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3. A Low-Effort, Clinic-Wide Intervention Improves Attendance for HIV Primary Care

Author

Retention in Care Study Group, Gardner, Lytt I., Marks, Gary, Craw, Jason A., Wilson, Tracey E., Drainoni, Mari-Lynn, Moore, Richard D., Mugavero, Michael J., Rodriguez, Allan E., Bradley-Springer, Lucy A., Holman, Susan, Keruly, Jeanne C., Sullivan, Meg, Skolnik, Paul R., Malitz, Faye, Metsch, Lisa R., Raper, James L., and Giordano, Thomas P.

Published
2012
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8. Phase 2 Study of the Safety and Efficacy of Vicriviroc, a CCR5 Inhibitor, in HIV-1-Infected, Treatment-Experienced Patients: AIDS Clinical Trials Group 5211

Author

AIDS Clinical Trials Group 5211 Team, Gulick, Roy M., Su, Zhaohui, Flexner, Charles, Hughes, Michael D., Skolnik, Paul R., Wilkin, Timothy J., Gross, Robert, Krambrink, Amy, Coakley, Eoin, Greaves, Wayne L., Zolopa, Andrew, Reichman, Richard, Godfrey, Catherine, Hirsch, Martin, and Kuritzkes, Daniel R.

Published
2007
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13. Sex differences in atazanavir pharmacokinetics and associations with time to clinical events: AIDS Clinical Trials Group Study A5202

Author

Venuto, Charles S., Mollan, Katie, Ma, Qing, Daar, Eric S., Sax, Paul E., Fischl, Margaret, Collier, Ann C., Smith, Kimberly Y., Tierney, Camlin, Morse, Gene D., Bolivar, Hector H., Navarro, Sandra, Koletar, Susan L., Gochnour, Diane, Seefried, Edward, Hoffman, Julie, Feinberg, Judith, Saemann, Michelle, Patterson, Kristine, Pittard, Donna, Currin, David, Upton, Kerry, Saag, Michael, Ray, Graham, Johnson, Steven, Santos, Bartolo, Funk, Connie A., Morgan, Michael, Jackson, Brenda, Tebas, Pablo, Thomas, Aleshia, Kim, Ge-Youl, Klebert, Michael K., Santana, Jorge L., Marrero, Santiago, Norris, Jane, Valle, Sandra, Cox, Gary Matthew, Silberman, Martha, Shaik, Sadia, Lopez, Ruben, Vasquez, Margie, Daskalakis, Demetre, Megill, Christina, Stroberg, Todd, Shore, Jessica, Taiwo, Babafemi, Goldman, Mitchell, Boston, Molly, Lennox, Jeffrey, del Rio, Carlos, Lane, Timothy W., Epperson, Kim, Luetkemeyer, Annie, Payne, Mary, Gripshover, Barbara, Antosh, Dawn, Reid, Jane, Adams, Mary, Storey, Sheryl S., Dunaway, Shelia B., Gallant, Joel, Wiggins, Ilene, Smith, Kimberly Y., Swiatek, Joan A., Timpone, Joseph, Kumar, Princy, Moe, Ardis, Palmer, Maria, Gothing, Jon, Delaney, Joanne, Whitely, Kim, Anderson, Ann Marie, Hammer, Scott M., Yin, Michael T., Jain, Mamta, Petersen, Tianna, Corales, Roberto, Hurley, Christine, Henry, Keith, Bordenave, Bette, Youmans, Amanda, Albrecht, Mary, Pollard, Richard B., Olusanya, Abimbola, Skolnik, Paul R., Adams, Betsy, Tashima, Karen T., Patterson, Helen, Ukwu, Michelle, Rogers, Lauren, Balfour, Henry H., Jr, Fox, Kathy A., Swindells, Susan, Van Meter, Frances, Robbins, Gregory, Burgett-Yandow, Nicole, Davis, Charles E., Jr, Boyce, Colleen, OʼBrien, William A., Casey, Gerianne, Morse, Gene D., Hsaio, Chiu-Bin, Meier, Jeffrey L., Stapleton, Jack T., Mildvan, Donna, Revuelta, Manuel, Currin, David, El Sadr, Wafaa, Loquere, Avelino, El-Daher, Nyef, Johnson, Tina, Gross, Robert, Maffei, Kathyrn, Hughes, Valery, Sturge, Glenn, McMahon, Deborah, Rutecki, Barbara, Wulfsohn, Michael, Cheng, Andrew, Bischofberger, Norbert, Dix, Lynn, and Liao, Qiming

