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3. Cardiovascular diseases after high‐dose chemotherapy and autologous stem cell transplant for lymphoma: A Danish population‐based study.

Author

Baech, Joachim, Husby, Simon, Trab, Trine, Kragholm, Kristian, Brown, Peter, Gørløv, Jette S., Jørgensen, Judit M., Gudbrandsdottir, Sif, Severinsen, Marianne Tang, Grønbæk, Kirsten, Larsen, Thomas Stauffer, Wästerlid, Tove, Eloranta, Sandra, Smeland, Knut B., Jakobsen, Lasse Hjort, and El‐Galaly, Tarec C.

Subjects
STEM cell transplantation, CARDIOVASCULAR diseases, LYMPHOMAS, CONGESTIVE heart failure, HEART diseases
Abstract

Summary: Cardiovascular diseases, especially congestive heart failure (CHF), are known complications of anthracyclines, but the risk for patients undergoing high‐dose chemotherapy and autologous stem cell transplant (HDT‐ASCT) is not well established. With T‐cell therapies emerging as alternatives, studies of long‐term complications after HDT‐ASCT are warranted. Danish patients treated with HDT‐ASCT for aggressive lymphoma between 2001 and 2017 were matched 1:5 on sex, birth year and Charlson comorbidity score to the general population. Events were captured using nationwide registers. A total of 787 patients treated with HDT‐ASCT were identified. Median follow‐up was 7.6 years. The risk of CHF was significantly increased in the HDT‐ASCT population compared to matched comparators with an adjusted hazard ratio (HR) of 5.5 (3.8–8.1). The 10‐year cumulative incidence of CHF was 8.0% versus 2.0% (p < 0.001). Male sex, ≥2 lines of therapy, hypertension and cumulative anthracycline dose (≥300 mg/m2) were risk factors for CHF. In a separate cohort of 4089 lymphoma patients, HDT‐ASCT was also significantly associated with increased risk of CHF (adjusted HR of 2.6 [1.8–3.8]) when analysed as a time‐dependent exposure. HDT‐ASCT also increased the risk of other cardiac diseases. These findings are applicable for the benefit/risk assessment of HDT‐ASCT versus novel therapies. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Reproduction patterns among non‐Hodgkin lymphoma survivors by subtype in Sweden, Denmark and Norway: A population‐based matched cohort study

Author

Entrop, Joshua P., primary, Weibull, Caroline E., additional, Smedby, Karin E., additional, Jakobsen, Lasse H., additional, Øvlisen, Andreas K., additional, Glimelius, Ingrid, additional, Marklund, Anna, additional, Larsen, Thomas S., additional, Holte, Harald, additional, Fosså, Alexander, additional, Smeland, Knut B., additional, El‐Galaly, Tarec C., additional, and Eloranta, Sandra, additional

Published
2023
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6. Reproduction patterns among classical Hodgkin lymphoma survivors treated with BEACOPP and ABVD in Sweden, Denmark and Norway—A population‐based matched cohort study

Author

Entrop, Joshua P., primary, Weibull, Caroline E., additional, Smedby, Karin E., additional, Jakobsen, Lasse H., additional, Øvlisen, Andreas K., additional, Molin, Daniel, additional, Glimelius, Ingrid, additional, Marklund, Anna, additional, Holte, Harald, additional, Fosså, Alexander, additional, Smeland, Knut B., additional, El‐Galaly, Tarec C., additional, and Eloranta, Sandra, additional

Published
2023
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7. Reproduction patterns among non-Hodgkin lymphoma survivors by subtype in Sweden, Denmark and Norway:A population-based matched cohort study

Author

Entrop, Joshua P., Weibull, Caroline E., Smedby, Karin E., Jakobsen, Lasse H., Øvlisen, Andreas K., Glimelius, Ingrid, Marklund, Anna, Larsen, Thomas S., Holte, Harald, Fosså, Alexander, Smeland, Knut B., El-Galaly, Tarec C., and Eloranta, Sandra

