7 results on '"Smilnak, Gordon J."'
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2. Novel Treatment of Cryptococcal Meningitis via Neurapheresis Therapy
- Author
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Smilnak, Gordon J., Charalambous, Lefko T., Cutshaw, Drew, Premji, Alykhan M., Giamberardino, Charles D., Ballard, Christi G., Bartuska, Andrew P., Ejikeme, Tiffany U., Sheng, Huaxin, Verbick, Laura Zitella, Hedstrom, Blake A., Pagadala, Promila C., McCabe, Aaron R., Perfect, John R., and Lad, Shivanand P.
- Published
- 2018
3. Pulmonary function and blood DNA methylation:A multi-ancestry epigenome-wide association meta-analysis
- Author
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Lee, Mikyeong, Huan, Tianxiao, McCartney, Daniel, Chittoor, Geetha, de Vries, Maaike, Lahousse, Lies, Nguyen, Jennifer N., Body, Jennifer, Castillo-Fernandez, Juan, Terzikhan, Natalie, Qi, Cancan, Joehanes, Roby, Min, Josine, Smilnak, Gordon J., Shaw, Jessica R, Yang, Chen Xi, Colicino, Elena, Hoang, Thanh T., Bermingham, Mairead L., Xu, Hanfei, Justice, Anne E., Xu, Chengjian, Rich, Stephen, Cox, Simon R., Vonk, Judith M., Prokic (Nedeljkovic), Ivana, Sotoodehnia, Nona, TSAI, PEI-CHIEN, Schwartz, Joel, Leung, Janice M., Sikdar, Sinjini, Walker, Rosie M., Harris, Sarah, van der Plaat, Diana A., Van Den Berg, David J, Bartz, Traci M. Bartz, Spector, Tim D., Vokonas, Pantel S., Marioni, Riccardo, Taylor, Adele M., Liu, Yongmei, Barr, Graham R., Lange, Leslie, Baccarelli, Andrea A., Obeidat, Ma'en, Fornage, Myriam, WANG, TIANYUAN, Ward, James M., Motsinger-Reif, Alison, Hemani, Gibran, Koppelman, Gerard, Bell, Jordana, GHARIB, SINA A., Brusselle, Guy, Boezen, H. Marike, North, Kari, Levy, Daniel, Evans, Kathryn, Dupuis, Josee, Breeze, Charles, Manichaikul, Ani, London, Stephanie, Biobank-based Integrative Omics Study (BIOS) Consortium, Genetics of DNA Methylation Consortium (GoDMC), Groningen Research Institute for Asthma and COPD (GRIAC), Life Course Epidemiology (LCE), Epidemiology, and Pulmonary Medicine
- Subjects
Epigenomics ,Pulmonary and Respiratory Medicine ,chronic obstructive ,epigenetics ,respiratory function tests ,spirometry ,Infant, Newborn ,DNA Methylation ,Critical Care and Intensive Care Medicine ,DISEASE ,Epigenesis, Genetic ,chronic obstructive pulmonary disease ,LUNG-FUNCTION ,Epigenome ,Medicine and Health Sciences ,Humans ,CpG Islands ,Lung ,POPULATION ,pulmonary disease ,Genome-Wide Association Study - Abstract
Rationale: Methylation integrates factors present at birth and modifiable across the lifespan that can influence pulmonary function. Studies are limited in scope and replication. Objectives: To conduct large-scale epigenome-wide meta-analyses of blood DNA methylation and pulmonary function. Methods: Twelve cohorts analyzed associations of methylation at cytosine-phosphate-guanine probes (CpGs), using Illumina 450K or EPIC/850K arrays, with FEV 1, FVC, and FEV 1/FVC. We performed multiancestry epigenome-wide meta-analyses (total of 17,503 individuals; 14,761 European, 2,549 African, and 193 Hispanic/Latino ancestries) and interpreted results using integrative epigenomics. Measurements and Main Results: We identified 1,267 CpGs (1,042 genes) differentially methylated (false discovery rate,,0.025) in relation to FEV 1, FVC, or FEV 1/FVC, including 1,240 novel and 73 also related to chronic obstructive pulmonary disease (1,787 cases). We found 294 CpGs unique to European or African ancestry and 395 CpGs unique to never or ever smokers. The majority of significant CpGs correlated with nearby gene expression in blood. Findings were enriched in key regulatory elements for gene function, including accessible chromatin elements, in both blood and lung. Sixty-nine implicated genes are targets of investigational or approved drugs. One example novel gene highlighted by integrative epigenomic and druggable target analysis is TNFRSF4. Mendelian randomization and colocalization analyses suggest that epigenome-wide association study signals capture causal regulatory genomic loci. Conclusions: We identified numerous novel loci differentially methylated in relation to pulmonary function; few were detected in large genome-wide association studies. Integrative analyses highlight functional relevance and potential therapeutic targets. This comprehensive discovery of potentially modifiable, novel lung function loci expands knowledge gained from genetic studies, providing insights into lung pathogenesis.
