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1. NMR metabolomics-guided DNA methylation mortality predictors

Author

Geleijnse, J.M., Boersma, E., van Spil, W.E., van Greevenbroek, M.M.J., Stehouwer, C.D.A., van der Kallen, C.J.H., Arts, I.C.W., Rutters, F., Beulens, J.W.J., Muilwijk, M., Elders, P.J.M., 't Hart, L.M., Ghanbari, M., Ikram, M.A., Netea, M.G., Kloppenburg, M., Ramos, Y.F.M., Bomer, N., Meulenbelt, I., Stronks, K., Snijder, M.B., Zwinderman, A.H., Heijmans, B.T., Lumey, L.H., Wijmenga, C., Fu, J., Zhernakova, A., Deelen, J., Mooijaart, S.P., Beekman, M., Slagboom, P.E., Onderwater, G.L.J., van den Maagdenberg, A.M.J.M., Terwindt, G.M., Thesing, C., Bot, M., Penninx, B.W.J.H., Trompet, S., Jukema, J.W., Sattar, N., van der Horst, I.C.C., van der Harst, P., So-Osman, C., van Hilten, J.A., Nelissen, R.G.H.H., Höfer, I.E., Asselbergs, F.W., Scheltens, P., Teunissen, C.E., van der Flier, W.M., van Dongen, J., Pool, R., Willemsen, A.H.M., Boomsma, D.I., Suchiman, H.E.D., Barkey Wolf, J.J.H., Cats, D., Mei, H., Slofstra, M., Swertz, M., Reinders, M.J.T., van den Akker, E.B., Bizzarri, Daniele, Reinders, Marcel J.T., Kuiper, Lieke, Beekman, Marian, Deelen, Joris, van Meurs, Joyce B.J., van Dongen, Jenny, Pool, René, Boomsma, Dorret I., Ghanbari, Mohsen, Franke, Lude, Slagboom, Pieternella E., and van den Akker, Erik B.

Published
2024
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2. Genetics and Not Shared Environment Explains Familial Resemblance in Adult Metabolomics Data

Author

Pool, Rene, Hagenbeek, Fiona A., Hendriks, Anne M., van Dongen, Jenny, Willemsen, Gonneke, de Geus, Eco, van Dijk, Ko Willems, Verhoeven, Aswin, Suchiman, H. Eka, Beekman, Marian, Slagboom, P. Eline, Harms, Amy C., Hankemeier, Thomas, Boomsma, Dorret, I, Beekman, M., Suchiman, H. E. D., Amin, N., Beulens, J. W., van der Bom, J. A., Bomer, N., Demirkan, A., van Hilten, J. A., Meessen, J. M. T. A., Pool, R., Moed, M. H., Fu, J., Onderwater, G. L. J., Rutters, F., So-Osman, C., van der Flier, W. M., van der Heijden, A. A. W. A., van der Spek, A., Asselbergs, F. W., Boersma, E., Elders, P. M., Geleijnse, J. M., Ikram, M. A., Kloppenburg, M., Meulenbelt, I, Mooijaart, S. P., Nelissen, R. G. H. H., Netea, M. G., Penninx, B. W. J. H., Stehouwer, C. D. A., Teunissen, C. E., Terwindt, G. M., 't Hart, L. M., van den Maagdenberg, A. M. J. M., van der Harst, P., van der Horst, I. C. C., van der Kallen, C. J. H., van Greevenbroek, M. M. J., van Spil, W. E., Wijmenga, C., Zwinderman, A. H., Zhernikova, A., Jukema, J. W., Wolf, J. J. H. Barkey, Cats, D., Mei, H., Slofstra, M., Swertz, M., van den Akker, E. B., Deelen, J., Reinders, M. J. T., Boomsma, D., I, van Duijn, C. M., Slagboom, P. E., Interne Geneeskunde, MUMC+: MA Interne Geneeskunde (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: MA Endocrinologie (9), MUMC+: MA Maag Darm Lever (9), MUMC+: MA Hematologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Nefrologie (9), MUMC+: MA Reumatologie (9), RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Molecular Neuroscience and Ageing Research (MOLAR), Cardiovascular Centre (CVC), Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Center for Liver, Digestive and Metabolic Diseases (CLDM), Medical Microbiology and Infection Prevention, Graduate School, Tytgat Institute for Liver and Intestinal Research, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Obstetrics and Gynaecology, Cardiology, Public and occupational health, Gastroenterology and Hepatology, Paediatric Endocrinology, Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, APH - Mental Health, APH - Methodology, Epidemiology and Data Science, Obstetrics and gynaecology, ACS - Diabetes & metabolism, ACS - Heart failure & arrhythmias, Anatomy and neurosciences, Anesthesiology, General practice, Internal medicine, Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Laboratory Medicine, Amsterdam Neuroscience - Neurodegeneration, Amsterdam Neuroscience - Neuroinfection & -inflammation, Amsterdam Reproduction & Development (AR&D), AMS - Musculoskeletal Health, AMS - Tissue Function & Regeneration, Rheumatology, Gastroenterology and hepatology, APH - Aging & Later Life, and APH - Digital Health

