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The purpose of this study is to discover the elements of fantasy in Martine Franck’s documentary photographs, as well as to analyse the completeness, intentionality, and persuasiveness of the created images of illusory existence. The object of the study is the projects of Martine Franck created in the 1970s‐1990s. What contributed to Franck’s creative method was education in art history, the artistic phenomena of the first half of the 20th century, and collaboration with her husband, a prominent figure in documentary photography, co‐founder and ideologist of Magnum Photos, Henri Cartier‐Bresson. Franck’s thematic repertoire is extremely diverse, which provides a sufficient array of images to identify patterns withing the stated research topic using mainly the method of comparative analysis. No other studies on the search for the elements of fantasy in Franck’s work have been found. The examination of Franck’s photographs has allowed systematizing the elements of fantasy in her documentary photography projects and analysing the master’s figurative language and selected technical solutions.

The crisis of moral principles of social development at the present stage, the need of Russian law to create new legal traditions, the need to form a new scale of social values necessitate the assessment of the existing criminal procedure regulation for compliance with moral and ethical standards, the main axiological determinants of modern society, among which faith and trust occupy a special place. Through these categories, it is necessary to assess the understanding of evidence reliability in criminal proceedings. Purpose: to analyze the evidence reliability by interpreting its criteria in law enforcement practice. Methods: methods of comparative and comparative law research, description, interpretation; axiological and axiomatic methods; specific scientific methods: legal-dogmatic and interpretation of legal norms. Results: the study allows to conclude that it is necessary to assess the evidence reliability due not only to its procedural significance, but also to its moral essence. The analysis of judicial practice allows to argue the thesis that, unlike faith, which does not require proof, reliability needs confirmation, but in practice the criteria for assessing the evidence reliability are highly differentiated.

The article examines fraudulent discourse – a special type of discourse, the purpose of which is to take possession of other people’s property and obtain benefits through deceit or breach of trust. The author differentiates the legal understanding of the phenomenon of “fraud” and its perception in the ordinary worldview. It is proved that the concept of fraudulent discourse should include a number of communicative acts qualified by the Criminal Code of the Russian Federation as theft or extortion. The central genre of fraudulent discourse is the speech genre “swindle” / “con game”, based on the conscious and purposeful manipulative influence of the initiator of communication (fraudster) on the addressee (victim). Nowadays, the wide spread of remote communication determines the predominance of “swindle” using various technical means that provide synchronous or asynchronous interaction between the subjects of communication. The “swindle” / “con game” genre embodies the formulaicity of fraudulent discourse and is implemented through a limited number of strategies, each of which uses a stable set of means of influence. The main strategies are the appeal to fear, the appeal to luck and creation of the illusion of routine. As part of the fear appeal strategy, three tactics are distinguished, namely, the tactics of instilling fear for one’s prosperity and well-being, the tactics of instilling fear for the safety of a family member, and the tactics of instilling fear of public reprimand. The analysis is carried out by a continuous sampling method and is based on messages (more than 400 units) of potential victims or victims of technically mediated fraud, presented in the form of a narrative and posted on various communication resources in the media space.

All-optical tunability of semiconductor metasurfaces offers unique opportunities for novel time-varying effects, including frequency conversion and light trapping. However, the all-optical processes often induce optical absorption that fundamentally limits the possible dynamic increase of their quality factor (Q-boosting). Here, we propose and numerically demonstrate the concept of large Q-boosting in a single-material metasurface by dynamically reducing its structural anisotropy on a femtosecond timescale. This balance is achieved by excitation with a structured pump and takes advantage of the band-filling effect in a GaAs direct-bandgap semiconductor to eliminate the free-carrier-induced loss. We show that this approach allows a dynamic boosting of the resonance quality factor over orders of magnitude, only limited by the free-carrier relaxation processes. The proposed approach offers complete dynamic control over the resonance bandwidth and opens applications in frequency conversion and light trapping.

We show how machine learning techniques can be applied for the classification of topological phases in finite leaky photonic lattices using limited measurement data. We propose an approach based solely on a single real-space bulk intensity image, thus exempt from complicated phase retrieval procedures. In particular, we design a fully connected neural network that accurately determines topological properties from the output intensity distribution in dimerized waveguide arrays with leaky channels, after propagation of a spatially localized initial excitation at a finite distance, in a setting that closely emulates realistic experimental conditions.

