaki, Tetsuro, Kadoguchi, Tomoyasu, Fujiwara, Kei, Abulimiti, Abidan, Honzawa, Akio, Yamada, Miki, Shimada, Akie, Yamamoto, Taira, Asai, Tohru, Amano, Atsushi, Smit, Andries J., and Daida, Hiroyuki

Published
2020
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20. A machine learning based approach to identify carotid subclinical atherosclerosis endotypes.

Author

Chen, Qiao Sen, Bergman, Otto, Ziegler, Louise, Baldassarre, Damiano, Veglia, Fabrizio, Tremoli, Elena, Strawbridge, Rona J, Gallo, Antonio, Pirro, Matteo, Smit, Andries J, Kurl, Sudhir, Savonen, Kai, Lind, Lars, Eriksson, Per, and Gigante, Bruna

Subjects
MACHINE learning, ATHEROSCLEROSIS, SYSTOLIC blood pressure, ATHEROSCLEROTIC plaque, CARDIOVASCULAR diseases risk factors
Abstract

Aims To define endotypes of carotid subclinical atherosclerosis. Methods and results We integrated demographic, clinical, and molecular data (n = 124) with ultrasonographic carotid measurements from study participants in the IMPROVE cohort (n = 3340). We applied a neural network algorithm and hierarchical clustering to identify carotid atherosclerosis endotypes. A measure of carotid subclinical atherosclerosis, the c-IMTmean-max, was used to extract atherosclerosis-related features and SHapley Additive exPlanations (SHAP) to reveal endotypes. The association of endotypes with carotid ultrasonographic measurements at baseline, after 30 months, and with the 3-year atherosclerotic cardiovascular disease (ASCVD) risk was estimated by linear (β , SE) and Cox [hazard ratio (HR), 95% confidence interval (CI)] regression models. Crude estimates were adjusted by common cardiovascular risk factors, and baseline ultrasonographic measures. Improvement in ASCVD risk prediction was evaluated by C -statistic and by net reclassification improvement with reference to SCORE2, c-IMTmean-max, and presence of carotid plaques. An ensemble stacking model was used to predict endotypes in an independent validation cohort, the PIVUS (n = 1061). We identified four endotypes able to differentiate carotid atherosclerosis risk profiles from mild (endotype 1) to severe (endotype 4). SHAP identified endotype-shared variables (age, biological sex, and systolic blood pressure) and endotype-specific biomarkers. In the IMPROVE, as compared to endotype 1, endotype 4 associated with the thickest c-IMT at baseline (β , SE) 0.36 (0.014), the highest number of plaques 1.65 (0.075), the fastest c-IMT progression 0.06 (0.013), and the highest ASCVD risk (HR, 95% CI) (1.95, 1.18–3.23). Baseline and progression measures of carotid subclinical atherosclerosis and ASCVD risk were associated with the predicted endotypes in the PIVUS. Endotypes consistently improved measures of ASCVD risk discrimination and reclassification in both study populations. Conclusions We report four replicable subclinical carotid atherosclerosis—endotypes associated with progression of atherosclerosis and ASCVD risk in two independent populations. Our approach based on endotypes can be applied for precision medicine in ASCVD prevention. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Cross-Sectional Gene-Smoking Interaction Analysis in Relation to Subclinical Atherosclerosis-Results From the IMPROVE Study

Author

Maitusong, Buamina, Laguzzi, Federica, Strawbridge, Rona J, Baldassarre, Damiano, Veglia, Fabrizio, Humphries, Steve E, Savonen, Kai, Kurl, Sudhir, Pirro, Matteo, Smit, Andries J, Giral, Philippe, Silveira, Angela, Tremoli, Elena, Hamsten, Anders, de Faire, Ulf, Gigante, Bruna, and Leander, Karin

Subjects
cardiovascular disease, carotid intima-media thickness, infarction, atherosclerosis, sample size
Published
2023

23. Genetic variation in CADM2 as a link between psychological traits and obesity

Author

Morris, Julia, Bailey, Mark E. S., Baldassarre, Damiano, Cullen, Breda, de Faire, Ulf, Ferguson, Amy, Gigante, Bruna, Giral, Philippe, Goel, Anuj, Graham, Nicholas, Hamsten, Anders, Humphries, Steve E., Johnston, Keira J. A., Lyall, Donald M., Lyall, Laura M., Sennblad, Bengt, Silveira, Angela, Smit, Andries J., Tremoli, Elena, Veglia, Fabrizio, Ward, Joey, Watkins, Hugh, Smith, Daniel J., and Strawbridge, Rona J.

