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202 results on '"Slingerland, Robbert J."'

2. Bacillus Calmette-Guérin vaccine for prevention of COVID-19 and other respiratory tract infections in older adults with comorbidities: a randomized controlled trial

Author

Aardenburg-van Huisstede, Astrid, Ammerlaan, Heidi S.M., Boersma, Willem G., Bonten, Marc J.M., van den Bosch, Maurice A.A.J., Brinkman, Kees, Bruijning-Verhagen, Patricia C.J., van Crevel, Reinout, Delsing, Corine, ten Doesschaten, Thijs, Dofferhoff, Anton S.M., Duijkers, Ruud, Fohse, Konstantin, Grobusch, Martin P., Groenwold, Rolf H.H., de Haas, Corine, Hassing, Robert-Jan, de Hoog, Marieke L.A., Hoogerwerf, Jacobien J., Huijts, Susanne M., van Hylckama-Vlieg, Astrid, Jong, Eefje, de Jong, Hanna K., Knap, Martijn, Koekenbier, Eva L., Koenders, Michael, Kouijzer, Ilse J.E., Kramer, Henk, van de Laar, Roel, Lalmohamed, Arief, Lensen, Karel-Jan D.F., Lijfering, Willem M., van de Maat, Josephine S., Magdelijns, Fabienne, Meek, Bob, Middelburg, Rutger A., Moeniralam, Hazra S., Mooijaart, Simon P., van Munster, Barbara C., Netea, Mihai G., van Nieuwkoop, Cees, ten Oever, Jaap, Oosterheert, Jan Jelrik, Goossens, Marc Padros, Peters, Vincent, Postma, Douwe F., Pouw, Niels, Reesink, Herre J., de Regt, Marieke J.A., van der Reijden, Anneli C.J., Rosendaal, Frits R., Schaakxs, R., Slieker, Kitty, Slingerland, Robbert J., van Sluis, Nicolette L.J., Stehouwer, Coen D.A., van de Veerdonk, Frank, Verbon, Annelies, van Werkhoven, C.H. (Henri), van de Wijgert, Janneke H.H., and Werkhoven, C.H. (Henri) van

Published
2023
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3. Comparator Data Characteristics and Testing Procedures for the Clinical Performance Evaluation of Continuous Glucose Monitoring Systems

Author

Eichenlaub, Manuel, primary, Pleus, Stefan, additional, Rothenbühler, Martina, additional, Bailey, Timothy S., additional, Bally, Lia, additional, Brazg, Ronald, additional, Bruttomesso, Daniela, additional, Diem, Peter, additional, Eriksson Boija, Elisabet, additional, Fokkert, Marion, additional, Haug, Cornelia, additional, Hinzmann, Rolf, additional, Jendle, Johan, additional, Klonoff, David C., additional, Mader, Julia K., additional, Makris, Konstantinos, additional, Moser, Othmar, additional, Nichols, James H., additional, Nørgaard, Kirsten, additional, Pemberton, John, additional, Selvin, Elizabeth, additional, Spanou, Loukia, additional, Thomas, Andreas, additional, Tran, Nam K., additional, Witthauer, Lilian, additional, Slingerland, Robbert J., additional, and Freckmann, Guido, additional

Published
2024
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9. Clinical Performance Evaluation of Continuous Glucose Monitoring Systems: A Scoping Review and Recommendations for Reporting

Author

Freckmann, Guido, primary, Eichenlaub, Manuel, additional, Waldenmaier, Delia, additional, Pleus, Stefan, additional, Wehrstedt, Stephanie, additional, Haug, Cornelia, additional, Witthauer, Lilian, additional, Jendle, Johan, additional, Hinzmann, Rolf, additional, Thomas, Andreas, additional, Eriksson Boija, Elisabet, additional, Makris, Konstantinos, additional, Diem, Peter, additional, Tran, Nam, additional, Klonoff, David C., additional, Nichols, James H., additional, and Slingerland, Robbert J., additional

Published
2023
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10. Bacillus Calmette-Guérin vaccine for prevention of COVID-19 and other respiratory tract infections in older adults with comorbidities: a randomized controlled trial