Subjects
Male, Netherlands Twin Register (NTR), 0301 basic medicine, Shared environment, Metabolite, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Genome-wide association study, heritability, METABOLITES, Keywords: Classical twin design, chemistry.chemical_compound, 0302 clinical medicine, metabolite classes, Twins, Dizygotic, EPIDEMIOLOGY, Classical twin design, Genetics (clinical), Genetics, HERITABILITY, shared environment, Obstetrics and Gynecology, Phenotype, Quartile, Metabolome, Female, Adult, Dizygotic twin, POWER, TWIN, Environment, Biology, enrichment analysis, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Metabolomics, AGE, Diseases in Twins, Humans, Family, GENOME-WIDE ASSOCIATION, Classical twin design [Keywords], Twins, Monozygotic, PROFILES, Heritability, Diet, Metabolomics data, 030104 developmental biology, chemistry, Pediatrics, Perinatology and Child Health, Gene-Environment Interaction, 030217 neurology & neurosurgery
Abstract

Metabolites are small molecules involved in cellular metabolism where they act as reaction substrates or products. The term ‘metabolomics’ refers to the comprehensive study of these molecules. The concentrations of metabolites in biological tissues are under genetic control, but this is limited by environmental factors such as diet. In adult mono- and dizygotic twin pairs, we estimated the contribution of genetic and shared environmental influences on metabolite levels by structural equation modeling and tested whether the familial resemblance for metabolite levels is mainly explained by genetic or by environmental factors that are shared by family members. Metabolites were measured across three platforms: two based on proton nuclear magnetic resonance techniques and one employing mass spectrometry. These three platforms comprised 237 single metabolic traits of several chemical classes. For the three platforms, metabolites were assessed in 1407, 1037 and 1116 twin pairs, respectively. We carried out power calculations to establish what percentage of shared environmental variance could be detected given these sample sizes. Our study did not find evidence for a systematic contribution of shared environment, defined as the influence of growing up together in the same household, on metabolites assessed in adulthood. Significant heritability was observed for nearly all 237 metabolites; significant contribution of the shared environment was limited to 6 metabolites. The top quartile of the heritability distribution was populated by 5 of the 11 investigated chemical classes. In this quartile, metabolites of the class lipoprotein were significantly overrepresented, whereas metabolites of classes glycerophospholipids and glycerolipids were significantly underrepresented.

Published
2020

3. Author Correction: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies (Nature Communications, (2020), 11, 1, (39), 10.1038/s41467-019-13770-6)

Author

Hagenbeek, Fiona A., Pool, René, van Dongen, Jenny, Draisma, H. M., Jan Hottenga, Jouke, Willemsen, Gonneke, Abdellaoui, Abdel, Fedko, Iryna O., den Braber, Anouk, Visser, Pieter Jelle, de Geus, Eco J.C.N., Willems van Dijk, Ko, Verhoeven, Aswin, Suchiman, H. Eka, Beekman, Marian, Slagboom, P. Eline, van Duijn, Cornelia M., Barkey Wolf, J. J.H., Cats, D., Amin, N., Beulens, J. W., van der Bom, J. A., Bomer, N., Demirkan, A., van Hilten, J. A., Meessen, J. M.T.A., Moed, M. H., Fu, J., Onderwater, G. L.J., Rutters, F., So-Osman, C., van der Flier, W. M., van der Heijden, A. A.W.A., van der Spek, A., Asselbergs, F. W., Boersma, E., Elders, P. M., Geleijnse, J. M., Ikram, M. A., Kloppenburg, M., Meulenbelt, I., Mooijaart, S. P., Nelissen, R. G.H.H., Netea, M. G., Penninx, B. W.J.H., Stehouwer, C. D.A., Teunissen, C. E., Terwindt, G. M., ‘t Hart, L. M., van den Maagdenberg, A. M.J.M., van der Harst, P., van der Horst, I. C.C., van der Kallen, C. J.H., van Greevenbroek, M. M.J., van Spil, W. E., Wijmenga, C., Zwinderman, A. H., Zhernikova, A., Jukema, J. W., Mei, H., Slofstra, M., Swertz, M., van den Akker, E. B., Deelen, J., Reinders, M. J.T., Harms, Amy C., Hankemeier, Thomas, Bartels, Meike, Nivard, Michel G., Boomsma, Dorret I., Neurology, APH - Health Behaviors & Chronic Diseases, ACS - Heart failure & arrhythmias, Epidemiology and Data Science, General practice, APH - Methodology, APH - Mental Health, Psychiatry, Clinical chemistry, APH - Aging & Later Life, APH - Personalized Medicine, APH - Digital Health, and ACS - Diabetes & metabolism

