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46 results on '"Skolnick, Adam H."'

2. Amyloid deposition in an explanted bioprosthetic aortic valve: case report and review of the literature

Author

Weerasekare, Jonika M., primary, Zhou, Fang, additional, Skolnick, Adam H., additional, Jilaihawi, Hasan, additional, Williams, Mathew R., additional, Dasari, Surendra, additional, McPhail, Ellen D., additional, Theis, Jason D., additional, Dao, Linda N., additional, Bois, John P., additional, Maleszewski, Joseph J., additional, and Bois, Melanie C., additional

Published
2022
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4. Comparison of Late Results of Percutaneous Coronary Intervention Among Stable Patients ≤65 Versus >65 Years of Age With an Occluded Infarct Related Artery (from the Occluded Artery Trial)

Author

Skolnick, Adam H., Reynolds, Harmony R., White, Harvey D., Menon, Venu, Carvalho, Antonio C., Maggioni, Aldo P., Pearte, Camille A., Gruberg, Luis, Azevedo, Rudyney E.U., Schroeder, Erwin, Forman, Sandra A., Lamas, Gervasio A., Hochman, Judith S., and Džavík, Vladimír

Published
2012
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25. Knowledge Gaps in Cardiovascular Care of Older Adults: A Scientific Statement from the American Heart Association, American College of Cardiology, and American Geriatrics Society: Executive Summary

Author

Rich, Michael W., primary, Chyun, Deborah A., additional, Skolnick, Adam H., additional, Alexander, Karen P., additional, Forman, Daniel E., additional, Kitzman, Dalane W., additional, Maurer, Mathew S., additional, McClurken, James B., additional, Resnick, Barbara M., additional, Shen, Win K., additional, and Tirschwell, David L., additional

Published
2016
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26. Knowledge Gaps in Cardiovascular Care of the Older Adult Population

Author

Rich, Michael W., primary, Chyun, Deborah A., additional, Skolnick, Adam H., additional, Alexander, Karen P., additional, Forman, Daniel E., additional, Kitzman, Dalane W., additional, Maurer, Mathew S., additional, McClurken, James B., additional, Resnick, Barbara M., additional, Shen, Win K., additional, and Tirschwell, David L., additional

Published
2016
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31. Comparison of late results of percutaneous coronary intervention among stable patients ≤65 versus >65 years of age with an occluded infarct related artery (from the Occluded Artery Trial)

Author

UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - SSS/IRSS - Institut de recherche santé et société, UCL - (MGD) Service de cardiologie, Skolnick, Adam H., Reynolds, Harmony R., White, Harvey D., Menon, Venu, Carvalho, Antonio C., Maggioni, Aldo P., Pearte, Camille A., Gruberg, Luis, Azevedo, Rudyney E.U., Schroeder, Erwin, Forman, Sandra A., Lamas, Gervasio A., Hochman, Judith S., Džavík, Vladimír, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - SSS/IRSS - Institut de recherche santé et société, UCL - (MGD) Service de cardiologie, Skolnick, Adam H., Reynolds, Harmony R., White, Harvey D., Menon, Venu, Carvalho, Antonio C., Maggioni, Aldo P., Pearte, Camille A., Gruberg, Luis, Azevedo, Rudyney E.U., Schroeder, Erwin, Forman, Sandra A., Lamas, Gervasio A., Hochman, Judith S., and Džavík, Vladimír