Subjects
fertility, non-Hodgkin lymphoma, late effects of therapy
Abstract

Previous studies concerning reproductive patterns among non-Hodgkin lymphoma (NHL) survivors are scarce and those available have reported conflicting results. Treatment regimens vary considerably between aggressive and indolent NHL and studies of reproductive patterns by subtypes are warranted. In this matched cohort study, we identified all NHL patients aged 18–40 years and diagnosed between 2000 and 2018 from the Swedish and Danish lymphoma registers, and the clinical database at Oslo University Hospital (n = 2090). Population comparators were matched on sex, birth year and country (n = 19 427). Hazard ratios (HRs) were estimated using Cox regression. Males and females diagnosed with aggressive lymphoma subtypes had lower childbirth rates (HRfemale: 0.43, 95% CI: 0.31–0.59, HRmale: 0.61, 95% CI: 0.47–0.78) than comparators during the first 3 years after diagnosis. For indolent lymphomas, childbirth rates were not significantly different from comparators (HRfemale: 0.71, 95% CI: 0.48–1.04, HRmale: 0.94, 95% CI: 0.70–1.27) during the same period. Childbirth rates reached those of comparators for all subtypes after 3 years but the cumulative incidence of childbirths was decreased throughout the 10-year follow-up for aggressive NHL. Children of NHL patients were more likely to be born following assisted reproductive technology than those of comparators, except for male indolent lymphoma patients. In conclusion, fertility counselling is particularly important for patients with aggressive NHL.

Published
2023

9. Reproduktiv Patterns Among Non-Hodgkin Lymphoma Survivors By Subtype in Sweden, Denmark and Norway

Author

Entrop, Joshua P.P., primary, Weibull, Caroline E., additional, Smedby, Karin E., additional, Jakobsen, Lasse Hjort, additional, Oevlisen, Andreas K., additional, Glimelius, Ingrid, additional, Marklund, Anna, additional, Larsen, Thomas S., additional, Holte, Harald, additional, Fosså, Alexander, additional, Smeland, Knut B., additional, El-Galaly, Tarec Christoffer Christoffer, additional, and Eloranta, Sandra, additional

Published
2022
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10. T065: Reproduction patterns among Classical Hodgkin Lymphoma Survivors Treated with BEACOPP and ABVD in Sweden, Denmark, and Norway

Author

Entrop, Joshua P., primary, Weibull, Caroline E., additional, Smedby, Karin E., additional, Jakobsen, Lasse Hjort, additional, øvlisen, Andreas K., additional, Molin, Daniel, additional, Glimelius, Ingrid, additional, Marklund, Anna, additional, Holte, Harald, additional, Fosså, Alexander, additional, Smeland, Knut B., additional, El-Galaly, Tarec Christoffer, additional, and Eloranta, Sandra, additional

Published
2022
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15. Burkitt Lymphoma International Prognostic Index

Author

Olszewski, Adam J., primary, Jakobsen, Lasse H., additional, Collins, Graham P., additional, Cwynarski, Kate, additional, Bachanova, Veronika, additional, Blum, Kristie A., additional, Boughan, Kirsten M., additional, Bower, Mark, additional, Dalla Pria, Alessia, additional, Danilov, Alexey, additional, David, Kevin A., additional, Diefenbach, Catherine, additional, Ellin, Fredrik, additional, Epperla, Narendranath, additional, Farooq, Umar, additional, Feldman, Tatyana A., additional, Gerrie, Alina S., additional, Jagadeesh, Deepa, additional, Kamdar, Manali, additional, Karmali, Reem, additional, Kassam, Shireen, additional, Kenkre, Vaishalee P., additional, Khan, Nadia, additional, Kim, Seo-Hyun, additional, Klein, Andreas K., additional, Lossos, Izidore S., additional, Lunning, Matthew A., additional, Martin, Peter, additional, Martinez-Calle, Nicolas, additional, Montoto, Silvia, additional, Naik, Seema, additional, Palmisiano, Neil, additional, Peace, David, additional, Phillips, Elizabeth H., additional, Phillips, Tycel J., additional, Portell, Craig A., additional, Reddy, Nishitha, additional, Santarsieri, Anna, additional, Sarraf Yazdy, Maryam, additional, Smeland, Knut B., additional, Smith, Scott E., additional, Smith, Stephen D., additional, Sundaram, Suchitra, additional, Zayac, Adam S., additional, Zhang, Xiao-Yin, additional, Zhu, Catherine, additional, Cheah, Chan Y., additional, El-Galaly, Tarec C., additional, and Evens, Andrew M., additional