Author

Koekenbier, Eva L., primary, Fohse, Konstantin, additional, van de Maat, Josephine S., additional, Oosterheert, Jan Jelrik, additional, van Nieuwkoop, Cees, additional, Hoogerwerf, Jacobien J., additional, Grobusch, Martin P., additional, van den Bosch, Maurice A.A.J., additional, van de Wijgert, Janneke H.H., additional, Netea, Mihai G., additional, Rosendaal, Frits R., additional, Bonten, Marc J.M., additional, Werkhoven, C.H. (Henri) van, additional, Aardenburg-van Huisstede, Astrid, additional, Ammerlaan, Heidi S.M., additional, Boersma, Willem G., additional, Brinkman, Kees, additional, Bruijning-Verhagen, Patricia C.J., additional, van Crevel, Reinout, additional, Delsing, Corine, additional, ten Doesschaten, Thijs, additional, Dofferhoff, Anton S.M., additional, Duijkers, Ruud, additional, Groenwold, Rolf H.H., additional, de Haas, Corine, additional, Hassing, Robert-Jan, additional, de Hoog, Marieke L.A., additional, Huijts, Susanne M., additional, van Hylckama-Vlieg, Astrid, additional, Jong, Eefje, additional, de Jong, Hanna K., additional, Knap, Martijn, additional, Koekenbier, Eva L., additional, Koenders, Michael, additional, Kouijzer, Ilse J.E., additional, Kramer, Henk, additional, van de Laar, Roel, additional, Lalmohamed, Arief, additional, Lensen, Karel-Jan D.F., additional, Lijfering, Willem M., additional, Magdelijns, Fabienne, additional, Meek, Bob, additional, Middelburg, Rutger A., additional, Moeniralam, Hazra S., additional, Mooijaart, Simon P., additional, van Munster, Barbara C., additional, ten Oever, Jaap, additional, Goossens, Marc Padros, additional, Peters, Vincent, additional, Postma, Douwe F., additional, Pouw, Niels, additional, Reesink, Herre J., additional, de Regt, Marieke J.A., additional, van der Reijden, Anneli C.J., additional, Schaakxs, R., additional, Slieker, Kitty, additional, Slingerland, Robbert J., additional, van Sluis, Nicolette L.J., additional, Stehouwer, Coen D.A., additional, van de Veerdonk, Frank, additional, Verbon, Annelies, additional, and van Werkhoven, C.H. (Henri), additional

Published
2023
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12. Referral decisions based on a pre-hospital HEART score in suspected non-ST-elevation acute coronary syndrome: final results of the FamouS Triage study

Author

Tolsma, Rudolf T, primary, Fokkert, Marion J, additional, van Dongen, Dominique N, additional, Badings, Erik A, additional, van der Sluis, Aize, additional, Slingerland, Robbert J, additional, van ’t Riet, Esther, additional, Ottervanger, Jan Paul, additional, and van ’t Hof, Arnoud W J, additional

Published
2021
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20. Impact of elevated HbA1c on long-term mortality in patients presenting with acute myocardial infarction in daily clinical practice: insights from a ‘real world’ prospective registry of the Zwolle Myocardial Infarction Study Group

Author

Hermanides, Renicus S, primary, Kennedy, Mark W, additional, Kedhi, Elvin, additional, van Dijk, Peter R, additional, Timmer, Jorik R, additional, Ottervanger, Jan Paul, additional, Dambrink, Jan-Henk, additional, Gosselink, AT Marcel, additional, Roolvink, Vincent, additional, Miedema, Kor, additional, Slingerland, Robbert J, additional, Koopmans, Petra, additional, Bilo, Henk JG, additional, and van ’t Hof, Arnoud WJ, additional

Published
2020
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22. Referral decisions based on a prehospital HEART score in suspected non-ST-elevation acute coronary syndrome: design of the FamouS Triage 3 study

Author

van Dongen, Dominique N, primary, Tolsma, Rudolf T, additional, Fokkert, Marion J, additional, Badings, Erik A, additional, van der Sluis, Aize, additional, Slingerland, Robbert J, additional, van ‘t Hof, Arnoud WJ, additional, van ’t Riet, Esther, additional, and Ottervanger, Jan Paul, additional

Published
2020
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36. Pre-hospital versus hospital acquired HEART score for risk classification of suspected non ST-elevation acute coronary syndrome.