Introduction. The concept of appropriateness of professional self-determination is analyzed, approaches to its analysis and measurement are described. Theoretical analysis. The significance of self-assessment of appropriateness of professional self-determination as a condition of sustainability to frequent stresses and prevention of professional burnout, including emotional exhaustion and depersonalization of personnel. Еmpirical analysis. The empirical study presents the results of the validation of the “Appropriateness of professional self-determination” Scale, developed by the author of the article. The empirical research base includes 396 workers, 277 men and 119 women. The performed in the study verification of the factor structure of the Scale confirmed its two-factor structure (subscale “Compliance of personal qualities of the job`s demands” (Cronbach`s α = 0.82) and subscale “Compliance of job of personal qualities” (Cronbach`s α. = 0.63)). The factor structure of the Scale was confirmed by the results of confirmatory factor analysis (RMSEA = 0.061, CFI = 0.964, TLI = 0.906). It was found that male workers and female workers evaluate their own appropriateness of professional self-determination in the same way. Negative correlations of appropriateness of professional self-determination with professional burnout, frequency of stresses and positive correlations with job satisfaction were revealed. Conclusion. The results of the study confirm the validity of the Appropriateness of Professional self-determination Scale, contribute the theoretical reflection of professional self-determination.

Environmental pollution due to anthropogenic activity in many regions of the planet and, in particular, in Ukraine has reached a critical level. Thus, the situation in the field of processing, utilization and, especially, disinfection of waste of various origins has become more complicated, which leads to regular accidents at municipal wastewater treatment plants and landfills. One of the main directions of solving these problems is the development of high-efficiency biological products aimed at minimizing and neutralizing the negative effects of environmental pollution. In order to create such biological products, competitive in the world market of biotechnology, on the basis of original domestic methods, a systematic study of ash and slag waste and the impact of various types of cultures of microorganisms on their neutralization was carried out. The study included the following: analysis of statistical data on periods of self-purification of soils and waters; analysis of the results of the use of biological products for cleaning cesspools, food waste processing, compost pits, farmland and polluted water; a comparative analysis of costs during the use of chemical and biotechnological methods of wastewater treatment with the subsequent calculation of the economic effect; analysis of the initial data of coal dust from the state CHP in order to substantiate the feasibility of its further processing both for the extraction of rare trace elements and to reduce the level of ecological damage; proposal and research of domestic biological products to solve the problems of municipal facilities for the purification of domestic wastewater, purification of water bodies and to eliminate emergency spills of petroleum products on the soil and water; computation of the economic efficiency of biotechnology application in comparison with the chemical method of water purification. On the basis of the data obtained, a scheme for the use of biological products for waste disposal, yield improvement, and accident elimination by methods safe for people, animals and the environment is proposed.

Distinguishing between the left- and right-handed versions of a chiral molecule (enantiomers) is vital, but also inherently difficult. Traditional optical methods using elliptically/circularly polarized light rely on linear effects which arise beyond the electric-dipole approximation, posing major limitations for ultrafast spectroscopy. Here we show how to turn an ultrashort elliptical pulse into an efficient chiro-optical tool: by tilting its polarization plane towards its propagation direction. This forward tilt can be achieved by focusing the beam tightly, creating structured light which exhibits a nontrivial polarization pattern in space. Using state-of-the-art computational modelling, we show that our structured field realizes a near-field interferometer for efficient chiral recognition that separates the nonlinear optical response of left- and right-handed molecules in space. Our work provides a simple, yet highly efficient, way of spatially structuring the polarization of light to image molecular chirality, with extreme enantio-efficiency and on ultrafast time scales.

We present a study of the interstellar medium parameters in star-forming complexes (SFCs) in NGC 3351, NGC 5055, and NGC 5457 galaxies. This study concludes our previous investigations of gas and dust in a number of spiral galaxies. The data for the three galaxies confirm the following. There is a tight correlation between near-infrared and far-infrared luminosities of the extragalactic SFCs. Emission at 8 μm also shows a strong correlation with the carbon monoxide emission. Atomic and molecular gas masses do not show any strong correlation with the corresponding velocity scatters; however, in NGC 5055, we see a hint of the SFC with the largest velocity scatter being located at the galaxy periphery.

Objectives: The aim of our study was to determine the effectiveness and biocompatibility of the use of solid clasp dentures with silver plating in the restoration of partial defects of the dentition.

