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Bei einem Fotovergleich, bei wessen Amtseinfuhrung mehr Menschen anwesend waren, verteidigte die damalige Regierungsberaterin von Donald Trump, Kellyanne Conway, die Aussage, Trump habe mehr Publikum angezogen als Obama. Da staunten Wissenschaftler, da staunten Philosophen, im Prinzip staunte die ganze Weltoffentlichkeit nicht schlecht – offenkundig war das Gegenteil der Fall. Bei Trump war, fur jeden erkennbar, gahnende Leere dort zu sehen, wo Obama seinerzeit Menschenmassen versammelt hatte.

Fragmentation of the system-on-chip supply chain has introduced many vulnerabilities in electronic devices. A proposed platform solution lets supply-chain participants authenticate, track, provision, and analyze their products during the entire chip life cycle through a single root of trust in the form of unique chip IDs.

This chapter provides an overview of the origins of monastic interreligious dialogue, identifies some of its major activities, including the multilingual journal Dilatato Corde and organizing meetings for interreligious dialogue such as the “Gethsemani Encounters,” “Nuns/Monks in the West,” and “Monks and Muslims,” and comments briefly on the evolution of the understanding of monastic interreligious dialogue in the light of Nostra Aetate. The author’s personal reflections as a monk and practitioner of dialogue permeate this analysis of the unique contribution monastics have made to interreligious engagement.

Antagonism of orexin receptors has shown clinical efficacy as a novel paradigm for the treatment of insomnia and related disorders. Herein, molecules related to the dual orexin receptor antagonist filorexant were transformed into compounds that were selective for the OX2R subtype. Judicious selection of the substituents on the pyridine ring and benzamide groups led to 6b; which was highly potent, OX2R selective, and exhibited excellent development properties.

In an ongoing effort to explore the use of orexin receptor antagonists for the treatment of insomnia, dual orexin receptor antagonists (DORAs) were structurally modified, resulting in compounds selective for the OX2R subtype and culminating in the discovery of 23, a highly potent, OX2R-selective molecule that exhibited a promising in vivo profile. Further structural modification led to an unexpected restoration of OX1R antagonism. Herein, these changes are discussed and a rationale for selectivity based on computational modeling is proposed.

Anomaly detection within non-numerical sequence data has developed into an important topic of data mining, but comparatively little research has been done regarding anomaly detection without training data unsupervised anomaly detection. One application found in computer security is the detection of a so-called masquerade attack, which consists of an attacker abusing a regular account. This leaves only the session input, which is basically a string of non-numerical commands, for analysis. Our previous approach to this problem introduced the use of the so-called average index difference function for mapping the non-numerical symbol data to a numerical space. In the present paper, we examine the theoretical properties of the average index difference function, present an enhanced unsupervised anomaly detection algorithm based on the average index difference function, show the parameters to be theoretically inferable, and evaluate the performance using real-world data. Copyright © 2014 John Wiley & Sons, Ltd.

Analogs of the dual orexin receptor antagonist filorexant were prepared. Replacement of the ether linkage proved highly sensitive toward modification with an acetylene linkage providing compounds with the best in vitro and in vivo potency profiles.

Largemouth bass (LMB) Micropterus salmoides fry do not accept prepared diets at first feeding. Fry are initially reared in fertilized ponds on natural live foods until large enough to be feed trained. Unpredictable weather patterns and depletion of natural forages can affect nursery pond survival. A series of experiments was conducted to investigate the use of Artemia nauplii prepared diets and optimal feeding schedules to raise LMB fry from first feeding through habituation to a commercial dry diet. In Studies 1, 2, and 3, swim-up fry were transferred to a recirculating system and stocked into either 3-L (Studies 1 and 2) or 10-L (Study 3) acrylic aquaria. Study 1 screened candidate diets to evaluate whether LMB fry could be transitioned directly to prepared diets or if they required live foods. In Study 2 the optimum duration for feeding live Artemia (1, 2, or 3 weeks) and the appropriate size of commercial diets (

The chemokine receptors, CCR(5) and CXCR(4), are the primary co-receptors responsible for mediating HIV-1 cell entry. Small molecules that antagonize these receptors utilize a fundamentally different approach for controlling viral replication than most other classes of antiretroviral agents in that they act on host cell factors rather than viral enzymes. Although CCR(5) modulators that demonstrate efficacy in the clinic against HIV have now become available, CXCR(4) antagonist development is at present at a more nascent stage. Due to the ability of HIV to switch between CCR(5) and CXCR(4) entry co-receptors, the development of a CXCR(4) antagonist is probably critical to prolonging the effectiveness of HIV therapies in patients. In addition, CXCR(4) antagonists represent a novel class of drugs that could be used for the treatment of diseases other than HIV/AIDS.An overview of the most pertinent chemical classes that modulate the CXCR(4) receptor, in addition to discussions of lead compound development.The review primarily covers patents and patent application publications filed in the past 8 years. However, earlier patents are included to provide a historical context.The early bicyclam class proved untenable for HIV treatment due to cardiotoxicity and lack of desirable pharmacokinetic properties. Second generation bicyclam mimics have the benefit of oral bioavailability but have, as yet, not proven successful in the clinic. The peptidomimetic analogues discussed capitalize on known receptor binding site interactions, which could lead to the development of potent and orally available CXCR(4) antagonists.