Abstract

The original version of the Supplementary Information associated with this Article included an incorrect Supplementary Data 1 file, in which additional delimiters were included in the first column for a number of rows, resulting in column shifts for some of these rows. The HTML has been updated to include a corrected version of Supplementary Data 1; the original incorrect version of Supplementary Data 1 can be found as Supplementary Information associated with this Correction. In addition, the original version of this Article contained an error in the author affiliations. An affiliation of Abdel Abdellaoui with Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands was inadvertently omitted. This has now been corrected in both the PDF and HTML versions of the Article.

Published
2020

4. Correction to: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies (vol 11, 39, 2020)

Author

Hagenbeek, F.A., Pool, R., Dongen, J. van, Draisma, H.M., Hottenga, J.J., Willemsen, G., Abdellaoui, A., Fedko, I.O., Braber, A. den, Visser, P.J., Geus, E.J.C.N. de, Duijn, C.M. van, Harms, A.C., Bartels, M., Nivard, M.G., Boomsma, D.I., Hankemeier, T., Beulens, J.W., Rutters, F., Flier, W.M. van der, Hart, L.M., Bom, J.A. van der, Kloppenburg, M., Harst, P. van der, Bomer, N., Hilten, J.A. van, So-Osman, C., Meessen, J.M.T.A., Fu, J., Wijmenga, C., Zhernikova, A., Slofstra, M., Swertz, M., Onderwater, G.L.J., Terwindt, G.M., Heijden, A.A.W.A. van der, Asselbergs, F.W., Boersma, E., Elders, P.M., Geleijnse, J.M., Ikram, M.A., Mooijaart, S.P., Nelissen, R.G.H.H., Netea, M.G., Penninx, B.W.J.H., Stehouwer, C.D.A., Kallen, C.J.H. van der, Greevenbroek, M.M.J. van, Teunissen, C.E., Maagdenberg, A.M.J.M. van den, Spil, W.E. van, Zwinderman, A.H., Jukema, J.W., Mei, H., Akker, E.B. van den, Deelen, J., Horst I.C.C. van der, Reinders M.J.T., and Abdel Abdellaoui

Abstract

Correction to: Nature Communications https://doi.org/10.1038/s41467-019-13770-6, published online 7 January 2020.The original version of the Supplementary Information associated with this Article included an incorrect Supplementary Data 1 file, in which additional delimiters were included in the first column for a number of rows, resulting in column shifts for some of these rows. The HTML has been updated to include a corrected version of Supplementary Data 1; the original incorrect version of Supplementary Data 1 can be found as Supplementary Information associated with this Correction.

