1. [Immunodiagnosis of retinoblastoma].
- Author
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Khvatova AV, Skriabina OA, Kargina IB, Arion VIa, and Kashirina NM
- Subjects
- Cell Migration Inhibition, Child, Preschool, Eye Neoplasms complications, Eye Neoplasms immunology, Humans, IgA Deficiency etiology, IgG Deficiency etiology, Immunodiffusion, Infant, Leukocyte Count, Lymphopenia etiology, Retinoblastoma complications, Retinoblastoma immunology, Rosette Formation, T-Lymphocytes pathology, Eye Neoplasms diagnosis, IgA Deficiency diagnosis, IgG Deficiency diagnosis, Lymphopenia diagnosis, Retinoblastoma diagnosis, T-Lymphocytes immunology
- Abstract
To improve the accuracy of early diagnosis of retinoblastoma, the authors have examined a number of cellular and humoral immunity parameters in 188 children with retinoblastomas, in 57 ones with nontumorous conditions of the eyes, and in healthy controls. Stages III-IV retinoblastoma was found associated with reduced blood levels of IgG and IgA and a still more marked reduction of both in the lacrimal fluid (4-fold), with reduced blood T lymphocyte count (by 1.5 times), decreased lymphocyte blastogenesis response to phytohemagglutinin (by 8-9 times), reduced leukocyte migration activity (MI = 79 +/- 10%), reduced serum thymic activity (by 2.5 times). The early (I-II) stage of the disease involves a lowering of only lacrimal fluid IgA (2-fold) and of the leukocyte migration index (MI) (89 +/- 2%). This index was found to be an important specific indicator for the early preoperative diagnosis of retinoblastoma. Leukocyte migration inhibition (MI less than 95%) by retinoblastoma antigens was observed only if this tumor was present. In cases with the nontumorous conditions and in health retinoblastoma antigens as a rule stimulated the leukocyte migration (MI over 95%).
- Published
- 1992