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2,100 results on '"Slutsky, Arthur S."'

1. Mental health sequelae in survivors of cardiogenic shock complicating myocardial infarction. A population-based cohort study

Author

Fernando, Shannon M., Qureshi, Danial, Talarico, Robert, Vigod, Simone N., McIsaac, Daniel I., Sterling, Lee H., van Diepen, Sean, Price, Susanna, Di Santo, Pietro, Kyeremanteng, Kwadwo, Fan, Eddy, Needham, Dale M., Brodie, Daniel, Bienvenu, Oscar Joseph, Combes, Alain, Slutsky, Arthur S., Scales, Damon C., Herridge, Margaret S., Thiele, Holger, Hibbert, Benjamin, Tanuseputro, Peter, and Mathew, Rebecca

Published
2024
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5. Resource Utilization and Costs Associated With Cardiogenic Shock Complicating Myocardial Infarction: A Population-Based Cohort Study

Author

Parlow, Simon, Fernando, Shannon M., Pugliese, Michael, Qureshi, Danial, Talarico, Robert, Sterling, Lee H., van Diepen, Sean, Herridge, Margaret S., Price, Susanna, Brodie, Daniel, Fan, Eddy, McIsaac, Daniel I., Di Santo, Pietro, Jung, Richard G., Slutsky, Arthur S., Scales, Damon C., Combes, Alain, Hibbert, Benjamin, Thiele, Holger, Tanuseputro, Peter, and Mathew, Rebecca

Published
2024
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8. Clinical relevance of timing of assessment of ICU mortality in patients with moderate-to-severe Acute Respiratory Distress Syndrome

Author

Villar, Jesús, González-Martin, Jesús M., Añón, José M., Ferrando, Carlos, Soler, Juan A., Mosteiro, Fernando, Mora-Ordoñez, Juan M., Ambrós, Alfonso, Fernández, Lorena, Montiel, Raquel, Vidal, Anxela, Muñoz, Tomás, Pérez-Méndez, Lina, Rodríguez-Suárez, Pedro, Fernández, Cristina, Fernández, Rosa L., Szakmany, Tamas, Burns, Karen E. A., Steyerberg, Ewout W., and Slutsky, Arthur S.

Published
2023
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10. ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies

Author

Grasselli, Giacomo, Calfee, Carolyn S., Camporota, Luigi, Poole, Daniele, Amato, Marcelo B. P., Antonelli, Massimo, Arabi, Yaseen M., Baroncelli, Francesca, Beitler, Jeremy R., Bellani, Giacomo, Bellingan, Geoff, Blackwood, Bronagh, Bos, Lieuwe D. J., Brochard, Laurent, Brodie, Daniel, Burns, Karen E. A., Combes, Alain, D’Arrigo, Sonia, De Backer, Daniel, Demoule, Alexandre, Einav, Sharon, Fan, Eddy, Ferguson, Niall D., Frat, Jean-Pierre, Gattinoni, Luciano, Guérin, Claude, Herridge, Margaret S., Hodgson, Carol, Hough, Catherine L., Jaber, Samir, Juffermans, Nicole P., Karagiannidis, Christian, Kesecioglu, Jozef, Kwizera, Arthur, Laffey, John G., Mancebo, Jordi, Matthay, Michael A., McAuley, Daniel F., Mercat, Alain, Meyer, Nuala J., Moss, Marc, Munshi, Laveena, Myatra, Sheila N., Ng Gong, Michelle, Papazian, Laurent, Patel, Bhakti K., Pellegrini, Mariangela, Perner, Anders, Pesenti, Antonio, Piquilloud, Lise, Qiu, Haibo, Ranieri, Marco V., Riviello, Elisabeth, Slutsky, Arthur S., Stapleton, Renee D., Summers, Charlotte, Thompson, Taylor B., Valente Barbas, Carmen S., Villar, Jesús, Ware, Lorraine B., Weiss, Björn, Zampieri, Fernando G., Azoulay, Elie, and Cecconi, Maurizio

Published
2023
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11. Heparin Dose Intensity and Organ Support-Free Days in Patients Hospitalized for COVID-19

Author

Godoy, Lucas C., Neal, Matthew D., Goligher, Ewan C., Cushman, Mary, Houston, Brett L., Bradbury, Charlotte A., McQuilten, Zoe K., Tritschler, Tobias, Kahn, Susan R., Berry, Lindsay R., Lorenzi, Elizabeth, Jensen, Tom, Higgins, Alisa M., Kornblith, Lucy Z., Berger, Jeffrey S., Gong, Michelle N., Paul, Jonathan D., Castellucci, Lana A., Le Gal, Grégoire, Lother, Sylvain A., Rosenson, Robert S., Derde, Lennie P.G., Kumar, Anand, McVerry, Bryan J., Nicolau, Jose C., Leifer, Eric, Escobedo, Jorge, Huang, David T., Reynolds, Harmony R., Carrier, Marc, Kim, Keri S., Hunt, Beverley J., Slutsky, Arthur S., Turgeon, Alexis F., Webb, Steven A., McArthur, Colin J., Farkouh, Michael E., Hochman, Judith S., Zarychanski, Ryan, and Lawler, Patrick R.