Published
2020

5. Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

Author

Hagenbeek, F.A., Pool, R., Dongen, J. van, Draisma, H.H.M., Hottenga, J.J., Willemsen, G., Abdellaoui, A., Fedko, I.O., Braber, A. den, Visser, P.J., Geus, E.J.C.N. de, Dijk, K.W. van, Verhoeven, A., Suchiman, H.E., Beekman, M., Slagboom, P.E., Duijn, C.M. van, Harms, A.C., Hankemeier, T., Bartels, M., Nivard, M.G., Boomsma, D.I., Wolf, J.J.H.B., Cats, D., Amin, N., Beulens, J.W., Bom, J.A. van der, Bomer, N., Demirkan, A., Hilten, J.A. van, Meessen, J.M.T.A., Moed, M.H., Fu, J., Onderwater, G.L.J., Rutters, F., So-Osman, C., Flier, W.M. van der, Heijden, A.A.W.A. van der, Spek, A. van der, Asselbergs, F.W., Boersma, E., Elders, P.M., Geleijnse, J.M., Ikram, M.A., Kloppenburg, M., Meulenbelt, I., Mooijaart, S.P., Nelissen, R.G.H.H., Netea, M.G., Penninx, B.W.J.H., Stehouwer, C.D.A., Teunissen, C.E., Terwindt, G.M., Hart, L.M. 't, Maagdenberg, A.M.J.M. van den, Harst, P. van der, Horst, I.C.C. van der, Kallen, C.J.H. van der, Greevenbroek, M.M.J. van, Spil, W.E. van, Wijmenga, C., Zwinderman, A.H., Zhernikova, A., Jukema, J.W., Mei, H., Slofstra, M., Swertz, M., Akker, E.B. van den, Deelen, J., Reinders, M.J.T., BBMRI Metabolomics Consortium, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Cardiovascular Centre (CVC), Center for Liver, Digestive and Metabolic Diseases (CLDM), Neurology, Epidemiology and Data Science, ACS - Heart failure & arrhythmias, APH - Health Behaviors & Chronic Diseases, General practice, APH - Methodology, Amsterdam Reproduction & Development (AR&D), APH - Mental Health, Amsterdam Neuroscience - Complex Trait Genetics, Psychiatry, Laboratory Medicine, Other Research, APH - Aging & Later Life, APH - Personalized Medicine, APH - Digital Health, ACS - Diabetes & metabolism, Adult Psychiatry, Epidemiology, Cardiology, Radiology & Nuclear Medicine, Biological Psychology, Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: HVC Pieken Maastricht Studie (9), MUMC+: MA Interne Geneeskunde (3), Interne Geneeskunde, MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: MA Endocrinologie (9), MUMC+: MA Maag Darm Lever (9), MUMC+: MA Hematologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Nefrologie (9), MUMC+: MA Reumatologie (9), and RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome

Subjects
Netherlands Twin Register (NTR), 0301 basic medicine, SELECTION, Quantitative trait loci, Nutrition and Disease, DATABASE, Metabolite, Science, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], General Physics and Astronomy, Genome-wide association study, VARIANCE-ESTIMATION, Biology, Quantitative trait locus, GENOTYPE IMPUTATION, METABOLOMICS, BIOBANK, Genome-wide association studies, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Metabolomics, All institutes and research themes of the Radboud University Medical Center, Missing heritability problem, MISSING HERITABILITY, Voeding en Ziekte, Genetic variation, Life Science, NETHERLANDS TWIN REGISTER, lcsh:Science, VLAG, Genetics, Multidisciplinary, General Chemistry, Heritability, Genetic architecture, 030104 developmental biology, chemistry, Lipidomics, lcsh:Q, 030217 neurology & neurosurgery
Abstract

Metabolomics examines the small molecules involved in cellular metabolism. Approximately 50% of total phenotypic differences in metabolite levels is due to genetic variance, but heritability estimates differ across metabolite classes. We perform a review of all genome-wide association and (exome-) sequencing studies published between November 2008 and October 2018, and identify >800 class-specific metabolite loci associated with metabolite levels. In a twin-family cohort (N = 5117), these metabolite loci are leveraged to simultaneously estimate total heritability (h2total), and the proportion of heritability captured by known metabolite loci (h2Metabolite-hits) for 309 lipids and 52 organic acids. Our study reveals significant differences in h2Metabolite-hits among different classes of lipids and organic acids. Furthermore, phosphatidylcholines with a high degree of unsaturation have higher h2Metabolite-hits estimates than phosphatidylcholines with low degrees of unsaturation. This study highlights the importance of common genetic variants for metabolite levels, and elucidates the genetic architecture of metabolite classes., Blood metabolite levels are under the influence of environmental and genetic factors. Here, Hagenbeek et al. perform heritability estimations for metabolite measures and determine the contribution of known metabolite loci to metabolite levels using data from 40 genome-wide association studies.

