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1. Multivariable prognostic modelling to improve prediction of colorectal cancer recurrence: the PROSPeCT trial

Author

Goh, Vicky, Mallett, Susan, Boulter, Victor, Glynne-Jones, Robert, Khan, Saif, Lessels, Sarah, Patel, Dominic, Prezzi, Davide, Rodriguez-Justo, Manuel, Taylor, Stuart A., Beable, Richard, Betts, Margaret, Breen, David J., Britton, Ingrid, Brush, John, Correa, Peter, Dodds, Nicholas, Dunlop, Joanna, Gourtsoyianni, Sofia, Griffin, Nyree, Higginson, Antony, Lowe, Andrew, Slater, Andrew, Strugnell, Madeline, Tolan, Damian, Zealley, Ian, and Halligan, Steve

Published
2024
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2. Diagnostic performance of sonographic activity scores for adult terminal ileal Crohn’s disease compared to magnetic resonance and histological reference standards: experience from the METRIC trial

Author

Kumar, Shankar, Parry, Thomas, Mallett, Sue, Plumb, Andrew, Bhatnagar, Gauraang, Beable, Richard, Betts, Margaret, Duncan, Gillian, Gupta, Arun, Higginson, Antony, Hyland, Rachel, Lapham, Roger, Patel, Uday, Pilcher, James, Slater, Andrew, Tolan, Damian, Zealley, Ian, Halligan, Steve, and Taylor, Stuart A.

Published
2024
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3. Influence of diffusion weighted imaging and contrast enhanced T1 sequences on the diagnostic accuracy of magnetic resonance enterography for Crohn’s disease

Author

Bhatnagar, Gauraang, Mallett, Sue, Beable, Richard, Greenhalgh, Rebecca, Ilangovan, Rajapandian, Lambie, Hannah, Mainta, Evgenia, Patel, Uday, Porté, François, Sidhu, Harbir, Gupta, Arun, Higginson, Anthony, Slater, Andrew, Tolan, Damian, Zealley, Ian, Halligan, Steve, and Taylor, Stuart A

Published
2024
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4. The Community Land Model Version 5: Description of New Features, Benchmarking, and Impact of Forcing Uncertainty

Author

Lawrence, David M, Fisher, Rosie A, Koven, Charles D, Oleson, Keith W, Swenson, Sean C, Bonan, Gordon, Collier, Nathan, Ghimire, Bardan, van Kampenhout, Leo, Kennedy, Daniel, Kluzek, Erik, Lawrence, Peter J, Li, Fang, Li, Hongyi, Lombardozzi, Danica, Riley, William J, Sacks, William J, Shi, Mingjie, Vertenstein, Mariana, Wieder, William R, Xu, Chonggang, Ali, Ashehad A, Badger, Andrew M, Bisht, Gautam, van den Broeke, Michiel, Brunke, Michael A, Burns, Sean P, Buzan, Jonathan, Clark, Martyn, Craig, Anthony, Dahlin, Kyla, Drewniak, Beth, Fisher, Joshua B, Flanner, Mark, Fox, Andrew M, Gentine, Pierre, Hoffman, Forrest, Keppel‐Aleks, Gretchen, Knox, Ryan, Kumar, Sanjiv, Lenaerts, Jan, Leung, L Ruby, Lipscomb, William H, Lu, Yaqiong, Pandey, Ashutosh, Pelletier, Jon D, Perket, Justin, Randerson, James T, Ricciuto, Daniel M, Sanderson, Benjamin M, Slater, Andrew, Subin, Zachary M, Tang, Jinyun, Thomas, R Quinn, Martin, Maria Val, and Zeng, Xubin

Subjects
Earth Sciences, Atmospheric Sciences, Geoinformatics, Climate Action, global land model, Earth System Modeling, carbon and nitrogen cycling, hydrology, benchmarking, Atmospheric sciences
Abstract

The Community Land Model (CLM) is the land component of the Community Earth System Model (CESM) and is used in several global and regional modeling systems. In this paper, we introduce model developments included in CLM version 5 (CLM5), which is the default land component for CESM2. We assess an ensemble of simulations, including prescribed and prognostic vegetation state, multiple forcing data sets, and CLM4, CLM4.5, and CLM5, against a range of metrics including from the International Land Model Benchmarking (ILAMBv2) package. CLM5 includes new and updated processes and parameterizations: (1) dynamic land units, (2) updated parameterizations and structure for hydrology and snow (spatially explicit soil depth, dry surface layer, revised groundwater scheme, revised canopy interception and canopy snow processes, updated fresh snow density, simple firn model, and Model for Scale Adaptive River Transport), (3) plant hydraulics and hydraulic redistribution, (4) revised nitrogen cycling (flexible leaf stoichiometry, leaf N optimization for photosynthesis, and carbon costs for plant nitrogen uptake), (5) global crop model with six crop types and time-evolving irrigated areas and fertilization rates, (6) updated urban building energy, (7) carbon isotopes, and (8) updated stomatal physiology. New optional features include demographically structured dynamic vegetation model (Functionally Assembled Terrestrial Ecosystem Simulator), ozone damage to plants, and fire trace gas emissions coupling to the atmosphere. Conclusive establishment of improvement or degradation of individual variables or metrics is challenged by forcing uncertainty, parametric uncertainty, and model structural complexity, but the multivariate metrics presented here suggest a general broad improvement from CLM4 to CLM5.

Published
2019

6. Radical surgery versus organ preservation via short-course radiotherapy followed by transanal endoscopic microsurgery for early-stage rectal cancer (TREC): a randomised, open-label feasibility study

Author

Brown, Gina, Antonio, Peter, Vince, Alex, Hilken, Nick, Sidile, Chakanaka, Wilcockson, Adrian, Peto, Richard, Crosby, Tom, Moran, Brendan, Olliff, Julie, Ashok, Katti, Slawik, Simone, Smethurst, Andrew, Sripadam, Rajaram, Tagore, Veena, Terlizzo, Monica, Philip, Bearn, Davies, Robert, Dodd, Susan, Essapen, Sharadah, Nisar, Pasha, Stewart, Alexandra, Trickett, Jonathan, Ashish, Bansal, Billings, Peter, Chandran, Palanichamy, Corr, Conor, Favill, Edward, Gollins, Simon, Marsh, Peter, Maw, Andrew, Neupane, Rakha, Rajagopal, Ramesh, Cooper, Rachel, Griffith, John, Hatfield, Paul, Lowe, Andy, Ostrowski, Julian, Robinson, Jonathan, Simpson, Rhian, Adams, Richard, Bleehen, Robert, Davies, Michael, Morgan, Meleri, Boone, Darren, Lacey, Nicola, Seddon, Ian, Sizer, Bruce, Stunell, Helen, Wu, Shaobin, Hadaki, Maher, Blunt, Dominic, Cleator, Susan, Darzi, Ara, Goldin, Robert, Ziprin, Paul, Dobson, Mike, Pitt, Mark, Susnerwala, Shabbir, Williamson, Deborah, Howarth, Georgina, Lee, Stephen, Wright, Paul, Hoare, Tim, Horgan, Alan, McDonald, Fiona, Needham, Stephanie, Scott, John, Simmons, Timothy, Biswas, Debashis, Hernon, James, Kapur, Gaurav, Kapur, Sandeep, Sington, James, Speakman, Christopher, Stebbings, William, Williams, Stuart, Adusumalli, Madhavi, Agarwal, Anil, Borowski, David, Garg, Dharmendra, Gill, Talvinder, Hegab, Mohammed, Hobday, Catherine, Rao, Veena, Shrimankar, Jyotsna, Tabaqchali, Mohamed, Wilson, David, Jones, Oliver, Mortensen, Neil, Slater, Andrew, Szuts, Aron, Wang, Lai, Warren, Bryan, Weaver, Andrew, Ahmad, Mukhtar, Alexander, Julian, Flubacher, Maxine, Tarver, David, Baluch, Suhail, Beable, Richard, Cowlishaw, David, Higginson, Antony, Vogiatzis, Prokopios, Cruickshank, Neil, Joy, Howard, Peake, David, Zanetto, Ulises, Saunders, Mark, Sun-Myint, Arthur, Teo, Mark, Allan, Arthur, Geh, Ian, Glaholm, John, Goldstein, Mark, Hejmadi, Rahul, Langman, Gerald, Morton, Dion, Nelson, Cyril, Tattersall, Deborah, Falk, Stephen, Longman, Robert, Roach, Huw, Shabbir, Jamshed, Shelley-Fraser, Golda, Thomas, Michael, Cripps, Neil, Haba, Yasser, Harris, Guy, Hookway, Max, Simson, Jay, Skull, Angela, Umar, Tijani, Bach, Simon P, Gilbert, Alexandra, Brock, Kristian, Korsgen, Stephan, Hill, James, Hainsworth, Paul, Tutton, Matthew G, Khan, Jim, Steward, Mark, Cunningham, Christopher, Levy, Bruce, Beveridge, Alan, Handley, Kelly, Kaur, Manjinder, Marchevsky, Natalie, Magill, Laura, Russell, Ann, Quirke, Philip, West, Nicholas P, and Sebag-Montefiore, David