The article considers the actual problem of improving the physico-mechanical, thermophysical and electrical properties of polyorganosiloxane coatings. In this article, we propose a method for obtaining a multifunctional heat-resistant composition based on oligodimethylsiloxane with terminal hydroxyl groups filled with boron nitride. The curing process of oligodimethylsiloxane and the possible interaction of boron nitride with reactive resin groups are described. The structure of the manufactured composition is investigated, it is established that the filler in the form of dispersed particles touching throughout the volume is evenly distributed in the polymer matrix. The results of experimental studies of the dependence of the tensile strength on the percentage of boron nitride, indicating the hardening of the composite, are graphically presented. Studies of the strength at separation of the cured composition from the substrate (adhesion) of various materials have shown that this value increases with the introduction of boron nitride. The dependence of the thermal conductivity coefficient on the ratio of components is established. The percolation point is determined by the Monte Carlo method. The dependences of the electrical resistivity and temperature dependence on the content of boron nitride are determined. The Poisson equation is solved in MathCad and graphical results of solving the heat transfer problem for traditional and developed composites are presented. Based on the results obtained, the areas of application of the developed composites in construction are proposed.

The article considers the main directions of France’s migration policy at the turn of 20th – 21st centuries and focuses on the measures taken by the French government to regulate migration policy. The author concludes that nowadays a lot of work has been done in the country to solve the problem of migration, which has slightly weakened migration flows.

The purpose of the study is to form strategic guidelines that will serve as the basis for maintaining the economic security of the enterprise in order to increase its competitiveness. The relation between the concepts of «economic security» and «competitiveness» is considered and summarized. It is substantiated that competitiveness are in close connection with economic security: an improve in economic security leads to increase in competitiveness. The views of researchers on the factors of the external and internal environment that affect the economic security of business entity are systematized. As result of the study, the views of various scholars were analyzed, identifying the factors that, according to the authors, have the greatest impact on the economic security of the enterprise. The importance of determining the factors is substantiated, because of their influence on the difficulties with the analysis and forecasting of activities, as well as the implementation of strategic management of the economic security of the enterprise. It is determined that efficient management in any field of activity can be carried out only under the condition of the formation of an integrated system of such management, designed to solve the main tasks. Therefore, a necessary condition for ensuring the viability of enterprises in a market economy is a successful set of strategic guidelines in the management of the economic security system, which prevents the destructive impact of changes in the factors of both the internal and the external environment of enterprise. The key strategic guidelines for building the system of economic security of enterprise are identified. The stages of development of diagnostics of the state of economic security of an economic entity are formed. Prospects for further research in this direction is to build a system of strategic management of economic security as a means of improving the competitiveness of the enterprise’s activities.

Objective. To assess the course and outcomes of COVID-19 in recipients of allogeneic and autologous hematopoietic stem cell transplant (HSCT). Materials and Methods. The retrospective study included 44 adult recipients (allogeneic – 33 [75%] and autologous – 11 [25%] of HSCT who diagnosed with COVID-19 after transplantation. Group mostly represented by acute leukemia – 18 (41%) and lymphoma – 10 (22.7%). The median follow-up time since the development of COVID-19 was 231 days (1–818 days), after HSCT – 507.5 days (14–3723 days). Overall and progression-free survival was assessed using the Kaplan–Meier and Log-Rank method. We also evaluated the characteristics of the course of a new coronavirus infection. Results. Median time for the development of COVID-19 from the moment of HSCT was 122.5 days (-1–3490 days). Twelve patients (27.2%) were in grade 3–4 neutropenia at the time of COVID-19 diagnosis, 16 (36.4%) patients were in grade 1–2 neutropenia. Sixteen (48.4%) allo-HSCT recipients had active graft-versus-host disease (GVHD) at the time of COVID-19 development. Disease severity was mild in 19 (43.2%) and moderate in 13 (29.5%) patients. Overall, 200-day survival from the onset of COVID-19 was 78.8% (95% CI [63.1–88.4]). Anemia (p = 0.02) and thrombocytopenia (p = 0.01) significantly decrease OS in patients with COVID-19 after HSCT. Patients with GVHD at the time of COVID-19 onset had a better survival rate (p = 0.02). The timing of COVID-19 development after HSCT did not affect outcomes. Conclusions. The key points of the course of COVID-19 in HSCT recipients are the presence of cytopenia and graft-versus-host disease. Overall survival was 78.8%.