Published
2024
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12. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19

Author

Lawler, Patrick R, Goligher, Ewan C, Berger, Jeffrey S, Neal, Matthew D, McVerry, Bryan J, Nicolau, Jose C, Gong, Michelle N, Carrier, Marc, Rosenson, Robert S, Reynolds, Harmony R, Turgeon, Alexis F, Escobedo, Jorge, Huang, David T, Bradbury, Charlotte A, Houston, Brett L, Kornblith, Lucy Z, Kumar, Anand, Kahn, Susan R, Cushman, Mary, McQuilten, Zoe, Slutsky, Arthur S, Kim, Keri S, Gordon, Anthony C, Kirwan, Bridget-Anne, Brooks, Maria M, Higgins, Alisa M, Lewis, Roger J, Lorenzi, Elizabeth, Berry, Scott M, Berry, Lindsay R, Aday, Aaron W, Al-Beidh, Farah, Annane, Djillali, Arabi, Yaseen M, Aryal, Diptesh, Baumann Kreuziger, Lisa, Beane, Abi, Bhimani, Zahra, Bihari, Shailesh, Billett, Henny H, Bond, Lindsay, Bonten, Marc, Brunkhorst, Frank, Buxton, Meredith, Buzgau, Adrian, Castellucci, Lana A, Chekuri, Sweta, Chen, Jen-Ting, Cheng, Allen C, Chkhikvadze, Tamta, Coiffard, Benjamin, Costantini, Todd W, de Brouwer, Sophie, Derde, Lennie PG, Detry, Michelle A, Duggal, Abhijit, Džavík, Vladimír, Effron, Mark B, Estcourt, Lise J, Everett, Brendan M, Fergusson, Dean A, Fitzgerald, Mark, Fowler, Robert A, Galanaud, Jean P, Galen, Benjamin T, Gandotra, Sheetal, García-Madrona, Sebastian, Girard, Timothy D, Godoy, Lucas C, Goodman, Andrew L, Goossens, Herman, Green, Cameron, Greenstein, Yonatan Y, Gross, Peter L, Hamburg, Naomi M, Haniffa, Rashan, Hanna, George, Hanna, Nicholas, Hegde, Sheila M, Hendrickson, Carolyn M, Hite, R Duncan, Hindenburg, Alexander A, Hope, Aluko A, Horowitz, James M, Horvat, Christopher M, Hudock, Kristin, Hunt, Beverley J, Husain, Mansoor, Hyzy, Robert C, Iyer, Vivek N, Jacobson, Jeffrey R, Jayakumar, Devachandran, Keller, Norma M, Khan, Akram, Kim, Yuri, Kindzelski, Andrei L, King, Andrew J, Knudson, M Margaret, Kornblith, Aaron E, and Krishnan, Vidya

Subjects
Cardiovascular, Clinical Trials and Supportive Activities, Clinical Research, Hematology, Transplantation, Good Health and Well Being, Adult, Aged, Anticoagulants, COVID-19, Female, Hemorrhage, Heparin, Heparin, Low-Molecular-Weight, Hospital Mortality, Humans, Male, Middle Aged, Survival Analysis, Thrombosis, COVID-19 Drug Treatment, ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundThrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve outcomes in noncritically ill patients who are hospitalized with Covid-19.MethodsIn this open-label, adaptive, multiplatform, controlled trial, we randomly assigned patients who were hospitalized with Covid-19 and who were not critically ill (which was defined as an absence of critical care-level organ support at enrollment) to receive pragmatically defined regimens of either therapeutic-dose anticoagulation with heparin or usual-care pharmacologic thromboprophylaxis. The primary outcome was organ support-free days, evaluated on an ordinal scale that combined in-hospital death (assigned a value of -1) and the number of days free of cardiovascular or respiratory organ support up to day 21 among patients who survived to hospital discharge. This outcome was evaluated with the use of a Bayesian statistical model for all patients and according to the baseline d-dimer level.ResultsThe trial was stopped when prespecified criteria for the superiority of therapeutic-dose anticoagulation were met. Among 2219 patients in the final analysis, the probability that therapeutic-dose anticoagulation increased organ support-free days as compared with usual-care thromboprophylaxis was 98.6% (adjusted odds ratio, 1.27; 95% credible interval, 1.03 to 1.58). The adjusted absolute between-group difference in survival until hospital discharge without organ support favoring therapeutic-dose anticoagulation was 4.0 percentage points (95% credible interval, 0.5 to 7.2). The final probability of the superiority of therapeutic-dose anticoagulation over usual-care thromboprophylaxis was 97.3% in the high d-dimer cohort, 92.9% in the low d-dimer cohort, and 97.3% in the unknown d-dimer cohort. Major bleeding occurred in 1.9% of the patients receiving therapeutic-dose anticoagulation and in 0.9% of those receiving thromboprophylaxis.ConclusionsIn noncritically ill patients with Covid-19, an initial strategy of therapeutic-dose anticoagulation with heparin increased the probability of survival to hospital discharge with reduced use of cardiovascular or respiratory organ support as compared with usual-care thromboprophylaxis. (ATTACC, ACTIV-4a, and REMAP-CAP ClinicalTrials.gov numbers, NCT04372589, NCT04505774, NCT04359277, and NCT02735707.).