Published
2021
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7. An Overlap of Anticoagulant-Related and IgA Nephropathy: A Case Report

Author

Galloway, Mercedes, Sim, John J., Slater, Andrew, Bray, Christopher, Bishev, Daniel, and Walker, Patrick

Abstract

Introduction:Anticoagulant-related nephropathy (ARN) is an increasingly recognized cause of acute kidney injury (AKI), initially associated with warfarin use. Supratherapeutic warfarin levels were implicated in kidney toxicity. With the widespread adoption of direct oral anticoagulants (DOACs), it becomes imperative to understand their potential risk for ARN and its clinical presentation. Case Presentation:We report a case of a 64-year-old male prescribed DOAC for paroxysmal atrial fibrillation management, presenting with heart failure and worsening AKI. Hematuria and mild proteinuria were also observed. Despite management attempts, AKI persisted, prompting a kidney biopsy. Histopathological examination revealed acute tubular injury with numerous intratubular red blood cell casts consistent with ARN. Additionally, findings indicative of IgA nephropathy (IgAN), including mesangial hypercellularity and IgA dominant deposition, were noted. Conclusion:This case underscores the emerging risk of ARN associated with DOACs and emphasizes the potential exacerbation of ARN in the presence of underlying glomerular diseases such as IgAN. Clinicians should maintain a high index of suspicion for ARN in patients on anticoagulation therapy, particularly DOACs, who present with AKI and urinary abnormalities, as early recognition and intervention are crucial in preventing further renal damage.

Published
2024
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8. Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases

Author

Tajuddin, Salman M, Schick, Ursula M, Eicher, John D, Chami, Nathalie, Giri, Ayush, Brody, Jennifer A, Hill, W David, Kacprowski, Tim, Li, Jin, Lyytikäinen, Leo-Pekka, Manichaikul, Ani, Mihailov, Evelin, O’Donoghue, Michelle L, Pankratz, Nathan, Pazoki, Raha, Polfus, Linda M, Smith, Albert Vernon, Schurmann, Claudia, Vacchi-Suzzi, Caterina, Waterworth, Dawn M, Evangelou, Evangelos, Yanek, Lisa R, Burt, Amber, Chen, Ming-Huei, van Rooij, Frank JA, Floyd, James S, Greinacher, Andreas, Harris, Tamara B, Highland, Heather M, Lange, Leslie A, Liu, Yongmei, Mägi, Reedik, Nalls, Mike A, Mathias, Rasika A, Nickerson, Deborah A, Nikus, Kjell, Starr, John M, Tardif, Jean-Claude, Tzoulaki, Ioanna, Edwards, Digna R Velez, Wallentin, Lars, Bartz, Traci M, Becker, Lewis C, Denny, Joshua C, Raffield, Laura M, Rioux, John D, Friedrich, Nele, Fornage, Myriam, Gao, He, Hirschhorn, Joel N, Liewald, David CM, Rich, Stephen S, Uitterlinden, Andre, Bastarache, Lisa, Becker, Diane M, Boerwinkle, Eric, de Denus, Simon, Bottinger, Erwin P, Hayward, Caroline, Hofman, Albert, Homuth, Georg, Lange, Ethan, Launer, Lenore J, Lehtimäki, Terho, Lu, Yingchang, Metspalu, Andres, O’Donnell, Chris J, Quarells, Rakale C, Richard, Melissa, Torstenson, Eric S, Taylor, Kent D, Vergnaud, Anne-Claire, Zonderman, Alan B, Crosslin, David R, Deary, Ian J, Dörr, Marcus, Elliott, Paul, Evans, Michele K, Gudnason, Vilmundur, Kähönen, Mika, Psaty, Bruce M, Rotter, Jerome I, Slater, Andrew J, Dehghan, Abbas, White, Harvey D, Ganesh, Santhi K, Loos, Ruth JF, Esko, Tõnu, Faraday, Nauder, Wilson, James G, Cushman, Mary, Johnson, Andrew D, Edwards, Todd L, Zakai, Neil A, Lettre, Guillaume, Reiner, Alex P, and Auer, Paul L

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Immunology, Stem Cell Research, Human Genome, Stem Cell Research - Nonembryonic - Non-Human, Autoimmune Disease, Hematology, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Underpinning research, Aetiology, Inflammatory and immune system, Blood Cell Count, Exome, Genetic Loci, Genetic Pleiotropy, Genome-Wide Association Study, Humans, Immune System Diseases, Leukocytes, Quality Control, Medical and Health Sciences, Genetics & Heredity, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

White blood cells play diverse roles in innate and adaptive immunity. Genetic association analyses of phenotypic variation in circulating white blood cell (WBC) counts from large samples of otherwise healthy individuals can provide insights into genes and biologic pathways involved in production, differentiation, or clearance of particular WBC lineages (myeloid, lymphoid) and also potentially inform the genetic basis of autoimmune, allergic, and blood diseases. We performed an exome array-based meta-analysis of total WBC and subtype counts (neutrophils, monocytes, lymphocytes, basophils, and eosinophils) in a multi-ancestry discovery and replication sample of ∼157,622 individuals from 25 studies. We identified 16 common variants (8 of which were coding variants) associated with one or more WBC traits, the majority of which are pleiotropically associated with autoimmune diseases. Based on functional annotation, these loci included genes encoding surface markers of myeloid, lymphoid, or hematopoietic stem cell differentiation (CD69, CD33, CD87), transcription factors regulating lineage specification during hematopoiesis (ASXL1, IRF8, IKZF1, JMJD1C, ETS2-PSMG1), and molecules involved in neutrophil clearance/apoptosis (C10orf54, LTA), adhesion (TNXB), or centrosome and microtubule structure/function (KIF9, TUBD1). Together with recent reports of somatic ASXL1 mutations among individuals with idiopathic cytopenias or clonal hematopoiesis of undetermined significance, the identification of a common regulatory 3' UTR variant of ASXL1 suggests that both germline and somatic ASXL1 mutations contribute to lower blood counts in otherwise asymptomatic individuals. These association results shed light on genetic mechanisms that regulate circulating WBC counts and suggest a prominent shared genetic architecture with inflammatory and autoimmune diseases.

Published
2016

9. Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals

Author

Eicher, John D, Chami, Nathalie, Kacprowski, Tim, Nomura, Akihiro, Chen, Ming-Huei, Yanek, Lisa R, Tajuddin, Salman M, Schick, Ursula M, Slater, Andrew J, Pankratz, Nathan, Polfus, Linda, Schurmann, Claudia, Giri, Ayush, Brody, Jennifer A, Lange, Leslie A, Manichaikul, Ani, Hill, W David, Pazoki, Raha, Elliot, Paul, Evangelou, Evangelos, Tzoulaki, Ioanna, Gao, He, Vergnaud, Anne-Claire, Mathias, Rasika A, Becker, Diane M, Becker, Lewis C, Burt, Amber, Crosslin, David R, Lyytikäinen, Leo-Pekka, Nikus, Kjell, Hernesniemi, Jussi, Kähönen, Mika, Raitoharju, Emma, Mononen, Nina, Raitakari, Olli T, Lehtimäki, Terho, Cushman, Mary, Zakai, Neil A, Nickerson, Deborah A, Raffield, Laura M, Quarells, Rakale, Willer, Cristen J, Peloso, Gina M, Abecasis, Goncalo R, Liu, Dajiang J, Consortium, Global Lipids Genetics, Deloukas, Panos, Samani, Nilesh J, Schunkert, Heribert, Erdmann, Jeanette, Consortium, CARDIoGRAM Exome, Consortium, Myocardial Infarction Genetics, Fornage, Myriam, Richard, Melissa, Tardif, Jean-Claude, Rioux, John D, Dube, Marie-Pierre, de Denus, Simon, Lu, Yingchang, Bottinger, Erwin P, Loos, Ruth JF, Smith, Albert Vernon, Harris, Tamara B, Launer, Lenore J, Gudnason, Vilmundur, Edwards, Digna R Velez, Torstenson, Eric S, Liu, Yongmei, Tracy, Russell P, Rotter, Jerome I, Rich, Stephen S, Highland, Heather M, Boerwinkle, Eric, Li, Jin, Lange, Ethan, Wilson, James G, Mihailov, Evelin, Mägi, Reedik, Hirschhorn, Joel, Metspalu, Andres, Esko, Tõnu, Vacchi-Suzzi, Caterina, Nalls, Mike A, Zonderman, Alan B, Evans, Michele K, Engström, Gunnar, Orho-Melander, Marju, Melander, Olle, O’Donoghue, Michelle L, Waterworth, Dawn M, Wallentin, Lars, White, Harvey D, Floyd, James S, Bartz, Traci M, Rice, Kenneth M, Psaty, Bruce M, Starr, JM, Liewald, David CM, Hayward, Caroline, and Deary, Ian J

Subjects
Genetics, Cardiovascular, Hematology, 1.1 Normal biological development and functioning, Underpinning research, Blood, Blood Platelets, Exome, Female, Genetic Variation, Genome-Wide Association Study, Humans, Male, Mean Platelet Volume, Platelet Count, Global Lipids Genetics Consortium, CARDIoGRAM Exome Consortium, Myocardial Infarction Genetics Consortium, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