- Published
- 2022
4. Pulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-analysis
- Author
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Lee, Mikyeong, primary, Huan, Tianxiao, additional, McCartney, Daniel L., additional, Chittoor, Geetha, additional, de Vries, Maaike, additional, Lahousse, Lies, additional, Nguyen, Jennifer N., additional, Brody, Jennifer A., additional, Castillo-Fernandez, Juan, additional, Terzikhan, Natalie, additional, Qi, Cancan, additional, Joehanes, Roby, additional, Min, Josine L., additional, Smilnak, Gordon J., additional, Shaw, Jessica R., additional, Yang, Chen Xi, additional, Colicino, Elena, additional, Hoang, Thanh T., additional, Bermingham, Mairead L., additional, Xu, Hanfei, additional, Justice, Anne E., additional, Xu, Cheng-Jian, additional, Rich, Stephen S., additional, Cox, Simon R., additional, Vonk, Judith M., additional, Prokić, Ivana, additional, Sotoodehnia, Nona, additional, Tsai, Pei-Chien, additional, Schwartz, Joel D., additional, Leung, Janice M., additional, Sikdar, Sinjini, additional, Walker, Rosie M., additional, Harris, Sarah E., additional, van der Plaat, Diana A., additional, Van Den Berg, David J., additional, Bartz, Traci M., additional, Spector, Tim D., additional, Vokonas, Pantel S., additional, Marioni, Riccardo E., additional, Taylor, Adele M., additional, Liu, Yongmei, additional, Barr, R. Graham, additional, Lange, Leslie A., additional, Baccarelli, Andrea A., additional, Obeidat, Ma’en, additional, Fornage, Myriam, additional, Wang, Tianyuan, additional, Ward, James M., additional, Motsinger-Reif, Alison A., additional, Hemani, Gibran, additional, Koppelman, Gerard H., additional, Bell, Jordana T., additional, Gharib, Sina A., additional, Brusselle, Guy, additional, Boezen, H. Marike, additional, North, Kari E., additional, Levy, Daniel, additional, Evans, Kathryn L., additional, Dupuis, Josée, additional, Breeze, Charles E., additional, Manichaikul, Ani, additional, and London, Stephanie J., additional
- Published
- 2022
- Full Text
- View/download PDF
5. Pulmonary Function and Blood DNA Methylation A Multiancestry Epigenome-Wide Association Meta-analysis
- Author
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Lee, Mikyeong, Huan, Tianxiao, McCartney, Daniel L., Chittoor, Geetha, de Vries, Maaike, Lahousse, Lies, Nguyen, Jennifer N., Brody, Jennifer A., Castillo-Fernandez, Juan, Terzikhan, Natalie, Qi, Cancan, Joehanes, Roby, Min, Josine L., Smilnak, Gordon J., Shaw, Jessica R., Yang, Chen Xi, Colicino, Elena, Hoang, Thanh T., Bermingham, Mairead L., Xu, Hanfei, Justice, Anne E., Xu, Cheng Jian, Rich, Stephen S., Cox, Simon R., Vonk, Judith M., Prokic, Ivana, Sotoodehnia, Nona, Tsai, Pei Chien, Schwartz, Joel D., Leung, Janice M., Sikdar, Sinjini, Walker, Rosie M., Harris, Sarah E., van der Plaat, Diana A., Van Den Berg, David J., Bartz, Traci M., Spector, Tim D., Vokonas, Pantel S., Marioni, Riccardo E., Taylor, Adele M., Liu, Yongmei, Barr, R. Graham, Lange, Leslie A., Baccarelli, Andrea A., Obeidat, Maen, Fornage, Myriam, Wang, Tianyuan, Ward, James M., Bell, Jordana T., Brusselle, Guy, Manichaikul, Ani, London, Stephanie J., Lee, Mikyeong, Huan, Tianxiao, McCartney, Daniel L., Chittoor, Geetha, de Vries, Maaike, Lahousse, Lies, Nguyen, Jennifer N., Brody, Jennifer A., Castillo-Fernandez, Juan, Terzikhan, Natalie, Qi, Cancan, Joehanes, Roby, Min, Josine L., Smilnak, Gordon J., Shaw, Jessica R., Yang, Chen Xi, Colicino, Elena, Hoang, Thanh T., Bermingham, Mairead L., Xu, Hanfei, Justice, Anne E., Xu, Cheng Jian, Rich, Stephen S., Cox, Simon R., Vonk, Judith M., Prokic, Ivana, Sotoodehnia, Nona, Tsai, Pei Chien, Schwartz, Joel D., Leung, Janice M., Sikdar, Sinjini, Walker, Rosie M., Harris, Sarah E., van der Plaat, Diana A., Van Den Berg, David J., Bartz, Traci M., Spector, Tim D., Vokonas, Pantel S., Marioni, Riccardo E., Taylor, Adele M., Liu, Yongmei, Barr, R. Graham, Lange, Leslie A., Baccarelli, Andrea A., Obeidat, Maen, Fornage, Myriam, Wang, Tianyuan, Ward, James M., Bell, Jordana T., Brusselle, Guy, Manichaikul, Ani, and London, Stephanie J.