Author

van Dongen, Dominique N, Badings, Erik A, Fokkert, Marion J, Tolsma, Rudolf T, van der Sluis, Aize, Slingerland, Robbert J, van't Hof, Arnoud W J, and Ottervanger, Jan Paul

Subjects
TROPONIN, AGE distribution, ACUTE coronary syndrome, HEALTH status indicators, MANN Whitney U Test, RISK assessment, T-test (Statistics), HOSPITAL care, ELECTROCARDIOGRAPHY, DESCRIPTIVE statistics, DATA analysis software, DISEASE risk factors
Abstract

Introduction: Although increasing evidence shows that in patients with suspected non-ST-elevation acute coronary syndrome (NSTE-ACS) both hospital and pre-hospital acquired HEART (History, ECG, Age, Risk factors, Troponin) scores have strong predictive value, pre-hospital and hospital acquired HEART scores have never been compared directly. Methods: In patients with suspected NSTE-ACS, the HEART score was independently prospectively assessed in the pre-hospital setting by ambulance paramedics and in the hospital by physicians. The hospital HEART score was considered the gold standard. Low-risk (HEART score ≤3) was considered a negative test. Endpoint was occurrence of major adverse events within 45 days. Results: A total of 699 patients were included in the analyses. In 516 (74%) patients pre-hospital and hospital risk classification was similar, in 50 (7%) pre-hospital risk classification was false negative (45 days mortality 0%) and in 133 (19%) false positive (45 days mortality 1.5%). False negative risk classifications were caused by differences in history (100%), risk factor assessment (66%) and troponin (18%) and were more common in older patients. Occurrence of major adverse events was comparable in pre-hospital and hospital low-risk patients (2.9% vs. 2.7%, p = 0.9). Incidence of major adverse events was 0% in the true negative group, 26% in the true positive group, 10% in the false negative group and 5% in the false positive group. Predictive value of both pre-hospital and hospital acquired HEART scores was high, although the 'area under the curve' of hospital acquired HEART score was higher (0.84 vs. 0.74, p < 0.001). Conclusion: In approximately 25% of patients hospital and pre-hospital HEART score risk classifications disagree, mainly by risk overestimation in the pre-hospital group. Since disagreement is primarily caused by different scoring of history and risk factors, additional training may improve pre-hospital scoring. [ABSTRACT FROM AUTHOR]

Published
2021
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38. Fast assessment and management of chest pain patients without ST-elevation in the pre-hospital gateway (FamouS Triage): ruling out a myocardial infarction at home with the modified HEART score

Author

Ishak, Maycel, primary, Ali, Danish, additional, Fokkert, Marion J, additional, Slingerland, Robbert J, additional, Tolsma, Rudolf T, additional, Badings, Erik, additional, van der Sluis, Aize, additional, van Eenennaam, Fred, additional, Mosterd, Arend, additional, ten Berg, Jurriën M, additional, and van ’t Hof, Arnoud WJ, additional

Published
2017
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39. Fast assessment and management of chest pain without ST-elevation in the pre-hospital gateway : rationale and design

Author

Ishak, Maycel, Ali, Danish, Fokkert, Marion J, Slingerland, Robbert J, Dikkeschei, Bert, Tolsma, Rudolf T, Lichtveld, Rob A, Bruins, Wendy, Boomars, René, Bruheim, Kim, van Eenennaam, Fred, Timmers, Leo, Voskuil, Michiel, Doevendans, Pieter A, Mosterd, Arend, Hoes, Arno W, ten Berg, Jurriën M, van 't Hof, Arnoud W J, and FAMOUS TRIAGE Study Group