Platelet production, maintenance, and clearance are tightly controlled processes indicative of platelets' important roles in hemostasis and thrombosis. Platelets are common targets for primary and secondary prevention of several conditions. They are monitored clinically by complete blood counts, specifically with measurements of platelet count (PLT) and mean platelet volume (MPV). Identifying genetic effects on PLT and MPV can provide mechanistic insights into platelet biology and their role in disease. Therefore, we formed the Blood Cell Consortium (BCX) to perform a large-scale meta-analysis of Exomechip association results for PLT and MPV in 157,293 and 57,617 individuals, respectively. Using the low-frequency/rare coding variant-enriched Exomechip genotyping array, we sought to identify genetic variants associated with PLT and MPV. In addition to confirming 47 known PLT and 20 known MPV associations, we identified 32 PLT and 18 MPV associations not previously observed in the literature across the allele frequency spectrum, including rare large effect (FCER1A), low-frequency (IQGAP2, MAP1A, LY75), and common (ZMIZ2, SMG6, PEAR1, ARFGAP3/PACSIN2) variants. Several variants associated with PLT/MPV (PEAR1, MRVI1, PTGES3) were also associated with platelet reactivity. In concurrent BCX analyses, there was overlap of platelet-associated variants with red (MAP1A, TMPRSS6, ZMIZ2) and white (PEAR1, ZMIZ2, LY75) blood cell traits, suggesting common regulatory pathways with shared genetic architecture among these hematopoietic lineages. Our large-scale Exomechip analyses identified previously undocumented associations with platelet traits and further indicate that several complex quantitative hematological, lipid, and cardiovascular traits share genetic factors.

Published
2016

10. Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits

Author

Chami, Nathalie, Chen, Ming-Huei, Slater, Andrew J, Eicher, John D, Evangelou, Evangelos, Tajuddin, Salman M, Love-Gregory, Latisha, Kacprowski, Tim, Schick, Ursula M, Nomura, Akihiro, Giri, Ayush, Lessard, Samuel, Brody, Jennifer A, Schurmann, Claudia, Pankratz, Nathan, Yanek, Lisa R, Manichaikul, Ani, Pazoki, Raha, Mihailov, Evelin, Hill, W David, Raffield, Laura M, Burt, Amber, Bartz, Traci M, Becker, Diane M, Becker, Lewis C, Boerwinkle, Eric, Bork-Jensen, Jette, Bottinger, Erwin P, O’Donoghue, Michelle L, Crosslin, David R, de Denus, Simon, Dubé, Marie-Pierre, Elliott, Paul, Engström, Gunnar, Evans, Michele K, Floyd, James S, Fornage, Myriam, Gao, He, Greinacher, Andreas, Gudnason, Vilmundur, Hansen, Torben, Harris, Tamara B, Hayward, Caroline, Hernesniemi, Jussi, Highland, Heather M, Hirschhorn, Joel N, Hofman, Albert, Irvin, Marguerite R, Kähönen, Mika, Lange, Ethan, Launer, Lenore J, Lehtimäki, Terho, Li, Jin, Liewald, David CM, Linneberg, Allan, Liu, Yongmei, Lu, Yingchang, Lyytikäinen, Leo-Pekka, Mägi, Reedik, Mathias, Rasika A, Melander, Olle, Metspalu, Andres, Mononen, Nina, Nalls, Mike A, Nickerson, Deborah A, Nikus, Kjell, O’Donnell, Chris J, Orho-Melander, Marju, Pedersen, Oluf, Petersmann, Astrid, Polfus, Linda, Psaty, Bruce M, Raitakari, Olli T, Raitoharju, Emma, Richard, Melissa, Rice, Kenneth M, Rivadeneira, Fernando, Rotter, Jerome I, Schmidt, Frank, Smith, Albert Vernon, Starr, John M, Taylor, Kent D, Teumer, Alexander, Thuesen, Betina H, Torstenson, Eric S, Tracy, Russell P, Tzoulaki, Ioanna, Zakai, Neil A, Vacchi-Suzzi, Caterina, van Duijn, Cornelia M, van Rooij, Frank JA, Cushman, Mary, Deary, Ian J, Edwards, Digna R Velez, Vergnaud, Anne-Claire, Wallentin, Lars, Waterworth, Dawn M, White, Harvey D, Wilson, James G, and Zonderman, Alan B

Subjects
Epidemiology, Biological Sciences, Health Sciences, Genetics, Rare Diseases, Hematology, Human Genome, Clinical Research, 2.1 Biological and endogenous factors, Aetiology, Black or African American, Allelic Imbalance, Erythrocyte Indices, Erythrocytes, Erythropoiesis, Exome, Gene Frequency, Genetic Pleiotropy, Genetic Variation, Genotype, Hematocrit, Hemoglobins, Humans, Quantitative Trait Loci, Medical and Health Sciences, Genetics & Heredity, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Red blood cell (RBC) traits are important heritable clinical biomarkers and modifiers of disease severity. To identify coding genetic variants associated with these traits, we conducted meta-analyses of seven RBC phenotypes in 130,273 multi-ethnic individuals from studies genotyped on an exome array. After conditional analyses and replication in 27,480 independent individuals, we identified 16 new RBC variants. We found low-frequency missense variants in MAP1A (rs55707100, minor allele frequency [MAF] = 3.3%, p = 2 × 10(-10) for hemoglobin [HGB]) and HNF4A (rs1800961, MAF = 2.4%, p < 3 × 10(-8) for hematocrit [HCT] and HGB). In African Americans, we identified a nonsense variant in CD36 associated with higher RBC distribution width (rs3211938, MAF = 8.7%, p = 7 × 10(-11)) and showed that it is associated with lower CD36 expression and strong allelic imbalance in ex vivo differentiated human erythroblasts. We also identified a rare missense variant in ALAS2 (rs201062903, MAF = 0.2%) associated with lower mean corpuscular volume and mean corpuscular hemoglobin (p < 8 × 10(-9)). Mendelian mutations in ALAS2 are a cause of sideroblastic anemia and erythropoietic protoporphyria. Gene-based testing highlighted three rare missense variants in PKLR, a gene mutated in Mendelian non-spherocytic hemolytic anemia, associated with HGB and HCT (SKAT p < 8 × 10(-7)). These rare, low-frequency, and common RBC variants showed pleiotropy, being also associated with platelet, white blood cell, and lipid traits. Our association results and functional annotation suggest the involvement of new genes in human erythropoiesis. We also confirm that rare and low-frequency variants play a role in the architecture of complex human traits, although their phenotypic effect is generally smaller than originally anticipated.

Published
2016

11. Diagnostic accuracy of magnetic resonance enterography and small bowel ultrasound for the extent and activity of newly diagnosed and relapsed Crohn's disease (METRIC): a multicentre trial

Author

Dyer, Jade, Veeramalla, Pranitha, Tebbs, Sue, Hibbert, Steve, Ellis, Richard, Thursby-Pelham, Fergus, Beable, Richard, Gibbons, Nicola, Ward, Claire, O'Connor, Anthony, Lambie, Hannah, Hyland, Rachel, Scott, Nigel, Lapham, Roger, Quartey, Doris, Scrimshaw, Deborah, Bungay, Helen, Betts, Maggie, Fourie, Simona, Power, Niall, Ilangovan, Rajapandian, Patel, Uday, Mainta, Evgenia, Lung, Phillip, Johnston, Ian, Naghibi, Mani, Moorghen, Morgan, Martinez, Adriana, Porte, Francois, Alexakis, Christopher, Pilcher, James, Rahman, Anisur, Vlahos, Jonny, Greenhalgh, Rebecca, Wale, Anita, Beeston, Teresita, Piga, Wivijin, Clemente, Joey, Rahman, Farooq, de Caro, Simona, Mehta, Shameer, Vega, Roser, Jastrub, Roman, Sidhu, Harbir, Rafiee, Hameed, Tennent, Mairead, Innes, Caron, Mowat, Craig, Duncan, Gillian, Morris, Steve, Taylor, Stuart A, Mallett, Susan, Bhatnagar, Gauraang, Baldwin-Cleland, Rachel, Bloom, Stuart, Gupta, Arun, Hamlin, Peter J, Hart, Ailsa L, Higginson, Antony, Jacobs, Ilan, McCartney, Sara, Miles, Anne, Murray, Charles D, Plumb, Andrew A, Pollok, Richard C, Punwani, Shonit, Quinn, Laura, Rodriguez-Justo, Manuel, Shabir, Zainib, Slater, Andrew, Tolan, Damian, Travis, Simon, Windsor, Alastair, Wylie, Peter, Zealley, Ian, and Halligan, Steve

Published
2018
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13. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