Published
2014
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15. The relationship of post-traumatic stress disorder and depression to antiretroviral medication adherence in persons with HIV

Author

Vranceanu, Ana Maria, Safren, Steven A., Lu, Minyi, Coady, William M., Skolnik, Paul R., Rogers, William H., and Wilson, Ira B.

Subjects
Post-traumatic stress disorder -- Health aspects, Highly active antiretroviral therapy -- Health aspects, Depression, Mental -- Health aspects, HIV patients -- Health aspects, Health
Abstract

In HIV/AIDS, symptoms of depression or post-traumatic stress may interfere with important self-care behaviors such as the ability to adhere to one's medical treatment regimen. However, these problems may frequently go undetected in HIV care settings. The present study used brief self-report screening measures of depression and post-traumatic stress disorder (PTSD) in the HIV/AIDS care settings to examine (1) frequency of positive screens for these diagnoses; (2) the degree to which those with a positive screen were prescribed antidepressant treatment; and (3) the association of continuous PTSD and depression symptom scores, and categorical (screening positive or negative) PTSD and depression screening status, to each other and to ART adherence as assessed by the Medication Event Monitoring System, regardless of antidepressant treatment. Participants were 164 HIV-infected individuals who took part in a multisite adherence intervention study in HIV treatment settings in Massachusetts. Available data from 5 time points was used, yielding 444 data points. Participants screened positive for PTSD at 20% of visits, and depression at 22% of visits. At visits when participants screened positive for both depression and PTSD, 53.6% of the time they were on an antidepressant. Those who screened positive for PTSD were more likely to also screen positive for depression. In multiple regression analyses that included both continuous and dichotomous PTSD and depression and controlled for shared variance due to clustering of multiple observations, only depression contributed significant unique variance, suggesting the primary role of depression and the secondary role of PTSD in poor adherence in individuals with HIV.

Published
2008

16. HIV type 1 chemokine coreceptor use among antiretroviral-experienced patients screened for a clinical trial of a CCR5 inhibitor: AIDS Clinical Trial Group A5211

Author

Wilkin, Timothy J., Su, Zhaohui, Kuritzkes, Daniel R., Hughes, Michael, Flexner, Charles, Gross, Robert, Coakley, Eoin, Greaves, Wayne, Godfrey, Catherine, Skolnik, Paul R., Timpone, Joseph, Rodriguez, Benigno, and Gulick, Roy M.

Subjects
Chemokine receptors -- Usage, HIV infection -- Development and progression, HIV infection -- Research, Health, Health care industry
Published
2007

18. Approaching the CDC's guidelines on the HIV testing of inpatients: physician-referral versus nonreferral-based testing

Author

Greenwald, Jeffrey L., Hall, Jonathan, and Skolnik, Paul R.

Subjects
United States. Centers for Disease Control and Prevention -- Powers and duties, HIV (Viruses) -- Testing, HIV (Viruses) -- Research, HIV patients -- Health aspects, Health
Abstract