Published
2020

6. Author Correction: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies (Nature Communications, (2020), 11, 1, (39), 10.1038/s41467-019-13770-6)

Author

Hagenbeek, F.A. (Fiona A.), Pool, R. (Reńe), Dongen, J. (Jenny) van, Draisma, G. (Gerrit), Hottenga, J.J. (Jouke Jan), Willemsen, G. (Gonneke), Abdellaoui, A. (Abdel), Fedko, I.O. (Iryna O.), Braber, A. (Anouk) den, Visser, P. (Pim), Geus, E.J.C. (Eco) de, Willems van Dijk, K. (Ko), Verhoeven, A. (Aswin), Suchiman, H.E. (H. Eka), Beekman, M. (Marian), Slagboom, P.E. (Eline), Duijn, C.M. (Cornelia) van, Barkey Wolf, J.J.H. (J. J.H.), Cats, D. (D.), Amin, N. (N.), Beulens, J.W.J. (Joline), van der Bom, J.A. (J. A.), Bomer, N. (Nils), Demirkan, A. (Ayşe), van Hilten, J.A. (J. A.), Meessen, J.M.T.A. (J. M.T.A.), Moed, H. (Heleen), Fu, J. (J.), Onderwater, G.L.J. (G. L.J.), Rutters, F. (F.), So-Osman, C. (Cynthia), van der Flier, W.M. (W. M.), Heijden, A.A.W.A. (Amber A. W.) van der, Spek, A. (Ashley) van der, Asselbergs, F.W. (F. W.), Boersma, H. (Eric), Elders, P.M. (P. M.), Geleijnse, J.M. (J. M.), Ikram, M.A. (Arfan), Kloppenburg, M. (Margreet), Meulenbelt, I. (I.), Mooijaart, S.P. (Simon), Nelissen, R.G.H.H. (Rob), Netea, M.G. (Mihai), Penninx, B.W.J.H. (Brenda), Stehouwer, C.D.A. (C. D.A.), Teunissen, C.E. (Charlotte), Terwindt, G.M. (G. M.), ‘t Hart, L.M. (L. M.), van den Maagdenberg, A.M.J.M. (A. M.J.M.), Harst, P. (Pim) van der, van der Horst, I.C.C. (I. C.C.), Kallen, C.J. van der, van Greevenbroek, M.M.J. (M. M.J.), Spil, W.E. (Willem) van, Wijmenga, C. (Cisca), Zwinderman, A.H. (Ailko), Zhernikova, A. (A.), Jukema, J.W. (Jan Wouter), Mei, H. (H.), Slofstra, M. (M.), Swertz, M. (M.), Akker, E.B. (Erik) van den, Deelen, J. (Joris), Reinders, M.J.T. (M. J.T.), Harms, A.C. (Amy), Hankemeier, T. (Thomas), Bartels, M. (Meike), Nivard, M. (Michel), Boomsma, D.I. (Dorret), Hagenbeek, F.A. (Fiona A.), Pool, R. (Reńe), Dongen, J. (Jenny) van, Draisma, G. (Gerrit), Hottenga, J.J. (Jouke Jan), Willemsen, G. (Gonneke), Abdellaoui, A. (Abdel), Fedko, I.O. (Iryna O.), Braber, A. (Anouk) den, Visser, P. (Pim), Geus, E.J.C. (Eco) de, Willems van Dijk, K. (Ko), Verhoeven, A. (Aswin), Suchiman, H.E. (H. Eka), Beekman, M. (Marian), Slagboom, P.E. (Eline), Duijn, C.M. (Cornelia) van, Barkey Wolf, J.J.H. (J. J.H.), Cats, D. (D.), Amin, N. (N.), Beulens, J.W.J. (Joline), van der Bom, J.A. (J. A.), Bomer, N. (Nils), Demirkan, A. (Ayşe), van Hilten, J.A. (J. A.), Meessen, J.M.T.A. (J. M.T.A.), Moed, H. (Heleen), Fu, J. (J.), Onderwater, G.L.J. (G. L.J.), Rutters, F. (F.), So-Osman, C. (Cynthia), van der Flier, W.M. (W. M.), Heijden, A.A.W.A. (Amber A. W.) van der, Spek, A. (Ashley) van der, Asselbergs, F.W. (F. W.), Boersma, H. (Eric), Elders, P.M. (P. M.), Geleijnse, J.M. (J. M.), Ikram, M.A. (Arfan), Kloppenburg, M. (Margreet), Meulenbelt, I. (I.), Mooijaart, S.P. (Simon), Nelissen, R.G.H.H. (Rob), Netea, M.G. (Mihai), Penninx, B.W.J.H. (Brenda), Stehouwer, C.D.A. (C. D.A.), Teunissen, C.E. (Charlotte), Terwindt, G.M. (G. M.), ‘t Hart, L.M. (L. M.), van den Maagdenberg, A.M.J.M. (A. M.J.M.), Harst, P. (Pim) van der, van der Horst, I.C.C. (I. C.C.), Kallen, C.J. van der, van Greevenbroek, M.M.J. (M. M.J.), Spil, W.E. (Willem) van, Wijmenga, C. (Cisca), Zwinderman, A.H. (Ailko), Zhernikova, A. (A.), Jukema, J.W. (Jan Wouter), Mei, H. (H.), Slofstra, M. (M.), Swertz, M. (M.), Akker, E.B. (Erik) van den, Deelen, J. (Joris), Reinders, M.J.T. (M. J.T.), Harms, A.C. (Amy), Hankemeier, T. (Thomas), Bartels, M. (Meike), Nivard, M. (Michel), and Boomsma, D.I. (Dorret)

