154 results on '"Skinhoj, P."'
Search Results
2. Long-term mortality in patients diagnosed with meningococcal disease: a Danish nationwide cohort study.
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Casper Roed, Lars Haukali Omland, Frederik Neess Engsig, Peter Skinhoj, and Niels Obel
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Medicine ,Science - Abstract
BACKGROUND: In contrast to the case fatality rate of patients diagnosed with meningococcal disease (MD) the long-term mortality in these patients is poorly documented. METHODOLOGY/PRINCIPAL FINDINGS: We performed a nationwide, population-based cohort study including all Danish patients diagnosed with MD from 1977 through 2006 and alive one year after diagnosis. Data was retrieved from the Danish National Hospital Register, the Danish Civil Registration System and the Danish Register of Causes of Death. For each patient four age- and gender-matched individuals were identified from the population cohort. The siblings of the MD patients and of the individuals from the population cohort were identified. We constructed Kaplan-Meier survival curves and used Cox regression analysis, cumulative incidence function and subdistribution hazard regression to estimate mortality rate ratios (MRR) and analyze causes of death. We identified 4,909 MD patients, 19,636 individuals from the population cohort, 8,126 siblings of MD patients and 31,140 siblings of the individuals from the population cohort. The overall MRR for MD patients was 1.27 (95% confidence interval (CI), 1.12-1.45), adjusted MRR, 1.21 (95% CI, 1.06-1.37). MD was associated with increased risk of death due to nervous system diseases (MRR 3.57 (95% CI, 1.82-7.00). No increased mortality due to infections, neoplasms or cardiovascular diseases was observed. The MRR for siblings of MD patients compared with siblings of the individuals from the population cohort was 1.17 (95% CI, 0.92-1.48). CONCLUSIONS: Patients surviving the acute phase of MD have increased long-term mortality, but the excess risk of death is small and stems mainly from nervous system diseases.
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- 2010
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- View/download PDF
3. Invasive group A, B, C and G streptococcal infections in Denmark 1999–2002: epidemiological and clinical aspects
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Ekelund, K., Skinhøj, P., Madsen, J., and Konradsen, H.B.
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- 2005
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4. TNF-α, leptin, and lymphocyte function in human aging
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Bruunsgaard, H., Pedersen, A.N., Schroll, M., Skinhøj, P., and Pedersen, B.K.
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- 2000
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5. Hepatitis and Hepatitis Associated Antigen (HAA) in Down's Syndrome
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Skinhoj, P.
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- 1971
6. Transmission Of Hepatitis Type B From Healthy HBsAg-Positive Mothers
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Skinhøj, P., Cohn, J., and Bradburne, A. F.
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- 1976
7. Hepatitis B Virus Infections among Danish Surgeons
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Hardt, F., Aldershvile, J., Dietrichson, O., Juhl, E., Nielsen, J. O., Schlichting, P., Skinhøj, P., and Tage-Jensen, U.
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- 1979
8. The Expression Pattern of Hepatitis B e Antigen and Antibody in Different Ethnic and Clinical Groups of Hepatitis B Surface Antigen Carriers
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Aldershvile, J., Skinhøj, P., Frösner, G. G., Black, F., Deinhardt, F., Hardt, F., and Nielsen, J. O.
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- 1980
9. Hepatitis B e Antigen and Antibody Measured by Radioimmunoassay in Acute Hepatitis B Surface Antigen-Positive Hepatitis
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Copenhagen Hepatitis Acuta Programme, Aldershvile, J., Frösner, G. G., Nielsen, J. O., Hardt, F., Deinhardt, F., and Skinhøj, P.
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- 1980
10. Nosocomial Outbreak Of Group C Meningococcal Disease
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Eriksen, N. H. Riewerts, Espersen, F., Laursen, L., Skinhøj, P., Høiby, N., and Lind, I.