Objective. To study effects of bacteriophages on biofilm formation and formed biofilm by S. aureus isolated from patients with orthopedic infection. Materials and Methods. A total of 50 clinical strains of S. aureus were tested. Species identification was performed by MALDI-TOF MS, antibiotic susceptibility – in accordance with the EUCAST v21. Isolates susceptibility to bacteriophages «Sextafag» (Microgen, Russia) was determined by MPA medium. The antibacterial activity of phages against S. aureus ATCC 29213 and S. aureus ATCC 43300 was evaluated by growth kinetic curves. Biofilms of bacteriophage-sensitive S. aureus strains were formed according to the protocol described by O’Toole. Isolates were divided into categories in accordance with the Stepanovic criteria. The effects of bacteriophages on the formation of S. aureus biofilm were studied by co-incubation of phages and bacteria followed by calculation of the percentage inhibition relative to the control without the introduction of the phages. The effect of phages on 24-hour biofilms formed by staphylococci was also evaluated in comparison with the control. Results. Out of 50 clinical S. aureus strains studied, 43 isolates (86%) were susceptible to phages, including 22 MSSA and 21 MRSA. All phage-susceptible cultures were characterized by biofilm-forming ability of varying degree: 28% – weak biofilm producer, 35% – moderate, 37% – strong. Inhibition of biofilm formation was determined in all tested MRSA strains, while in 73% of isolates the index of biofilm formation inhibition was more than 80%, which exceeded this indicator for MSSA by 2.5 times. In turn, the destruction of the formed biofilm under the action of the bacteriophage was 72% for all S. aureus. In 57% of MSSA strains, the decrease in biofilm biomass in comparison with the control was more than 80%, while this indicator was 2 times higher than for MRSA. Conclusions. The results demonstrated a high in vitro efficacy of bacteriophages against biofilm formation in S. aureus.

The synthesis of colloidal quantum dots of mercury selenide using mercury oxide as a precursor is proposed. The proposed method is characterized by the use of a less toxic component in the reaction mixture - mercury oxide. The transmission electron microscopy method established an average diameter of 5–6 nm and the shape of quantum dots. A histogram of the size distribution of synthesized nanoparticles is presented. An important property of the synthesized nanoparticles is the crystal structure established by X-ray diff raction analysis. The established properties of the synthesized nanocrystals coincide with the literature data. The elemental composition of the nanoparticles was controlled by X-ray microanalysis. It is established that the chemical composition of quantum dots corresponds to the stoichiometric ratio of Hg elements : Se = 0,98 : 1,00. In addition, it follows from the X-ray that the oxygen content has been identifi ed in silicon and carbon compounds, HgSe-based quantum dots do not contain traces of oxidation. The optical properties of quantum dots depend on the size of the nanoparticles. If the average diameter does not exceed 10 nm, mercury selenide particles are characterized by a monocrystalline structure with intraband absorption, the spectral energy distribution of which is subjected to dimensional quantization. As can be seen from the absorption spectra, the synthesized nanoparticles are characterized by absorption bands in the IR region, in the wavelength range up to 40 microns. The synthesized quantum dots do not possess luminescent properties, which, according to the literature data, is associated with a low probability of exciton formation for small nanoparticles (5–6 nm).

Fatigue failure of metal structures during operation is a frequent cause of machinery and equipment failure, and sometimes of human losses. This is especially true for operating conditions in the presence of corrosive environment. Reliable and safe operation of metal products and engineering devices during operation is largely determined by the structure and properties of the used materials and is ensured by optimizing the process operating conditions. The analysis of domestic and foreign literature data has shown that systematic theoretical and experimental studies of the impact of corrosive environment on the resistance to alternating loads on strained metals and alloys are practically absent. In this regard, the issue of identifying the patterns of corrosion and fatigue failure seems to be urgent in order to increase the corrosion fatigue life of plastically strained metals and alloys. This paper analyzes the impact of the status of surface layers of structural metals in a thermally treated and plastically strained state. The factors influencing the metals oxidation susceptibility have been established. During cyclic loading all processes related to vacancies’ concentration and fatigue cracks nucleation are ahead of schedule in the surface layers of metal, and all structural damage is concentrated at the surface, especially in case of corrosion fatigue. Plastic deformation increases both the thermodynamic possibility of oxide formation on the metal surface and the speed of this process. An increase in the active sites density on the surface of the strained metal contributes to the emerging of a large number of oxide nuclei, the growth of which leads to a faster formation of a continuous passivating film than on the surface of an unstrained metal.

