Search

Your search keyword '"Smetsers, A.F.C.M."' showing total 12 results
Start Over Author "Smetsers, A.F.C.M."
12 results on '"Smetsers, A.F.C.M."'

2. Bias in nucleotide composition of antisense oligonucleotides

Author

Smetsers, A.F.C.M., Boezeman, J.B.M., and Mensink, E.J.B.M.

Subjects
Investigation of the role and relation of p210 bcr-abl and wild type p53 in chronic myeloid leukemia, Studie naar het ontstaan van chronische myeloïde leukemie met behulp van antisense oligonucleotiden
Abstract

Item does not contain fulltext

Published
1996

3. Phosphorithioate BCR-ABL antisense oligonucleotides induce cell death, but fail to reduce cellular BCR-ABL protein levels

Author

Smetsers, A.F.C.M., Locht, A.T.F. van de, Pennings, A.H.M., Wessels, J.M.C., Witte, T.J.M. de, and Mensink, E.J.B.M.

Subjects
Investigation of the role and relation of p210 bcr-abl and wild type p53 in chronic myeloid leukemia, Studie naar het ontstaan van chronische myeloïde leukemie met behulp van antisense oligonucleotiden
Abstract

Item does not contain fulltext

Published
1995

5. Antisense BCR-ABL oligonucleotides in chronic myeloid leukemia

Author

Smetsers, A.F.C.M., Witte, T.J.M. de, Mensink, E.J.B.M., and Radboud University Nijmegen

Subjects
Investigation of the role and relation of p210 bcr-abl and wild type p53 in chronic myeloid leukemia, Myeloïde leukemie, Chronische ziekten, Antisense-ketens, Studie naar het ontstaan van chronische myeloïde leukemie met behulp van antisense oligonucleotiden, hematologie, Oligonucleotiden, Hardware_REGISTER-TRANSFER-LEVELIMPLEMENTATION, Hematopoiesis and stem cell transplantation
Abstract

Item does not contain fulltext Dept. of Hematology University Hospital Nijmegen, 09 oktober 1997 Promotor : Witte, T.J.M. de Co-promotor : Mensink, E.J.B.M. 174 p.

Published
1997

6. Bax mutations in cell lines derived from hematological malignancies

Author

Meijerink, J.P.P., Smetsers, A.F.C.M., Sloetjes, A.W., Linders, E.H.P., and Mensink, E.J.B.M.

Subjects
Klinische betekenis van kwantitatieve bcl-2 monitoring tijdens en na behandeling van patienten met laaggradig folliculair non-Hodgkin lymfoom myeloïde leukemie, Clinical significance of quantitative bcl-2 monitoring during and after treatment of patients with low-grade follicular non-Hodgkin's lymphoma, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Contains fulltext : 21561___.PDF (Publisher’s version ) (Open Access)

Published
1995

7. Specificity of bcr-abl antisense oligonucleotides

Author

Smetsers, A.F.C.M. and Mensink, E.J.B.M.

Subjects
Investigation of the role and relation of p210 bcr-abl and wild type p53 in chronic myeloid leukemia, Studie naar het ontstaan van chronische myeloïde leukemie met behulp van antisense oligonucleotiden, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Contains fulltext : 21162___.PDF (Publisher’s version ) (Open Access)

Published
1995

8. A DNA probe combination for improved detection of MLL/11q23 breakpoints by double-color interphase-FISH in acute leukemias.

Author

Bergh, A. von, Emanuel, B., Zelderen-Bhola, S. van, Smetsers, A.F.C.M., Soest, R. van, Stul, M., Vranckx, H., Schuuring, E., Hagemeijer, A., Kluin, P., Bergh, A. von, Emanuel, B., Zelderen-Bhola, S. van, Smetsers, A.F.C.M., Soest, R. van, Stul, M., Vranckx, H., Schuuring, E., Hagemeijer, A., and Kluin, P.

Abstract

Item does not contain fulltext, Reciprocal translocations involving the MLL gene on chromosome band 11q23 have been observed in both acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). In AML, identification of MLL breakpoints is an important prognostic factor. Breakpoints are clustered in an 8 kb DNA fragment (bcr) and can be detected by Southern blotting or fluorescence in situ hybridization (FISH) analysis. Our objective in this study was to design a DNA probe set that enables optimal detection of MLL rearrangements using interphase FISH. Two PAC clones, 217A21 and 167K13, spanning the MLL gene with a minimal overlap in the bcr were isolated and labeled. Twenty-seven AML/ALL patients with cytogenetic 11q23 abnormalities, seven AML/ALL patients without 11q23 abnormalities but MLL rearrangement by Southern blotting, and eight healthy donors were analyzed by FISH. We compared this double-color FISH analysis with FISH using a YAC clone (yB22B2) and with Southern blotting. The PAC probe combination detects an MLL breakpoint in all cases with MLL rearrangement detected by Southern blotting except for cases with a partial tandem duplication detected by reverse transcriptase-polymerase chain reaction (RT-PCR). FISH using the PAC probes also detected MLL breakpoints in four cases with MLL deletions telomeric to the breakpoint that could not be detected by the single probe yB22B2. This new probe set provides a reliable and rapid assay for the diagnosis of AML and ALL patients with MLL/11q23 breakpoints.

Published
2000

11. Antisense BCR-ABL oligonucleotides in chronic myeloid leukemia

Author

Witte, T.J.M. de, Mensink, E.J.B.M., Smetsers, A.F.C.M., Witte, T.J.M. de, Mensink, E.J.B.M., and Smetsers, A.F.C.M.

Abstract

Dept. of Hematology University Hospital Nijmegen, 9 oktober 1997, Promotor : Witte, T.J.M. de Co-promotor : Mensink, E.J.B.M., Item does not contain fulltext

Published
1997

Catalog

Books, media, physical & digital resources
See catalog results