Abstract

The original version of the Supplementary Information associated with this Article included an incorrect Supplementary Data 1 file, in which additional delimiters were included in the first column for a number of rows, resulting in column shifts for some of these rows. The HTML has been updated to include a corrected version of Supplementary Data 1; the original incorrect version of Supplementary Data 1 can be found as Supplementary Information associated with this Correction. In addition, the original version of this Article contained an error in the author affiliations. An affiliation of Abdel Abdellaoui with Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands was inadvertently omitted. This has now been corrected in both the PDF and HTML versions of the Article.

Published
2020
Full Text
View/download PDF

7. Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

Author

Hagenbeek, F.A. (Fiona A.), Pool, R. (Reńe), Dongen, J. (Jenny) van, Draisma, G. (Gerrit), Hottenga, J.J. (Jouke Jan), Willemsen, G. (Gonneke), Abdellaoui, A. (Abdel), Fedko, I.O. (Iryna O.), Braber, A. (Anouk) den, Visser, P.J. (Pieter Jelle), de Geus, E.J.C.N. (Eco J. C. N.), Willems van Dijk, K. (Ko), Verhoeven, A. (Aswin), Suchiman, H.E. (H. Eka), Beekman, M. (Marian), Slagboom, P.E. (Eline), Duijn, C.M. (Cornelia) van, Barkey Wolf, J.J.H. (J. J.H.), Cats, D. (D.), Amin, N. (N.), Beulens, J.W.J. (Joline), van der Bom, J.A. (J. A.), Bomer, N. (Nils), Demirkan, A. (Ayşe), van Hilten, J.A. (J. A.), Meessen, J.M.T.A. (J. M.T.A.), Moed, H. (Heleen), Fu, J. (J.), Onderwater, G.L.J. (G. L.J.), Rutters, F. (F.), So-Osman, C. (Cynthia), Flier, W.M. (Wiesje) van der, Heijden, A.A.W.A. (Amber A. W.) van der, Spek, A. (Ashley) van der, Asselbergs, F.W. (F. W.), Boersma, H. (Eric), Elders, P.M. (P. M.), Geleijnse, J.M. (Marianne), Ikram, M.A. (Arfan), Kloppenburg, M. (Margreet), Meulenbelt, I. (I.), Mooijaart, S.P. (Simon), Nelissen, R.G.H.H. (Rob), Netea, M.G. (Mihai), Penninx, B.W.J.H. (Brenda), Stehouwer, C.D. (Coen), Teunissen, C.E. (Charlotte), Terwindt, G.M. (Gisela), ‘t Hart, L.M. (L. M.), Maagdenberg, A.M.J.M. (Arn), Harst, P. (Pim) van der, van der Horst, I.C.C. (I. C.C.), Kallen, C.J. van der, van Greevenbroek, M.M.J. (M. M.J.), Spil, W.E. (Willem) van, Wijmenga, C. (C.), Zwinderman, A.H. (A. H.), Zhernikova, A. (A.), Jukema, J.W. (Jan Wouter), Mei, H. (H.), Slofstra, M. (M.), Swertz, M. (M.), Akker, E.B. (Erik) van den, Deelen, J. (Joris), Reinders, M.J.T. (M. J.T.), Harms, A.C. (Amy C.), Hankemeier, T. (Thomas), Bartels, M. (Meike), Nivard, M. (Michel), Boomsma, D.I. (Dorret), Hagenbeek, F.A. (Fiona A.), Pool, R. (Reńe), Dongen, J. (Jenny) van, Draisma, G. (Gerrit), Hottenga, J.J. (Jouke Jan), Willemsen, G. (Gonneke), Abdellaoui, A. (Abdel), Fedko, I.O. (Iryna O.), Braber, A. (Anouk) den, Visser, P.J. (Pieter Jelle), de Geus, E.J.C.N. (Eco J. C. N.), Willems van Dijk, K. (Ko), Verhoeven, A. (Aswin), Suchiman, H.E. (H. Eka), Beekman, M. (Marian), Slagboom, P.E. (Eline), Duijn, C.M. (Cornelia) van, Barkey Wolf, J.J.H. (J. J.H.), Cats, D. (D.), Amin, N. (N.), Beulens, J.W.J. (Joline), van der Bom, J.A. (J. A.), Bomer, N. (Nils), Demirkan, A. (Ayşe), van Hilten, J.A. (J. A.), Meessen, J.M.T.A. (J. M.T.A.), Moed, H. (Heleen), Fu, J. (J.), Onderwater, G.L.J. (G. L.J.), Rutters, F. (F.), So-Osman, C. (Cynthia), Flier, W.M. (Wiesje) van der, Heijden, A.A.W.A. (Amber A. W.) van der, Spek, A. (Ashley) van der, Asselbergs, F.W. (F. W.), Boersma, H. (Eric), Elders, P.M. (P. M.), Geleijnse, J.M. (Marianne), Ikram, M.A. (Arfan), Kloppenburg, M. (Margreet), Meulenbelt, I. (I.), Mooijaart, S.P. (Simon), Nelissen, R.G.H.H. (Rob), Netea, M.G. (Mihai), Penninx, B.W.J.H. (Brenda), Stehouwer, C.D. (Coen), Teunissen, C.E. (Charlotte), Terwindt, G.M. (Gisela), ‘t Hart, L.M. (L. M.), Maagdenberg, A.M.J.M. (Arn), Harst, P. (Pim) van der, van der Horst, I.C.C. (I. C.C.), Kallen, C.J. van der, van Greevenbroek, M.M.J. (M. M.J.), Spil, W.E. (Willem) van, Wijmenga, C. (C.), Zwinderman, A.H. (A. H.), Zhernikova, A. (A.), Jukema, J.W. (Jan Wouter), Mei, H. (H.), Slofstra, M. (M.), Swertz, M. (M.), Akker, E.B. (Erik) van den, Deelen, J. (Joris), Reinders, M.J.T. (M. J.T.), Harms, A.C. (Amy C.), Hankemeier, T. (Thomas), Bartels, M. (Meike), Nivard, M. (Michel), and Boomsma, D.I. (Dorret)

