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26 results on '"Slooff, Willem-Bart M"'

1. Survival after Resection of Malignant Peripheral Nerve Sheath Tumors: introducing and validating a novel type-specific prognostic model

Author

Acem, Ibtissam, primary, Steyerberg, Ewout W, additional, Spreafico, Marta, additional, Grünhagen, Dirk J, additional, Callegaro, Dario, additional, Spinner, Robert J, additional, Pendleton, Courtney, additional, Coert, J Henk, additional, Miceli, Rosalba, additional, Abruzzese, Giulia, additional, Flucke, Uta E, additional, Slooff, Willem-Bart M, additional, van Dalen, Thijs, additional, Been, Lukas B, additional, Bonenkamp, Han J, additional, Anten, Monique H M E, additional, Broen, Martinus P G, additional, Bemelmans, Marc H A, additional, Bramer, Jos A M, additional, Schaap, Gerard R, additional, Kievit, Arthur J, additional, van der Hage, Jos, additional, van Houdt, Winan J, additional, van de Sande, Michiel A J, additional, Gronchi, Alessandro, additional, Verhoef, Cornelis, additional, and Martin, Enrico, additional

Published
2024
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3. Surgical versus conservative treatment for odontoid fractures in older people: an international prospective comparative study.

Author

Huybregts, Jeroen G J, Polak, Samuel B, Jacobs, Wilco C, Arts, Mark P, Meyer, Bernhard, Wostrack, Maria, Butenschön, Vicki M, Osti, Michael, Öner, F Cumhur, Slooff, Willem-Bart M, Feller, Ricardo E, Bouma, Gert-Joan, Harhangi, Biswadjiet S, Depreitere, Bart, Nygaard, Øystein P, Weber, Clemens, Müller, Kay, Timothy, Jake, Pellisé, Ferran, and Rasmussen, Mikkel M

Subjects
CERVICAL vertebrae injuries, NECK pain treatment, CONSERVATIVE treatment, PAIN measurement, SURGERY, PATIENTS, T-test (Statistics), CERVICAL collars, RESEARCH funding, COMPUTED tomography, QUESTIONNAIRES, LOGISTIC regression analysis, ORTHOPEDIC implants, DISABILITY evaluation, VERTEBRAL fractures, TREATMENT effectiveness, DECISION making, DESCRIPTIVE statistics, CHI-squared test, LONGITUDINAL method, SPINAL fusion, CERVICAL vertebrae, COMPARATIVE studies, DATA analysis software, CONFIDENCE intervals, REGRESSION analysis, OLD age
Abstract

Background The optimal treatment for odontoid fractures in older people remains debated. Odontoid fractures are increasingly relevant to clinical practice due to ageing of the population. Methods An international prospective comparative study was conducted in fifteen European centres, involving patients aged ≥55 years with type II/III odontoid fractures. The surgeon and patient jointly decided on the applied treatment. Surgical and conservative treatments were compared. Primary outcomes were Neck Disability Index (NDI) improvement, fracture union and stability at 52 weeks. Secondary outcomes were Visual Analogue Scale neck pain, Likert patient-perceived recovery and EuroQol-5D-3L at 52 weeks. Subgroup analyses considered age, type II and displaced fractures. Multivariable regression analyses adjusted for age, gender and fracture characteristics. Results The study included 276 patients, of which 144 (52%) were treated surgically and 132 (48%) conservatively (mean (SD) age 77.3 (9.1) vs. 76.6 (9.7), P  = 0.56). NDI improvement was largely similar between surgical and conservative treatments (mean (SE) −11 (2.4) vs. −14 (1.8), P  = 0.08), as were union (86% vs. 78%, aOR 2.3, 95% CI 0.97–5.7) and stability (99% vs. 98%, aOR NA). NDI improvement did not differ between patients with union and persistent non-union (mean (SE) −13 (2.0) vs. −12 (2.8), P  = 0.78). There was no difference for any of the secondary outcomes or subgroups. Conclusions Clinical outcome and fracture healing at 52 weeks were similar between treatments. Clinical outcome and fracture union were not associated. Treatments should prioritize favourable clinical over radiological outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Low-Threshold-For-Surgery Versus Primarily-Conservative Treatment for Odontoid Fractures in the Elderly: Evaluating Practice Variation in The Netherlands