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- 1989
11. Infection-related and -unrelated malignancies, HIV and the aging population
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Shepherd, L., Borges, A. H., Ledergerber, B., Domingo, P., Castagna, A., Rockstroh, J., Knysz, B., Tomazic, J., Karpov, I., Kirk, O., Lundgren, J., Mocroft, A., Losso, M., Kundro, M., Vetter, N., Zangerle, R., Vassilenko, A., Mitsura, V. M., Suetnov, O., Clumeck, N., De Wit, S., Delforge, M., Florence, E., Vandekerckhove, L., Hadziosmanovic, V., Kostov, K., Begovac, J., Machala, L., Jilich, D., Sedlacek, D., Nielsen, J., Kronborg, G., Benfield, T., Larsen, M., Gerstoft, J., Katzenstein, T., Hansen, A. -B. E., Skinhoj, P., Pedersen, C., Ostergaard, L., Dragsted, U. B., Nielsen, L. N., Zilmer, K., Smidt, J., Ristola, M., Katlama, C., Viard, J. -P., Girard, P. -M., Vanhems, P., Pradier, C., Dabis, F., Neau, D., Duvivier, C., Schmidt, R., van Lunzen, J., Degen, O., Stellbrink, H. J., Bickel, M., Bogner, J., Fatkenheuer, G., Kosmidis, J., Gargalianos, P., Xylomenos, G., Perdios, J., Sambatakou, H., Banhegyi, D., Gottfredsson, M., Mulcahy, F., Yust, I., Turner, D., Burke, M., Pollack, S., Hassoun, G., Elinav, H., Haouzi, M., D'Arminio Monforte, A., Esposito, R., Mazeu, I., Mussini, C., Arici, C., Pristera, R., Mazzotta, F., Gabbuti, A., Vullo, V., Lichtner, M., Chirianni, A., Montesarchio, E., Gargiulo, M., D'Offizi, G., Taibi, C., Antinori, A., Lazzarin, A., Gianotti, N., Galli, M., Ridolfo, A., Rozentale, B., Zeltina, I., Chaplinskas, S., Staub, T., Hemmer, R., Reiss, P., Ormaasen, V., Maeland, A., Bruun, J., Gasiorowski, J., Horban, A., Bakowska, E., Grzeszczuk, A., Flisiak, R., Boron-Kaczmarska, A., Pynka, M., Parczewski, M., Beniowski, M., Mularska, E., Trocha, H., Jablonowska, E., Malolepsza, E., Wojcik, K., Doroana, M., Caldeira, L., Mansinho, K., Maltez, F., Duiculescu, D., Rakhmanova, A., Buzunova, S., Khromova, I., Kuzovatova, E., Jevtovic, D., Mokras, M., Stanekova, D., Gonzalez-Lahoz, J., Soriano, V., Labarga, P., Moreno, S., Rodriguez, J. M., Clotet, B., Jou, A., Paredes, R., Tural, C., Puig, J., Bravo, I., Gatell, J. M., Miro, J. M., Gutierrez, M., Mateo, G., Sambeat, M. A., Medrano, J., Blaxhultblaxhult, A., Flamholc, L., Thalme, A., Sonnerborg, A., Weber, R., Francioli, P., Cavassini, M., Hirschel, B., Boffi, E., Furrer, H., Battegay, M., Elzi, L., Vernazza, P., Kravchenko, E., Chentsova, N., Frolov, V., Kutsyna, G., Servitskiy, S., Kuznetsova, A., Kyselyova, G., Gazzard, B., Johnson, A. M., Simons, E., Phillips, A., Johnson, M. A., Orkin, C., Weber, J., Scullard, G., Fisher, M., Leen, C., Gatell, J., De Witt, S., Cozzi-Lepri, A., Grint, D., Schultze, A., Raben, D., Podlekareva, D., Kjaer, J., Peters, L., Nielsen, J. E., Matthews, C., Fischer, A. H., Bojesen, A., Grarup, J., Thiebaut, R., Burger, D., Shepherd, L, Borges, Ah, Ledergerber, B, Domingo, P, Castagna, A, Rockstroh, J, Knysz, B, Tomazic, B, Karpov, I, Kirk, O, Lundgren, J, Mocroft, A, on behalfo of the EuroSIDA, Eurocoord, AII - Amsterdam institute for Infection and Immunity, APH - Amsterdam Public Health, Global Health, and University of Zurich
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Male ,Aging ,virus-associated malignancie ,HIV Infections ,Rate ratio ,10234 Clinic for Infectious Diseases ,Cohort Studies ,0302 clinical medicine ,malignancie ,Neoplasms ,80 and over ,2736 Pharmacology (medical) ,HIV Infection ,Pharmacology (medical) ,030212 general & internal medicine ,Prospective Studies ,Prospective cohort study ,Aged, 80 and over ,education.field_of_study ,Incidence (epidemiology) ,Incidence ,Health Policy ,Middle Aged ,Infectious Diseases ,030220 oncology & carcinogenesis ,Cohort ,symbols ,aging ,HIV ,malignancies ,virus-associated malignancies ,AIDS-Related Opportunistic Infections ,Adult ,Aged ,Female ,Humans ,Cohort study ,Human ,medicine.medical_specialty ,Population ,610 Medicine & health ,AIDS-Related Opportunistic Infection ,03 medical and health sciences ,symbols.namesake ,Internal medicine ,medicine ,Poisson regression ,education ,business.industry ,2725 Infectious Diseases ,2719 Health Policy ,Confidence interval ,Surgery ,Prospective Studie ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,Neoplasm ,Cohort Studie ,business - Abstract