Author

Justice, Anne E., Karaderi, Tugce, Highland, Heather M., Young, Kristin L., Graff, Mariaelisa, Lu, Yingchang, Turcot, Valérie, Auer, Paul L., Fine, Rebecca S., Guo, Xiuqing, Schurmann, Claudia, Lempradl, Adelheid, Marouli, Eirini, Mahajan, Anubha, Winkler, Thomas W., Locke, Adam E., Medina-Gomez, Carolina, Esko, Tõnu, Vedantam, Sailaja, Giri, Ayush, Lo, Ken Sin, Alfred, Tamuno, Mudgal, Poorva, Ng, Maggie C. Y., Heard-Costa, Nancy L., Feitosa, Mary F., Manning, Alisa K., Willems, Sara M., Sivapalaratnam, Suthesh, Abecasis, Goncalo, Alam, Dewan S., Allison, Matthew, Amouyel, Philippe, Arzumanyan, Zorayr, Balkau, Beverley, Bastarache, Lisa, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bork-Jensen, Jette, Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Broer, Linda, Burt, Amber A., Butterworth, Adam S., Caulfield, Mark J., Cesana, Giancarlo, Chambers, John C., Chasman, Daniel I., Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Collins, Francis S., Cook, James P., Cox, Amanda J., Crosslin, David S., Danesh, John, de Bakker, Paul I. W., Denus, Simon de, Mutsert, Renée de, Dedoussis, George, Demerath, Ellen W., Dennis, Joe G., Denny, Josh C., Di Angelantonio, Emanuele, Dörr, Marcus, Drenos, Fotios, Dubé, Marie-Pierre, Dunning, Alison M., Easton, Douglas F., Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Fornage, Myriam, Fox, Caroline S., Franks, Paul W., Friedrich, Nele, Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Girotto, Giorgia, Gorski, Mathias, Grallert, Harald, Grarup, Niels, Grove, Megan L., Gustafsson, Stefan, Haessler, Jeff, Hansen, Torben, Hattersley, Andrew T., Hayward, Caroline, Heid, Iris M., Holmen, Oddgeir L., Hovingh, G. Kees, Howson, Joanna M. M., Hu, Yao, Hung, Yi-Jen, Hveem, Kristian, Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jarvik, Gail P., Jia, Yucheng, Jørgensen, Torben, Jousilahti, Pekka, Justesen, Johanne M., Kahali, Bratati, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kee, Frank, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S., Kovacs, Peter, Krämer, Bernhard K., Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lamparter, David, Lange, Leslie A., Langenberg, Claudia, Larson, Eric B., Lee, Nanette R., Lee, Wen-Jane, Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J., Luan, Jian’an, Lyytikäinen, Leo-Pekka, MacGregor, Stuart, Mägi, Reedik, Männistö, Satu, Marenne, Gaëlle, Marten, Jonathan, Masca, Nicholas G. D., McCarthy, Mark I., Meidtner, Karina, Mihailov, Evelin, Moilanen, Leena, Moitry, Marie, Mook-Kanamori, Dennis O., Morgan, Anna, Morris, Andrew P., Müller-Nurasyid, Martina, Munroe, Patricia B., Narisu, Narisu, Nelson, Christopher P., Neville, Matt, Ntalla, Ioanna, O’Connell, Jeffrey R., Owen, Katharine R., Pedersen, Oluf, Peloso, Gina M., Pennell, Craig E., Perola, Markus, Perry, James A., Perry, John R. B., Pers, Tune H., Ewing, Ailith, Polasek, Ozren, Raitakari, Olli T., Rasheed, Asif, Raulerson, Chelsea K., Rauramaa, Rainer, Reilly, Dermot F., Reiner, Alex P., Ridker, Paul M., Rivas, Manuel A., Robertson, Neil R., Robino, Antonietta, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo, Sim, Xueling, Slater, Andrew J., Small, Kerrin S., Smith, Blair H., Smith, Jennifer A., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swart, Karin M. A., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Torres, Mina, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van Duijn, Cornelia M., Vanhala, Mauno, Varma, Rohit, Vermeulen, Sita H., Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wareham, Nicholas J., Warren, Helen R., Waterworth, Dawn M., Wessel, Jennifer, White, Harvey D., Willer, Cristen J., Wilson, James G., Wood, Andrew R., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zheng, He, Zhou, Wei, Zillikens, M. Carola, Rivadeneira, Fernando, Borecki, Ingrid B., Pospisilik, J. Andrew, Deloukas, Panos, Frayling, Timothy M., Lettre, Guillaume, Mohlke, Karen L., Rotter, Jerome I., Kutalik, Zoltán, Hirschhorn, Joel N., Cupples, L. Adrienne, Loos, Ruth J. F., North, Kari E., and Lindgren, Cecilia M.

Published
2019
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15. Supplementary Figures 1-4 from Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype

Author

Xiao, Run, primary, Bergin, Stephen M., primary, Huang, Wei, primary, Slater, Andrew M., primary, Liu, Xianglan, primary, Judd, Ryan T., primary, Lin, En-Ju D., primary, Widstrom, Kyle J., primary, Scoville, Steven D., primary, Yu, Jianhua, primary, Caligiuri, Michael A., primary, and Cao, Lei, primary

Published
2023
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17. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Author

Turcot, Valérie, Lu, Yingchang, Highland, Heather M., Schurmann, Claudia, Justice, Anne E., Fine, Rebecca S., Bradfield, Jonathan P., Esko, Tõnu, Giri, Ayush, Graff, Mariaelisa, Guo, Xiuqing, Hendricks, Audrey E., Karaderi, Tugce, Lempradl, Adelheid, Locke, Adam E., Mahajan, Anubha, Marouli, Eirini, Sivapalaratnam, Suthesh, Young, Kristin L., Alfred, Tamuno, Feitosa, Mary F., Masca, Nicholas G. D., Manning, Alisa K., Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie C. Y., Reiner, Alex P., Vedantam, Sailaja, Willems, Sara M., Winkler, Thomas W., Abecasis, Gonçalo, Aben, Katja K., Alam, Dewan S., Alharthi, Sameer E., Allison, Matthew, Amouyel, Philippe, Asselbergs, Folkert W., Auer, Paul L., Balkau, Beverley, Bang, Lia E., Barroso, Inês, Bastarache, Lisa, Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bork-Jensen, Jette, Bots, Michiel L., Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H., Broer, Linda, Brumat, Marco, Burt, Amber A., Butterworth, Adam S., Campbell, Peter T., Cappellani, Stefania, Carey, David J., Catamo, Eulalia, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der I., Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Cocca, Massimiliano, Collins, Francis S., Cook, James P., Corley, Janie, Corominas Galbany, Jordi, Cox, Amanda J., Crosslin, David S., Cuellar-Partida, Gabriel, D’Eustacchio, Angela, Danesh, John, Davies, Gail, Bakker, Paul I. W., Groot, Mark C. H., Mutsert, Renée, Deary, Ian J., Dedoussis, George, Demerath, Ellen W., Heijer, Martin, Hollander, Anneke I., Ruijter, Hester M., Dennis, Joe G., Denny, Josh C., Di Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dubé, Marie-Pierre, Dunning, Alison M., Easton, Douglas F., Edwards, Todd L., Ellinghaus, David, Ellinor, Patrick T., Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Farooqi, I. Sadaf, Faul, Jessica D., Fauser, Sascha, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Ford, Ian, Fornage, Myriam, Franco, Oscar H., Franke, Andre, Franks, Paul W., Friedrich, Nele, Frikke-Schmidt, Ruth, Galesloot, Tessel E., Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Gibson, Jane, Giedraitis, Vilmantas, Gjesing, Anette P., Gordon-Larsen, Penny, Gorski, Mathias, Grabe, Hans-Jörgen, Grant, Struan F. A., Grarup, Niels, Griffiths, Helen L., Grove, Megan L., Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeff, Hakonarson, Hakon, Hammerschlag, Anke R., Hansen, Torben, Harris, Kathleen Mullan, Harris, Tamara B., Hattersley, Andrew T., Have, Christian T., Hayward, Caroline, He, Liang, Heard-Costa, Nancy L., Heath, Andrew C., Heid, Iris M., Helgeland, Øyvind, Hernesniemi, Jussi, Hewitt, Alex W., Holmen, Oddgeir L., Hovingh, G. Kees, Howson, Joanna M. M., Hu, Yao, Huang, Paul L., Huffman, Jennifer E., Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jansson, Jan-Håkan, Jarvik, Gail P., Jensen, Gorm B., Jia, Yucheng, Johansson, Stefan, Jørgensen, Marit E., Jørgensen, Torben, Jukema, J. Wouter, Kahali, Bratati, Kahn, René S., Kähönen, Mika, Kamstrup, Pia R., Kanoni, Stavroula, Kaprio, Jaakko, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kathiresan, Sekar, Kee, Frank, Kiemeney, Lambertus A., Kim, Eric, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S., Kooperberg, Charles, Korhonen, Tellervo, Kovacs, Peter, Kuivaniemi, Helena, Kutalik, Zoltán, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lamparter, David, Lange, Ethan M., Lange, Leslie A., Langenberg, Claudia, Larson, Eric B., Lee, Nanette R., Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Honghuang, Lin, Keng-Hung, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J., Liu, Yongmei, Lo, Ken S., Lophatananon, Artitaya, Lotery, Andrew J., Loukola, Anu, Luan, Jian’an, Lubitz, Steven A., Lyytikäinen, Leo-Pekka, Männistö, Satu, Marenne, Gaëlle, Mazul, Angela L., McCarthy, Mark I., McKean-Cowdin, Roberta, Medland, Sarah E., Meidtner, Karina, Milani, Lili, Mistry, Vanisha, Mitchell, Paul, Mohlke, Karen L., Moilanen, Leena, Moitry, Marie, Montgomery, Grant W., Mook-Kanamori, Dennis O., Moore, Carmel, Mori, Trevor A., Morris, Andrew D., Morris, Andrew P., Müller-Nurasyid, Martina, Munroe, Patricia B., Nalls, Mike A., Narisu, Narisu, Nelson, Christopher P., Neville, Matt, Nielsen, Sune F., Nikus, Kjell, Njølstad, Pål R., Nordestgaard, Børge G., Nyholt, Dale R., O’Connel, Jeffrey R., O’Donoghue, Michelle L., Olde Loohuis, Loes M., Ophoff, Roel A., Owen, Katharine R., Packard, Chris J., Padmanabhan, Sandosh, Palmer, Colin N. A., Palmer, Nicholette D., Pasterkamp, Gerard, Patel, Aniruddh P., Pattie, Alison, Pedersen, Oluf, Peissig, Peggy L., Peloso, Gina M., Pennell, Craig E., Perola, Markus, Perry, James A., Perry, John R. B., Pers, Tune H., Person, Thomas N., Peters, Annette, Petersen, Eva R. B., Peyser, Patricia A., Pirie, Ailith, Polasek, Ozren, Polderman, Tinca J., Puolijoki, Hannu, Raitakari, Olli T., Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F., Renström, Frida, Rheinberger, Myriam, Ridker, Paul M., Rioux, John D., Rivas, Manuel A., Roberts, David J., Robertson, Neil R., Robino, Antonietta, Rolandsson, Olov, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Sapkota, Yadav, Sattar, Naveed, Schoen, Robert E., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo P., Shah, Svati H., Sheu, Wayne H.-H., Sim, Xueling, Slater, Andrew J., Small, Kerrin S., Smith, Albert V., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Starr, John M., Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swift, Amy J., Tada, Hayato, Tansey, Katherine E., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Tromp, Gerard, Trompet, Stella, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, Tyrer, Jonathan P., Uher, Rudolf, Uitterlinden, André G., Uusitupa, Matti, Laan, Sander W., Duijn, Cornelia M., Leeuwen, Nienke, van Setten, Jessica, Vanhala, Mauno, Varbo, Anette, Varga, Tibor V., Varma, Rohit, Velez Edwards, Digna R., Vermeulen, Sita H., Veronesi, Giovanni, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Völker, Uwe, Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wang, Yiqin, Ware, Erin B., Wareham, Nicholas J., Warren, Helen R., Waterworth, Dawn M., Wessel, Jennifer, White, Harvey D., Willer, Cristen J., Wilson, James G., Witte, Daniel R., Wood, Andrew R., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yao, Pang, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zhao, Wei, Zhou, Wei, Zondervan, Krina T, Rotter, Jerome I., Pospisilik, John A., Rivadeneira, Fernando, Borecki, Ingrid B., Deloukas, Panos, Frayling, Timothy M., Lettre, Guillaume, North, Kari E., Lindgren, Cecilia M., Hirschhorn, Joel N., and Loos, Ruth J. F.