Abstract

BACKGROUND: For chest pain patients without ST-segment elevation in the pre-hospital setting, current clinical guidelines merely offer in-hospital risk stratification and management, as opposed to chest pain patients with ST-segment elevation for whom there is a straightforward pre-hospital strategy for diagnosis, medication regimen and logistics. The FAMOUS TRIAGE study will assess the effects of introducing a pre-hospital triage system that reliably stratifies chest pain patients without ST-segment elevation into 1) patients at high risk for NSTEMI requiring a direct transfer to a PCI-hospital; 2) patients at intermediate risk for a major adverse cardiac event (MACE) who could be evaluated at the nearest non-PCI hospital; and 3) patients at low risk for MACE (benign non-cardiac chest pain) who could have further evaluation at home or in a primary care setting. METHODS: The FAMOUS TRIAGE study will be performed in three phases. In the first phase an appropriate pre-hospital risk stratification tool will be designed for chest pain patients without ST-segment elevation by means of a retrospective and a prospective study. The second phase of the project represents the external validation of the risk stratification models, and in the third and final phase an optimal risk stratification tool will be implemented into clinical practice. Clinical and economical endpoints before and after implementation of the pre-hospital risk stratification tool will be compared to assess clinical benefit and cost-effectiveness. CONCLUSION: The FAMOUS TRIAGE project is a triple phase study that aims to optimize the pre-hospital management of chest pain patients without ST-segment elevation by providing tools for pre-hospital identification of NSTEMI or exclusion of acute coronary syndrome at home. TRIAL ID: NTR4205. Dutch Trial Register [http://www.trialregister.nl]: trial number 4205.

Published
2015

40. Pre-hospital risk assessment in suspected non-ST-elevation acute coronary syndrome: A prospective observational study

Author

van Dongen, Dominique N, Tolsma, Rudolf T, Fokkert, Marion J, Badings, Erik A, van der Sluis, Aize, Slingerland, Robbert J, van ’t Hof, Arnoud WJ, and Ottervanger, Jan Paul

Abstract

Background: Pre-hospital risk stratification of non-ST-elevation acute coronary syndrome (NSTE-ACS) by the complete HEART score has not yet been assessed. We investigated whether pre-hospital risk stratification of patients with suspected NSTE-ACS using the HEART score is accurate in predicting major adverse cardiac events (MACE).Methods: This is a prospective observational study, including 700 patients with suspected NSTE-ACS. Risk stratification was performed by ambulance paramedics, using the HEART score; low risk was defined as HEART score ⩽ 3. Primary endpoint was occurrence of MACE within 45 days after inclusion. Secondary endpoint was myocardial infarction or death.Results: A total of 172 patients (24.6%) were stratified as low risk and 528 patients (75.4%) as intermediate to high risk. Mean age was 53.9 years in the low risk group and 66.7 years in the intermediate to high risk group (p<0.001), 50% were male in the low risk group versus 60% in the intermediate to high risk group (p=0.026). MACE occurred in five patients in the low risk group (2.9%) and in 111 (21.0%) patients at intermediate or high risk (p<0.001). There were no deaths in the low risk group and the occurrence of acute myocardial infarction in this group was 1.2%. In the high risk group six patients died (1.1%) and 76 patients had myocardial infarction (14.4%).Conclusions: In suspected NSTE-ACS, pre-hospital risk stratification by ambulance paramedics, including troponin measurement, is accurate in differentiating between low and intermediate to high risk. Future studies should investigate whether transportation of low risk patients to a hospital can be avoided, and whether high risk patients benefit from immediate transfer to a hospital with early coronary angiography possibilities.

Published
2020
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41. Repeat whole blood donors with a ferritin level of 30 μg/L or less show functional iron depletion.

Author

Dijkstra, Angelique, van den Hurk, Katja, Bilo, Henk J. G., Slingerland, Robbert J., and Vos, Michel J.