Abstract

Metabolomics examines the small molecules involved in cellular metabolism. Approximately 50% of total phenotypic differences in metabolite levels is due to genetic variance, but heritability estimates differ across metabolite classes. We perform a review of all genome-wide association and (exome-) sequencing studies published between November 2008 and October 2018, and identify >800 class-specific metabolite loci associated with metabolite levels. In a twin-family cohort (N = 5117), these metabolite loci are leveraged to simultaneously estimate total heritability (h2 total), and the proportion of heritability captured by known metabolite loci (h2 Metabolite-hits) for 309 lipids and 5

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2020
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8. Change Causes Unease, Study Says

Author

Slofstra, M.

Subjects
Social Issue, Canada, Technology-Induced Unemployment, Reports, Computerphobia, Study, Issues/Society
Published
1985

9. Telex Evolves, Exists with E-Mail

Author

Slofstra, M.

Subjects
TELEX, Telegraph Systems, Demand, Market, Canada, E-Mail, Special-Purpose Terminal
Published
1985

12. New Text Processor Is Multilingual

Author

Slofstra, M.

Subjects
Workstations, Laser Printer, Product Development, Language, Multilingual Capability, Computer Systems, Xerox Canada Inc. -- Product introduction
Published
1985

13. Announcement of New IBM PC LAN May Be Imminent

Author

Slofstra, M.

Subjects
LAN, Product Development, Product Introduction, Networks, Token Passing, International Business Machines Corp. -- Product introduction
Published
1985

15. Rethink R&D Policy: Economist

Author

Slofstra, M.

Subjects
Research and Development, Policy, Canada, Reports, Study, Government, National Government
Published
1985

19. Telecom Manager's Role Expands

Author

Slofstra, M.

Subjects
Communications Managers, Job Responsibility, EDP Personnel, Communications Management, Career Development, Outlook, Trends
Published
1985

21. PC-to-Mainframe Link Has 56Kbps

Author

Slofstra, M.

