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The performance of version 4 of the NOAA High-Resolution Rapid Refresh (HRRR) numerical weather prediction model for near-surface variables, including wind, humidity, temperature, surface latent and sensible fluxes, and longwave and shortwave radiative fluxes, is examined over the Atmospheric Radiation Measurement (ARM) Southern Great Plains (SGP) region. The study evaluated the model’s bias and bias-corrected mean absolute error relative to the observations on different time scales. Forecasts of near-surface geophysical variables at five SGP sites (HRRR at 3-km scale) were found to agree well with observations, but some consistent observation–forecast differences also occurred. Sensible and latent heat fluxes are the most challenging variables to be reproduced. The diurnal cycle is the main temporal scale affecting observation–forecast differences of the near-surface variables, and almost all of the variables showed different biases throughout the diurnal cycle. Results show that the overestimation of downward shortwave and the underestimation of downward longwave radiative flux are the two major biases found in this study. The timing and magnitude of downward longwave flux, wind speed, and sensible and latent heat fluxes are also different with contributions from model representations, data assimilation limitations, and differences in scales between HRRR and SGP sites. The positive bias in downward shortwave and negative bias in longwave radiation suggests that the model is underestimating cloud fraction in the study domain. The study concludes by showing a brief comparison with version 3 of the HRRR and shows that version 4 has better performance in almost all near-surface variables. [ABSTRACT FROM AUTHOR]

Application of lake models coupled within earth-system prediction models, especially for short-term predictions from days to weeks, requires accurate initialization of lake temperatures. Here, we describe a lake initialization method by cycling within an hourly updated weather prediction model to constrain lake temperature evolution. We compare these simulated lake temperature values with other estimates from satellite and in situ and interpolated-SST data sets for a multi-month period in 2021. The lake cycling initialization, now applied to two operational US NOAA weather models, was found to decrease errors in lake temperature from as much as 5-10 K (using interpolated-SST data) to about 1-2 K (comparing with available in situ and satellite observations. [ABSTRACT FROM AUTHOR]

Because of limitations of variational and ensemble data assimilation schemes, resulting analysis fields exhibit some noise from imbalance in subsequent model forecasts. Controlling finescale noise is desirable in the NOAA's Rapid Refresh (RAP) assimilation/forecast system, which uses an hourly data assimilation cycle. Hence, a digital filter initialization (DFI) capability has been introduced into the Weather Research and Forecasting Model and applied operationally in the RAP, for which hourly intermittent assimilation makes DFI essential. A brief overview of the DFI approach, its implementation, and some of its advantages are discussed. Results from a 1-week impact test with and without DFI demonstrate that DFI is effective at reducing high-frequency noise in short-term operational forecasts as well as providing evidence of reduced errors in the 1-h mass and momentum fields. However, DFI is also shown to reduce the strength of parameterized deep moist convection during the first hour of the forecast. [ABSTRACT FROM AUTHOR]

Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential. Their synthesis and the results of the subsequent biological activity are reported herein. [ABSTRACT FROM AUTHOR]

The RUC Land-Surface Model (LSM) is used as a land surface component in the NOAA operational Rapid Refresh (RAP) short-range weather prediction model over North America domain and in the High-Resolution Rapid Refresh (HRRR) over CONUS and Alaska domains. It is also implemented in the Next Generation Global Prediction System (NGGPS) as part of the advanced physics (RAP/HRRR) suite. The RUC LSM performance has been evaluated for almost two decades within the real-time operational weather prediction systems focused on storm-scale predictions for severe weather and safer aviation. Valuable feedback from the National Weather Service forecast offices has motivated further advances in RUC LSM towards providing a more accurate lower boundary condition, including in snow-covered regions. One of them is the new treatment of energy budget for grid cells partially covered with snow. Sub-grid variability of snow depth is important for the evolution of the atmospheric boundary layer, since spatial distribution of snow is generally very heterogeneous and its properties are quite different from properties of snow-free surfaces. In this paper, a new "mosaic" approach considers snow-covered and non-snow-covered portions of a grid cell independently, and independently determined surface fluxes are aggregated to feed back into the surface-layer scheme at the end of each time step. This new approach removes the constraint of keeping skin temperature of partially covered with snow grid cells at or below the freezing point, and helps to reduce cold biases in these regions. It also helps to improve the evolution of cycled model snow cover together with the new semi-empirical formulations for the density of frozen precipitation depending on hydrometeor type and surface temperature. With the new "mosaic" approach for patchy snow, specification of a snow-covered fraction of a grid cell becomes critical. A scheme that gives more objective evaluation of snow fraction and represents sub-grid variability of snow depth has been implemented in RUC LSM. This new parameterization scheme is a stochastic model that describes spatial distribution of snow through an advection-diffusion equation, which is also called Fokker-Planck Equation (FPE). This enhancement to the RUC snow model, referred to as RUC-FPE LSM, is currently being validated through participation in the new Earth System Model-Snow Model Intercomparison Project (ESM-SnowMIP), and also is being tested in the experimental versions of RAP/HRRR at the NOAA Earth System Research Laboratory (ESRL). The RUC-FPE LSM is planned to be implemented in the next operational versions of RAP and HRRR at the NOAA National Centers for Environmental Prediction (NCEP). Description of the snow model enhancements and results from RUC-FPE LSM validation will be presented at the meeting. [ABSTRACT FROM AUTHOR]

A series of novel 5′-norcarbocyclic derivatives of 5-alkoxymethyl or 5-alkyltriazolyl-methyl uracil were synthesized and the activity of the compounds evaluated against both Gram-positive and Gram-negative bacteria. The growth of Mycobacterium smegmatis was completely inhibited by the most active compounds at a MIC99 of 67 μg/mL (mc2155) and a MIC99 of 6.7–67 μg/mL (VKPM Ac 1339). Several compounds also showed the ability to inhibit the growth of attenuated strains of Mycobacterium tuberculosis ATCC 25177 (MIC99 28–61 μg/mL) and Mycobacterium bovis ATCC 35737 (MIC99 50–60 μg/mL), as well as two virulent strains of M. tuberculosis; a laboratory strain H37Rv (MIC99 20–50 μg/mL) and a clinical strain with multiple drug resistance MS-115 (MIC99 20–50 μg/mL). Transmission electron microscopy (TEM) evaluation of M. tuberculosis H37Rv bacterial cells treated with one of the compounds demonstrated destruction of the bacterial cell wall, suggesting that the mechanism of action for these compounds may be related to their interactions with bacteria cell walls. [ABSTRACT FROM AUTHOR]