Tracing is mathematically the most complicated problem of choosing the optimal solution from a huge number of variants. The development of methods and algorithms for solving the tracing problem has been carried out for many years, but it is still urgent. It is connected, first of all, with the fact that this problem is NP-complete, and it is difficult to develop a universal algorithm allowing one to find the exact optimal solution for an acceptable time. The emergence of new and more advanced means of computing technology, giving powerful computing resources, as well as increased requirements to the designed devices, all this is an incentive to develop new algorithms for solving the problem of tracing. There are several approaches to solving NP -complete problems. The first class of algorithms includes, explicitly or implicitly providing for the possibility of exponential running time of the algorithm, such methods as the method of complete enumeration, linear and nonlinear programming, etc. The second class includes the so-called heuristic algorithms that allow to obtain good solutions in an acceptable time. The third class includes random-directed search algorithms based on modeling principles (Lebedev, 2012). We propose a swarm algorithm for reallocating connections between leads based on the integration of models of adaptive behavior of an ant colony and collective alternative adaptation. The essence of integration consists of the fact that during the execution of the search procedure, the alternation of separate procedures of the ant algorithm and collective alternative adaptation is performed. Experimental studies were carried out that confirm the effectiveness of the proposed paradigm.

The article presents an assessment of the level of energy security using the example of the subjects of the Russian Federation located in the territory of the Northwestern Federal District. The approach to the assessment is based on the use of the apparatus for monitoring and indicative analysis of energy security (ES), developed in the ISEM SB RAS. An assessment of the level of ES in the regions is carried out based on modeling the situation with the cessation of operation of the most important facilities of the gas industry, and an analysis of the dynamics, scale and trends in the change in the state of the level of ES when modeling the situation using peak UGS facilities provided for by the General Scheme for the Development of the Gas Industry for the Period up to 2030, for the analyzed subjects of the Russian Federation.

The article defines the importance of artificial cultivation of hydrobionts. The article analyzes the state of fish farming in Russia. The main trend of the industry is the need for digital transformation of processes that provide management, control and monitoring of hydrobiont farming processes. This requires the development and implementation of “smart” digital solutions based on data. The analysis of the subject area has shown that there is a large amount of heterogeneous data related to, for example, the microclimate of water bodies, the state of hydrobionts, the works performed, the sanitary condition, and so on. All this requires the creation of a unified data model that meets the requirements of integrity, consistency, redundancy and normalization. This defines the purpose of the work to be performed. The application of methods that allow to obtain a description of the key aspects of the subject area, provided the opportunity to use the methodology of relational database design. With its help, key entities, their key and non-key attributes, as well as relationships between them are developed. The developed data model provides the principles of data storage and management, scalability of the model and its integration with other specialized software solutions.

The article explores sustainable development in terms of the green growth concept relative to the Ural-Siberian macro-region of Russia. To implement the principles of sustainable development in conditions of uncertainty, environmental preservation and economic progress, the main directions, problems and prospects have been analysed. The study aims to assess the potential for sustainable development of the Ural-Siberian macro-region and analyse the most promising directions in the sphere of the green economy. The results and conclusions of the article can be useful for formulating regional sustainable socio-economic development strategies with regard to the green growth principles.

The paper presents the results of experimental studies of the effect of cyclic exposure to elevated temperatures up to 90оС and 150оС and moistening to full water saturation on the strength of heavy concrete. Quantitative data on the change of concrete strength properties depending on the influence factors are obtained. Proposals are formulated to take into account in calculations the influence of heating and moistening modes on the strength of concrete in axial compression. Under cyclic exposure to elevated temperatures and subsequent moistening at normal temperature, there are significant changes in the compressive strength of concrete at different stages of each cycle. At the short-term heating stage, the reduction in the prismatic strength of the concrete amounted to 15 - 22% of the concrete strength before heating. Prolonged isothermal heating results in a 13 - 25% increase in concrete strength. At the stage of subsequent moistening of concrete after heating, there is a decrease in strength by 25 - 27%, while the relative magnitude of strength reduction does not significantly depend on the number of previous cycles. In the investigated interval of up to twenty-five cycles of exposure to elevated temperatures and moistening, the greatest reduction in concrete strength was observed in the first and last cycles. For cycles with heating temperature up to 90⁰C at short-term heating at the beginning of the second cycle the concrete strength drop was 45.5%, and the concrete strength drop at short-term heating for the 25th cycle was 9.7%. For cycles with heating temperature of 150⁰C the strength drop was 45.9% and 52.5%, respectively. The accepted experimental mode according to the formula of cycle (6+1) + (6+1) is the most unfavorable for the strength of concrete under cyclic effects of elevated temperatures and subsequent moistening.