Published
2021
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16. The Burkitt Lymphoma International Prognostic Index (BL-IPI)

Author

Olszewski, Adam J, Jakobsen, Lasse H., Collins, Graham P., Cwynarski, Kate, Bachanova, Veronika, Blum, Kristie A., Boughan, Kirsten M, Bower, Mark, Dalla Pria, Alessia, Danilov, Alexey, David, Kevin A., Diefenbach, Catherine, Ellin, Fredrik, Epperla, Narendranath, Farooq, Umar, Feldman, Tatyana A., Gerrie, Alina S., Jagadeesh, Deepa, Kamdar, Manali, Karmali, Reem, Kassam, Shireen, Kenkre, Vaishalee P., Khan, Nadia, Klein, Andreas, Lossos, Izidore S., Lunning, Matthew A., Martin, Peter, Martinex-Calle, Nicolas, Montoto, Silvia, Naik, Seema, Palmisiano, Neil, Peace, David, Phillips, Elizabeth H, Phillips, Tycel J., Portell, Craig A., Reddy, Nishitha, Santarsieri, Anna, Yazdy, Maryam Sarraf, Smeland, Knut B., Smith, Scott E., Smith, Stephen D., Sundaram, Suchitra, Venugopal, Parameswaran, Zayac, Adam, Zhang, Xiao-Yin, Zhu, Catherine, Cheah, Chan Yoon, El-Galaly, Tarec Christoffer, and Evens, Andrew M.

Published
2020
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17. Minimal relapse risk and early normalization of survival for patients with Burkitt lymphoma treated with intensive immunochemotherapy: an international study of 264 real‐world patients

Author

Jakobsen, Lasse H., primary, Ellin, Fredrik, additional, Smeland, Knut B., additional, Wästerlid, Tove, additional, Christensen, Jacob H., additional, Jørgensen, Judit M., additional, Josefsson, Pär L., additional, Øvlisen, Andreas K., additional, Holte, Harald, additional, Blaker, Yngvild N., additional, Grauslund, Jacob H., additional, Bjørn, Jon, additional, Molin, Daniel, additional, Lagerlöf, Ingemar, additional, Smedby, Karin E., additional, Colvin, Katherine, additional, Thanarajasingam, Gita, additional, Maurer, Matthew J., additional, Habermann, Thomas M., additional, Song, Kevin W., additional, Zhu, Katie Y., additional, Gerrie, Alina S., additional, Cheah, Chan Y., additional, and El‐Galaly, Tarec C., additional

Published
2020
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18. Inferior Outcomes for Older Patients in the Adolescent and Young Adult (AYA) Population with Burkitt Lymphoma Treated with Intensive Immunochemotherapy: An International Study of 108 Patients