Published
2018
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18. Simulations of a Boreal Grassland Hydrology at Valdai, Russia: PILPS Phase 2(d)

Author

Schlosser, C Adam, Slater, Andrew G, Robock, Alan, Pitman, Andrew J, Vinnikov, Konstantin Ya, Henderson-Sellers, Ann, Speranskaya, Nina A, Mitchell, Ken, and The PILPS 2(D) Contributors

Subjects
Applied Mathematics, Atmospheric Sciences, Meteorology & Atmospheric Sciences
Abstract

The Project for the Intercomparison of Land-Surface Parameterization Schemes (PILPS) aims to improve understanding and modeling of land surface processes. PILPS phase 2(d) uses a set of meteorological and hydrological data spanning 18 yr (1966-83) from a grassland catchment at the Valdai water-balance research site in Russia. A suite of stand-alone simulations is performed by 21 land surface schemes (LSSs) to explore the LSSs' sensitivity to downward longwave radiative forcing, timescales of simulated hydrologic variability, and biases resulting from single-year simulations that use recursive spinup. These simulations are the first in PILPS to investigate the performance of LSSs at a site with a well-defined seasonal snow cover and frozen soil. Considerable model scatter for the control simulations exists. However, nearly all the LSS scatter in simulated root-zone soil moisture is contained within the spatial variability observed inside the catchment. In addition, all models show a considerable sensitivity to longwave forcing for the simulation of the snowpack, which during the spring melt affects runoff, meltwater infiltration, and subsequent evapotranspiration. A greater sensitivity of the ablation, compared to the accumulation, of the winter snowpaek to the choice of snow parameterization is found. Sensitivity simulations starting at prescribed conditions with no spinup demonstrate that the treatment of frozen soil (moisture) processes can affect the long-term variability of the models. The single-year recursive runs show large biases, compared to the corresponding year of the control run, that can persist through the entire year and underscore the importance of performing multiyear simulations.

Published
2000

20. Cussing, fighting, bullying : aspects of pupil interaction in the lower years of a mixed, multicultural, inner city comprehensive school

Author

Slater, Andrew James

Subjects
370, Education & training
Abstract

Bullying has been a source of disquiet, if not moral panic, in recent years. Yet pupil experience outside the classroom has rarely been given the attention it deserves in educational research devoted to the problem. This study examines the social relations between pupils in the lower years of a mixed, multicultural, inner city school. It is based upon long term participant observation as a teacher researcher and aims to develop a sociological appreciation of aggression and bullying during school-day free-time. Part One explains the origins of the research. Recent studies of 'cussing' (verbal abuse), fighting (a topic which has hitherto received very little attention), and bullying are then examined in detail. The research seeks to identify the links, if any, between hostile social relations in school and broader social inequalities at a societal level. Further, it aims to tease out ways in which micro level divisions of power within the pupils' social world shape, and are used by children within interactions. Close attention is therefore given to the meaning, or meanings, of the term 'power'. Models of relative power which inform research focusing upon pupil experience are also identified. In Part Two, both the research site, City School, and the research techniques used are described. Cussing, fighting and bullying, forms of aggressive interaction which distress pupils and obstruct the achievement of curricular goals, are then examined closely. Consideration of gender, 'race' and age grading provides a sharper awareness of underlying power divisions and of how these constrain opportunities for the relatively weak. In Part Three, ways of improving the quality of experience available for pupils during school-day free-time are identified. Whilst the complexity of this task is acknowledged, the study concludes with a renewed sense of optimism about what may be achieved when teachers are more effectively equipped with the skills to understand and, where necessary, make sensitive interventions.

Published
1993

21. Quality-of-life outcomes in older patients with early-stage rectal cancer receiving organ-preserving treatment with hypofractionated short-course radiotherapy followed by transanal endoscopic microsurgery (TREC): non-randomised registry of patients unsuitable for total mesorectal excision

