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10 results on '"Slaitas, Andis"'

1. Whole-Genome Sequencing of 502 Individuals from Latvia: The First Step towards a Population-Specific Reference of Genetic Variation

Author

Reščenko, Raimonds, primary, Brīvība, Monta, additional, Atava, Ivanna, additional, Rovīte, Vita, additional, Pečulis, Raitis, additional, Silamiķelis, Ivars, additional, Ansone, Laura, additional, Megnis, Kaspars, additional, Birzniece, Līga, additional, Leja, Mārcis, additional, Xu, Liqin, additional, Shi, Xulian, additional, Zhou, Yan, additional, Slaitas, Andis, additional, Hou, Yong, additional, and Kloviņš, Jānis, additional

Published
2023
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2. The Precision Toxicology Initiative

Author

Busquet, François, primary, Laperrouze, Jeanne, additional, Jankovic, Katica, additional, Krsmanovic, Tamara, additional, Ignasiak, Tomasz, additional, Leoni, Benedetta, additional, Apic, Gordana, additional, Asole, Giovanni, additional, Guigó, Roderic, additional, Marangio, Paolo, additional, Palumbo, Emilio, additional, Perez-Lluch, Silvia, additional, Wucher, Valentin, additional, Vlot, Anna Hendrika, additional, Anholt, Robert, additional, Mackay, Trudy, additional, Escher, Beate I., additional, Grasse, Nico, additional, Huchthausen, Julia, additional, Massei, Riccardo, additional, Reemtsma, Thorsten, additional, Scholz, Stefan, additional, Schüürmann, Gerrit, additional, Bondesson, Maria, additional, Cherbas, Peter, additional, Freedman, Jonathan H., additional, Glaholt, Stephen, additional, Holsopple, Jessica, additional, Jacobson, Stephen C., additional, Kaufman, Thomas, additional, Popodi, Ellen, additional, Shaw, Joseph J., additional, Smoot, Shannon, additional, Tennessen, Jason M., additional, Churchill, Gary, additional, von Clausbruch, Christina Cramer, additional, Dickmeis, Thomas, additional, Hayot, Gaëlle, additional, Pace, Giuseppina, additional, Peravali, Ravindra, additional, Weiss, Carsten, additional, Cistjakova, Nadezda, additional, Liu, Xin, additional, Slaitas, Andis, additional, Brown, James (Ben), additional, Ayerbe, Rafael, additional, Cabellos, Joan, additional, Cerro-Gálvez, Elena, additional, Diez-Ortiz, María, additional, González, Verónica, additional, Martínez, Rubén, additional, Vives, Patricia Solórzano, additional, Barnett, Rosemary, additional, Lawson, Thomas, additional, Lee, Robert G., additional, Sostare, Elena, additional, Viant, Mark, additional, Grafström, Roland, additional, Hongisto, Vesa, additional, Kohonen, Pekka, additional, Patyra, Konrad, additional, Bhaskar, Pradeep Kumar, additional, Garmendia-Cedillos, Marcial, additional, Farooq, Ibraheem, additional, Oliver, Brian, additional, Pohida, Tom, additional, Salem, Ghadi, additional, Jacobson, Daniel, additional, Andrews, Elisabeth, additional, Barnard, Marianne, additional, Čavoški, Aleksandra, additional, Chaturvedi, Anurag, additional, Colbourne, John K., additional, Epps, David J.T., additional, Holden, Laura, additional, Jones, Martin R., additional, Li, Xiaojing, additional, Müller, Ferenc, additional, Ormanin-Lewandowska, Agata, additional, Orsini, Luisa, additional, Roberts, Ruth, additional, Weber, Ralf J.M., additional, Zhou, Jiarui, additional, Chung, Mu-En, additional, Sanchez, Juan Carlos Gonzalez, additional, Diwan, Gaurav D., additional, Singh, Gurdeep, additional, Strähle, Uwe, additional, Russell, Robert B., additional, Batista, Dominique, additional, Sansone, Susanna-Assunta, additional, Rocca-Serra, Philippe, additional, Du Pasquier, David, additional, Lemkine, Gregory, additional, Robin-Duchesne, Barbara, additional, and Tindall, Andrew, additional