Author

Ellin, Fredrik, primary, Smeland, Knut B., additional, Wästerlid, Tove, additional, Christensen, Jacob H., additional, Jørgensen, Judit, additional, Josefsson, Pär L., additional, Holte, Harald, additional, Blaker, Yngvild Nuvin, additional, Grauslund, Jacob H., additional, Bjoern, Jon, additional, Molin, Daniel, additional, Lagerlöf, Ingemar, additional, Ekstroem Smedby, Karin Ekstrom, additional, Colvin, Katherine, additional, Thanarajasingam, Gita, additional, Maurer, Matthew J, additional, Habermann, Thomas M., additional, Song, Kevin, additional, Zhu, Katie Yuan, additional, Gerrie, Alina S, additional, Cheah, Chan Y., additional, El-Galaly, Tarec Christoffer C., additional, and Jakobsen, Lasse H., additional

Published
2019
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20. Relapse Risk and Loss of Lifetime After Modern Combined Modality Treatment of Young Patients With Hodgkin Lymphoma: A Nordic Lymphoma Epidemiology Group Study

Author

Biccler, Jorne Lionel, primary, Glimelius, Ingrid, additional, Eloranta, Sandra, additional, Smeland, Knut B., additional, Brown, Peter de Nully, additional, Jakobsen, Lasse Hjort, additional, Frederiksen, Henrik, additional, Jerkeman, Mats, additional, Fosså, Alexander, additional, Andersson, Therese M.L., additional, Holte, Harald, additional, Bøgsted, Martin, additional, El-Galaly, Tarec Christoffer, additional, and Smedby, Karin E., additional

Published
2019
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21. Normalization of Survival and No Relapses after One Year in Adult Burkitt Lymphoma Patients Treated with Intensive Immunochemotherapy: An International Study of 159 Real-World Patients

Author

Jakobsen, Lasse H., primary, Ellin, Fredrik, additional, Smeland, Knut B., additional, Wästerlid, Tove, additional, Christensen, Jacob H., additional, Jørgensen, Judit, additional, Josefsson, Pär L., additional, Holte, Harald, additional, Blaker, Yngvild N., additional, Grauslund, Jacob H., additional, Bjørn, Jon, additional, Molin, Daniel, additional, Lagerlöf, Ingemar, additional, Ekstroem Smedby, Karin, additional, Colvin, Katherine, additional, Thanarajasingam, Gita, additional, Gerrie, Alina S., additional, Cheah, Chan Y., additional, and El-Galaly, Tarec C., additional

Published
2018
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22. Relapse Risk and Loss in Expectation of Lifetime in Young Classical Hodgkin Lymphoma Patients - a Nordic Lymphoma Group Study of 2,582 Patients

Author

Biccler, Jorne Lionel, primary, Glimelius, Ingrid, additional, Eloranta, Sandra, additional, Smeland, Knut B., additional, Brown, Peter de Nully, additional, Jakobsen, Lasse H., additional, Frederiksen, Henrik, additional, Jerkeman, Mats, additional, Fosså, Alexander, additional, Andersson, Therese M.L., additional, Holte, Harald, additional, Bøgsted, Martin, additional, El-Galaly, Tarec C., additional, and Ekstroem Smedby, Karin, additional

Published
2018
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23. Chronic fatigue is highly prevalent in survivors of autologous stem cell transplantation and associated with IL-6, neuroticism, cardiorespiratory fitness, and obesity

Author

Smeland, Knut B., primary, Loge, Jon H., additional, Aass, Hans C. D., additional, Aspelin, Trude, additional, Bersvendsen, Hanne, additional, Bolstad, Nils, additional, Fagerli, Unn-Merete, additional, Falk, Ragnhild S., additional, Fluge, Øystein, additional, Fosså, Alexander, additional, Holte, Harald, additional, Lund, May B., additional, Murbræch, Klaus, additional, Reinertsen, Kristin V., additional, Stenehjem, Jo S., additional, and Kiserud, Cecilie E., additional

Published
2018
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25. Bone mineral density is close to normal for age in long-term lymphoma survivors treated with high-dose therapy with autologous stem cell transplantation

Author

Seland, Mette, primary, Smeland, Knut B., additional, Bjøro, Trine, additional, Falk, Ragnhild S., additional, Fosså, Sophie D., additional, Gjesdal, Clara G., additional, Godang, Kristin, additional, Holte, Harald, additional, Svartberg, Johan, additional, Syversen, Unni, additional, Bollerslev, Jens, additional, and Kiserud, Cecilie E., additional

Published
2017
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28. Obstructive and restrictive pulmonary dysfunction in long-term lymphoma survivors after high-dose therapy with autologous stem cell transplantation.

