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1. FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy

Author

Chan, Jack D., Scheffler, Christina M., Munoz, Isabelle, Sek, Kevin, Lee, Joel N., Huang, Yu-Kuan, Yap, Kah Min, Saw, Nicole Y. L., Li, Jasmine, Chen, Amanda X. Y., Chan, Cheok Weng, Derrick, Emily B., Todd, Kirsten L., Tong, Junming, Dunbar, Phoebe A., Li, Jiawen, Hoang, Thang X., de Menezes, Maria N., Petley, Emma V., Kim, Joelle S., Nguyen, Dat, Leung, Patrick S. K., So, Joan, Deguit, Christian, Zhu, Joe, House, Imran G., Kats, Lev M., Scott, Andrew M., Solomon, Benjamin J., Harrison, Simon J., Oliaro, Jane, Parish, Ian A., Quinn, Kylie M., Neeson, Paul J., Slaney, Clare Y., Lai, Junyun, Beavis, Paul A., and Darcy, Phillip K.

Published
2024
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3. Enterotoxins can support CAR T cells against solid tumors

Author

von Scheidt, Bianca, Wang, Minyu, Oliver, Amanda J., Chan, Jack D., Jana, Metta K., Ali, Aesha I., Clow, Fiona, Fraser, John D., Quinn, Kylie M., Darcy, Phillip K., Kershaw, Michael H., and Slaney, Clare Y.

Published
2019

4. Supplementary Figure 2 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer

Author

Rautela, Jai, primary, Baschuk, Nikola, primary, Slaney, Clare Y., primary, Jayatilleke, Krishnath M., primary, Xiao, Kun, primary, Bidwell, Bradley N., primary, Lucas, Erin C., primary, Hawkins, Edwin D., primary, Lock, Peter, primary, Wong, Christina S., primary, Chen, Weisan, primary, Anderson, Robin L., primary, Hertzog, Paul J., primary, Andrews, Daniel M., primary, Möller, Andreas, primary, and Parker, Belinda S., primary

Published
2023
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5. Data from Dual PD-1 and CTLA-4 Checkpoint Blockade Promotes Antitumor Immune Responses through CD4+Foxp3− Cell–Mediated Modulation of CD103+ Dendritic Cells

Author

Beavis, Paul A., primary, Henderson, Melissa A., primary, Giuffrida, Lauren, primary, Davenport, Alexander J., primary, Petley, Emma V., primary, House, Imran G., primary, Lai, Junyun, primary, Sek, Kevin, primary, Milenkovski, Nicole, primary, John, Liza B., primary, Mardiana, Sherly, primary, Slaney, Clare Y., primary, Trapani, Joseph A., primary, Loi, Sherene, primary, Kershaw, Michael H., primary, Haynes, Nicole M., primary, and Darcy, Phillip K., primary

Published
2023
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6. Figure S2 from Dual PD-1 and CTLA-4 Checkpoint Blockade Promotes Antitumor Immune Responses through CD4+Foxp3− Cell–Mediated Modulation of CD103+ Dendritic Cells

Author

Beavis, Paul A., primary, Henderson, Melissa A., primary, Giuffrida, Lauren, primary, Davenport, Alexander J., primary, Petley, Emma V., primary, House, Imran G., primary, Lai, Junyun, primary, Sek, Kevin, primary, Milenkovski, Nicole, primary, John, Liza B., primary, Mardiana, Sherly, primary, Slaney, Clare Y., primary, Trapani, Joseph A., primary, Loi, Sherene, primary, Kershaw, Michael H., primary, Haynes, Nicole M., primary, and Darcy, Phillip K., primary

Published
2023
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7. Supplementary Figure 3 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer

Author

Rautela, Jai, primary, Baschuk, Nikola, primary, Slaney, Clare Y., primary, Jayatilleke, Krishnath M., primary, Xiao, Kun, primary, Bidwell, Bradley N., primary, Lucas, Erin C., primary, Hawkins, Edwin D., primary, Lock, Peter, primary, Wong, Christina S., primary, Chen, Weisan, primary, Anderson, Robin L., primary, Hertzog, Paul J., primary, Andrews, Daniel M., primary, Möller, Andreas, primary, and Parker, Belinda S., primary