The article deals with the actual problem of one of the tasks of realization of personnel provision of a large industrial enterprise. At the beginning of the article the comparative analysis of methods of forecasting of dynamics of demand for specialists of the enterprise is given. On the basis of this analysis the possible approach to the solution of the problem of forecasting of personnel needs of an industrial enterprise is suggested. A possible formulation of the problem of forecasting the demand for specialists is given, the proposed formulation is based on the long-term experience of the authors of the article in educational institutions in Russia, as well as on the analysis of the data obtained when the authors communicate with employees of industrial enterprises. The urgency of solving the proposed problem is substantiated and the necessity of using fuzzy logic methods is argued. The method of demand forecasting is offered, the advantages of which are simplicity of use, sufficient efficiency in the presence of a sufficient number of statistics and convenience of realization in the form of a software product. The paper concludes with a brief assessment of the effectiveness and usability of the proposed method.

The article presents the results of the study of the problem of long-term care system implementation, taking into account the specific conditions of a psychoneurological residential institution. Today, the longterm care system is relevant and in demand due to the fact that it provides an opportunity for people with disabilities to enjoy a better and full quality of life. It is especially important for people suffering from neuropsychiatric diseases, who are unable to lead independent life activities and need longterm care. The greatest successes in theory and practice in the implementation of long-term care systems have been achieved in developed foreign countries: the USA, Japan, and Europe. In Russia today we can observe the formation of a comprehensive system of long-term care in the conditions of a psychoneurological residential institution. Therefore, the aim of our work was to study the specifics of the implementation of long-term care in the conditions of a psychoneurological residential institution on the basis of an integrated approach. The study is based on the scientific works of various domestic and foreign researchers of this problem. Research methods: analysis, generalization, systematization. The results obtained - a detailed analysis of the essence of the problem under study, allowed to identify and analyze the specifics of the implementation of this system.

The paper defines the importance of resort treatment in Russia. It is established that the system is being reformed in terms of creating new recreational clusters and consolidating existing organizations by merging and modernizing them. All this complicates the structure of new organizations and increases the number of business processes. Effective management requires specialized software products that direct and monitor processes and resources of medical organizations; this substantiates the relevance of the work carried out. Using structural and mathematical analysis, quantitative and qualitative characteristics of key processes are established. Based on the results obtained, their formal model is developed and the concept of an information system is created. A description of the functional capabilities of the system and the categories of users to whom they are available is presented.

The peculiarities of the current situation with the environmental crisis require careful study of the waste recycling of previously accumulated and newly generated solid municipal waste. The use of technological developments and solutions for environmental conservation meets the most stringent ecological standards. These demands are due to the special natural and climatic status of Sevastopol. The purpose of the study is to substantiate the use of effective and simple method of sorting solid waste –hydraulic separation of solid household waste as one of the types of industrial waste separation. The article presents its advantages and possible application in Sevastopol. This advanced technology is stated to be effective in waste recycling as it provides separating unsorted waste and utilizing almost 80 percent of the volume. A feature of this method is the use of equipment manufactured for the paper industry for sorting and processing solid waste. In conclusion it is noted that the particularbenefit of the hydraulic separation is in its relative simplicity, as well as economic and environmental profits.

Nowadays the level of development of finite element (FE) calculation systems allows us to count on the maximum level of design solutions quality, provided that is created an adequate and at the same time simple design model, which directly determines the level of accuracy of the results obtained when determining the parameters of the stress-strain state, as well as dynamic characteristics of buildings and structures. It is fundamentally necessary for the designer to know the degree of influence of various factors to the creation of a finite element design model on the dynamic response of the design object. There is no doubt the relevance of the problem of identifying the features of modeling tower-type structures, which will simplify the work of an engineer and at the same time reach a qualitatively new level in making design decisions. The purpose of this work is a comprehensive assessment of the influence of the features of creating a design model to the resulting parameter - the frequency behavior of a tubular tower for wind turbines which is the most popular at wind parks in Russia over the past two decades. For numerical research was used the domestic design complex SCAD Office. To create calculation models and perform a comparative analysis of the resulting parameters of tubular towers were used FE types 41, 42, 44, and 50. When determining the influence of the finite element type calculations were made for a cylindrical tower with fixed parameters, taking into account changes in the type and size of the FE. In the calculations the evaluating factors were: changing in the main and equivalent stresses, as well as the change in the frequency of the first form of own oscillations. When comparing the values of the main and equivalent stresses, the plate of the third row from the base was taken as the calculated one.