Author

Gilbert, Alexandra, primary, Homer, Victoria, additional, Brock, Kristian, additional, Korsgen, Stephan, additional, Geh, Ian, additional, Hill, James, additional, Gill, Talvinder, additional, Hainsworth, Paul, additional, Tutton, Matthew, additional, Khan, Jim, additional, Robinson, Jonathan, additional, Steward, Mark, additional, Cunningham, Christopher, additional, Kaur, Manjinder, additional, Magill, Laura, additional, Russell, Ann, additional, Quirke, Philip, additional, West, Nicholas P, additional, Sebag-Montefiore, David, additional, Bach, Simon P, additional, Beveridge, Alan, additional, Levy, Bruce, additional, Handley, Kelly, additional, Brown, Gina, additional, Antonio, Peter, additional, Vince, Alex, additional, Hilken, Nick, additional, Sidile, Chakanaka, additional, Wilcockson, Adrian, additional, Peto, Richard, additional, Crosby, Tom, additional, Moran, Brendan, additional, Olliff, Julie, additional, Ashok, Katti, additional, Slawik, Simone, additional, Smethurst, Andrew, additional, Sripadam, Rajaram, additional, Tagore, Veena, additional, Terlizzo, Monica, additional, Philip, Bearn, additional, Davies, Robert, additional, Dodd, Susan, additional, Essapen, Sharadah, additional, Nisar, Pasha, additional, Stewart, Alexandra, additional, Trickett, Jonathan, additional, Ashish, Bansal, additional, Billings, Peter, additional, Chandran, Palanichamy, additional, Corr, Conor, additional, Favill, Edward, additional, Gollins, Simon, additional, Marsh, Peter, additional, Maw, Andrew, additional, Neupane, Rakha, additional, Rajagopal, Ramesh, additional, Cooper, Rachel, additional, Griffith, John, additional, Hatfield, Paul, additional, Lowe, Andy, additional, Ostrowski, Julian, additional, Simpson, Rhian, additional, Adams, Richard, additional, Bleehen, Robert, additional, Davies, Michael, additional, Morgan, Meleri, additional, Boone, Darren, additional, Lacey, Nicola, additional, Seddon, Ian, additional, Sizer, Bruce, additional, Stunell, Helen, additional, Wu, Shaobin, additional, Hadaki, Maher, additional, Blunt, Dominic, additional, Cleator, Susan, additional, Darzi, Ara, additional, Goldin, Robert, additional, Ziprin, Paul, additional, Dobson, Mike, additional, Pitt, Mark, additional, Susnerwala, Shabbir, additional, Williamson, Deborah, additional, Howarth, Georgina, additional, Lee, Stephen, additional, Wright, Paul, additional, Hoare, Tim, additional, Horgan, Alan, additional, McDonald, Fiona, additional, Needham, Stephanie, additional, Scott, John, additional, Simmons, Timothy, additional, Biswas, Debashis, additional, Hernon, James, additional, Kapur, Gaurav, additional, Kapur, Sandeep, additional, Sington, James, additional, Speakman, Christopher, additional, Stebbings, William, additional, Williams, Stuart, additional, Adusumalli, Madhavi, additional, Agarwal, Anil, additional, Borowski, David, additional, Garg, Dharmendra, additional, Hegab, Mohammed, additional, Hobday, Catherine, additional, Rao, Veena, additional, Shrimankar, Jyotsna, additional, Tabaqchali, Mohamed, additional, Wilson, David, additional, Jones, Oliver, additional, Mortensen, Neil, additional, Slater, Andrew, additional, Szuts, Aron, additional, Wang, Lai, additional, Warren, Bryan, additional, Weaver, Andrew, additional, Ahmad, Mukhtar, additional, Alexander, Julian, additional, Flubacher, Maxine, additional, Tarver, David, additional, Baluch, Suhail, additional, Beable, Richard, additional, Cowlishaw, David, additional, Higginson, Antony, additional, Vogiatzis, Prokopios, additional, Cruickshank, Neil, additional, Joy, Howard, additional, Peake, David, additional, Zanetto, Ulises, additional, Saunders, Mark, additional, Sun-Myint, Arthur, additional, Teo, Mark, additional, Allan, Arthur, additional, Glaholm, John, additional, Goldstein, Mark, additional, Hejmadi, Rahul, additional, Langman, Gerald, additional, Morton, Dion, additional, Nelson, Cyril, additional, Tattersall, Deborah, additional, Falk, Stephen, additional, Longman, Robert, additional, Roach, Huw, additional, Shabbir, Jamshed, additional, Shelley-Fraser, Golda, additional, Thomas, Michael, additional, Cripps, Neil, additional, Haba, Yasser, additional, Harris, Guy, additional, Hookway, Max, additional, Simson, Jay, additional, Skull, Angela, additional, and Umar, Tijani, additional

Published
2022
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24. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Author

Turcot, Valérie, Lu, Yingchang, Highland, Heather M., Schurmann, Claudia, Justice, Anne E., Fine, Rebecca S., Bradfield, Jonathan P., Esko, Tõnu, Giri, Ayush, Graff, Mariaelisa, Guo, Xiuqing, Hendricks, Audrey E., Karaderi, Tugce, Lempradl, Adelheid, Locke, Adam E., Mahajan, Anubha, Marouli, Eirini, Sivapalaratnam, Suthesh, Young, Kristin L., Alfred, Tamuno, Feitosa, Mary F., Masca, Nicholas G. D., Manning, Alisa K., Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie C. Y., Reiner, Alex P., Vedantam, Sailaja, Willems, Sara M., Winkler, Thomas W., Abecasis, Gonçalo, Aben, Katja K., Alam, Dewan S., Alharthi, Sameer E., Allison, Matthew, Amouyel, Philippe, Asselbergs, Folkert W., Auer, Paul L., Balkau, Beverley, Bang, Lia E., Barroso, Inês, Bastarache, Lisa, Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bork-Jensen, Jette, Bots, Michiel L., Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H., Broer, Linda, Brumat, Marco, Burt, Amber A., Butterworth, Adam S., Campbell, Peter T., Cappellani, Stefania, Carey, David J., Catamo, Eulalia, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der I., Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Cocca, Massimiliano, Collins, Francis S., Cook, James P., Corley, Janie, Galbany, Jordi Corominas, Cox, Amanda J., Crosslin, David S., Cuellar-Partida, Gabriel, D’Eustacchio, Angela, Danesh, John, Davies, Gail, Bakker, Paul I. W., Groot, Mark C. H., Mutsert, Renée, Deary, Ian J., Dedoussis, George, Demerath, Ellen W., Heijer, Martin, Hollander, Anneke I., Ruijter, Hester M., Dennis, Joe G., Denny, Josh C., Di Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dubé, Marie-Pierre, Dunning, Alison M., Easton, Douglas F., Edwards, Todd L., Ellinghaus, David, Ellinor, Patrick T., Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Farooqi, I. Sadaf, Faul, Jessica D., Fauser, Sascha, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Ford, Ian, Fornage, Myriam, Franco, Oscar H., Franke, Andre, Franks, Paul W., Friedrich, Nele, Frikke-Schmidt, Ruth, Galesloot, Tessel E., Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Gibson, Jane, Giedraitis, Vilmantas, Gjesing, Anette P., Gordon-Larsen, Penny, Gorski, Mathias, Grabe, Hans-Jörgen, Grant, Struan F. A., Grarup, Niels, Griffiths, Helen L., Grove, Megan L., Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeff, Hakonarson, Hakon, Hammerschlag, Anke R., Hansen, Torben, Harris, Kathleen Mullan, Harris, Tamara B., Hattersley, Andrew T., Have, Christian T., Hayward, Caroline, He, Liang, Heard-Costa, Nancy L., Heath, Andrew C., Heid, Iris M., Helgeland, Øyvind, Hernesniemi, Jussi, Hewitt, Alex W., Holmen, Oddgeir L., Hovingh, G. Kees, Howson, Joanna M. M., Hu, Yao, Huang, Paul L., Huffman, Jennifer E., Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jansson, Jan-Håkan, Jarvik, Gail P., Jensen, Gorm B., Jia, Yucheng, Johansson, Stefan, Jørgensen, Marit E., Jørgensen, Torben, Jukema, J. Wouter, Kahali, Bratati, Kahn, René S., Kähönen, Mika, Kamstrup, Pia R., Kanoni, Stavroula, Kaprio, Jaakko, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kathiresan, Sekar, Kee, Frank, Kiemeney, Lambertus A., Kim, Eric, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S., Kooperberg, Charles, Korhonen, Tellervo, Kovacs, Peter, Kuivaniemi, Helena, Kutalik, Zoltán, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lamparter, David, Lange, Ethan M., Lange, Leslie A., Langenberg, Claudia, Larson, Eric B., Lee, Nanette R., Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Honghuang, Lin, Keng-Hung, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J., Liu, Yongmei, Lo, Ken S., Lophatananon, Artitaya, Lotery, Andrew J., Loukola, Anu, Luan, Jian’an, Lubitz, Steven A., Lyytikäinen, Leo-Pekka, Männistö, Satu, Marenne, Gaëlle, Mazul, Angela L., McCarthy, Mark I., McKean-Cowdin, Roberta, Medland, Sarah E., Meidtner, Karina, Milani, Lili, Mistry, Vanisha, Mitchell, Paul, Mohlke, Karen L., Moilanen, Leena, Moitry, Marie, Montgomery, Grant W., Mook-Kanamori, Dennis O., Moore, Carmel, Mori, Trevor A., Morris, Andrew D., Morris, Andrew P., Müller-Nurasyid, Martina, Munroe, Patricia B., Nalls, Mike A., Narisu, Narisu, Nelson, Christopher P., Neville, Matt, Nielsen, Sune F., Nikus, Kjell, Njølstad, Pål R., Nordestgaard, Børge G., Nyholt, Dale R., O’Connel, Jeffrey R., O’Donoghue, Michelle L., Loohuis, Loes M. Olde, Ophoff, Roel A., Owen, Katharine R., Packard, Chris J., Padmanabhan, Sandosh, Palmer, Colin N. A., Palmer, Nicholette D., Pasterkamp, Gerard, Patel, Aniruddh P., Pattie, Alison, Pedersen, Oluf, Peissig, Peggy L., Peloso, Gina M., Pennell, Craig E., Perola, Markus, Perry, James A., Perry, John R. B., Pers, Tune H., Person, Thomas N., Peters, Annette, Petersen, Eva R. B., Peyser, Patricia A., Pirie, Ailith, Polasek, Ozren, Polderman, Tinca J., Puolijoki, Hannu, Raitakari, Olli T., Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F., Renström, Frida, Rheinberger, Myriam, Ridker, Paul M., Rioux, John D., Rivas, Manuel A., Roberts, David J., Robertson, Neil R., Robino, Antonietta, Rolandsson, Olov, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Sapkota, Yadav, Sattar, Naveed, Schoen, Robert E., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo P., Shah, Svati H., Sheu, Wayne H.-H., Sim, Xueling, Slater, Andrew J., Small, Kerrin S., Smith, Albert V., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Starr, John M., Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swift, Amy J., Tada, Hayato, Tansey, Katherine E., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Tromp, Gerard, Trompet, Stella, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, Tyrer, Jonathan P., Uher, Rudolf, Uitterlinden, André G., Uusitupa, Matti, Laan, Sander W., Duijn, Cornelia M., Leeuwen, Nienke, van Setten, Jessica, Vanhala, Mauno, Varbo, Anette, Varga, Tibor V., Varma, Rohit, Edwards, Digna R. Velez, Vermeulen, Sita H., Veronesi, Giovanni, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Völker, Uwe, Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wang, Yiqin, Ware, Erin B., Wareham, Nicholas J., Warren, Helen R., Waterworth, Dawn M., Wessel, Jennifer, White, Harvey D., Willer, Cristen J., Wilson, James G., Witte, Daniel R., Wood, Andrew R., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yao, Pang, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zhao, Wei, Zhou, Wei, Zondervan, Krina T, CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Understanding Society Scientific Group, Rotter, Jerome I., Pospisilik, John A., Rivadeneira, Fernando, Borecki, Ingrid B., Deloukas, Panos, Frayling, Timothy M., Lettre, Guillaume, North, Kari E., Lindgren, Cecilia M., Hirschhorn, Joel N., and Loos, Ruth J. F.