Abstract

Although opening an occluded infarct-related artery >24 hours after myocardial infarction in stable patients in the Occluded Artery Trial (OAT) did not reduce events over 7 years, there was a suggestion that the effect of treatment might differ by patient age. Baseline characteristics and outcomes by treatment with percutaneous coronary intervention (PCI) versus optimal medical therapy alone were compared by prespecified stratification at age 65 years. A p value <0.01 was prespecified as significant for OAT secondary analyses. The primary outcome was death, myocardial infarction, or New York Heart Association class IV heart failure. Patients aged >65 years (n = 641) were more likely to be female, to be nonsmokers, and to have hypertension, lower estimated glomerular filtration rates, and multivessel disease compared to younger patients (aged ≤65 years, n = 1,560) (p <0.001). There was no significant observed interaction between treatment assignment and age for the primary outcome after adjustment (p = 0.10), and there was no difference between PCI and optimal medical therapy observed in either age group. At 7-year follow-up, younger patients tended to have angina more often compared to the older group (hazard ratio 1.21, 99% confidence interval 1.00 to 1.46, p = 0.01). The 7-year composite primary outcome was more common in older patients (p <0.001), and age remained significant after covariate adjustment (hazard ratio 1.42, 99% confidence interval 1.09 to 1.84). The rate of early PCI complications was low in the 2 age groups. The trend toward a differential effect of PCI in the young versus the old for the primary outcome was likely driven by measured and unmeasured confounders and by chance. PCI reduces angina to a similar degree in the young and old. In conclusion, there is no indication for routine PCI to open a persistently occluded infarct-related artery in stable patients after myocardial infarction, regardless of age. © 2012 Elsevier Inc.

Published
2012

40. Association Between Advanced Age and Vascular Disease in Different Arterial Territories A Population Database of Over 3.6 Million Subjects

Author

Savji, Nazir, Rockman, Caron B., Skolnick, Adam H., Guo, Yu, Adelman, Mark A., Riles, Thomas, and Berger, Jeffrey S.

Subjects
abdominal aortic aneurysm, age, vascular disease, carotid artery stenosis, peripheral artery disease
Abstract

ObjectivesThis study sought to determine the relationship between vascular disease in different arterial territories and advanced age.BackgroundVascular disease in the peripheral circulation is associated with significant morbidity and mortality. There is little data to assess the prevalence of different phenotypes of vascular disease in the very elderly.MethodsOver 3.6 million self-referred participants from 2003 to 2008 who completed a medical and lifestyle questionnaire in the United States were evaluated by screening ankle brachial indices 50% and abdominal aortic aneurysm (AAA) >3 cm. Participants were stratified by decade of life. Multivariate logistic regression analysis was used to estimate odds of disease in different age categories.ResultsOverall, the prevalence of PAD, CAS, and AAA, was 3.7%, 3.9%, and 0.9%, respectively. Prevalence of any vascular disease increased with age (40 to 50 years: 2%, 51 to 60 years: 3.5%, 61 to 70 years: 7.1%, 71 to 80 years: 13.0%, 81 to 90 years: 22.3%, 91 to 100 years: 32.5%; p < 0.0001). Prevalence of disease in each vascular territory increased with age. After adjustment for sex, race/ethnicity, body mass index, family history of cardiovascular disease, smoking, diabetes, hypertension, hypercholesterolemia, and exercise, the odds of PAD (odds ratio [OR]: 2.14; 95% confidence interval [CI]: 2.12 to 2.15), CAS (OR: 1.80; 95% CI: 1.79 to 1.81), and AAA (OR: 2.33; 95% CI: 2.30 to 2.36) increased with every decade of life.ConclusionsThere is a dramatic increase in the prevalence of PAD, CAS, and AAA with advanced age. More than 20% and 30% of octogenarians and nonagenarians, respectively, have vascular disease in at least 1 arterial territory.

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41. Characteristics, Management, and Outcomes of 5,557 Patients Age ≥90 Years With Acute Coronary Syndromes Results From the CRUSADE Initiative

Author

Skolnick, Adam H., Alexander, Karen P., Chen, Anita Y., Roe, Matthew T., Pollack, Charles V., Ohman, E. Magnus, Rumsfeld, John S., Gibler, W. Brian, Peterson, Eric D., and Cohen, David J.