Author

Stenehjem, Jo S., Smeland, Knut B., Murbraech, Klaus, Holte, Harald, Kvaløy, Stein Olav, Wethal, Torgeir, Kiserud, Cecilie E., and Samersaw-Lund, May Brit

Subjects
*LYMPHOMA treatment, *STEM cell transplantation, *ACADEMIC medical centers, *AUTOGRAFTS, *CANCER chemotherapy, *CANCER patients, *DOXORUBICIN, *ECHOCARDIOGRAPHY, *LYMPHOMAS, *OBSTRUCTIVE lung diseases, *POISSON distribution, *QUESTIONNAIRES, *REGRESSION analysis, *SMOKING, *SMOKING cessation, *SPIROMETRY, *MULTIPLE regression analysis, *VITAL capacity (Respiration), *LUNG volume measurements, *DISEASE risk factors
Abstract

Background: Obstructive and restrictive dysfunction in long-term lymphoma survivors (LSs) after highdose therapy with autologous stem-cell transplantation (HDT-ASCT) has not been addressed systematically previously. Material and methods: LSs treated in Norway 1987-2008 with HDT-ASCT who performed spirometry, measurement of static lung volumes and echocardiography 2012-2014 at either Oslo or St. Olavs University Hospitals was eligible. Smoking data were recorded by questionnaire. Treatment data were collected from medical records or hospital databases. Factors associated with obstructive and restrictive impairments (dichotomous outcomes) were examined by Poisson regression. Linear regression with the margins post-estimation command was used to derive adjusted mean values of forced expiratory volume in 1 s (FEV1). We used the normative reference data recommended by the European Respiratory Society for calculating percent predicted values. Results: A total of 226 LSs were studied, of whom 11.5 and 5.8% had obstructive and restrictive impairment, respectively. For women and men, mean FEV1 was 2.31 and 3.34 l corresponding to 11.4%- and 11.1%-points below that predicted from norms, respectively. In multivariable regression analyses, cumulative doxorubicin dose (400-775 mg/m²) and current smoking were associated with increased risk of obstructive impairment, and chest RT (>13-66 Gy) was associated with increased risk of restrictive impairment. Currently smoking LSs within the highest doxorubicin category (400-775mg/m²), had the lowest adjusted mean FEV1. Conclusions: Despite intensive cancer treatment, our analysis showed modest reductions in obstructive parameters among long-term LSs after HDT-ASCT compared to normative reference data. To limit obstructive impairments in LSs after HDT-ASCT, we suggest that targeted smoking-cessation advice is directed towards patients who have received high cumulative doses of doxorubicin. [ABSTRACT FROM AUTHOR]

Published
2018
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29. Chronic fatigue is highly prevalent in survivors of autologous stem cell transplantation and associated with IL-6, neuroticism, cardiorespiratory fitness, and obesity

Author

Smeland, Knut B., Loge, Jon H., Aass, Hans C. D., Aspelin, Trude, Bersvendsen, Hanne, Bolstad, Nils, Fagerli, Unn-Merete, Falk, Ragnhild S., Fluge, Øystein, Fosså, Alexander, Holte, Harald, Lund, May B., Murbræch, Klaus, Reinertsen, Kristin V., Stenehjem, Jo S., and Kiserud, Cecilie E.