Published
2023
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8. Supplementary Figure Legend from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer

Author

Rautela, Jai, primary, Baschuk, Nikola, primary, Slaney, Clare Y., primary, Jayatilleke, Krishnath M., primary, Xiao, Kun, primary, Bidwell, Bradley N., primary, Lucas, Erin C., primary, Hawkins, Edwin D., primary, Lock, Peter, primary, Wong, Christina S., primary, Chen, Weisan, primary, Anderson, Robin L., primary, Hertzog, Paul J., primary, Andrews, Daniel M., primary, Möller, Andreas, primary, and Parker, Belinda S., primary

Published
2023
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9. Supplementary Figure 4 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer

Author

Rautela, Jai, primary, Baschuk, Nikola, primary, Slaney, Clare Y., primary, Jayatilleke, Krishnath M., primary, Xiao, Kun, primary, Bidwell, Bradley N., primary, Lucas, Erin C., primary, Hawkins, Edwin D., primary, Lock, Peter, primary, Wong, Christina S., primary, Chen, Weisan, primary, Anderson, Robin L., primary, Hertzog, Paul J., primary, Andrews, Daniel M., primary, Möller, Andreas, primary, and Parker, Belinda S., primary

Published
2023
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10. Data from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer

Author

Rautela, Jai, primary, Baschuk, Nikola, primary, Slaney, Clare Y., primary, Jayatilleke, Krishnath M., primary, Xiao, Kun, primary, Bidwell, Bradley N., primary, Lucas, Erin C., primary, Hawkins, Edwin D., primary, Lock, Peter, primary, Wong, Christina S., primary, Chen, Weisan, primary, Anderson, Robin L., primary, Hertzog, Paul J., primary, Andrews, Daniel M., primary, Möller, Andreas, primary, and Parker, Belinda S., primary

Published
2023
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11. Supplementary Figure 1 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer

Author

Rautela, Jai, primary, Baschuk, Nikola, primary, Slaney, Clare Y., primary, Jayatilleke, Krishnath M., primary, Xiao, Kun, primary, Bidwell, Bradley N., primary, Lucas, Erin C., primary, Hawkins, Edwin D., primary, Lock, Peter, primary, Wong, Christina S., primary, Chen, Weisan, primary, Anderson, Robin L., primary, Hertzog, Paul J., primary, Andrews, Daniel M., primary, Möller, Andreas, primary, and Parker, Belinda S., primary

Published
2023
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12. Supplementary Figure legends from Dual PD-1 and CTLA-4 Checkpoint Blockade Promotes Antitumor Immune Responses through CD4+Foxp3− Cell–Mediated Modulation of CD103+ Dendritic Cells

Author

Beavis, Paul A., primary, Henderson, Melissa A., primary, Giuffrida, Lauren, primary, Davenport, Alexander J., primary, Petley, Emma V., primary, House, Imran G., primary, Lai, Junyun, primary, Sek, Kevin, primary, Milenkovski, Nicole, primary, John, Liza B., primary, Mardiana, Sherly, primary, Slaney, Clare Y., primary, Trapani, Joseph A., primary, Loi, Sherene, primary, Kershaw, Michael H., primary, Haynes, Nicole M., primary, and Darcy, Phillip K., primary

Published
2023
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13. Data from A Multifunctional Role for Adjuvant Anti-4-1BB Therapy in Augmenting Antitumor Response by Chimeric Antigen Receptor T Cells

Author

Mardiana, Sherly, primary, John, Liza B., primary, Henderson, Melissa A., primary, Slaney, Clare Y., primary, von Scheidt, Bianca, primary, Giuffrida, Lauren, primary, Davenport, Alexander J., primary, Trapani, Joseph A., primary, Neeson, Paul J., primary, Loi, Sherene, primary, Haynes, Nicole M., primary, Kershaw, Michael H., primary, Beavis, Paul A., primary, and Darcy, Phillip K., primary

Published
2023
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14. Data from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Author