Published
2019
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25. Interobserver variation in the interpretation of magnetic resonance enterography in Crohn’s disease

Author

Bhatnagar, Gauraang, primary, Mallett, Sue, additional, Quinn, Laura, additional, Beable, Richard, additional, Bungay, Helen, additional, Betts, Margaret, additional, Greenhalgh, Rebecca, additional, Gupta, Arun, additional, Higginson, Anthony, additional, Hyland, Rachel, additional, Ilangovan, Rajapandian, additional, Lambie, Hannah, additional, Mainta, Evgenia, additional, Patel, Uday, additional, Pilcher, James, additional, Plumb, Andrew, additional, Porté, François, additional, Sidhu, Harbir, additional, Slater, Andrew, additional, Tolan, Damian, additional, Zealley, Ian, additional, Halligan, Steve, additional, and Taylor, Stuart, additional

Published
2022
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26. The use of the axiophyte species concept to describe the ecological network of the Birmingham and Black Country of the UK West Midlands

Author

Trueman Ian C., Carvalho Sara, and Slater Andrew

Subjects
urban ecology, indicator species, flora, landscape, conservation, Environmental sciences, GE1-350
Abstract

The UK conurbation of Birmingham and the Black Country has recently been surveyed for a new Flora, on the basis of a 1 km square grid. The present paper uses the data to describe the ecological network of the conurbation. The total number of taxa per 1 km squares is shown to be moderately but significantly correlated, and the number of native taxa more strongly correlated, with the area of the previously-established network of protected sites. Nevertheless coincidence maps of total numbers or numbers of native species per 1 km square give only poor representations of the ecological network compared with maps of protected sites. Axiophytes are defined as plant species 90% restricted to conservation habitats and recorded in fewer than 25% of 2km × 2km squares in a county. Applying the concept to 1 km squares in Birmingham and the Black Country creates a list of 256 axiophytes. Numbers of axiophytes are shown to be more strongly correlated with areas of protected sites than total taxa or native taxa and a coincidence map of the axiophytes is found to provide a useful quantitative assessment of the ecological network. Maps of axiophytes are used to divide the network into core and linking areas and their use in consolidating and improving the botanical ecological network is explored.

Published
2013
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27. Process-level model evaluation: a snow and heat transfer metric

Author

Slater, Andrew G, Lawrence, David M, and Koven, Charles D

Subjects
Earth Sciences, Atmospheric Sciences, Climate Action, Oceanography, Physical Geography and Environmental Geoscience, Meteorology & Atmospheric Sciences, Physical geography and environmental geoscience
Abstract

Land models require evaluation in order to understand results and guide future development. Examining functional relationships between model variables can provide insight into the ability of models to capture fundamental processes and aid in minimizing uncertainties or deficiencies in model forcing. This study quantifies the proficiency of land models to appropriately transfer heat from the soil through a snowpack to the atmosphere during the cooling season (Northern Hemisphere: October-March). Using the basic physics of heat diffusion, we investigate the relationship between seasonal amplitudes of soil versus air temperatures due to insulation from seasonal snow. Observations demonstrate the anticipated exponential relationship of attenuated soil temperature amplitude with increasing snow depth and indicate that the marginal influence of snow insulation diminishes beyond an "effective snow depth" of about 50 cm. A snow and heat transfer metric (SHTM) is developed to quantify model skill compared to observations. Land models within the CMIP5 experiment vary widely in SHTM scores, and deficiencies can often be traced to model structural weaknesses. The SHTM value for individual models is stable over 150 years of climate, 1850-2005, indicating that the metric is insensitive to climate forcing and can be used to evaluate each model's representation of the insulation process.

Published
2017

28. Modelling More Realistic SAT Problems

Author

Slater, Andrew, Goos, G., editor, Hartmanis, J., editor, van Leeuwen, J., editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, McKay, Bob, editor, and Slaney, John, editor

Published
2002
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37. cardT A P: Automated deduction on a smart card

Author

Slater, Andrew, Goré, Rajeev, Posegga, Joachim, Vogt, Harald, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Goos, G., editor, Hartmanis, J., editor, van Leeuwen, J., editor, Antoniou, Grigoris, editor, and Slaney, John, editor

Published
1998
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38. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Author