Published
2019
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24. Release of High-Mobility Group Box-1 after a Raynaud's Attack Leads to Fibroblast Activation and Interferon-γ Induced Protein-10 Production: Role in Systemic Sclerosis Pathogenesis.

Author

Al-Adwi, Yehya, Atzeni, Isabella M., Doornbos-van der Meer, Berber, Abdulle, Amaal Eman, van Roon, Anniek M., Stel, Alja, van Goor, Harry, Smit, Andries J., Westra, Johanna, and Mulder, Douwe J.

Subjects
RECEPTOR for advanced glycation end products (RAGE), SYSTEMIC scleroderma, CONNECTIVE tissue growth factor, TRANSFORMING growth factors, ADVANCED glycation end-products, RAYNAUD'S disease
Abstract

Raynaud's Phenomenon (RP) leading to repetitive ischemia and reperfusion (IR) stress, is the first recognizable sign of systemic sclerosis (SSc) leading to increased oxidative stress. High-mobility group box-1 (HMGB1) is a nuclear factor released by apoptotic and necrotic cells after oxidative stress. Since HMGB1 can signal through the receptor for advanced glycation end products (RAGE), we investigated whether an RP attack promotes the release of HMGB1, leading to fibroblast activation and the upregulation of interferon (IFN)-inducible genes. A cold challenge was performed to simulate an RP attack in patients with SSc, primary RP (PRP), and healthy controls. We measured levels of HMGB1 and IFN gamma-induced Protein 10 (IP-10) at different time points in the serum. Digital perfusion was assessed by photoplethysmography. In vitro, HMGB1 or transforming growth factor (TGF-β1) (as control) was used to stimulate healthy human dermal fibroblasts. Inflammatory, profibrotic, and IFN-inducible genes, were measured by RT-qPCR. In an independent cohort, sera were obtained from 20 patients with SSc and 20 age- and sex-matched healthy controls to determine HMGB1 and IP-10 levels. We found that HMGB1 levels increased significantly 30 min after the cold challenge in SSc compared to healthy controls. In vitro stimulation with HMGB1 resulted in increased mRNA expression of IP-10, and interleukin-6 (IL-6) while TGF-β1 stimulation promoted IL-6 and Connective Tissue Growth Factor (CTGF). In serum, both HMGB1 and IP-10 levels were significantly higher in patients with SSc compared to healthy controls. We show that cold challenge leads to the release of HMGB1 in SSc patients. HMGB1 induces IP-10 expression in dermal fibroblasts partly through the soluble RAGE (sRAGE) axis suggesting a link between RP attacks, the release of HMGB1 and IFN-induced proteins as a putative early pathogenetic mechanism in SSc. [ABSTRACT FROM AUTHOR]

Published
2023
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30. A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima–media thickness)

Author

Strawbridge, Rona J., Deleskog, Anna, McLeod, Olga, Folkersen, Lasse, Kavousi, Maryam, Gertow, Karl, Baldassarre, Damiano, Veglia, Fabrizio, Leander, Karin, Gigante, Bruna, Kauhanen, Jussi, Rauramaa, Rainer, Smit, Andries J., Mannarino, Elmo, Giral, Philippe, Dehghan, Abbas, Hofman, Albert, Franco, Oscar H., Humphries, Steve E., Tremoli, Elena, de Faire, Ulf, Gustafsson, Sven, Östensson, Claes-Göran, Eriksson, Per, Öhrvik, John, and Hamsten, Anders

Published
2014
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31. Intake of food rich in saturated fat in relation to subclinical atherosclerosis and potential modulating effects from single genetic variants