Item does not contain fulltext OBJECTIVES: HIV-positive people have increased risk of infection-related malignancies (IRMs) and infection-unrelated malignancies (IURMs). The aim of the study was to determine the impact of aging on future IRM and IURM incidence. METHODS: People enrolled in EuroSIDA and followed from the latest of the first visit or 1 January 2001 until the last visit or death were included in the study. Poisson regression was used to investigate the impact of aging on the incidence of IRMs and IURMs, adjusting for demographic, clinical and laboratory confounders. Linear exponential smoothing models forecasted future incidence. RESULTS: A total of 15 648 people contributed 95 033 person-years of follow-up, of whom 610 developed 643 malignancies [IRMs: 388 (60%); IURMs: 255 (40%)]. After adjustment, a higher IRM incidence was associated with a lower CD4 count [adjusted incidence rate ratio (aIRR) CD4 count < 200 cells/muL: 3.77; 95% confidence interval (CI) 2.59, 5.51; compared with >/= 500 cells/muL], independent of age, while a CD4 count < 200 cells/muL was associated with IURMs in people aged < 50 years only (aIRR: 2.51; 95% CI 1.40-4.54). Smoking was associated with IURMs (aIRR: 1.75; 95% CI 1.23, 2.49) compared with never smokers in people aged >/= 50 years only, and not with IRMs. The incidences of both IURMs and IRMs increased with older age. It was projected that the incidence of IRMs would decrease by 29% over a 5-year period from 3.1 (95% CI 1.5-5.9) per 1000 person-years in 2011, whereas the IURM incidence would increase by 44% from 4.1 (95% CI 2.2-7.2) per 1000 person-years over the same period. CONCLUSIONS: Demographic and HIV-related risk factors for IURMs (aging and smoking) and IRMs (immunodeficiency and ongoing viral replication) differ markedly and the contribution from IURMs relative to IRMs will continue to increase as a result of aging of the HIV-infected population, high smoking and lung cancer prevalence and a low prevalence of untreated HIV infection. These findings suggest the need for targeted preventive measures and evaluation of the cost-benefit of screening for IURMs in HIV-infected populations.
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- 2016
12. Changing utilization of Stavudine (d4T) in HIV-positive people in 2006-2013 in the EuroSIDA study
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Podlekareva, D., Grint, D., Karpov, I., Vassilenko, A., Rakmanova, A., Mansinho, K., Chentsova, N., Kravchenko, E., Zeltina, I., Losso, M., Parczewski, M., Lundgren, J., Mocroft, A., Kirk, O., Kundro, M., Vetter, N., Zangerle, R., Mitsura, V. M., Suetnov, O., Clumeck, N., De Wit, S., Delforge, M., Florence, E., Vandekerckhove, L., Hadziosmanovic, V., Kostov, K., Begovac, J., Machala, L., Jilich, D., Sedlacek, D., Nielsen, J., Kronborg, G., Benfield, T., Larsen, M., Gerstoft, J., Katzenstein, T., Hansen, A. -B. E., Skinhoj, P., Pedersen, C., Ostergaard, L., Dragsted, U. B., Nielsen, L. N., Zilmer, K., Jelena, Smidt, Ristola, M., Katlama, C., Viard, J. -P., Girard, P. -M., Vanhems, P., Pradier, C., Dabis, F., Neau, D., Duvivier, C., Rockstroh, J., Schmidt, van Lunzen, J., Degen, O., Stellbrink, H. J., Bickel, M., Goethe, J. W., Bogner, J., Fatkenheuer, G., Kosmidis, J., Gargalianos, P., Xylomenos, G., Perdios, J., Sambatakou, H., Banhegyi, D., Gottfredsson, M., Mulcahy, F., Yust, I., Turner, D., Burke, M., Pollack, S., Hassoun, G., Elinav, H., Haouzi, M., D'Arminio Monforte, A., Esposito, R., Mazeu, I., Mussini, C., Arici, C., Pristera, R., Mazzotta, F., Gabbuti, A., Vullo, V., Lichtner, M., Chirianni, A., Montesarchio, E., Gargiulo, M., D'Offizi, G., Taibi, C., Antinori, A., Lazzarin, A., Castagna, A., Gianotti, N., Galli, M., Ridolfo, A., Rozentale, B., Chaplinskas, S., Staub, T., Hemmer, R., Reiss, P., Ormaasen, V., Maeland, A., Bruun, J., Knysz, B., Gasiorowski, J., Horban, A., Bakowska, E., Grzeszczuk, A., Flisiak, R., Boron-Kaczmarska, A., Pynka, M., Beniowski, M., Mularska, E., Trocha, H., Jablonowska, E., Malolepsza, E., Wojcik, K., Doroana, M., Caldeira, L., Maltez, F., Duiculescu, D., Rakhmanova, A., Buzunova, S., Khromova, I., Kuzovatova, E., Jevtovic, D., Mokras, M., Stanekova, D., Tomazic, J., Gonzalez-Lahoz, J., Soriano, V., Labarga, P., Moreno, S., Rodriguez, J. M., Clotet, B., Jou, A., Paredes, R., Tural, C., Puig, J., Bravo, I., Gatell, J. M., Miro, J. M., Domingo, P., Gutierrez, M., Mateo, G., Sambeat, M. A., Medrano, J., Blaxhult, A., Flamholc, L., Thalme, A., Sonnerborg, A., Ledergerber, B., Weber, R., Francioli, P., Cavassini, M., Hirschel, B., Boffi, E., Furrer, H., Battegay, M., Elzi, L., Vernazza, P., Frolov, V., Kutsyna, G., Servitskiy, S., Kuznetsova, A., Kyselyova, G., Gazzard, B., Johnson, A. M., Simons, E., Phillips, A., Johnson, M. A., Orkin, C., Weber, J., Scullard, G., Fisher, M., and Leen, C.