Turcot, Valérie, Lu, Yingchang, Highland, Heather M., Schurmann, Claudia, Justice, Anne E., Fine, Rebecca S., Bradfield, Jonathan P., Esko, Tõnu, Giri, Ayush, Graff, Mariaelisa, Guo, Xiuqing, Hendricks, Audrey E., Karaderi, Tugce, Lempradl, Adelheid, Locke, Adam E., Mahajan, Anubha, Marouli, Eirini, Sivapalaratnam, Suthesh, Young, Kristin L., Alfred, Tamuno, Feitosa, Mary F., Masca, Nicholas G. D., Manning, Alisa K., Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie C. Y., Reiner, Alex P., Vedantam, Sailaja, Willems, Sara M., Winkler, Thomas W., Abecasis, Gonçalo, Aben, Katja K., Alam, Dewan S., Alharthi, Sameer E., Allison, Matthew, Amouyel, Philippe, Asselbergs, Folkert W., Auer, Paul L., Balkau, Beverley, Bang, Lia E., Barroso, Inês, Bastarache, Lisa, Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bork-Jensen, Jette, Bots, Michiel L., Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H., Broer, Linda, Brumat, Marco, Burt, Amber A., Butterworth, Adam S., Campbell, Peter T., Cappellani, Stefania, Carey, David J., Catamo, Eulalia, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der I., Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Cocca, Massimiliano, Collins, Francis S., Cook, James P., Corley, Janie, Corominas Galbany, Jordi, Cox, Amanda J., Crosslin, David S., Cuellar-Partida, Gabriel, D’Eustacchio, Angela, Danesh, John, Davies, Gail, Bakker, Paul I. W., Groot, Mark C. H., Mutsert, Renée, Deary, Ian J., Dedoussis, George, Demerath, Ellen W., Heijer, Martin, Hollander, Anneke I., Ruijter, Hester M., Dennis, Joe G., Denny, Josh C., Di Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dubé, Marie-Pierre, Dunning, Alison M., Easton, Douglas F., Edwards, Todd L., Ellinghaus, David, Ellinor, Patrick T., Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Farooqi, I. Sadaf, Faul, Jessica D., Fauser, Sascha, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Ford, Ian, Fornage, Myriam, Franco, Oscar H., Franke, Andre, Franks, Paul W., Friedrich, Nele, Frikke-Schmidt, Ruth, Galesloot, Tessel E., Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Gibson, Jane, Giedraitis, Vilmantas, Gjesing, Anette P., Gordon-Larsen, Penny, Gorski, Mathias, Grabe, Hans-Jörgen, Grant, Struan F. A., Grarup, Niels, Griffiths, Helen L., Grove, Megan L., Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeff, Hakonarson, Hakon, Hammerschlag, Anke R., Hansen, Torben, Harris, Kathleen Mullan, Harris, Tamara B., Hattersley, Andrew T., Have, Christian T., Hayward, Caroline, He, Liang, Heard-Costa, Nancy L., Heath, Andrew C., Heid, Iris M., Helgeland, Øyvind, Hernesniemi, Jussi, Hewitt, Alex W., Holmen, Oddgeir L., Hovingh, G. Kees, Howson, Joanna M. M., Hu, Yao, Huang, Paul L., Huffman, Jennifer E., Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jansson, Jan-Håkan, Jarvik, Gail P., Jensen, Gorm B., Jia, Yucheng, Johansson, Stefan, Jørgensen, Marit E., Jørgensen, Torben, Jukema, J. Wouter, Kahali, Bratati, Kahn, René S., Kähönen, Mika, Kamstrup, Pia R., Kanoni, Stavroula, Kaprio, Jaakko, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kathiresan, Sekar, Kee, Frank, Kiemeney, Lambertus A., Kim, Eric, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S., Kooperberg, Charles, Korhonen, Tellervo, Kovacs, Peter, Kuivaniemi, Helena, Kutalik, Zoltán, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lamparter, David, Lange, Ethan M., Lange, Leslie A., Langenberg, Claudia, Larson, Eric B., Lee, Nanette R., Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Honghuang, Lin, Keng-Hung, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J., Liu, Yongmei, Lo, Ken S., Lophatananon, Artitaya, Lotery, Andrew J., Loukola, Anu, Luan, Jian’an, Lubitz, Steven A., Lyytikäinen, Leo-Pekka, Männistö, Satu, Marenne, Gaëlle, Mazul, Angela L., McCarthy, Mark I., McKean-Cowdin, Roberta, Medland, Sarah E., Meidtner, Karina, Milani, Lili, Mistry, Vanisha, Mitchell, Paul, Mohlke, Karen L., Moilanen, Leena, Moitry, Marie, Montgomery, Grant W., Mook-Kanamori, Dennis O., Moore, Carmel, Mori, Trevor A., Morris, Andrew D., Morris, Andrew P., Müller-Nurasyid, Martina, Munroe, Patricia B., Nalls, Mike A., Narisu, Narisu, Nelson, Christopher P., Neville, Matt, Nielsen, Sune F., Nikus, Kjell, Njølstad, Pål R., Nordestgaard, Børge G., Nyholt, Dale R., O’Connel, Jeffrey R., O’Donoghue, Michelle L., Olde Loohuis, Loes M., Ophoff, Roel A., Owen, Katharine R., Packard, Chris J., Padmanabhan, Sandosh, Palmer, Colin N. A., Palmer, Nicholette D., Pasterkamp, Gerard, Patel, Aniruddh P., Pattie, Alison, Pedersen, Oluf, Peissig, Peggy L., Peloso, Gina M., Pennell, Craig E., Perola, Markus, Perry, James A., Perry, John R. B., Pers, Tune H., Person, Thomas N., Peters, Annette, Petersen, Eva R. B., Peyser, Patricia A., Pirie, Ailith, Polasek, Ozren, Polderman, Tinca J., Puolijoki, Hannu, Raitakari, Olli T., Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F., Renström, Frida, Rheinberger, Myriam, Ridker, Paul M., Rioux, John D., Rivas, Manuel A., Roberts, David J., Robertson, Neil R., Robino, Antonietta, Rolandsson, Olov, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Sapkota, Yadav, Sattar, Naveed, Schoen, Robert E., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo P., Shah, Svati H., Sheu, Wayne H.-H., Sim, Xueling, Slater, Andrew J., Small, Kerrin S., Smith, Albert V., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Starr, John M., Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swift, Amy J., Tada, Hayato, Tansey, Katherine E., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Tromp, Gerard, Trompet, Stella, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, Tyrer, Jonathan P., Uher, Rudolf, Uitterlinden, André G., Uusitupa, Matti, Laan, Sander W., Duijn, Cornelia M., Leeuwen, Nienke, van Setten, Jessica, Vanhala, Mauno, Varbo, Anette, Varga, Tibor V., Varma, Rohit, Velez Edwards, Digna R., Vermeulen, Sita H., Veronesi, Giovanni, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Völker, Uwe, Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wang, Yiqin, Ware, Erin B., Wareham, Nicholas J., Warren, Helen R., Waterworth, Dawn M., Wessel, Jennifer, White, Harvey D., Willer, Cristen J., Wilson, James G., Witte, Daniel R., Wood, Andrew R., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yao, Pang, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zhao, Wei, Zhou, Wei, Zondervan, Krina T, Rotter, Jerome I., Pospisilik, John A., Rivadeneira, Fernando, Borecki, Ingrid B., Deloukas, Panos, Frayling, Timothy M., Lettre, Guillaume, North, Kari E., Lindgren, Cecilia M., Hirschhorn, Joel N., Loos, Ruth J. F., CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, and Understanding Society Scientific Group

Published
2018
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41. Carbon Cycling in Northern Peatlands

Author

Andrew J. Baird, Lisa R. Belyea Belyea, Xavier Comas, A. S. Reeve, Lee D. Slater, Andrew J. Baird, Lisa R. Belyea Belyea, Xavier Comas, A. S. Reeve, Lee D. Slater and Andrew J. Baird, Lisa R. Belyea Belyea, Xavier Comas, A. S. Reeve, Lee D. Slater, Andrew J. Baird, Lisa R. Belyea Belyea, Xavier Comas, A. S. Reeve, Lee D. Slater

Published
2013

44. As far inside as he can go: Iraq war veteran and the yellow birds author Kevin Powers talks about his new book of poems, writing about the effects of violence as a perpetrator and a victim, and about the sense of isolation that drives his work in both poetry and prose

Author

Slater, Andrew

Subjects
Literature/writing
Abstract

KEVIN POWERS first appeared on readers' radar in September 2012 when his debut novel, The Yellow Birds, was published to great acclaim by Little, Brown. Drawn from his experiences as [...]

Published
2014

45. Quality control within the multicentre perfusion CT study of primary colorectal cancer (PROSPeCT): results of an iodine density phantom study

Author

Lewis, Maria, Goh, Vicky, Beggs, Shaun, Bridges, Andrew, Clewer, Philip, Davis, Anne, Foy, Trevelyan, Fuller, Karen, George, Jennifer, Higginson, Antony, Honey, Ian, Iball, Gareth, Mutch, Steve, Neil, Shellagh, Rivett, Cat, Slater, Andrew, Sutton, David, Weir, Nick, Wayte, Sarah, and on behalf of the PROSPeCT Investigators

Published
2014
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47. 2016 International Land Model Benchmarking (ILAMB) Workshop Report

Author

Hoffman, Forrest M, Koven, Charles D, Keppel-Aleks, Gretchen, Lawrence, David M, Riley, William J, Randerson, James T, Ahlstrom, Anders, Abramowitz, Gabriel, Baldocchi, Dennis D, Best, Martin J, Bond-Lamberty, Ben, De Kauwe, Martin G, Denning, A. Scott, Desai, Ankur, Eyring, Veronika, Fisher, Joshua B, Fisher, Rosie A, Gleckler, Peter J, Huang, Maoyi, Hugelius, Gustaf, Jain, Atul K, Kiang, Nancy Y, Kim, Hyungjun, Koster, Randal D, Kumar, Sujay V, Li, Hongyi, Luo, Yiqi, Mao, Jiafu, McDowell, Nathan G, Mishra, Umakant, Moorcroft, Paul R, Pau, George S. H, Ricciuto, Daniel M, Schaefer, Kevin, Schwalm, Christopher R, Serbin, Shawn P, Shevliakova, Elena, Slater, Andrew G, Tang, Jinyun, Williams, Mathew, Xia, Jianyang, Xu, Chonggang, Joseph, Renu, and Koch, Dorothy

Subjects
Meteorology And Climatology
Abstract

As earth system models (ESMs) become increasingly complex, there is a growing need for comprehensive and multi-faceted evaluation of model projections. To advance understanding of terrestrial biogeochemical processes and their interactions with hydrology and climate under conditions of increasing atmospheric carbon dioxide, new analysis methods are required that use observations to constrain model predictions, inform model development, and identify needed measurements and field experiments. Better representations of biogeochemistryclimate feedbacks and ecosystem processes in these models are essential for reducing the acknowledged substantial uncertainties in 21st century climate change projections.

Published
2016
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48. Effects of Frozen Soil on Soil Temperature, Spring Infiltration, and Runoff : Results from the PILPS 2(d) Experiment at Valdai, Russia

Author

Luo, Lifeng, Robock, Alan, Vinnikov, Konstantin Y., Schlosser, C. Adam, Slater, Andrew G., Boone, Aaron, Braden, Harald, Cox, Peter, de Rosnay, Patricia, Dickinson, Robert E., Dai, Yongjiu, Duan, Qingyun, Etchevers, Pierre, Henderson-Sellers, Ann, Gedney, Nicola, Gusev, Yevgeniy M., Habets, Florence, Kim, Jinwon, Kowalczyk, Eva, Mitchell, Kenneth, Nasonova, Olga N., Noilhan, Joel, Pitman, Andrew J., Schaake, John, Shmakin, Andrey B., Smirnova, Tatiana G., Wetzel, Peter, Xue, Yongkang, Yang, Zong-Liang, and Zeng, Qing-Cun

Published
2003

50. Angkor W(h)at? And why?

Author

Slater, Andrew

Subjects
*INDUSTRIAL revolution, *PROGRESS, *BRITISH Civil War, 1642-1649, *RECOLLECTION (Psychology)
Abstract

The article discusses the importance of teaching students the significance of history and empowering them to question why certain topics are studied. The author shares his experience of using the Khmer Empire as a substantive content to teach Year 7 students the importance of history. The author argues that historical significance should be explicitly tackled in Key Stage 3 and proposes using the structure of historical research as a framework for curriculum design.

Published
2023

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