Abstract

ObjectivesThe goal of this work was to explore the treatment and outcomes of patients with non–ST-segment elevation acute coronary syndromes (NSTE-ACS) age ≥90 years.BackgroundThe elderly are often excluded from clinical trials of NSTE-ACS and are underrepresented in clinical registries.MethodsWe used data from the CRUSADE registry to study 5,557 patients with NSTE-ACS age ≥90 years and compared their baseline characteristics, treatment patterns, and in-hospital outcomes with a cohort age 75 to 89 years (n = 46,270).ResultsAlthough both groups had much in common, compared with the younger elderly, the older elderly were less likely to be diabetic, smokers, or obese. Among patients without contraindications, the older elderly were less likely to receive glycoprotein IIb/IIIa inhibitors and statins during the first 24 h and were less likely to undergo cardiac catheterization within 48 h. The older elderly were more likely to die (12.0% vs. 7.8%) and experienced more frequent adverse events (26.8% vs. 21.3%) during the hospitalization—differences that persisted after adjustment for baseline patient and hospital characteristics. Increasing adherence to guideline-recommended therapies was associated with both increased bleeding and a graded reduction in risk-adjusted in-hospital mortality across both age groups.ConclusionsIn this large population of nonagenarians and centenarians with NSTE-ACS, increasing adherence to guideline-recommended therapies was associated with decreased mortality. These findings reinforce the importance of optimizing care patterns for even the oldest patients with NSTE-ACS, while examining novel approaches to reduce the risk of bleeding in this rapidly expanding patient population.

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44. Knowledge Gaps in Cardiovascular Care of the Older Adult Population: A Scientific Statement From the American Heart Association, American College of Cardiology, and American Geriatrics Society.

Author

Rich, Michael W, Chyun, Deborah A, Skolnick, Adam H, Alexander, Karen P, Forman, Daniel E, Kitzman, Dalane W, Maurer, Mathew S, McClurken, James B, Resnick, Barbara M, Shen, Win K, Tirschwell, David L, American Heart Association Older Populations Committee of the Council on Clinical Cardiology, Council on Cardiovascular and Stroke Nursing, Council on Cardiovascular Surgery and Anesthesia, and Stroke Council, and American College of Cardiology; and American Geriatrics Society

Subjects
*CARDIOVASCULAR disease treatment, *CLINICAL trials, *LIFE expectancy, *MEDICAL protocols, *NEEDS assessment, *PROGNOSIS, *RISK assessment, *HUMAN research subjects, *PERIOPERATIVE care, CARDIAC arrest prevention
Abstract

The incidence and prevalence of most cardiovascular disorders increase with age, and cardiovascular disease is the leading cause of death and major disability in adults ≥75 years of age; however, despite the large impact of cardiovascular disease on quality of life, morbidity, and mortality in older adults, patients aged ≥75 years have been markedly underrepresented in most major cardiovascular trials, and virtually all trials have excluded older patients with complex comorbidities, significant physical or cognitive disabilities, frailty, or residence in a nursing home or assisted living facility. As a result, current guidelines are unable to provide evidence-based recommendations for diagnosis and treatment of older patients typical of those encountered in routine clinical practice. The objectives of this scientific statement are to summarize current guideline recommendations as they apply to older adults, identify critical gaps in knowledge that preclude informed evidence-based decision making, and recommend future research to close existing knowledge gaps. To achieve these objectives, we conducted a detailed review of current American College of Cardiology/American Heart Association and American Stroke Association guidelines to identify content and recommendations that explicitly targeted older patients. We found that there is a pervasive lack of evidence to guide clinical decision making in older patients with cardiovascular disease, as well as a paucity of data on the impact of diagnostic and therapeutic interventions on key outcomes that are particularly important to older patients, such as quality of life, physical function, and maintenance of independence. Accordingly, there is a critical need for a multitude of large population-based studies and clinical trials that include a broad spectrum of older patients representative of those seen in clinical practice and that incorporate relevant outcomes important to older patients in the study design. The results of these studies will provide the foundation for future evidence-based guidelines applicable to older patients, thereby enhancing patient-centered evidence-based care of older people with cardiovascular disease in the United States and around the world. [ABSTRACT FROM AUTHOR]

Published
2016
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46. Apico-aortic valved conduit for the treatment of severe aortic stenosis and porcelain aorta.

Author

Tran HA, Srichai MB, Lim R, Skolnick AH, Loulmet D, and Saric M

Subjects
Aged, Aorta diagnostic imaging, Aorta pathology, Aortic Valve diagnostic imaging, Aortic Valve pathology, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis pathology, Echocardiography, Humans, Male, Stroke Volume, Tomography, X-Ray Computed, Ventricular Function, Left, Aorta surgery, Aortic Valve surgery, Aortic Valve Stenosis surgery
Published
2012
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