- Abstract
Rationale: Methylation integrates factors present at birth and modifiable across the lifespan that can influence pulmonary function. Studies are limited in scope and replication. Objectives: To conduct large-scale epigenome-wide meta-analyses of blood DNA methylation and pulmonary function. Methods: Twelve cohorts analyzed associations of methylation at cytosine-phosphate-guanine probes (CpGs), using Illumina 450K or EPIC/850K arrays, with FEV1, FVC, and FEV1/FVC. We performed multiancestry epigenome-wide meta-analyses (total of 17,503 individuals; 14,761 European, 2,549 African, and 193 Hispanic/Latino ancestries) and interpreted results using integrative epigenomics. Measurements and Main Results: We identified 1,267 CpGs (1,042 genes) differentially methylated (false discovery rate,,0.025) in relation to FEV1, FVC, or FEV1/FVC, including 1,240 novel and 73 also related to chronic obstructive pulmonary disease (1,787 cases). We found 294 CpGs unique to European or African ancestry and 395 CpGs unique to never or ever smokers. The majority of significant CpGs correlated with nearby gene expression in blood. Findings were enriched in key regulatory elements for gene function, including accessible chromatin elements, in both blood and lung. Sixty-nine implicated genes are targets of investigational or approved drugs. One example novel gene highlighted by integrative epigenomic and druggable target analysis is TNFRSF4. Mendelian randomization and colocalization analyses suggest that epigenome-wide association study signals capture causal regulatory genomic loci. Conclusions: We identified numerous novel loci differentially methylated in relation to pulmonary function; few were detected in large genome-wide association studies. Integrative analyses highlight functional relevance and potential therapeutic targets. This comprehensive discovery of potentially modifiable, novel lung function loci expands knowledge gained from
- Published
- 2022
6. Pulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-analysis.
- Author
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Mikyeong Lee, Tianxiao Huan, McCartney, Daniel L., Chittoor, Geetha, de Vries, Maaike, Lahousse, Lies, Nguyen, Jennifer N., Brody, Jennifer A., Castillo-Fernandez, Juan, Terzikhan, Natalie, Cancan Qi, Joehanes, Roby, Min, Josine L., Smilnak, Gordon J., Shaw, Jessica R., Chen Xi Yang, Colicino, Elena, Hoang, Thanh T., Bermingham, Mairead L., and Hanfei Xu
- Subjects
SEQUENCE analysis ,DNA ,META-analysis ,LUNGS ,DNA methylation ,GENES ,RESEARCH funding ,EPIGENOMICS - Abstract
Rationale: Methylation integrates factors present at birth and modifiable across the lifespan that can influence pulmonary function. Studies are limited in scope and replication. Objectives: To conduct large-scale epigenome-wide meta-analyses of blood DNA methylation and pulmonary function. Methods: Twelve cohorts analyzed associations of methylation at cytosine-phosphate-guanine probes (CpGs), using Illumina 450K or EPIC/850K arrays, with FEV1, FVC, and FEV1/FVC. We performed multiancestry epigenome-wide meta-analyses (total of 17,503 individuals; 14,761 European, 2,549 African, and 193 Hispanic/Latino ancestries) and interpreted results using integrative epigenomics. Measurements and Main Results: We identified 1,267 CpGs (1,042 genes) differentially methylated (false discovery rate, <0.025) in relation to FEV1, FVC, or FEV1/FVC, including 1,240 novel and 73 also related to chronic obstructive pulmonary disease (1,787 cases). We found 294 CpGs unique to European or African ancestry and 395 CpGs unique to never or ever smokers. The majority of significant CpGs correlated with nearby gene expression in blood. Findings were enriched in key regulatory elements for gene function, including accessible chromatin elements, in both blood and lung. Sixty-nine implicated genes are targets of investigational or approved drugs. One example novel gene highlighted by integrative epigenomic and druggable target analysis is TNFRSF4. Mendelian randomization and colocalization analyses suggest that epigenome-wide association study signals capture causal regulatory genomic loci. Conclusions: We identified numerous novel loci differentially methylated in relation to pulmonary function; few were detected in large genome-wide association studies. Integrative analyses highlight functional relevance and potential therapeutic targets. This comprehensive discovery of potentially modifiable, novel lung function loci expands knowledge gained from genetic studies, providing insights into lung pathogenesis. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
7. Comorbidity of age-related macular degeneration with Alzheimer’s disease: A histopathologic case-control study
- Author
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Smilnak, Gordon J., primary, Deans, John R., additional, Doraiswamy, P. Murali, additional, Stinnett, Sandra, additional, Whitson, Heather E., additional, and Lad, Eleonora M., additional
- Published
- 2019
- Full Text
- View/download PDF
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