Subjects
IRON deficiency anemia, BLOOD donors, BLOOD transfusion, ERYTHROCYTES, BLOOD diseases, FERRITIN, IRON, RETICULOCYTES
Abstract

Background: Whole blood donors are screened for iron depletion through hemoglobin measurement alone or in combination with ferritin. Ferritin measurement gives the advantage of earlier detection of iron depletion. In a previous study we identified a ferritin level of 30 μg/L or less as a possible indicator of suboptimal erythropoiesis. In this study, erythropoietic parameters were measured to determine if a ferritin level of 30 μg/L or less is indicative of iron-deficient erythropoiesis in repeat whole blood donors.Study Design and Methods: Twenty-one healthy male repeat whole blood donors were divided into two groups according to their predonation ferritin values: 30 μg/L or less (low-ferritin group) and greater than 30 μg/L (normal-ferritin group). Ferritin and erythropoietic parameters were measured before whole blood donation and weekly in the 8 weeks after donation.Results: A significantly lower value was found for hemoglobin, mean corpuscular volume (MCV), reticulocytes, and reticulocyte hemoglobin content on at least three of the nine time points in the low-ferritin group compared to the normal-ferritin group (p < 0.05). Of these parameters, MCV and reticulocyte hemoglobin content were significantly lower before donation as well as during all 8 weeks following donation (p < 0.05).Conclusion: Based on the lower values of the erythropoietic parameters in the low-ferritin group, it can be concluded that repeat whole blood donors with a ferritin value of 30 μg/L or less have iron-deficient erythropoiesis and therefore require a longer donation interval than the current 56 days. [ABSTRACT FROM AUTHOR]

Published
2019
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44. Performance Evaluation of a Glucose Monitoring System for Point-of-Care Testing With the Critically Ill Patient Population—A Multicenter Study

Author

Louie, Richard F., primary, Curtis, Corbin M., additional, Toffaletti, John G., additional, Handel, Elizabeth A., additional, Slingerland, Robbert J., additional, Fokkert, Marion J., additional, Muller, Wim, additional, Weinert, Sandra E., additional, Lee, Debra M., additional, and Kotagiri, Sheela, additional

Published
2015
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47. Can the Afinion HbA1c Point-of-Care instrument be an alternative method for the Tosoh G8 in the case of Hb-Tacoma?

Author

Lenters-Westra, Erna, Strunk, Annuska, Campbell, Paul, and Slingerland, Robbert J.

Subjects
POINT-of-care testing, HEMOGLOBIN polymorphisms, TREATMENT of diabetes, PATIENT monitoring, CHROMATOGRAMS, ION exchange chromatography, LIQUID chromatography equipment, AUTOMATION equipment, LABORATORY equipment & supplies, IMMUNOASSAY, CLINICAL medicine, DIAGNOSTIC errors, GLYCOSYLATED hemoglobin, HEMOGLOBINS, HEMOGLOBINOMETRY, MEDICAL databases, INFORMATION storage & retrieval systems, GENETIC carriers, MEDICAL artifacts, EQUIPMENT & supplies
Abstract

Background: Hb-variant interference when reporting HbA1c has been an ongoing challenge since HbA1c was introduced to monitor patients with diabetes mellitus. Most Hb-variants show an abnormal chromatogram when cation-exchange HPLC is used for the determination of HbA1c. Unfortunately, the Tosoh G8 generates what appears to be normal chromatogram in the presence of Hb-Tacoma, yielding a falsely high HbA1c value. The primary aim of the study was to investigate if the Afinion HbA1c point-of-care (POC) instrument could be used as an alternative method for the Tosoh G8 when testing for HbA1c in the presence of Hb-Tacoma.Methods: Whole blood samples were collected in K2EDTA tubes from individuals homozygous for HbA (n = 40) and heterozygous for Hb-Tacoma (n = 20). Samples were then immediately analyzed with the Afinion POC instrument. After analysis, aliquots of each sample were frozen at -80 °C. The frozen samples were shipped on dry ice to the European Reference Laboratory for Glycohemoglobin (ERL) and analyzed with three International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) and National Glycohemoglobin Standardization Program (NGSP) Secondary Reference Measurement Procedures (SRMPs). The Premier Hb9210 was used as the reference method.Results: When compared to the reference method, samples with Hb-Tacoma yielded mean relative differences of 31.8% on the Tosoh G8, 21.5% on the Roche Tina-quant Gen. 2 and 16.8% on the Afinion.Conclusions: The Afinion cannot be used as an alternative method for the Tosoh G8 when testing for HbA1c in the presence of Hb-Tacoma. [ABSTRACT FROM AUTHOR]

Published
2017
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48. Whole Blood Donation Affects the Interpretation of Hemoglobin A1c.