Published
2021

13. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.

Author

ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Lawler, Patrick R, Goligher, Ewan C, Berger, Jeffrey S, Neal, Matthew D, McVerry, Bryan J, Nicolau, Jose C, Gong, Michelle N, Carrier, Marc, Rosenson, Robert S, Reynolds, Harmony R, Turgeon, Alexis F, Escobedo, Jorge, Huang, David T, Bradbury, Charlotte A, Houston, Brett L, Kornblith, Lucy Z, Kumar, Anand, Kahn, Susan R, Cushman, Mary, McQuilten, Zoe, Slutsky, Arthur S, Kim, Keri S, Gordon, Anthony C, Kirwan, Bridget-Anne, Brooks, Maria M, Higgins, Alisa M, Lewis, Roger J, Lorenzi, Elizabeth, Berry, Scott M, Berry, Lindsay R, Aday, Aaron W, Al-Beidh, Farah, Annane, Djillali, Arabi, Yaseen M, Aryal, Diptesh, Baumann Kreuziger, Lisa, Beane, Abi, Bhimani, Zahra, Bihari, Shailesh, Billett, Henny H, Bond, Lindsay, Bonten, Marc, Brunkhorst, Frank, Buxton, Meredith, Buzgau, Adrian, Castellucci, Lana A, Chekuri, Sweta, Chen, Jen-Ting, Cheng, Allen C, Chkhikvadze, Tamta, Coiffard, Benjamin, Costantini, Todd W, de Brouwer, Sophie, Derde, Lennie PG, Detry, Michelle A, Duggal, Abhijit, Džavík, Vladimír, Effron, Mark B, Estcourt, Lise J, Everett, Brendan M, Fergusson, Dean A, Fitzgerald, Mark, Fowler, Robert A, Galanaud, Jean P, Galen, Benjamin T, Gandotra, Sheetal, García-Madrona, Sebastian, Girard, Timothy D, Godoy, Lucas C, Goodman, Andrew L, Goossens, Herman, Green, Cameron, Greenstein, Yonatan Y, Gross, Peter L, Hamburg, Naomi M, Haniffa, Rashan, Hanna, George, Hanna, Nicholas, Hegde, Sheila M, Hendrickson, Carolyn M, Hite, R Duncan, Hindenburg, Alexander A, Hope, Aluko A, Horowitz, James M, Horvat, Christopher M, Hudock, Kristin, Hunt, Beverley J, Husain, Mansoor, Hyzy, Robert C, Iyer, Vivek N, Jacobson, Jeffrey R, Jayakumar, Devachandran, Keller, Norma M, Khan, Akram, Kim, Yuri, Kindzelski, Andrei L, and King, Andrew J

Subjects
ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Humans, Thrombosis, Hemorrhage, Heparin, Heparin, Low-Molecular-Weight, Anticoagulants, Hospital Mortality, Survival Analysis, Adult, Aged, Middle Aged, Female, Male, COVID-19, Hematology, Clinical Trials and Supportive Activities, Transplantation, Clinical Research, Cardiovascular, General & Internal Medicine, Medical and Health Sciences
Abstract

BackgroundThrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve outcomes in noncritically ill patients who are hospitalized with Covid-19.MethodsIn this open-label, adaptive, multiplatform, controlled trial, we randomly assigned patients who were hospitalized with Covid-19 and who were not critically ill (which was defined as an absence of critical care-level organ support at enrollment) to receive pragmatically defined regimens of either therapeutic-dose anticoagulation with heparin or usual-care pharmacologic thromboprophylaxis. The primary outcome was organ support-free days, evaluated on an ordinal scale that combined in-hospital death (assigned a value of -1) and the number of days free of cardiovascular or respiratory organ support up to day 21 among patients who survived to hospital discharge. This outcome was evaluated with the use of a Bayesian statistical model for all patients and according to the baseline d-dimer level.ResultsThe trial was stopped when prespecified criteria for the superiority of therapeutic-dose anticoagulation were met. Among 2219 patients in the final analysis, the probability that therapeutic-dose anticoagulation increased organ support-free days as compared with usual-care thromboprophylaxis was 98.6% (adjusted odds ratio, 1.27; 95% credible interval, 1.03 to 1.58). The adjusted absolute between-group difference in survival until hospital discharge without organ support favoring therapeutic-dose anticoagulation was 4.0 percentage points (95% credible interval, 0.5 to 7.2). The final probability of the superiority of therapeutic-dose anticoagulation over usual-care thromboprophylaxis was 97.3% in the high d-dimer cohort, 92.9% in the low d-dimer cohort, and 97.3% in the unknown d-dimer cohort. Major bleeding occurred in 1.9% of the patients receiving therapeutic-dose anticoagulation and in 0.9% of those receiving thromboprophylaxis.ConclusionsIn noncritically ill patients with Covid-19, an initial strategy of therapeutic-dose anticoagulation with heparin increased the probability of survival to hospital discharge with reduced use of cardiovascular or respiratory organ support as compared with usual-care thromboprophylaxis. (ATTACC, ACTIV-4a, and REMAP-CAP ClinicalTrials.gov numbers, NCT04372589, NCT04505774, NCT04359277, and NCT02735707.).