Despite ongoing evidence that one quarter of HIV-infected people in the United States are unaware of their infection, widespread implementation of the Centers for Disease Control and Prevention's 1993 recommendations regarding routine inpatient HIV testing has not occurred. This study compares two HIV testing strategies: the initial phase of inpatient HIV testing (1999-2001) utilized a physician-referral-based system. The second phase (2001-2003) included the first 2 years' experience with having trained HIV counselors directly approach inpatients regarding their willingness to undergo voluntary HIV counseling and testing (VCT) without physician referral. This latter phase was prompted by a patient attitude survey demonstrating favorable responses to unsolicited approaches by staff regarding HIV testing. Barriers to implementing the latter strategy are discussed and initial experience with rapid HIV testing on this service is also presented. Referral-based testing yielded 2.3 patient referrals (6.4% of total admissions) resulting in 1.2 HIV tests and 0.7 counseling only sessions per day. Nonreferral based testing resulted 6.2 HIV tests and another 3.0 counseling-only sessions per day. HIV VCT on an inpatient service is feasible but challenging. Most patients respond favorably to being approached for VCT. Routinely offering HIV tests to inpatients yields higher testing rates than physician referral-based systems and increases the number of patients who know their HIV status. Recommendations for implementing routing HIV testing on an inpatient service are made.

Published
2006

19. Stimulation of peroxisome proliferator-activated receptors alpha and gamma blocks HIV-1 replication and TNFalpha production in acutely infected primary blood cells, chronically infected U1 celle, and alveolar macrophages from HIV-infected subjects

Author

Skolnik, Paul R., Rabbi, Mohammed F., Mathys, Jean-Marie, and Greenberg, Andrew S.

Subjects
Metabolism -- Genetic aspects, Blood cells -- Genetic aspects, Cytokines -- Genetic aspects, HIV infection -- Health aspects, HIV infection -- Research, Macrophages -- Genetic aspects, Health
Abstract

Research has been conducted on the metabolic disorders in HIV-infected patients. The hypothesis that mitogen-activated protein kinase signaling pathway's alterations have interrelated effect on HIV replication, lipid metabolism and cytokine production has been tested and the results are reported.

Published
2002

20. Role of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men

Author

Roubenoff, Ronenn, Grinspoon, Steven, Skolnik, Paul R., Tchetgen, Eric, Abad, Leslie, Spiegelman, Donna, Knox, Tamsin, and Gorbach, Sherwood

Subjects
Cytokines -- Physiological aspects, Testosterone -- Physiological aspects, Body composition -- Physiological aspects, HIV patients -- Physiological aspects, Biological sciences
Abstract

Role of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men. Am J Physiol Endocrinol Metab 283: E138-E145, 2002. First published March 27, 2002; 10.1152/ajpendo.00426.2001.--Although catastrophic weight loss is no longer common in HIV-infected men, we hypothesized that a more gradual process of cachexia [loss of lean body mass (LBM) without severe weight loss, often accompanied by elevated resting energy expenditure (REE)] is still common and is driven by excessive production of the catabolic cytokines tumor necrosis factor-[alpha] (TNF-[alpha]) and interleukin-1[beta] (IL-1[beta]). We performed a longitudinal analysis of an ongoing cohort study of nutritional status in 172 men with HIV infection. LBM loss of >1 kg occurred in 35% of the cohort, and LBM loss of >5% occurred in 12.2% over 8 mo of observation, but classical wasting (loss of [approximately equal to] 10% of weight) was rare (2%). Both TNF-[alpha] (-150 g LBM*[ng.sup.-1]* [ml.sup.-1], P < 0.02) and IL-1[beta] production (-130 g LBM*[ng.sup.-1]* [ml.sup.-1], P < 0.01) by peripheral blood mononuclear cells predicted loss of LBM. A rise in REE of >200 kcal/day was found in 17.7% of the subjects regardless of weight change. IL-1[beta] (+9 kcal/day per ng/ml, P < 0.002) and TNF-[alpha] (+10 kcal/day per ng/ml, P < 0.02) production predicted [delta]REE. Serum free testosterone was inversely associated with TNF-[alpha] production and was not an independent predictor of either [DELTA]LBM or [DELTA]REE after adjustment for cytokine production. Even though weight loss was rare in this cohort of patients treated with highly active antiretroviral therapy, loss of LBM was common and was driven by catabolic cytokines and not by inadequate dietary intake or hypogonadism.