Providing the country’s population with high-quality vegetables remains one of the priority areas for agricultural development. The task of agricultural science in solving this problem is to improve agrotechnological techniques and individual operations of soil cultivation, sowing and harvesting, as well as measures to protect against infections and pests. The purpose of this study was to determine the effectiveness of using biofertilizers when cultivating carrots on gray forest soils of medium loamy granulometric composition. Small-plot experiments to improve the technology for cultivating carrots of the Losinoostrovskaya variety were carried out on the basis of the experimental collection site of the Chuvash State Agrarian University during 2022–2023. To stimulate the processes of growth and accumulation of plant biomass, three-time root and leaf feeding of vegetative plants with biological preparations Microbionic and Gumat EM was used. In the course of monitoring the growth processes of carrots, the accumulation of tops and root crops biomass, the authors recorded positive changes in the reduction of the duration of phenophases and a positive trend in increasing carrot yields. The timing of the onset of bunching and trimming ripeness in carrots in plots using root and leaf fertilizing with biological products was shifted by 2–5 days, the total biomass of aboveground mass and root crops was increased to 36%, the yield and marketability of finished products was up to 43% compared with a control group.

Infectious bovine keratoconjunctivitis is a bacterial eye disease. The disease is characterized by inflammation of the conjunctiva, corneal ulceration and excessive lacrimation. Although this disease does not lead to the death of animals, its economic importance is enormous, since it leads to a decrease in livestock weight gain and a reduction in dairy productivity. The main etiological role in IBK belongs to Moraxella spp. (including in associations with Staphylococcus spp., Streptococcus spp., Pseudomonas aeruginosa, E. coli, Proteus). The use of traditional treatment methods, such as the use of antibacterial chemicals, for Moraxella infection may be ineffective due to the factors of resistance and immunity of these bacteria. The development of a vaccine can be expensive and time-consuming, due to the external localization of the infection; it will be difficult to achieve a protective effect. New strategies for the treatment and prevention of bacterial infection open up prospects for the use of bacteriophages. Due to the growing antibiotic resistance of circulating bacterial pathogens and to increase the effectiveness of therapeutic and preventive measures in IBK, the development of phage therapy is relevant. Fundamental studies of biological properties and exploratory studies of virulent active bacteriophages to zoopathogenic Moraxelles are an urgent problem.

The article presents the results of the effect of the feed additive Protein containing bacteria strains Bacillus subtilis, Saccharomyces the dynamics of growth and cerevisiae, Trichoderma development of foals. As a result of the conducted studies, it was found that the feed additive has a positive effect on the body of foals whose mothers received ProVetin during foaling. The weight of foals of the experimental group at birth was 6.7% higher compared to the control group. Further introduction of a feed additive into the diet of foals in the postnatal period also had a beneficial effect, which contributed to higher growth rates – at the age of 3 months, the live weight of the experimental group of foals receiving daily feed additive was 6.3% greater than in the control group; at 6 months – 6.5% more.

At present, the threat of technogenesis is not weakening despite the measures taken to reduce the levels of negative impact on the environment. In this regard, the authors analyze the standardization of risk management as an effective tool for monitoring the safety of not only design decisions in housing construction, but also any economic activity. The article discusses the safety aspects set out in Russian standards (GOSTs) and international guidelines. The analyzed regulatory documentation answers the question of how to achieve an acceptable level of risk. The basic concepts of risk assessment are given. There are positive changes in state standards in the safety area. Federal Law N7 regulates the leadership of the employer, and not his responsibility. As part of the improvement of environmental management for housing construction, the use of certain penalties, interest fines and forfeits looks quite natural. The main goal of the international standard ISO 14001 is not to point out the need for managers to have leadership qualities as the main factor in ensuring environmental safety for the construction industry, but to form a responsible attitude towards the environment and natural resources as the most important asset of economic activity. The article raises the issue that risk analysts cannot be fully guided by domestic standards due to their lack of development and inconsistency with the universal international documents ISO 31000:2018 "Risk management - Guidelines" and ISO 14001:2016 "Environmental management systems". A special risk assessment approach should be developed that describes the interaction of various scenarios, which will provide an increased environmental and economic effect in the field of housing construction safety.

In this short communication, we focus on the ability of chlorin e$_{6}$ photosensitizers (PSs) with one, two or three cationic groups to generate singlet oxygen species ($^{1}$O$_{2}$) in an apolar model medium, viz. 1-octanol (OctOH). The quantum yield of $^{1}$O$_{2}$ ($\Phi _{\Delta }$) is determined indirectly by the chemical method for seven synthesized PSs using 1,3-diphenylisobenzofuran (DPBF) as a singlet oxygen trap. The $\Phi _{\Delta }$ values of four PSs with one or two cationic groups occupying opposite positions in the macrocycle are equal to 0.6, which is nearly identical to the values obtained by the time-resolved fluorescence spectroscopy method. In contrast, three PSs containing a 3(1),3(2)-bis-(N,N,N-trimethylaminomethylvinyl) iodide fragment with two adjacent cationic groups have an abnormally high quantum yield reaching 0.8. It is apparent that this phenomenon results from faster trap oxidation induced by radical reactions leading to molecular iodine formation.