Author

Dijkstra, Angelique, Lenters-Westra, Erna, de Kort, Wim, Bokhorst, Arlinke G., Bilo, Henk J. G., Slingerland, Robbert J., and Vos, Michel J.

Subjects
TREATMENT of diabetes, DIRECTED blood donations, HEMOGLOBINS, ERYTHROCYTES, GENERAL practitioners
Abstract

Introduction: Several factors, including changed dynamics of erythrocyte formation and degradation, can influence the degree of hemoglobin A1c (HbA1c) formation thereby affecting its use in monitoring diabetes. This study determines the influence of whole blood donation on HbA1c in both non-diabetic blood donors and blood donors with type 2 diabetes. Methods: In this observational study, 23 non-diabetic blood donors and 21 blood donors with type 2 diabetes donated 475 mL whole blood and were followed prospectively for nine weeks. Each week blood samples were collected and analyzed for changes in HbA1c using three secondary reference measurement procedures. Results: Twelve non-diabetic blood donors (52.2%) and 10 (58.8%) blood donors with type 2 diabetes had a significant reduction in HbA1c following blood donation (reduction >-4.28%, P < 0.05). All non-diabetic blood donors with a normal ferritin concentration predonation had a significant reduction in HbA1c. In the non-diabetic group the maximum reduction was -11.9%, in the type 2 diabetes group -12.0%. When eligible to donate again, 52.2% of the non-diabetic blood donors and 41.2% of the blood donors with type 2 diabetes had HbA1c concentrations significantly lower compared to their predonation concentration (reduction >-4.28%, P < 0.05). Conclusion: Patients with type 2 diabetes contributing to whole blood donation programs can be at risk of falsely lowered HbA1c. This could lead to a wrong interpretation of their glycemic control by their general practitioner or internist. [ABSTRACT FROM AUTHOR]

Published
2017
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50. Fast assessment and management of chest pain patients without ST-elevation in the pre-hospital gateway (FamouS Triage): ruling out a myocardial infarction at home with the modified HEART score

Author

Ishak, Maycel, Ali, Danish, Fokkert, Marion J, Slingerland, Robbert J, Tolsma, Rudolf T, Badings, Erik, van der Sluis, Aize, van Eenennaam, Fred, Mosterd, Arend, ten Berg, Jurriën M, and van ’t Hof, Arnoud WJ

Abstract

Background: The first study of the FamouS Triage project investigates the feasibility of ruling out a myocardial infarction in pre-hospital chest pain patients without electrocardiographic ST-segment elevation by using the modified HEART score at the patient’s home, incorporating only a single highly sensitive troponin T measurement.Methods: A venous blood sample was drawn in the ambulance from 1127 consecutive chest pain patients for measurement of the pre-hospital highly sensitive troponin T levels, in order to establish a pre-hospital HEART score (i.e. the modified HEART score) and evaluate the possibility of triage at the patient’s home. The primary endpoint was the occurrence of a major adverse cardiac event (MACE) i.e. acute myocardial infarction, percutaneous coronary intervention, coronary artery bypass grafting or death within 30 days after initial presentation.Results: Two hundred and six patients (18%) developed a MACE during 30 days of follow-up. Thirty-six per cent of the patients (n=403) had a low modified HEART score (0–3 points) and none of them developed a MACE during follow-up. Forty-four per cent of the patients (n=494) had an intermediate modified HEART score (4–6 points) and 18% of them developed a MACE. Twenty per cent of the patients (n=230) had a high modified HEART score (7–10 points) of which 52% developed a MACE during follow-up.Conclusion: It seems feasible to rule out a myocardial infarction at home in chest pain patients without ST-segment elevation by using the modified HEART score. TRIAL ID: NTR4205. Dutch Trial Register [http://www.trialregister.nl]: trial number 4205.

Published
2018
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