Slaney, Clare Y., primary, von Scheidt, Bianca, primary, Davenport, Alexander J., primary, Beavis, Paul A., primary, Westwood, Jennifer A., primary, Mardiana, Sherly, primary, Tscharke, David C., primary, Ellis, Sarah, primary, Prince, H. Miles, primary, Trapani, Joseph A., primary, Johnstone, Ricky W., primary, Smyth, Mark J., primary, Teng, Michele W., primary, Ali, Aesha, primary, Yu, Zhiya, primary, Rosenberg, Steven A., primary, Restifo, Nicholas P., primary, Neeson, Paul, primary, Darcy, Phillip K., primary, and Kershaw, Michael H., primary

Published
2023
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15. Supplementary Figure 5 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Author

Slaney, Clare Y., primary, von Scheidt, Bianca, primary, Davenport, Alexander J., primary, Beavis, Paul A., primary, Westwood, Jennifer A., primary, Mardiana, Sherly, primary, Tscharke, David C., primary, Ellis, Sarah, primary, Prince, H. Miles, primary, Trapani, Joseph A., primary, Johnstone, Ricky W., primary, Smyth, Mark J., primary, Teng, Michele W., primary, Ali, Aesha, primary, Yu, Zhiya, primary, Rosenberg, Steven A., primary, Restifo, Nicholas P., primary, Neeson, Paul, primary, Darcy, Phillip K., primary, and Kershaw, Michael H., primary

Published
2023
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16. Supplementary Figure 4 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Author

Slaney, Clare Y., primary, von Scheidt, Bianca, primary, Davenport, Alexander J., primary, Beavis, Paul A., primary, Westwood, Jennifer A., primary, Mardiana, Sherly, primary, Tscharke, David C., primary, Ellis, Sarah, primary, Prince, H. Miles, primary, Trapani, Joseph A., primary, Johnstone, Ricky W., primary, Smyth, Mark J., primary, Teng, Michele W., primary, Ali, Aesha, primary, Yu, Zhiya, primary, Rosenberg, Steven A., primary, Restifo, Nicholas P., primary, Neeson, Paul, primary, Darcy, Phillip K., primary, and Kershaw, Michael H., primary

Published
2023
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17. Supplementary Figures 1 through 8 from A Multifunctional Role for Adjuvant Anti-4-1BB Therapy in Augmenting Antitumor Response by Chimeric Antigen Receptor T Cells

Author

Mardiana, Sherly, primary, John, Liza B., primary, Henderson, Melissa A., primary, Slaney, Clare Y., primary, von Scheidt, Bianca, primary, Giuffrida, Lauren, primary, Davenport, Alexander J., primary, Trapani, Joseph A., primary, Neeson, Paul J., primary, Loi, Sherene, primary, Haynes, Nicole M., primary, Kershaw, Michael H., primary, Beavis, Paul A., primary, and Darcy, Phillip K., primary

Published
2023
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18. Supplementary Figure 2 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Author

Slaney, Clare Y., primary, von Scheidt, Bianca, primary, Davenport, Alexander J., primary, Beavis, Paul A., primary, Westwood, Jennifer A., primary, Mardiana, Sherly, primary, Tscharke, David C., primary, Ellis, Sarah, primary, Prince, H. Miles, primary, Trapani, Joseph A., primary, Johnstone, Ricky W., primary, Smyth, Mark J., primary, Teng, Michele W., primary, Ali, Aesha, primary, Yu, Zhiya, primary, Rosenberg, Steven A., primary, Restifo, Nicholas P., primary, Neeson, Paul, primary, Darcy, Phillip K., primary, and Kershaw, Michael H., primary

Published
2023
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19. Supplementary Figure 7 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer

Author

Ali, Aesha I., primary, Wang, Minyu, primary, von Scheidt, Bianca, primary, Dominguez, Pilar M., primary, Harrison, Aaron J., primary, Tantalo, Daniela G.M., primary, Kang, Jian, primary, Oliver, Amanda J., primary, Chan, Jack D., primary, Du, Xin, primary, Bai, Yuchen, primary, Lee, Belinda, primary, Johnstone, Ricky W., primary, Darcy, Phillip K., primary, Kershaw, Michael H., primary, and Slaney, Clare Y., primary