Author

Huybregts, Jeroen G. J., primary, Polak, Samuel B., additional, Jacobs, Wilco C. H., additional, Krekels-Huijbregts, Ilse A., additional, Smeets, Anouk Y. J. M., additional, Arts, Mark P., additional, Slooff, Willem-Bart M., additional, Öner, F. Cumhur, additional, Peul, Wilco C., additional, van Santbrink, Henk, additional, and Vleggeert-Lankamp, Carmen L. A., additional

Published
2023
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6. Diagnostic accuracy of computed tomography angiography (CTA) for diagnosing blunt cerebrovascular injury in trauma patients: a systematic review and meta-analysis

Author

Zorgeenheid Orthopaedie Medisch, Neurochirurgen, Researchgr. Systems Radiology, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Cancer, MS Orthopaedie Algemeen, Other research (not in main researchprogram), Kik, Charlotte C., Slooff, Willem-Bart M., Moayeri, Nizar, de Jong, Pim A., Muijs, Sander P. J., Oner, F. Cumhur, Zorgeenheid Orthopaedie Medisch, Neurochirurgen, Researchgr. Systems Radiology, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Cancer, MS Orthopaedie Algemeen, Other research (not in main researchprogram), Kik, Charlotte C., Slooff, Willem-Bart M., Moayeri, Nizar, de Jong, Pim A., Muijs, Sander P. J., and Oner, F. Cumhur

Published
2022

9. Blunt cerebrovascular injury: incidence and long-term follow-up

Author

Zorglijn AN/AAN Medisch, ZL Algemene en Acute Nec Medisch, Zorgeenheid Orthopaedie Medisch, Zorgeenheid Traumatologie, Zorgeenheid Vaatchirurgie Medisch, Regenerative Medicine and Stem Cells, Brain, Circulatory Health, MS Orthopaedie Spine, Other research (not in main researchprogram), Infection & Immunity, Hundersmarck, Dennis, Slooff, Willem Bart M., Homans, Jelle F., van der Vliet, Quirine M.J., Moayeri, Nizar, Hietbrink, Falco, de Borst, Gert J., Öner, Fetullah Cumhur, Muijs, Sander P.J., Leenen, Luke P.H., Zorglijn AN/AAN Medisch, ZL Algemene en Acute Nec Medisch, Zorgeenheid Orthopaedie Medisch, Zorgeenheid Traumatologie, Zorgeenheid Vaatchirurgie Medisch, Regenerative Medicine and Stem Cells, Brain, Circulatory Health, MS Orthopaedie Spine, Other research (not in main researchprogram), Infection & Immunity, Hundersmarck, Dennis, Slooff, Willem Bart M., Homans, Jelle F., van der Vliet, Quirine M.J., Moayeri, Nizar, Hietbrink, Falco, de Borst, Gert J., Öner, Fetullah Cumhur, Muijs, Sander P.J., and Leenen, Luke P.H.

Published
2021

10. A nationwide cohort study on treatment and survival in patients with malignant peripheral nerve sheath tumours

Author

Martin, Enrico, Henk Coert, J., Flucke, U.E., Slooff, Willem-Bart M., Ho, Vincent K.Y., Graaf, W.T.A. van der, Grunhagen, Dirk J., Verhoef, C., Martin, Enrico, Henk Coert, J., Flucke, U.E., Slooff, Willem-Bart M., Ho, Vincent K.Y., Graaf, W.T.A. van der, Grunhagen, Dirk J., and Verhoef, C.