Author

Laguzzi, Federica, Maitusong, Buamina, Strawbridge, Rona J., Baldassarre, Damiano, Veglia, Fabrizio, Humphries, Steve E., Rauramaa, Rainer, Kurl, Sudhir, Smit, Andries J., Giral, Philippe, Silveira, Angela, Tremoli, Elena, Hamsten, Anders, de Faire, Ulf, Gigante, Bruna, Leander, Karin, Sirtori, C. R., Calabresi, L., Amato, M., Frigerio, B., Ravani, A., Sansaro, D., Tedesco, C., Coggi, D., Capra, N., Bonomi, A., Eriksson, P., Cooper, J., Acharya, J., Savonen, K., Huttunen, K., Rauramaa, E., Penttila, I. M., Törrönen, J., van Gessel, A. I., van Roon, A. M., Nicolai, A., Mulder, D. J., Kontush, A., Carrié, A., Gallo, A., Karppi, J., Nurmi, T., Nyyssönen, K., Tuomainen, T. P., Tuomainen, J., Kauhanen, J., Sennblad, B., Pirro, M., Vaudo, G., Siepi, D., Lupattelli, G., Mannarino, M. R., Bianconi, V., Groningen Kidney Center (GKC), Translational Immunology Groningen (TRIGR), Karolinska Institutet [Stockholm], Xinjiang University, University of Glasgow, Università degli Studi di Milano [Milano] (UNIMI), Centro Cardiologico Monzino [Milano], Dpt di Scienze Cliniche e di Comunità [Milano] (DISCCO), Università degli Studi di Milano [Milano] (UNIMI)-Università degli Studi di Milano [Milano] (UNIMI)-Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), University College of London [London] (UCL), University of Kuopio, University of Eastern Finland, University Medical Center Groningen [Groningen] (UMCG), Service d’Endocrinologie, Métabolisme et Prévention des Risques Cardio-Vasculaires [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
Male, medicine.medical_specialty, Multivariate analysis, Cross-sectional study, Science, [SDV]Life Sciences [q-bio], Saturated fat, Cardiology, Disease, 030204 cardiovascular system & hematology, Logistic regression, Carotid Intima-Media Thickness, Article, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Genetics, Medicine, Humans, Genetic Predisposition to Disease, 030212 general & internal medicine, Aged, Multidisciplinary, business.industry, Middle Aged, Atherosclerosis, Dietary Fats, 3. Good health, Endocrinology, Blood pressure, Intima-media thickness, Cohort, cardiovascular system, Dietary Fats/adverse effects, Female, Atherosclerosis/epidemiology, business, Biomarkers
Abstract

The relationship between intake of saturated fats and subclinical atherosclerosis, as well as the possible influence of genetic variants, is poorly understood and investigated. We aimed to investigate this relationship, with a hypothesis that it would be positive, and to explore whether genetics may modulate it, using data from a European cohort including 3,407 participants aged 54–79 at high risk of cardiovascular disease. Subclinical atherosclerosis was assessed by carotid intima-media thickness (C-IMT), measured at baseline and after 30 months. Logistic regression (OR; 95% CI) was employed to assess the association between high intake of food rich in saturated fat (vs. low) and: (1) the mean and the maximum values of C-IMT in the whole carotid artery (C-IMTmean, C-IMTmax), in the bifurcation (Bif-), the common (CC-) and internal (ICA-) carotid arteries at baseline (binary, cut-point ≥ 75th), and (2) C-IMT progression (binary, cut-point > zero). For the genetic-diet interaction analyses, we considered 100,350 genetic variants. We defined interaction as departure from additivity of effects. After age- and sex-adjustment, high intake of saturated fat was associated with increased C-IMTmean (OR:1.27;1.06–1.47), CC-IMTmean (OR:1.22;1.04–1.44) and ICA-IMTmean (OR:1.26;1.07–1.48). However, in multivariate analysis results were no longer significant. No clear associations were observed between high intake of saturated fat and risk of atherosclerotic progression. There was no evidence of interactions between high intake of saturated fat and any of the genetic variants considered, after multiple testing corrections. High intake of saturated fats was not independently associated with subclinical atherosclerosis. Moreover, we did not identify any significant genetic-dietary fat interactions in relation to risk of subclinical atherosclerosis.

Published
2021

34. Additional file 3 of Skin autofluorescence predicts new cardiovascular disease and mortality in people with type 2 diabetes

Author

Boersma, Henderikus E., Waateringe, Robert P. Van, Klauw, Melanie M. Van Der, Graaff, Reindert, Paterson, Andrew D., Smit, Andries J., and Wolffenbuttel, Bruce H. R.

Abstract

Additional file 3: Table S1. Univariable and multivariable logistic regression analyses for the separate primary outcomes (CVD or death) at a median of 3.7 year follow-up.

Published
2021
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35. Additional file 4 of Skin autofluorescence predicts new cardiovascular disease and mortality in people with type 2 diabetes

Author

Boersma, Henderikus E., Waateringe, Robert P. Van, Klauw, Melanie M. Van Der, Graaff, Reindert, Paterson, Andrew D., Smit, Andries J., and Wolffenbuttel, Bruce H. R.

Abstract

Additional file 4: Table S2. Univariable and multivariable logistic regression analyses for the composite primary outcome (CVD or death) at a median of 3.7 years’ follow-up of people with baseline type 2 diabetes without clinically-manifest CVD.