Published
2002

25. The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation

Author

Pereyra, Florencia, Jia, Xiaoming, McLaren, Paul J., Telenti, Amalio, de Bakker, Paul I.W., Walker, Bruce D., Ripke, Stephan, Brumme, Chanson J., Pulit, Sara L, Carrington, Mary, Kadie, Carl M., Carlson, Jonathan M., Heckerman, David, Graham, Robert R., Plenge, Robert M., Deeks, Steven G., Gianniny, Lauren, Crawford, Gabriel, Sullivan, Jordan, Gonzalez, Elena, Davies, Leela, Camargo, Amy, Moore, Jamie M., Beattie, Nicole, Gupta, Supriya, Crenshaw, Andrew, Burtt, Noël P., Guiducci, Candace, Gupta, Namrata, Gao, Xiaojiang, Qi, Ying, Yuki, Yuko, Piechocka-Trocha, Alicja, Cutrell, Emily, Rosenberg, Rachel, Moss, Kristin L., Lemay, Paul, OʼLeary, Jessica, Schaefer, Todd, Verma, Pranshu, Toth, Ildiko, Block, Brian, Baker, Brett, Rothchild, Alissa, Lian, Jeffrey, Proudfoot, Jacqueline, Alvino, Marie L, Vine, Seanna, Addo, Marylyn M., Allen, Todd M., Altfeld, Marcus, Henn, Matthew R., Gall, Sylvie Le, Streeck, Hendrik, Haas, David W., Kuritzkes, Daniel R., Shafer, Robert W., Gulick, Roy M., Shikuma, Cecilia M., Haubrich, Richard, Riddler, Sharon, Sax, Paul E., Daar, Eric S., Ribaudo, Heather J., Agan, Brian, Agarwal, Shanu, Ahem, Richard L, Allen, Brady L., Altidor, Sherly, Altschuler, Eric L, Ambardar, Sujata, Anastos, Kathryn, Anderson, Ben, Anderson, Val, Andrady, Ushan, Antoniskis, Diana, Bangsberg, David, Barbaro, Daniel, Barrie, William, Bartzak, J., Barton, Simon, Basden, Patricia, Basgoz, Nesli, Bazner, Suzane, Bellos, Nicholaos C., Benson, Anne M., Berger, Judith, Bernard, Nicole F., Bemard, Annette M., Birch, Christopher, Bodner, Stanley J., Bolan, Robert K., Boudreaux, Emilie T., Bradley, Meg, Braun, James F., Brndjar, Jon E., Brown, Stephen J., Brown, Katherine, Brown, Sheldon T., Burack, Jedidiah, Bush, Larry M., Cafaro, Virginia, Campbell, Omobolaji, Campbell, John, Carlson, Robert H., Carmichael, Kevin J., Casey, Kathleen K., Cavacuiti, Chris, Celestin, Gregory, Chambers, Steven T., Chez, Nancy, Chirch, Lisa M., Cimoch, Paul J., Cohen, Daniel, Cohn, Lillian E., Conway, Brian, Cooper, David A., Cornelson, Brian, Cox, David T., Cristofano, Michael V., Cuchural, George, Jr., Czartoski, Julie L., Dahman, Joseph M., Daly, Jennifer S., Davis, Benjamin T., Davis, Kristine, Davod, Sheila M., DeJesus, Edwin, Dietz, Craig A., Dunham, Eleanor, Dunn, Michael E., Ellerin, Todd B., Eron, Joseph J., Fangman, John J.W., Farel, Claire E., Ferlazzo, Helen, Fidler, Sarah, Fleenor-Ford, Anita, Frankel, Renee, Freedberg, Kenneth A., French, Neel K., Fuchs, Jonathan D., Fuller, Jon D., Gaberman, Jonna, Gallant, Joel E., Gandhi, Rajesh T., Garcia, Efrain, Garmon, Donald, Gathe, Joseph C., Jr., Gaultier, Cyril R., Gebre, Wondwoosen, Gilman, Frank D., Gilson, Ian, Goepfert, Paul A., Gottlieb, Michael S., Goulston, Claudia, Groger, Richard K., Gurley, Douglas T., Haber, Stuart, Hardwicke, Robin, Hardy, David W., Harrigan, Richard P., Hawkins, Trevor N., Heath, Sonya, Hecht, Frederick M., Henry, Keith W., Hladek, Melissa, Hoffman, Robert P., Horton, James