Published
2023
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20. Supplementary Figure 3 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Author

Slaney, Clare Y., primary, von Scheidt, Bianca, primary, Davenport, Alexander J., primary, Beavis, Paul A., primary, Westwood, Jennifer A., primary, Mardiana, Sherly, primary, Tscharke, David C., primary, Ellis, Sarah, primary, Prince, H. Miles, primary, Trapani, Joseph A., primary, Johnstone, Ricky W., primary, Smyth, Mark J., primary, Teng, Michele W., primary, Ali, Aesha, primary, Yu, Zhiya, primary, Rosenberg, Steven A., primary, Restifo, Nicholas P., primary, Neeson, Paul, primary, Darcy, Phillip K., primary, and Kershaw, Michael H., primary

Published
2023
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21. Supplementary Figure 3 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer

Author

Ali, Aesha I., primary, Wang, Minyu, primary, von Scheidt, Bianca, primary, Dominguez, Pilar M., primary, Harrison, Aaron J., primary, Tantalo, Daniela G.M., primary, Kang, Jian, primary, Oliver, Amanda J., primary, Chan, Jack D., primary, Du, Xin, primary, Bai, Yuchen, primary, Lee, Belinda, primary, Johnstone, Ricky W., primary, Darcy, Phillip K., primary, Kershaw, Michael H., primary, and Slaney, Clare Y., primary

Published
2023
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22. Supplementary Figure 4 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer

Author

Ali, Aesha I., primary, Wang, Minyu, primary, von Scheidt, Bianca, primary, Dominguez, Pilar M., primary, Harrison, Aaron J., primary, Tantalo, Daniela G.M., primary, Kang, Jian, primary, Oliver, Amanda J., primary, Chan, Jack D., primary, Du, Xin, primary, Bai, Yuchen, primary, Lee, Belinda, primary, Johnstone, Ricky W., primary, Darcy, Phillip K., primary, Kershaw, Michael H., primary, and Slaney, Clare Y., primary

Published
2023
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23. Supplementary Figure 6 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Author

Slaney, Clare Y., primary, von Scheidt, Bianca, primary, Davenport, Alexander J., primary, Beavis, Paul A., primary, Westwood, Jennifer A., primary, Mardiana, Sherly, primary, Tscharke, David C., primary, Ellis, Sarah, primary, Prince, H. Miles, primary, Trapani, Joseph A., primary, Johnstone, Ricky W., primary, Smyth, Mark J., primary, Teng, Michele W., primary, Ali, Aesha, primary, Yu, Zhiya, primary, Rosenberg, Steven A., primary, Restifo, Nicholas P., primary, Neeson, Paul, primary, Darcy, Phillip K., primary, and Kershaw, Michael H., primary

Published
2023
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24. Supplementary Figure 1 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer

Author

Ali, Aesha I., primary, Wang, Minyu, primary, von Scheidt, Bianca, primary, Dominguez, Pilar M., primary, Harrison, Aaron J., primary, Tantalo, Daniela G.M., primary, Kang, Jian, primary, Oliver, Amanda J., primary, Chan, Jack D., primary, Du, Xin, primary, Bai, Yuchen, primary, Lee, Belinda, primary, Johnstone, Ricky W., primary, Darcy, Phillip K., primary, Kershaw, Michael H., primary, and Slaney, Clare Y., primary

Published
2023
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25. Supplementary Figure 8 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer

Author

Ali, Aesha I., primary, Wang, Minyu, primary, von Scheidt, Bianca, primary, Dominguez, Pilar M., primary, Harrison, Aaron J., primary, Tantalo, Daniela G.M., primary, Kang, Jian, primary, Oliver, Amanda J., primary, Chan, Jack D., primary, Du, Xin, primary, Bai, Yuchen, primary, Lee, Belinda, primary, Johnstone, Ricky W., primary, Darcy, Phillip K., primary, Kershaw, Michael H., primary, and Slaney, Clare Y., primary

Published
2023
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26. Supplementary Figure 5 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer

Author

Ali, Aesha I., primary, Wang, Minyu, primary, von Scheidt, Bianca, primary, Dominguez, Pilar M., primary, Harrison, Aaron J., primary, Tantalo, Daniela G.M., primary, Kang, Jian, primary, Oliver, Amanda J., primary, Chan, Jack D., primary, Du, Xin, primary, Bai, Yuchen, primary, Lee, Belinda, primary, Johnstone, Ricky W., primary, Darcy, Phillip K., primary, Kershaw, Michael H., primary, and Slaney, Clare Y., primary

Published
2023
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27. Supplementary Figure 1 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Author

Slaney, Clare Y., primary, von Scheidt, Bianca, primary, Davenport, Alexander J., primary, Beavis, Paul A., primary, Westwood, Jennifer A., primary, Mardiana, Sherly, primary, Tscharke, David C., primary, Ellis, Sarah, primary, Prince, H. Miles, primary, Trapani, Joseph A., primary, Johnstone, Ricky W., primary, Smyth, Mark J., primary, Teng, Michele W., primary, Ali, Aesha, primary, Yu, Zhiya, primary, Rosenberg, Steven A., primary, Restifo, Nicholas P., primary, Neeson, Paul, primary, Darcy, Phillip K., primary, and Kershaw, Michael H., primary

Published
2023
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28. Supplementary Figure 6 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer

Author

Ali, Aesha I., primary, Wang, Minyu, primary, von Scheidt, Bianca, primary, Dominguez, Pilar M., primary, Harrison, Aaron J., primary, Tantalo, Daniela G.M., primary, Kang, Jian, primary, Oliver, Amanda J., primary, Chan, Jack D., primary, Du, Xin, primary, Bai, Yuchen, primary, Lee, Belinda, primary, Johnstone, Ricky W., primary, Darcy, Phillip K., primary, Kershaw, Michael H., primary, and Slaney, Clare Y., primary

Published
2023
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29. Supplementary Figure 2 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer

Author

Ali, Aesha I., primary, Wang, Minyu, primary, von Scheidt, Bianca, primary, Dominguez, Pilar M., primary, Harrison, Aaron J., primary, Tantalo, Daniela G.M., primary, Kang, Jian, primary, Oliver, Amanda J., primary, Chan, Jack D., primary, Du, Xin, primary, Bai, Yuchen, primary, Lee, Belinda, primary, Johnstone, Ricky W., primary, Darcy, Phillip K., primary, Kershaw, Michael H., primary, and Slaney, Clare Y., primary

Published
2023
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34. Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

Author

Beavis, Paul A., Henderson, Melissa A., Giuffrida, Lauren, Mills, Jane K., Sek, Kevin, Cross, Ryan S., Davenport, Alexander J., John, Liza B., Mardiana, Sherly, Slaney, Clare Y., Johnstone, Ricky W., Trapani, Joseph A., Stagg, John, Loi, Sherene, Kats, Lev, Gyorki, David, Kershaw, Michael H., and Darcy, Phillip K.

Subjects
Antigens -- Physiological aspects -- Research, Leukemia -- Drug therapy, T cells -- Health aspects -- Research, Health care industry
Abstract

Chimeric antigen receptor (CAR) T cells have been highly successful in treating hematological malignancies, including acute and chronic lymphoblastic leukemia. However, treatment of solid tumors using CAR T cells has been largely unsuccessful to date, partly because of tumor-induced immunosuppressive mechanisms, including adenosine production. Previous studies have shown that adenosine generated by tumor cells potently inhibits endogenous antitumor T cell responses through activation of adenosine 2A receptors ([A.sub.2A]Rs). Herein, we have observed that CAR activation resulted in increased [A.sub.2A]R expression and suppression of both murine and human CAR T cells. This was reversible using either [A.sub.2A]R antagonists or genetic targeting of A2AR using shRNA. In 2 syngeneic [HER2.sup.+] self-antigen tumor models, we found that either genetic or pharmacological targeting of the [A.sub.2A]R profoundly increased CAR T cell efficacy, particularly when combined with PD-1 blockade. Mechanistically, this was associated with increased cytokine production of [CD8.sup.+] CAR T cells and increased activation of both [CD8.sup.+] and [CD4.sup.+] CAR T cells. Given the known clinical relevance of the CD73/adenosine pathway in several solid tumor types, and the initiation of phase I trials for [A.sub.2A]R antagonists in oncology, this approach has high translational potential to enhance CAR T cell efficacy in several cancer types., Introduction The success of immunotherapy in cancer in recent years has highlighted the potential to utilize a patient's immune system to eradicate cancer. With adoptive cellular therapy, this conventionally involves [...]