Published
2021
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47. A priori-defined Mediterranean-like dietary pattern predicts cardiovascular events better in north Europe than in Mediterranean countries

Author

Veglia, Fabrizio, Baldassarre, Damiano, de Faire, Ulf, Kurl, Sudhir, Smit, Andries J., Rauramaa, Rainer, Giral, Philippe, Amato, Mauro, Di Minno, Alessandro, Ravani, Alessio, Frigerio, B., Castelnuovo, S., Sansaro, Daniela, Coggi, Daniela, Bonomi, Alice, Tedesco, C., Mannarino, Elmo, Humphries, Steve E., Hamsten, Anders, Tremoli, Elena, Veglia, Fabrizio, Baldassarre, Damiano, de Faire, Ulf, Kurl, Sudhir, Smit, Andries J., Rauramaa, Rainer, Giral, Philippe, Amato, Mauro, Di Minno, Alessandro, Ravani, Alessio, Frigerio, Beatrice, Castelnuovo, Samuela, Sansaro, Daniela, Coggi, Daniela, Bonomi, Alice, Tedesco, Calogero C., Mannarino, Elmo, Humphries, Steve E., Hamsten, Ander, Tremoli, Elena, Groningen Kidney Center (GKC), and Lifestyle Medicine (LM)

Subjects
Male, Mediterranean diet score, TIA, transient ischemic attack, PROGRESSION, Diet, Mediterranean, INTIMA-MEDIA THICKNESS, Vascular disease, DISEASE, Article, CAD, Coronary artery disease, Cohort Studies, ADHERENCE, VEs, Vascular Events, Predictive Value of Tests, Humans, hs-CRP, high sensitive C-Reactive Protein, Longitudinal Studies, Prospective Studies, cIMT, carotid intima media thickness, Vascular diseases, POPULATION, Aged, RISK, VASCULAR EVENTS, Mediterranean Region, MORTALITY, MD, Mediterranean Diet, VRFs, vascular risk factors, IMPROVE study, Middle Aged, PREVENTION, Europe, Cardiovascular Diseases, LIFE-STYLE, Female, Diet, Healthy, Cardiology and Cardiovascular Medicine, Follow-Up Studies
Abstract

Background The Mediterranean Diet (MD) is a model of healthy eating contributing to a favorable health status, but its clinical usefulness is still debated. The aim of this study was to relate the adherence to MD with the incidence of cardio/cerebro-vascular events (VEs) in north and south European participants of the IMPROVE study. Methods IMPROVE is an observational, longitudinal, prospective cohort study involving 3703 individuals from five European countries (Finland, Sweden, Netherlands, France and Italy). The study end-point was the incidence of the first combined cardio/cerebro-vascular event occurring during 36-months follow-up. At baseline, a dietary questionnaire about the usual intake during the year preceding enrollment was administered. Based on 7 nutritional items, a MD Score was constructed in which minimal adherence was 0 and maximal adherence was 7. Results Latitude was the strongest determinant of MD score (p, Highlights • Mediterranean Diet score is able to detect changes of risk of vascular events. • Latitude is the strongest determinant of Mediterranean Diet score. • North Europeans are the best candidates for intervention with Mediterranean Diet.

Published
2019

49. Additional file 2 of Association between the tissue accumulation of advanced glycation end products and exercise capacity in cardiac rehabilitation patients

Author

Kunimoto, Mitsuhiro, Shimada, Kazunori, Yokoyama, Miho, Matsubara, Tomomi, Tatsuro Aikawa, Ouchi, Shohei, Shimizu, Megumi, Fukao, Kosuke, Miyazaki, Tetsuro, Tomoyasu Kadoguchi, Fujiwara, Kei, Abidan Abulimiti, Honzawa, Akio, Yamada, Miki, Akie Shimada, Taira Yamamoto, Asai, Tohru, Amano, Atsushi, Smit, Andries J., and Daida, Hiroyuki

Subjects
fungi
Abstract

Additional file 2: Table S2. Comparison of clinical characteristics between (> 2.7 a.u.) and Low SAF (≤ 2.7 a.u.) groups in non DM (diabetes mellitus) patients.

Published
2020
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50. Additional file 1 of Association between the tissue accumulation of advanced glycation end products and exercise capacity in cardiac rehabilitation patients

Author

Kunimoto, Mitsuhiro, Shimada, Kazunori, Yokoyama, Miho, Matsubara, Tomomi, Tatsuro Aikawa, Ouchi, Shohei, Shimizu, Megumi, Fukao, Kosuke, Miyazaki, Tetsuro, Tomoyasu Kadoguchi, Fujiwara, Kei, Abidan Abulimiti, Honzawa, Akio, Yamada, Miki, Akie Shimada, Taira Yamamoto, Asai, Tohru, Amano, Atsushi, Smit, Andries J., and Daida, Hiroyuki

Subjects
fungi
Abstract

Additional file 1: Table S1. Comparison of clinical characteristics between High SAF (> 3.0 a. u.) and Low SAF (≤ 3.0 a.u.) groups in DM (diabetes mellitus) patients.

Published
2020
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