M., Hsu, Ricky K., Huhn, Gregory D., Hunt, Peter, Hupert, Mark J., Illeman, Mark L., Jaeger, Hans, Jellinger, Robert M., John, Mina, Johnson, Jennifer A., Johnson, Kristin L, Johnson, Heather, Johnson, Kay, Joly, Jennifer, Jordan, Wilbert C., Kauffman, Carol A., Khanlou, Homayoon, Kiltian, Robert K., Kim, Arthur Y., Kim, David D., Kinder, Clifford A., Kirchner, Jeffrey T., Kogelman, Laura, Kojic, Ema Milunka, Korthuis, Todd P., Kurisu, Wayne, Kwon, Douglas S., LaMar, Melissa, Lampiris, Harry, Lanzafame, Massimiliano, Lederman, Michael M., Lee, David M., Lee, Jean M.L, Lee, Marah J., Lee, Edward T.Y., Lemoine, Janice, Levy, Jay A., Llibre, Josep M., Liguori, Michael A., Little, Susan J., Liu, Anne Y., Lopez, Alvaro J., Loutfy, Mono R., Loy, Dawn, Mohammed, Debbie Y., Man, Alan, Mansour, Michael K., Marconi, Vincent C., Markowitz, Martin, Marques., Rui, Martin, Jeffrey N., Martin, Harold L., Jr., Mayer, Kenneth Hugh, McElrath, Juliana M., McGhee, Theresa A, McGovem, Barbara H., McGowan, Katherine, Mclntyre, Dawn, Mcleod, Gavin X., Menezes, Prema, Mesa, Greg, Metroka, Craig E., Meyer-Olson, Dirk, Miller, Andy O., Montgomery, Kate, Mounzer, Karam C., Nagami, Ellen H., Nagin, Iris, Nahass, Ronald G., Nelson, Margret O., Nielsen, Craig, Norene, David L, OʼConnor, David H., Ojikutu, Bisola O., Okulicz, Jason, Oladehin, Olakunle O., Oldfield, Edward C, III, Olender, Susan A., Ostrowski, Mario, Owen, William F., Jr., Pae, Eunice, Parsonnet, Jeffrey, Pavlatos, Andrew M., Perlmutter, Aaron M., Pierce, Michael N., Pincus, Jonathan M., Pisani, Leandro, Price, Lawrence Jay, Proia, Laurie, Prokesch, Richard C., Pujet, Heather Calderon, Ramgopal, Moti, Rathod, Almas, Rausch, Michael, Ravishankar, J., Rhame, Frank S., Richards, Constance Shamuyarira, Richman, Douglas D., Robbins, Gregory K., Rodes, Berta, Rodriguez, Milagros, Rose, Richard C., III, Rosenberg, Eric S., Rosenthal, Daniel, Ross, Polly E., Rubin, David S., Rumbaugh, Elease, Saenz, Luis, Salvaggio, Michelle R., Sanchez, William C., Sanjana, Veeraf M., Santiago, Steven, Schmidt, Wolfgang, Schuitemaker, Hanneke, Sestak, Philip M., Shalit, Peter, Shay, William, Shirvani, Vivian N., Silebi, Vanessa I., Sizemore, James M., Jr., Skolnik, Paul R., Sokol-Anderson, Marcia, Sosman, James M., Stabile, Paul, Stapleton, Jack T., Starrett, Sheree, Stein, Francine, Stellbrink, Hans-Jurgen, Sterman, Lisa F., Stone, Valerie E., Stone, David R., Tambussi, Giuseppe, Taplitz, Randy A., Tedaldi, Ellen M., Theisen, William, Torres, Richard, Tosiello, Lorraine, Tremblay, Cecile, Tribble, Marc A., Trinh, Phuong D., Tsao, Alice, Ueda, Peggy, Vaccaro, Anthony, Valadas, Emilia, Vanig, Thanes J., Vecino, Isabel, Vega, Vilma M., Veikley, Wenoah, Wade, Barbara H., Walworth, Charles, Wanidworanun, Chingchai, Ward, Douglas J., Warner, Daniel A., Weber, Robert D., Webster, Duncan, Weis, Steve, Wheeler, David A., White, David J., Wilkins, Ed, Winston, Alan, Wlodaver, Clifford G., vanʼt Wout, Angelique, Wright, David P., Yang, Otto O., Yurdin, David L, Zabukovic, Brandon W., Zachary, Kimon C., Zeeman, Beth, and Zhao, Meng

