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In this paper we present two different analyses of R1234yf and R1234ze(E) as drop-in replacements for R134a in a small power refrigeration system. The first analysis is based on equal evaporation and condensation temperatures before and after the refrigerant replacement. The second analysis is carried out for equal cooling medium conditions in the condenser, so that the transport properties and the heat transfer features in the condenser are considered for the three refrigerants. In order to perform the analyses, a simulation model was developed, that takes into account specific data, characteristics and dimensions of the main components of a small power refrigeration system. The model was validated with experimental data for R134a and later used to predict the behavior with R1234yf and R1234ze(E). Results show that different conclusions may be drawn if the drop-in analysis is carried out for equal condensation temperatures or for equal temperatures of the cooling medium in the condenser, as well as that these results are affected by the condenser design. In general, R1234yf seems as an adequate drop-in refrigerant for R134a, but R1234ze(E) may perform better when an overridden compressor can be used to match the refrigerating system cooling power.