Daniel P Nemeth,1– 3 Xiaoyu Liu,3 Daniel B McKim,4 Damon J DiSabato,2,5 Braedan Oliver,2 Anu Herd,3 Asish Katta,1 Christina E Negray,1,2 James Floyd,3 Samantha McGovern,3 Paige S Pruden,2 Feiyang Zhutang,2 Maria Smirnova,3 Jonathan P Godbout,2,5 John Sheridan,1,2 Ning Quan3 1College of Dentistry, The Ohio State University, Columbus, OH, USA; 2Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, USA; 3Stiles-Nicholson Brain Institute, Florida Atlantic University, Jupiter, FL, USA; 4Department of Animal Sciences, University of Illinois Urbana-Champaign, Champaign, IL, USA; 5Department of Neuroscience, The Ohio State University, Columbus, OH, USACorrespondence: Daniel P Nemeth; Ning Quan, 5353 Parkside Drive, Jupiter, FL, 33458, USA, Email nemethd@fau.edu; nquan@health.fau.eduIntroduction: Lipopolysaccharide (LPS) preconditioning involves repeated, systemic, and sub-threshold doses of LPS, which induces a neuroprotective state within the CNS, thus preventing neuronal death and functional losses. Recently, proinflammatory cytokine, Interleukin-1 (IL-1), and its primary signaling partner, interleukin-1 receptor type 1 (IL-1R1), have been associated with neuroprotection in the CNS. However, it is still unknown how IL-1/IL-1R1 signaling impacts the processes associated with neuroprotection.Methods: Using our IL-1R1 restore genetic mouse model, mouse lines were generated to restrict IL-1R1 expression either to endothelia (Tie2-Cre-Il1r1r/r) or microglia (Cx3Cr1-Cre-Il1r1r/r), in addition to either global ablation (Il1r1r/r) or global restoration of IL-1R1 (Il1r1GR/GR). The LPS preconditioning paradigm consisted of four daily i.p. injections of LPS at 1 mg/kg (4d LPS). 24 hrs following the final i.p. LPS injection, tissue was collected for qPCR analysis, immunohistochemistry, or FAC sorting.Results: Following 4d LPS, we found multiple phenotypes that are dependent on IL-1R1 signaling such as microglia morphology alterations, increased microglial M2-like gene expression, and clustering of microglia onto the brain vasculature. We determined that 4d LPS induces microglial morphological changes, clustering at the vasculature, and gene expression changes are dependent on endothelial IL-1R1, but not microglial IL-1R1. A novel observation was the induction of microglial IL-1R1 (mIL-1R1) following 4d LPS. The induced mIL-1R1 permits a unique response to central IL-1β: the mIL-1R1 dependent induction of IL-1R1 antagonist (IL-1RA) and IL-1β gene expression. Analysis of RNA sequencing datasets revealed that mIL-1R1 is also induced in neurodegenerative diseases.Discussion: Here, we have identified cell type-specific IL-1R1 mediated mechanisms, which may contribute to the neuroprotection observed in LPS preconditioning. These findings identify key cellular and molecular contributors in LPS-induced neuroprotection.Graphical Abstract: Keywords: BBB, neuroinflammation, perivascular microglia

Object of study. We investigate Hewlett Packard green LEDs (λmax = 525 nm at room temperature) based on an InGaN solid solution with quantum wells. Purpose of the Study. It is known that in light-emitting structures, optical characteristics are closely related to electrical characteristics. Analysis of the literature has shown the effect of the structure (number and width of quantum wells) on the electrical characteristics of the objects under study. Thus, the determination of the parameters of structures based on GaN and its solid solutions from the analysis of electrical characteristics is an urgent problem. The aim of this work is to test the application of the generalized recombination model for analyzing the reverse current-voltage characteristics of InGaN-based structures under illumination. Methods and Approaches Used. The paper considers the reverse current-voltage characteristics of structures with quantum wells under illumination with the same “junction-to-junction” LED from the point of view of the generalized model of recombination. The results of measurements and calculations using the generalized recombination model are compared with the distribution profile of the dopant obtained from the inverse capacitance-voltage characteristics. Main Results. It has been shown that three processes are involved in the formation of reverse current-voltage characteristics under illumination: photogeneration, recombination, and tunneling. When the structure is illuminated with the same LED in quantum wells, the photorecombination process plays a leading role. An expression has been obtained that describes the current through the sample in this case.