Published
2010
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26. A 37-year-old man with fever and diffuse lymphadenopathy

Author

Skolnik, Paul R. and Mark, Eugene J.

Subjects
Tuberculosis -- Case studies, HIV infection -- Case studies
Abstract

A 37-year-old man was admitted to a hospital with fever, chills, weight loss, anemia, and enlarged lymph nodes. He was homeless and had a history of alcohol and drug abuse. He tested positive for HIV although a test one month before admission had been negative. He was diagosed with acute HIV infection. Examination of a lymph node biopsy sample revealed that he also had disseminated tuberculosis. Normally, the bacterium that causes tuberculosis only infects the lungs, but it can infect other tissues. When it does, the infection is called miliary, or disseminated, tuberculosis.

Published
1999

28. Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-infected, treatment-experienced patients: AIDS clinical trials group 5211

Author

Gulick, Roy M., Su, Zhaohui, Flexner, Charles, Hughes, Michael D., Skolnik, Paul R., Wilkin, Timothy J., Gross, Robert, Krambrink, Amy, Coakley, Eoin, Greaves, Wayne L., Zolopa, Andrew, Reichman, Richard, Godfrey, Catherine, Hirsch, Martin, and Kuritzkes, Daniel R.

Subjects
Chemokine receptors -- Research, Chemokine receptors -- Dosage and administration, Clinical trials -- Reports, HIV infection -- Care and treatment, HIV infection -- Drug therapy, HIV infection -- Prognosis, Health
Published
2007

36. Race/Ethnicity and Protease Inhibitor Use Influence Plasma Tenofovir Exposure in Adults Living with HIV-1 in AIDS Clinical Trials Group Study A5202