Published
2021

14. Prognostic factors associated with favourable functional outcome among adult patients requiring extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: A systematic review and meta-analysis

Author

Tran, Alexandre, Rochwerg, Bram, Fan, Eddy, Belohlavek, Jan, Suverein, Martje M., Poll, Marcel C.G. van de, Lorusso, Roberto, Price, Susanna, Yannopoulos, Demetris, MacLaren, Graeme, Ramanathan, Kollengode, Ling, Ryan Ruiyang, Thiara, Sonny, Tonna, Joseph E., Shekar, Kiran, Hodgson, Carol L., Scales, Damon C., Sandroni, Claudio, Nolan, Jerry P., Slutsky, Arthur S., Combes, Alain, Brodie, Daniel, and Fernando, Shannon M.

Published
2023
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15. Predicting ICU Mortality in Acute Respiratory Distress Syndrome Patients Using Machine Learning: The Predicting Outcome and STratifiCation of severity in ARDS (POSTCARDS) Study*

Author

Villar, Jesús, González-Martín, Jesús M., Hernández-González, Jerónimo, Armengol, Miguel A., Fernández, Cristina, Martín-Rodríguez, Carmen, Mosteiro, Fernando, Martínez, Domingo, Sánchez-Ballesteros, Jesús, Ferrando, Carlos, Domínguez-Berrot, Ana M., Añón, José M., Parra, Laura, Montiel, Raquel, Solano, Rosario, Robaglia, Denis, Rodríguez-Suárez, Pedro, Gómez-Bentolila, Estrella, Fernández, Rosa L., Szakmany, Tamas, Steyerberg, Ewout W., Slutsky, Arthur S., Ambrós, Alfonso, del Campo, Rafael, Bueno-González, Ana, Hornos-López, Carmen, Pita-García, Lidia, Díaz-Lamas, Ana M., Arrojo, Regina, Soler, Juan A., Conesa-Cayuela, Luís A., del Saz-Ortiz, Ana M., Capilla, Lucia, Fernández, Lorena, Blanco, Jesús, Muriel, Arturo, Blanco-Schweizer, Pablo, Aldecoa, César, Rico-Feijoo, Jesús, Pérez, Alba, Martín-Alfonso, Silvia, Domínguez, Ana M., Díaz-Domínguez, Francisco J., González-Luengo, Raúl I., Carriedo, Demetrio, Soro, Marina, Belda, Javier, Gutiérrez, Andrea, Aguilar, Gerardo, Ferrando, Carlos, Civantos, Belén, Hernández, Mónica, Andaluz, David, Nogales, Leonor, Parrilla, Dácil, Peinado, Eduardo, Pérez-Méndez, Lina, González-Higueras, Elena, Vidal, Anxela, Pérez, César, and Kacmarek, Robert M.

Published
2023
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16. Inhalation of ACE2 as a therapeutic target on sex-bias differences in SARS-CoV-2 infection and variant of concern

Author

Onodera, Yu, Liang, Jady, Li, Yuchong, Griffin, Bryan, Thanabalasingam, Thenuka, Lu, Cong, Zhu, JiaYi, Liu, Mingyao, Moraes, Theo, Zheng, Wenhua, Khateeb, Jasmin, Khang, Julie, Huang, Yongbo, Jerkic, Mirjana, Nakane, Masaki, Baker, Andrew, Orser, Beverley, Chen, Ya-Wen, Wirnsberger, Gerald, Penninger, Josef M., Rotstein, Ori D., Slutsky, Arthur S., Li, Yimin, Mubareka, Samira, and Zhang, Haibo

Published
2023
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18. Prognostic factors associated with mortality among patients receiving venovenous extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis

Author

Tran, Alexandre, Fernando, Shannon M, Rochwerg, Bram, Barbaro, Ryan P, Hodgson, Carol L, Munshi, Laveena, MacLaren, Graeme, Ramanathan, Kollengode, Hough, Catherine L, Brochard, Laurent J, Rowan, Kathryn M, Ferguson, Niall D, Combes, Alain, Slutsky, Arthur S, Fan, Eddy, and Brodie, Daniel

Published
2023
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21. Respiratory indications for ECMO: focus on COVID-19

Author

Supady, Alexander, Combes, Alain, Barbaro, Ryan P., Camporota, Luigi, Diaz, Rodrigo, Fan, Eddy, Giani, Marco, Hodgson, Carol, Hough, Catherine L., Karagiannidis, Christian, Kochanek, Matthias, Rabie, Ahmed A., Riera, Jordi, Slutsky, Arthur S., and Brodie, Daniel

Published
2022
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25. Noninvasive respiratory support following extubation in critically ill adults: a systematic review and network meta-analysis

Author

Fernando, Shannon M., Tran, Alexandre, Sadeghirad, Behnam, Burns, Karen E. A., Fan, Eddy, Brodie, Daniel, Munshi, Laveena, Goligher, Ewan C., Cook, Deborah J., Fowler, Robert A., Herridge, Margaret S., Cardinal, Pierre, Jaber, Samir, Møller, Morten Hylander, Thille, Arnaud W., Ferguson, Niall D., Slutsky, Arthur S., Brochard, Laurent J., Seely, Andrew J. E., and Rochwerg, Bram

Published
2022
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28. Assessment of Ventilation Using Adult and Pediatric Manual Resuscitators in a Simulated Adult Patient.

Author

Justice, Joshua M., Slutsky, Arthur S., Stanford, Nathan, Isennock, Christopher, Siddiqui, Sameer, Zamir, Hamza, Walker III, J. Richard, and Brady, Mark F.

Subjects
ARTIFICIAL respiration equipment, RESPIRATORY therapy equipment, CONTINUING education units, PULMONARY function tests, RESPIRATORY therapy, PROFESSIONAL practice, HUMAN anatomical models, DATA analysis, PULMONARY alveoli, MULTIPLE regression analysis, QUESTIONNAIRES, RESPIRATORY insufficiency, RESUSCITATION, EMERGENCY medicine, DESCRIPTIVE statistics, SIMULATED patients, MEDICAL masks, RESPIRATORY measurements, STATISTICS, AIRWAY (Anatomy), DATA analysis software, CHILDREN, ADULTS
Abstract

BACKGROUND: The bag-valve-mask (BVM) or manual resuscitator bag is used as a first-line technique to ventilate patients with respiratory failure. Volume-restricted manual resuscitator bags (eg, pediatric bags) have been suggested to minimize overventilation and associated complications. There are studies that both support and caution against the use of a pediatric resuscitator bag to ventilate an adult patient. In this study, we evaluated the ability of pre-hospital clinicians to adequately ventilate an adult manikin with both an adult- and pediatric-size manual resuscitator bag without the assistance of an advanced airway or airway adjunct device. METHODS: This study was conducted at an international conference in 2022. Conference attendees with pre-hospital health care experience were recruited to ventilate an adult manikin using a BVM for 1 min with both an adult and pediatric resuscitator bag, without the use of adjunct airway devices, while 6 ventilatory variables were collected or calculated: tidal volume (VT), breathing frequency, adequate breaths (VT > 150 mL), proportion of adequate breaths, peak inspiratory pressure (PIP), and estimated alveolar ventilation (EAV). RESULTS: A total of 208 participants completed the study. Ventilation with the adult-sized BVM delivered an average VT of 290.4 mL compared to 197.1 mL (P < .001) when using the pediatric BVM. PIP with the adult BVM was higher than with the pediatric BVM (10.6 cm H2O vs 8.6 cm H2O, P < .001). The median EAV with the adult bag (1,138.1 [interquartile range [IQR] 194.0-2,869.9] mL/min) was markedly greater than with the pediatric BVM (67.7 [IQR 0-467.3] mL/min, P < .001). CONCLUSIONS: Both pediatric- and adult-sized BVM provided lower ventilation volumes than those recommended by professional guidelines for an adult. Ventilation with the pediatric BVM was significantly worse than with the adult bag when ventilating a simulated adult subject. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Canada's response to the initial 2 years of the COVID-19 pandemic: a comparison with peer countries

Author

Razak, Fahad, Shin, Saeha, Naylor, C. David, and Slutsky, Arthur S.

Subjects
Europe -- Comparative analysis -- Health aspects -- Economic aspects, Japan -- Comparative analysis -- Health aspects -- Economic aspects, Canada -- Comparative analysis -- Health aspects -- Economic aspects, United States -- Comparative analysis -- Health aspects -- Economic aspects, Epidemics -- Statistics -- Control -- Economic aspects -- United States, Vaccination -- Statistics -- Economic aspects, Health
Abstract

The first known diagnosis of SARS-CoV-2 infection in Canada was in a patient in hospital in Toronto on Jan. 25, 2020. (1) At the time, few anticipated the intensity and [...]