Abstract

Contains fulltext : 214450.pdf (Publisher’s version ) (Open Access)

Published
2020

11. Neurofibromatosis-associated malignant peripheral nerve sheath tumors in children have a worse prognosis:A nationwide cohort study

Author

Martin, Enrico, Coert, J Henk, Flucke, Uta E, Slooff, Willem-Bart M, van de Sande, Michiel A J, van Noesel, Max M, Grünhagen, Dirk J, Wijnen, Marc H W A, Verhoef, Cornelis, Martin, Enrico, Coert, J Henk, Flucke, Uta E, Slooff, Willem-Bart M, van de Sande, Michiel A J, van Noesel, Max M, Grünhagen, Dirk J, Wijnen, Marc H W A, and Verhoef, Cornelis

Abstract

BACKGROUND: Malignant peripheral nerve sheath tumors (MPNST) are rare and aggressive non-rhabdomyoblastic soft-tissue sarcomas (NRSTS) in children. This study set out to investigate clinical presentation, treatment modalities, and factors associated with survival in pediatric MPNST using Dutch nationwide databases.METHODS: Data were obtained from the Netherlands Cancer Registry (NCR) and the Dutch Pathology Database (PALGA) from 1989 to 2017. All primary MPNSTs were collected. Demographic differences were analyzed between adult and pediatric (age ≤18 years) MPNST. In children, demographic and treatment differences between neurofibromatosis type 1 (NF1) and non-NF1 were analyzed. A Cox proportional hazard model was constructed for localized pediatric MPNSTs.RESULTS: A total of 70/784 MPNST patients were children (37.1% NF1). Children did not present differently from adults. In NF1 children, tumor size was more commonly large (> 5 cm, 92.3% vs 59.1%). Localized disease was primarily resected in 90.6%, and radiotherapy was administered in 37.5%. Non-NF1 children tended to receive chemotherapy more commonly (39.5% vs 26.9%). Overall, estimated five-year survival rates of localized NF1-MPNST was 52.4% (SE: 10.1%) compared with 75.8% (SE: 7.1%) in non-NF1 patients. The multivariate model showed worse survival in NF1 patients (HR: 2.98; 95% CI, 1.17-7.60, P = 0.02) and increased survival in patients diagnosed after 2005 (HR: 0.20; 95% CI, 0.06-0.69, P = 0.01). No treatment factors were independently associated with survival.CONCLUSION: Pediatric MPNSTs have presentations similar to adult MPNSTs. In children, NF1 patients present with larger tumors, but are treated similarly to non-NF1 MPNSTs. In localized pediatric MPNST, NF1 is associated with worse survival. Promisingly, survival has increased for pediatric MPNSTs after 2005.

Published
2020

12. Oncological Treatment Considerations Differ across Surgical Subspecialties Treating Malignant Peripheral Nerve Sheath Tumors: An International Survey

Author

Zorgeenheid Plastische Chirurgie Medisch, Neurochirurgen, Zorglijn AN/AAN Medisch, Perfusie, MS CGO, Brain, Martin, Enrico, Slooff, Willem-Bart M, van Houdt, Winan J, van Dalen, Thijs, Verhoef, Cornelis, Coert, J Henk, Zorgeenheid Plastische Chirurgie Medisch, Neurochirurgen, Zorglijn AN/AAN Medisch, Perfusie, MS CGO, Brain, Martin, Enrico, Slooff, Willem-Bart M, van Houdt, Winan J, van Dalen, Thijs, Verhoef, Cornelis, and Coert, J Henk

Published
2020

13. Neurofibromatosis-associated malignant peripheral nerve sheath tumors in children have a worse prognosis: A nationwide cohort study

Author

Zorgeenheid Plastische Chirurgie Medisch, Brain, Pathologie Pathologen staf, Neurochirurgen, Zorglijn AN/AAN Medisch, Martin, Enrico, Coert, J Henk, Flucke, Uta E, Slooff, Willem-Bart M, van de Sande, Michiel A J, van Noesel, Max M, Grünhagen, Dirk J, Wijnen, Marc H W A, Verhoef, Cornelis, Zorgeenheid Plastische Chirurgie Medisch, Brain, Pathologie Pathologen staf, Neurochirurgen, Zorglijn AN/AAN Medisch, Martin, Enrico, Coert, J Henk, Flucke, Uta E, Slooff, Willem-Bart M, van de Sande, Michiel A J, van Noesel, Max M, Grünhagen, Dirk J, Wijnen, Marc H W A, and Verhoef, Cornelis