Published
2017
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35. Enhancing Adoptive Cell Transfer with Combination BRAF-MEK and CDK4/6 Inhibitors in Melanoma

Author

Lau, Peter Kar Han, primary, Cullinane, Carleen, additional, Jackson, Susan, additional, Walker, Rachael, additional, Smith, Lorey K., additional, Slater, Alison, additional, Kirby, Laura, additional, Patel, Riyaben P., additional, von Scheidt, Bianca, additional, Slaney, Clare Y., additional, McArthur, Grant A., additional, and Sheppard, Karen E., additional

Published
2021
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37. A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer

Author

Ali, Aesha I., primary, Wang, Minyu, additional, von Scheidt, Bianca, additional, Dominguez, Pilar M., additional, Harrison, Aaron J., additional, Tantalo, Daniela G.M., additional, Kang, Jian, additional, Oliver, Amanda J., additional, Chan, Jack D., additional, Du, Xin, additional, Bai, Yuchen, additional, Lee, Belinda, additional, Johnstone, Ricky W., additional, Darcy, Phillip K., additional, Kershaw, Michael H., additional, and Slaney, Clare Y., additional

Published
2021
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38. Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

Author

Bidwell, Bradley N., Slaney, Clare Y., Withana, Nimali P., Forster, Sam, Cao, Yuan, Loi, Sherene, Andrews, Daniel, Mikeska, Thomas, Mangan, Niamh E., Samarajiwa, Shamith A., Weerd, Nicole A. de, Gould, Jodee, Argani, Pedram, Moller, Andreas, Smyth, Mark J., Anderson, Robin L., Hertzog, Paul J., and Parker, Belinda S.

Subjects
Metastasis -- Genetic aspects, Gene silencing -- Research, Cancer cells -- Genetic aspects, Human immunogenetics -- Research, Breast cancer -- Development and progression -- Care and treatment, Bones -- Genetic aspects, Biological sciences, Health
Abstract

Breast cancer metastasis is a key determinant of long-term patient survival. By comparing the transcriptomes of primary and metastatic tumor cells in a mouse model of spontaneous bone metastasis, we found that a substantial number of genes suppressed in bone metastases are targets of the interferon regulatory factor Irf7. Restoration of Irf7 in tumor cells or administration of interferon led to reduced bone metastases and prolonged survival time. In mice deficient in the interferon (IFN) receptor or in natural killer (NK) and CD8+ T cell responses, metastasis was accelerated, indicating that Irf7-driven suppression of metastasis was reliant on IFN signaling to host immune cells. We confirmed the clinical relevance of these findings in over 800 patients in which high expression of Irf7-regulated genes in primary tumors was associated with prolonged bone metastasis-free survival. This gene signature may identify patients that could benefit from IFN-based therapies. Thus, we have identified an innate immune pathway intrinsic to breast cancer cells, the suppression of which restricts immunosurveillance to enable metastasis., Breast cancer can be treated successfully when detected early, but patient survival decreases markedly once metastatic spread to tissues such as bone and lung occurs (1). Key factors influencing metastases [...]

Published
2012
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49. Enhancing chimeric antigen receptor T‐cell immunotherapy against cancer using a nanoemulsion‐based vaccine targeting cross‐presenting dendritic cells

Author

Chan, Jack D, primary, Scheidt, Bianca, additional, Zeng, Bijun, additional, Oliver, Amanda J, additional, Davey, Ashleigh S, additional, Ali, Aesha I, additional, Thomas, Ranjeny, additional, Trapani, Joseph A, additional, Darcy, Phillip K, additional, Kershaw, Michael H, additional, Dolcetti, Riccardo, additional, and Slaney, Clare Y, additional

Published
2020
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