Author

Bednasz, Cindy J., primary, Venuto, Charles S., additional, Ma, Qing, additional, Daar, Eric S., additional, Sax, Paul E., additional, Fischl, Margaret A., additional, Collier, Ann C., additional, Smith, Kimberly Y., additional, Tierney, Camlin, additional, Acosta, Edward P., additional, Mager, Donald E., additional, Morse, Gene D., additional, Bolivar, Hector H., additional, Navarro, Sandra, additional, Koletar, Susan L., additional, Gochnour, Diane, additional, Seefried, Edward, additional, Hoffman, Julie, additional, Feinberg, Judith, additional, Saemann, Michelle, additional, Patterson, Kristine, additional, Pittard, Donna, additional, Currin, David, additional, Upton, Kerry, additional, Saag, Michael, additional, Ray, Graham, additional, Johnson, Steven, additional, Santos, Bartolo, additional, Funk, Connie A., additional, Morgan, Michael, additional, Jackson, Brenda, additional, Tebas, Pablo, additional, Thomas, Aleshia, additional, Kim, Ge-Youl, additional, Klebert, Michael K., additional, Santana, Jorge L., additional, Marrero, Santiago, additional, Norris, Jane, additional, Valle, Sandra, additional, Cox, Gary Matthew, additional, Silberman, Martha, additional, Shaik, Sadia, additional, Lopez, Ruben, additional, Vasquez, Margie, additional, Daskalakis, Demetre, additional, Megill, Christina, additional, Stroberg, Todd, additional, Shore, Jessica, additional, Taiwo, Babafemi, additional, Goldman, Mitchell, additional, Boston, Molly, additional, Lennox, Jeffrey, additional, del Rio, Carlos, additional, Lane, Timothy W., additional, Epperson, Kim, additional, Luetkemeyer, Annie, additional, Payne, Mary, additional, Gripshover, Barbara, additional, Antosh, Dawn, additional, Reid, Jane, additional, Adams, Mary, additional, Storey, Sheryl S., additional, Dunaway, Shelia B., additional, Gallant, Joel, additional, Wiggins, Ilene, additional, Swiatek, Joan A., additional, Timpone, Joseph, additional, Kumar, Princy, additional, Moe, Ardis, additional, Palmer, Maria, additional, Gothing, Jon, additional, Delaney, Joanne, additional, Whitely, Kim, additional, Anderson, Ann Marie, additional, Hammer, Scott M., additional, Yin, Michael T., additional, Jain, Mamta, additional, Petersen, Tianna, additional, Corales, Roberto, additional, Hurley, Christine, additional, Henry, Keith, additional, Bordenave, Bette, additional, Youmans, Amanda, additional, Albrecht, Mary, additional, Pollard, Richard B., additional, Olusanya, Abimbola, additional, Skolnik, Paul R., additional, Adams, Betsy, additional, Tashima, Karen T., additional, Patterson, Helen, additional, Ukwu, Michelle, additional, Rogers, Lauren, additional, Balfour, Henry H., additional, Fox, Kathy A., additional, Swindells, Susan, additional, Van Meter, Frances, additional, Robbins, Gregory, additional, Burgett-Yandow, Nicole, additional, Davis, Charles E., additional, Boyce, Colleen, additional, O’Brien, William A., additional, Casey, Gerianne, additional, Hsaio, Chiu-Bin, additional, Meier, Jeffrey L., additional, Stapleton, Jack T., additional, Mildvan, Donna, additional, Revuelta, Manuel, additional, El Sadr, Wafaa, additional, Loquere, Avelino, additional, El-Daher, Nyef, additional, Johnson, Tina, additional, Gross, Robert, additional, Maffei, Kathyrn, additional, Hughes, Valery, additional, Sturge, Glenn, additional, McMahon, Deborah, additional, Rutecki, Barbara, additional, Wulfsohn, Michael, additional, Cheng, Andrew, additional, Bischofberger, Norbert, additional, Dix, Lynn, additional, and Liao, Qiming, additional

Published
2019
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44. Soluble tumor necrosis factor receptors inhibit phorbol myristate acetate and cytokine-induced HIV-1 expression chronically infected U1 cells

Author

Granowitz, Eric V., Saget, Bradford M., Angel, Jonathan B., Wang, Monica Z., Wang, Alicia, Dinarello, Charles A., and Skolnik, Paul R.

Subjects
HIV (Viruses) -- Reproduction, Cell receptors -- Research, Tumor necrosis factor -- Research, Health
Abstract

A soluble form of the receptor for tumor necrosis factor (TNF) or the TNF-binding protein may inhibit the activation of HIV in HIV-infected cells. Researchers used recombinant forms of soluble TNF receptor (TNFR) and the TNF-binding protein (TBP) in an HIV-infected cell line to determine their effect on HIV activation. Phorbol myristate acetate (PMA) normally activates HIV in cells lines by stimulating TNF synthesis, which ultimately activates HIV replication. TBP and TNFR inhibited the PMA-induced production of p24 antigen in the cell line by 88%. Both compounds reduced HIV activation by PMA even when they were added up to 20 hours after PMA stimulation. TPB also inhibited HIV activation by phytohemagglutinin (PHA), GM-CSF and interleukin 6. TNFR inhibited HIV activation by PHA, GM-CSF and TNF alpha. Recombinant forms of TNFR and TBP could be used to suppress HIV activity in people with HIV infection.

Published
1996

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