Published
2020

14. A nationwide cohort study on treatment and survival in patients with malignant peripheral nerve sheath tumours

Author

Zorgeenheid Plastische Chirurgie Medisch, Brain, Pathologie Pathologen staf, Neurochirurgen, MS CGO, Martin, Enrico, Coert, J Henk, Flucke, Uta E, Slooff, Willem-Bart M, Ho, Vincent K Y, van der Graaf, Winette T, van Dalen, Thijs, van de Sande, Michiel A J, van Houdt, Winan J, Grünhagen, Dirk J, Verhoef, Cornelis, Zorgeenheid Plastische Chirurgie Medisch, Brain, Pathologie Pathologen staf, Neurochirurgen, MS CGO, Martin, Enrico, Coert, J Henk, Flucke, Uta E, Slooff, Willem-Bart M, Ho, Vincent K Y, van der Graaf, Winette T, van Dalen, Thijs, van de Sande, Michiel A J, van Houdt, Winan J, Grünhagen, Dirk J, and Verhoef, Cornelis

Published
2020

16. A nationwide cohort study on treatment and survival in patients with malignant peripheral nerve sheath tumours

Author

Martin, Enrico, primary, Coert, J. Henk, additional, Flucke, Uta E., additional, Slooff, Willem-Bart M., additional, Ho, Vincent K.Y., additional, van der Graaf, Winette T., additional, van Dalen, Thijs, additional, van de Sande, Michiel A.J., additional, van Houdt, Winan J., additional, Grünhagen, Dirk J., additional, and Verhoef, Cornelis, additional

Published
2020
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20. Blunt cerebrovascular injury: incidence and long-term follow-up

Author

Hundersmarck, Dennis, primary, Slooff, Willem-Bart M., additional, Homans, Jelle F., additional, van der Vliet, Quirine M. J., additional, Moayeri, Nizar, additional, Hietbrink, Falco, additional, de Borst, Gert J., additional, Öner, Fetullah Cumhur, additional, Muijs, Sander P. J., additional, and Leenen, Luke P. H., additional

Published
2019
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21. Low-Threshold-For-Surgery Versus Primarily-Conservative Treatment for Odontoid Fractures in the Elderly: Evaluating Practice Variation in The Netherlands

Author

Huybregts, Jeroen G. J., Polak, Samuel B., Jacobs, Wilco C. H., Krekels-Huijbregts, Ilse A., Smeets, Anouk Y. J. M., Arts, Mark P., Slooff, Willem-Bart M., Öner, F. Cumhur, Peul, Wilco C., van Santbrink, Henk, and Vleggeert-Lankamp, Carmen L. A.

Abstract

Study Design Retrospective cohort study.Objectives Odontoid fractures are the most common cervical spine fractures in the elderly. The optimal treatment remains controversial. The aim of this study was to compare results of a low-threshold-for-surgery strategy (surgery for dislocated fractures in relatively healthy patients) to a primarily-conservative strategy (for all patients).Methods Patient records from 5 medical centers were reviewed for patients who met the selection criteria (e.g. age ≥55 years, type II/III odontoid fractures). Demographics, fracture types/characteristics, fracture union/stability, clinical outcome and mortality were compared. The influence of age on outcome was studied (≥55-80 vs ≥80 years).Results A total of 173 patients were included: 120 treated with low-threshold-for-surgery (of which 22 primarily operated, and 23 secondarily) vs 53 treated primarily-conservative. No differences in demographics and fracture characteristics between the groups were identified. Fracture union (53% vs 43%) and fracture stability (90% vs 85%) at last follow-up did not differ between groups. The majority of patients (56%) achieved clinical improvement compared to baseline. Analysis of differences in clinical outcome between groups was infeasible due to data limitations. In both strategies, patients ≥80 years achieved worse union (64% vs 30%), worse stability (97% vs 77%), and – as to be expected – increased mortality <104 weeks (2% vs 22%).Conclusions Union and stability rates did not differ between the treatment strategies. Advanced age (≥80 years) negatively influenced both radiological outcome and mortality. No cases of secondary neurological deficits were identified, suggesting that concerns for the consequences of under-treatment may be unjustified.

Published
2024
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