Published
2022
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33. The PANDORA Study: Prevalence and Outcome of Acute Hypoxemic Respiratory Failure in the Pre-COVID-19 Era

Author

Villar, Jesús, Mora-Ordoñez, Juan M., Soler, Juan A., Mosteiro, Fernando, Vidal, Anxela, Ambrós, Alfonso, Fernández, Lorena, Murcia, Isabel, Civantos, Belén, Romera, Miguel A., Mira, Adrián, Díaz-Domínguez, Francisco J., Parrilla, Dácil, Martínez-Carmona, J. Francisco, Martínez, Domingo, Pita-García, Lidia, Robaglia, Denis, Bueno-González, Ana, Sánchez-Ballesteros, Jesús, Pereyra, Ángel E., Hernández, Mónica, Chamorro-Jambrina, Carlos, Cobeta, Pilar, González-Luengo, Raúl I., Montiel, Raquel, Nogales, Leonor, Fernández, M. Mar, Arocas, Blanca, Valverde-Montoro, Álvaro, del Saz-Ortiz, Ana M., Olea-Jiménez, Victoria, Añón, José M., Rodríguez-Suárez, Pedro, Fernández, Rosa L., Fernández, Cristina, Szakmany, Tamas, González-Martín, Jesús M., Ferrando, Carlos, Kacmarek, Robert M., Slutsky, Arthur S., Añón, José M., Civantos, Belén, Hernández, Mónica, González, Elena, Solano, Rosario, Díaz-Domínguez, F. Javier, Carriedo, Demetrio, González Luengo, Raul I., Ferrando, Carlos, Arocas, Blanca, Belda, Javier, Soro, Marina, Aguilar, Gerardo, Pastor, Ernesto, Fernández, Lorena, Sánchez-Ballesteros, Jesús, Muriel, Arturo, Blanco-Schweizer, Pablo, de Ayala, José Ángel, Blanco, Jesús, Aldecoa, César, Pérez, Alba, Rico-Feijoo, Jesús, Nogales, Leonor, Andaluz, David, Parra, Laura, Soler, Juan A., Martínez, Domingo, del Saz-Ortiz, Ana M., Ambrós, Alfonso, Bueno-González, Ana, Hornos-López, Carmen, Montiel, Raquel, Parrilla, Dácil, Peinado, Eduardo, Prieto, Isidro, Chico, Mario, Romera, Miguel A., Chamorro-Jambrina, Carlos, Mora-Ordoñez, Juan M., Martínez-Carmona, J. Francisco, Valverde-Montoro, Álvaro, Olea-Jiménez, Victoria, Alba, Paco, Corpas, Ruth, Mosteiro, Fernando, Pita-García, Lidia, Merayo, Eleuterio, Martínez, Chanel, de Célis-Álvarez, Ángeles, Martín-Delgado, Carmen, Mira, Adrián, Cobeta, Pilar, Pestaña, David, del Mar Fernández, María, Tarancón, Concepción, Cortés-Díaz, Silvia, Vidal, Anxela, Robaglia, Denis, Pérez, César, Murcia, Isabel, Pereyra-Pache, Ángel E., Szakmany, Tamas, Villar, Jesús, Fernández, Rosa L., Fernández, Cristina, Rodríguez-Pérez, Pedro, González-Martín, Jesús M., Kacmarek, Robert M., and Slutsky, Arthur S.

Published
2022
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36. COVID-19-associated autoimmunity as a feature of acute respiratory failure

Author

Trahtemberg, Uriel, Fritzler, Marvin J., Rottapel, Robert, dos Santos, Claudia C., Di Battista, Alex P., Slutsky, Arthur S., and Baker, Andrew J.

Subjects
Autoimmunity, Autoantibodies, Coronaviruses, Acute respiratory distress syndrome, Health care industry, University of Toronto
Abstract

Author(s): Uriel Trahtemberg [sup.1], Marvin J. Fritzler [sup.2], Robert Rottapel, Claudia C. dos Santos, Alex P. Di Battista, Arthur S. Slutsky, Andrew J. Baker Author Affiliations: Dear Editor, Coronavirus disease [...]