Published
2023
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3. 2′-O-(N-(Aminoethyl)carbamoyl)methyl Modification Allows for Lower Phosphorothioate Content in Splice-Switching Oligonucleotides with Retained Activity

Author

Honcharenko, Dmytro, primary, Rocha, Cristina S.J., additional, Lundin, Karin E., additional, Maity, Jyotirmoy, additional, Milton, Stefan, additional, Tedebark, Ulf, additional, Murtola, Merita, additional, Honcharenko, Malgorzata, additional, Slaitas, Andis, additional, Smith, C.I. Edvard, additional, Zain, Rula, additional, and Strömberg, Roger, additional

Published
2022
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4. Potent and orally efficacious benzothiazole amides as TRPV1 antagonists

Author

Besidski, Yevgeni, Brown, William, Bylund, Johan, Dabrowski, Michael, Dautrey, Sophie, Harter, Magali, Horoszok, Lucy, Hu, Yin, Johnson, Dean, Johnstone, Shawn, Jones, Paul, Leclerc, Sandrine, Kolmodin, Karin, Kers, Inger, Labarre, Maryse, Labrecque, Denis, Laird, Jennifer, Lundström, Therese, Martino, John, Maudet, Mickaël, Munro, Alexander, Nylöf, Martin, Penwell, Andrea, Rotticci, Didier, Slaitas, Andis, Sundgren-Andersson, Anna, Svensson, Mats, Terp, Gitte, Villanueva, Huascar, Walpole, Christopher, Zemribo, Ronald, and Griffin, Andrew M.

Published
2012
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5. Development of a new PNA analogue as a potential antisense drug and tool for life-science studies

Author

Slaitas, Andis and Slaitas, Andis

Abstract

The work described in this thesis focuses on applying synthetic organic chemistry methods (supported by modem synthesizers and analytical techniques) for the preparation of peptides and modified nucleic acids in order to affect certain properties in these biomolecules, which can lead to their application as drugs and/or tools for life sciences studies. The first part of the thesis reports the design and synthesis of a novel pyrrolidine-based peptide nucleic acid (PNA). Two enantiomers of the chiral pyrrolidine-containing unit were chemically synthesized and further incorporated into PNA fragments using modem automated solid-phase assembly methods. By comparison of their binding affinities to both DNA and RNA targets, it was found that such PNAs, due to their enhanced rigidity are able to recognize and bind to the complementary RNA strands with significantly larger affinity than to the complementary DNA. These findings may be utilized in the development of RNA-specific molecular probes, binding assays for cell extracts that contain mixtures of RNA and DNA, or targeting of viral RNAs, i.e. act as basis for the development of antisense drugs. With the rapid advancement of biochemistry and related sciences, there is an increasing demand for synthetic peptides. The development and application of a new type of peptide-coupling agent is described. This coupling agent is superior in some ways to the most commonly used commercial agents, since peptides obtained by its action are generally of higher enantiopurity, i.e. a significant reduction of racemization of the amino acid during coupling is obtained. The potential use of this agent in linking peptide segments has been studied and discussed. So called 'segment coupling' becomes economically valuable when either large synthetic peptides are to be made, or when a number of peptides, consisting mainly of highly conserved parts with differences in only a few amino acid residues, are desired. Alternatively, this coupling agent

Published
2004

9. SYNTHESIS AND HYBRIDIZATION OF NOVEL CHIRAL PYRROLIDINE BASED PNA ANALOGUE.

Author

Slaitas, Andis and Yeheskiely, Esther

Subjects
*NUCLEAR isomers, *PYRROLIDINE, *THYMINE, *RNA
Abstract

Four different PNA fragments containing units of either the R- or S- isomer of N-(2-pyrrolidine-methyl)-N-(thymine-1-acetyl)-glycine (Pmg) were synthesized on a solid support. UV thermal melting experiments with complementary RNAs were performed and it was found that R-Pmg containing PNAs bind better to RNA than those containing the S-Pmg units. [ABSTRACT FROM AUTHOR]

Published
2001
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