Published
2019
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30. Heart Failure and Asymptomatic Left Ventricular Systolic Dysfunction in Lymphoma Survivors Treated With Autologous Stem-Cell Transplantation: A National Cross-Sectional Study

Author

Murbraech, Klaus, primary, Smeland, Knut B., additional, Holte, Harald, additional, Loge, Jon Håvard, additional, Lund, May Brit, additional, Wethal, Torgeir, additional, Holte, Espen, additional, Rösner, Assami, additional, Dalen, Håvard, additional, Kvaløy, Stein, additional, Falk, Ragnhild S., additional, Aakhus, Svend, additional, and Kiserud, Cecilie E., additional

Published
2015
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31. Distressed personality is associated with late adverse effects in long-term survivors of Hodgkin lymphoma.

Author

Dahl AA, Smeland KB, Eikeland S, Fagerli UM, Bersvendsen HS, Fosså A, and Kiserud CE

Subjects
Humans, Female, Male, Middle Aged, Adult, Cross-Sectional Studies, Adolescent, Young Adult, Child, Surveys and Questionnaires, Fatigue epidemiology, Fatigue etiology, Fatigue psychology, Stress Disorders, Post-Traumatic epidemiology, Stress Disorders, Post-Traumatic etiology, Stress Disorders, Post-Traumatic psychology, Sleep Wake Disorders etiology, Sleep Wake Disorders epidemiology, Sleep Wake Disorders psychology, Long Term Adverse Effects psychology, Long Term Adverse Effects epidemiology, Long Term Adverse Effects etiology, Hodgkin Disease psychology, Cancer Survivors psychology, Cancer Survivors statistics & numerical data, Personality
Abstract

Background and Purpose: There are few studies of personality traits in long-term Hodgkin lymphoma survivors (HLSs) treated according to contemporary stage-and risk-adapted approaches. The Distressed Personality (DP) Scale covers negative affectivity and social inhibition. We examined differences in self-reported late adverse effects (LAEs) between HLSs with and without DP and other explanatory variables., Material and Methods: This cross-sectional questionnaire-based study included a population-based cohort of HLSs treated from 1997 to 2006, aged 8-49 years at diagnosis, and alive in 2016. Among 518 eligible HLSs, 303 responded (58%), and 294 completed the DP scale. DP was defined by scores above cut-off on both the negative affectivity and social inhibition subscales. LAEs studied were major depression, posttraumatic stress disorder, sleep problems, obesity, neuropathy, fatigue, memory problems, and general health. DP and 10 other explanatory variables were tested against LAEs as dependent variables in multivariable regression analyses., Results: The mean age at survey was 45.9 years (standard deviation [SD] 4.6), mean follow-up time 16.7 years (SD 3.0), and 48% were females. Eighty-two HLSs had DP (28%, 95% confidence interval 23% - 33%). All LAEs except obesity were significantly more common/had higher mean score in HLSs with DP. In multivariable analyses, presence of DP was significantly associated with all LAEs except obesity., Interpretation: The presence of DP is common among HLSs. The presence of DP was associated with most self-report LAEs examined. Including assessment of personality traits in the survivorship care plans of HLSs should be considered. Prospective studies assessing the influence of pretreatment DP on LAEs are warranted.

Published
2024
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32. Conditional survival and excess mortality after high-dose therapy with autologous stem cell transplantation for adult refractory or relapsed Hodgkin lymphoma in Norway.

Author

Smeland KB, Kiserud CE, Lauritzsen GF, Fagerli UM, Falk RS, Fluge Ø, Fosså A, Kolstad A, Loge JH, Maisenhölder M, Kvaløy S, and Holte H

Subjects
Cohort Studies, Female, Hematopoietic Stem Cell Transplantation trends, Humans, Male, Neoplasms, Second Primary diagnosis, Norway epidemiology, Recurrence, Registries, Survival Rate trends, Transplantation, Autologous, Hematopoietic Stem Cell Transplantation mortality, Hodgkin Disease mortality, Hodgkin Disease therapy, Neoplasms, Second Primary mortality
Published
2015
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