Published
2021
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39. Heparin Dose Intensity and Organ Support-Free Days in Patients Hospitalized for COVID-19

Author

Medische Staf Intensive Care, Infection & Immunity, Godoy, Lucas C., Neal, Matthew D., Goligher, Ewan C., Cushman, Mary, Houston, Brett L., Bradbury, Charlotte A., McQuilten, Zoe K., Tritschler, Tobias, Kahn, Susan R., Berry, Lindsay R., Lorenzi, Elizabeth, Jensen, Tom, Higgins, Alisa M., Kornblith, Lucy Z., Berger, Jeffrey S., Gong, Michelle N., Paul, Jonathan D., Castellucci, Lana A., Le Gal, Grégoire, Lother, Sylvain A., Rosenson, Robert S., Derde, Lennie P.G., Kumar, Anand, McVerry, Bryan J., Nicolau, Jose C., Leifer, Eric, Escobedo, Jorge, Huang, David T., Reynolds, Harmony R., Carrier, Marc, Kim, Keri S., Hunt, Beverley J., Slutsky, Arthur S., Turgeon, Alexis F., Webb, Steven A., McArthur, Colin J., Farkouh, Michael E., Hochman, Judith S., Zarychanski, Ryan, Lawler, Patrick R., Medische Staf Intensive Care, Infection & Immunity, Godoy, Lucas C., Neal, Matthew D., Goligher, Ewan C., Cushman, Mary, Houston, Brett L., Bradbury, Charlotte A., McQuilten, Zoe K., Tritschler, Tobias, Kahn, Susan R., Berry, Lindsay R., Lorenzi, Elizabeth, Jensen, Tom, Higgins, Alisa M., Kornblith, Lucy Z., Berger, Jeffrey S., Gong, Michelle N., Paul, Jonathan D., Castellucci, Lana A., Le Gal, Grégoire, Lother, Sylvain A., Rosenson, Robert S., Derde, Lennie P.G., Kumar, Anand, McVerry, Bryan J., Nicolau, Jose C., Leifer, Eric, Escobedo, Jorge, Huang, David T., Reynolds, Harmony R., Carrier, Marc, Kim, Keri S., Hunt, Beverley J., Slutsky, Arthur S., Turgeon, Alexis F., Webb, Steven A., McArthur, Colin J., Farkouh, Michael E., Hochman, Judith S., Zarychanski, Ryan, and Lawler, Patrick R.

Published
2024

40. Understanding the Post COVID-19 Condition (Long COVID) in Adults and the Expected Burden for Ontario

Author

Quinn, Kieran L., primary, Katz, Gabrielle M., additional, Bobos, Pavlos, additional, Sander, Beate, additional, McNaughton, Candace D., additional, Cheung, Angela M., additional, Herridge, Margaret S., additional, Atzema, Clare L., additional, Born, Karen B., additional, Chan, Christine, additional, Chien, Vincent, additional, Kaplan, David M., additional, Kwong, Jeffrey, additional, Leung, Susan, additional, Mishra, Sharmistha, additional, Morris, Andrew M., additional, Rendely, Alexandra, additional, Slutsky, Arthur S., additional, Stalteri, Rosa, additional, and Razak, Fahad A., additional

Published
2022
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41. Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study

Author

Lissoni, Alfredo, Rossi, Nicola, Guzzardella, Amedeo, Valsecchi, Carlo, Madotto, Fabiana, Bevilacqua, Francesca, Di Laudo, Marco, Querci, Lorenzo, Seccafico, Carmen, Grasselli, Giacomo, Tonetti, Tommaso, Protti, Alessandro, Langer, Thomas, Girardis, Massimo, Bellani, Giacomo, Laffey, John, Carrafiello, Gianpaolo, Carsana, Luca, Rizzuto, Chiara, Zanella, Alberto, Scaravilli, Vittorio, Pizzilli, Giacinto, Grieco, Domenico Luca, Di Meglio, Letizia, de Pascale, Gennaro, Lanza, Ezio, Monteduro, Francesco, Zompatori, Maurizio, Filippini, Claudia, Locatelli, Franco, Cecconi, Maurizio, Fumagalli, Roberto, Nava, Stefano, Vincent, Jean-Louis, Antonelli, Massimo, Slutsky, Arthur S, Pesenti, Antonio, and Ranieri, V Marco

Published
2020
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42. Evaluation of PEEP and prone positioning in early COVID-19 ARDS

Author

Mittermaier, Mirja, Pickerodt, Philipp, Kurth, Florian, de Jarcy, Laure Bosquillon, Uhrig, Alexander, Garcia, Carmen, Machleidt, Felix, Pergantis, Panagiotis, Weber, Susanne, Li, Yaosi, Breitbart, Astrid, Bremer, Felix, Knape, Philipp, Dewey, Marc, Doellinger, Felix, Weber-Carstens, Steffen, Slutsky, Arthur S., Kuebler, Wolfgang M., Suttorp, Norbert, and Müller-Redetzky, Holger

Published
2020
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44. Hybrid immunity from severe acute respiratory syndrome coronavirus 2 infection and vaccination in Canadian adults: A cohort study.