Subjects
New Product, Micro-Mainframe Communication, Personal Computers, Data Communications Software, I/O Boards/Cards, Boards/Cards, Micro Plus
Published
1985

23. MAP Standard Goes Interantional

Author

Slofstra, M.

Subjects
Automation, Protocol, Manufacturing, Standard, Conferences, Conferences and Meetings
Published
1985

24. Telecommunications Grads Still an Unknown Quantity

Author

Slofstra, M.

Subjects
Career Development, Canada, Education, Careers, Telecommunications, Telecommunications Industry, Computer Education, Professional Associations, Organizations, Trade and Professional Associations
Published
1985

26. Dupont Will Costs of Software

Author

Slofstra, M.

Subjects
Software Packages, Personal Computers, Microcomputer, Canada, Compugen -- Statistics, DuPont Canada Inc. -- Purchasing
Published
1985

27. Survey Examines Hesitance to CAD-CAM Acceptance

Author

Slofstra, M.

Subjects
Survey, Robots, Canada, Attitude, Executive, Ontario, Manufacturers, Computerphobia, Resistance to Computer Technology, Social Issue, CAD/CAM
Published
1985

31. The Prime Minister's Office to Automate with Gandalf Gear

Author

Slofstra, M.

Subjects
Equipment Acquisition, Applications, Government, National Government, Office Automation, Canada, Workstations, Microcomputer, Government Contracts, Contracts, Gandalf Technologies Inc. Gandalf Systems Group -- Contracts
Published
1985

32. Inventory-Software Market on Rise

Author

Slofstra, M.

Subjects
Canada, Conferences, Ontario, Conferences and Meetings, Computer Software Industry, Software, Market, Trade and Professional Associations, Manufacturing, Inventory Control, Software Packages
Published
1985

33. Speaker Praises Paperless Factory

Author

Slofstra, M.

Subjects
Automation, Conferences, Conferences and Meetings, Implementation, Manufacturing, Factory Management
Published
1985

34. Industry Rife with Merger Rumours

Author

Slofstra, M.

Subjects
Merger, Companies, Computer Industry, Manufacturers, Takeovers, Burroughs Corp. -- Mergers, acquisitions and divestments, Sperry Corp. -- Mergers, acquisitions and divestments
Published
1985

35. AT&T Plans Canadian Expansion

Author

Slofstra, M.

Subjects
Companies, Canada, Manufacturers, Office Automation, Market, Expansion, Telecommunications, AT&T Canada -- Marketing
Published
1985

38. Emerald City to Ride 'Third Wave'

Author

Slofstra, M.

Subjects
Integrated Software, Software Packages, Workstations, Data Communications Software, Word Processing, Graphics Software, Spreadsheet Software, Time Management, Products Introduction, Expert Systems, Voice Recognition, Computer-Assisted Instruction, Emerald One
Published
1985

39. NorTel Adds Integrated Voice-Data Features to PBX

Author

Slofstra, M.

Subjects
Communications Equipment, New Product, PBX, Computer Terminal, Telephones, Modem, LAN, 19,200 Bps, Integrated Voice/Data, DV 1 Data Voice System, Meridian SL 1 (local area network), Meridian SL 100, M3000 Touchphone, M2000 Series
Published
1985

40. NT, AT&T Reveal Future Plans

Author

Slofstra, M.

Subjects
New Product, Communications Equipment, ISDN, Networks, Telecommunications, Multiplexer, Network Management Software, Packet Switch, Outlook, DMS 1 Urban, Northern Telecom DNX 100, Northern Telecom DNC 500, Northern Telecom DNC 100, Northern Telecom DMT 400
Published
1985

41. OA to Bring 'New Kind of Company'

Author

Slofstra, M.

Subjects
Office Automation, Integrated Systems, Telecommunications, Data Processing, Compatibility, Voice Communications, Image Processing, Word Processing
Published
1985

48. Long-Awaited LAN Gets Mixed Reactions

Author

Slofstra, M.

Subjects
Token Passing, LAN, Ring Networks, Communications Equipment, Networks, Telecommunications Services Industry, Product Introduction, New Product
Published
1985

49. Computers As Telemarketing Aid

Author

Slofstra, M.

Subjects
Communications Applications, Marketing, Marketing Applications, Direct Market Channel, Selling, Workstations, Teknekron Infoswitch Telemarketing System
Published
1985

50. Restudy Japan: NorTel Speaker

Author

Slofstra, M.

Subjects
Management, Management Style, Quality Circles, Japanese Competition, Seminars, Conferences and Meetings
Published
1985

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