Author

Brown, Patrick E., Sze Hang Fu, Newcombe, Leslie, Xuyang Tang, Nagelkerke, Nico, Birnboim, H. Chaim, Bansal, Aiyush, Colwill, Karen, Mailhot, GeneviÃ?ve, Delgado-Brand, Melanie, Tursun, Tulunay, Qi, Freda, Gingras, Anne-Claude, Slutsky, Arthur S., Pasic, Maria D., Companion, Jeffrey, Bogoch, Isaac I., Morawski, Ed, Lam, Teresa, and Reid, Angus

Published
2024
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46. Prevention of viral transmission during lung transplantation with hepatitis C-viraemic donors: an open-label, single-centre, pilot trial

Author

Cypel, Marcelo, Feld, Jordan J, Galasso, Marcos, Pinto Ribeiro, Rafaela V, Marks, Nikki, Kuczynski, Magdalena, Kumar, Deepali, Bahinskaya, Ilona, Bagnato, Vanderlei S, Kurachi, Cristina, Slutsky, Arthur S, Yeung, Jonathan C, Donahoe, Laura, de Perrot, Marc, Yasufuku, Kazuhiro, Pierre, Andrew, Binnie, Matthew, Chaparro, Cecilia, Martinu, Tereza, Chen, Manyin, Tikkanen, Jussi, Chow, Chung-Wai, Sidhu, Aman, Waddell, Thomas K, Keshavjee, Shaf, Singer, Lianne G, and Humar, Atul

Published
2020
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47. Current and evolving standards of care for patients with ARDS

Author

Menk, Mario, Estenssoro, Elisa, Sahetya, Sarina K., Neto, Ary Serpa, Sinha, Pratik, Slutsky, Arthur S., and Summers, Charlotte

Subjects
Patients -- Care and treatment, Medical colleges, Acute respiratory distress syndrome -- Care and treatment, Health care industry
Abstract

Care for patients with acute respiratory distress syndrome (ARDS) has changed considerably over the 50 years since its original description. Indeed, standards of care continue to evolve as does how this clinical entity is defined and how patients are grouped and treated in clinical practice. In this narrative review we discuss current standards - treatments that have a solid evidence base and are well established as targets for usual care - and also evolving standards - treatments that have promise and may become widely adopted in the future. We focus on three broad domains of ventilatory management, ventilation adjuncts, and pharmacotherapy. Current standards for ventilatory management include limitation of tidal volume and airway pressure and standard approaches to setting PEEP, while evolving standards might focus on limitation of driving pressure or mechanical power, individual titration of PEEP, and monitoring efforts during spontaneous breathing. Current standards in ventilation adjuncts include prone positioning in moderate-severe ARDS and veno-venous extracorporeal life support after prone positioning in patients with severe hypoxemia or who are difficult to ventilate. Pharmacotherapy current standards include corticosteroids for patients with ARDS due to COVID-19 and employing a conservative fluid strategy for patients not in shock; evolving standards may include steroids for ARDS not related to COVID-19, or specific biological agents being tested in appropriate sub-phenotypes of ARDS. While much progress has been made, certainly significant work remains to be done and we look forward to these future developments., Author(s): Mario Menk [sup.1] [sup.2], Elisa Estenssoro [sup.3] [sup.4], Sarina K. Sahetya [sup.5], Ary Serpa Neto [sup.6] [sup.7] [sup.8], Pratik Sinha [sup.9], Arthur S. Slutsky [sup.10], Charlotte Summers [sup.11], Takeshi [...]

Published
2020
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49. The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline

Author

Rochwerg, Bram, Einav, Sharon, Chaudhuri, Dipayan, Mancebo, Jordi, Mauri, Tommaso, Helviz, Yigal, Goligher, Ewan C., Jaber, Samir, Ricard, Jean-Damien, Rittayamai, Nuttapol, Roca, Oriol, Antonelli, Massimo, Maggiore, Salvatore Maurizio, Demoule, Alexandre, Hodgson, Carol L., Mercat, Alain, Wilcox, M. Elizabeth, Granton, David, Wang, Dominic, Azoulay, Elie, Ouanes-Besbes, Lamia, Cinnella, Gilda, Rauseo, Michela, Carvalho, Carlos, Dessap-Mekontso, Armand, Fraser, John, Frat, Jean-Pierre, Gomersall, Charles, Grasselli, Giacomo, Hernandez, Gonzalo, Jog, Sameer, Pesenti, Antonio, Riviello, Elisabeth D., Slutsky, Arthur S., Stapleton, Renee D., Talmor, Daniel, Thille, Arnaud W., Brochard, Laurent, and Burns, Karen E. A.

Published
2020
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50. Biotrauma during ultra-low tidal volume ventilation and venoarterial extracorporeal membrane oxygenation in cardiogenic shock: a randomized crossover clinical trial

Author

Amado-Rodríguez, Laura, Del Busto, Cecilia, López-Alonso, Inés, Parra, Diego, Mayordomo-Colunga, Juan, Arias-Guillén, Miguel, Albillos-Almaraz, Rodrigo, Martín-Vicente, Paula, López-Martínez, Cecilia, Huidobro, Covadonga, Camporota, Luigi, Slutsky, Arthur S., and Albaiceta, Guillermo M.

Published
2021
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