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Adult ,Male ,Anti-HIV Agents ,Combination antiretroviral therapy ,Europe ,EuroSIDA ,HIV ,Stavudine utilization ,Antiretroviral Therapy, Highly Active ,Female ,Follow-Up Studies ,HIV Infections ,HIV-1 ,Humans ,Middle Aged ,Prospective Studies ,RNA, Viral ,Regression Analysis ,Stavudine - Abstract
The long-term side effects of stavudine (d4T) led to recommendations in 2009 to phase out use of this drug. We aimed to describe temporal patterns of d4T use across Europe.Patients taking combination antiretroviral therapy (cART) in EuroSIDA with follow-up after 1 January 2006 were included in the study. cART was defined as d4T-containing [d4T plus at least two other antiretrovirals (ARVs) from any class] or non-d4T-containing (at least three ARVs from any class, excluding d4T). Poisson regression was used to describe temporal changes in the prevalence of d4T use and factors associated with initiating d4T.A total of 5850 patients receiving cART on 1 January 2006 were included in the current analysis, rising to 7768 patients on January 1 2013. During this time, the prevalence of d4T use fell from 11.2% to 0.7%, with an overall decline of 19% per 6 months [95% confidence interval (CI) 19-20%]. d4T use declined fastest in Northern Europe [26% (95% CI 23-29%) per 6 months], and slowest in Eastern Europe [17% (95% CI 16-19%) per 6 months]. In multivariable Poisson regression models, new d4T initiations decreased by 14% per 6 months [adjusted incidence rate ratio (aIRR) 0.86; 95% CI 0.80-0.91]. Factors associated with initiating d4T were residence in Eastern Europe (aIRR 4.31; 95% CI 2.17-9.98) versus other European regions and HIV RNA 400 copies/mL (aIRR 3.11; 95% CI 1.60-6.02) versus HIV RNA 400 copies/mL.d4T use has declined sharply since 2006 to low levels in most regions; however, a low but persistent level of d4T use remains in Eastern Europe, where new d4T initiations post 2006 are also more common. The reasons for the regional differences may be multifactorial, but it is important to ensure that all clinicians treating HIV-positive patients are aware of the potential harmful effects associated with d4T.
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- 2015
13. Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study
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Mocroft, A., Lundgren, J. D., Ross, M., Law, M., Reiss, P., Kirk, O., Smith, C., Wentworth, D., Neuhaus, J., Fux, C. A., Moranne, O., Morlat, P., Johnson, M. A., Ryom, L., Powderly, B., Shortman, N., Moecklinghoff, C., Reilly, G., Franquet, X., Sabin, C. A., Phillips, A., Weber, R., Pradier, C., d'Arminio Monforte, A., Dabis, F., El-Sadr, W. M., De Wit, S., Kamara, D., Tverland, J., Mansfeld, M., Nielsen, J., Raben, D., Salbol Brandt, R., Rickenbach, M., Fanti, I., Krum, E., Hillebregt, M., Geffard, S., Sundstrom, A., Delforge, M., Fontas, E., Torres, F., Mcmanus, H., Wright, S., Kjaer, J., Sjol, A., Meidahl, P., Helweg-Larsen, J., Schmidt Iversen, J., Kesselring, A. M., Friis-Moller, N., Kowalska, J., Sabin, C., Bruyand, M., Kamara, D. A., Bower, M., Fatkenheuer, G., Donald, A., Grulich, A., Prins, J. M., Kuijpers, T. W., Scherpbier, H. J., van der Meer, J. T. M., Wit, F. W. M. N., Godfried, M. H., van der Poll, T., Nellen, F. J. B., Geerlings, S. E., van Vugt, M., Pajkrt, D., Bos, J. C., Wiersinga, W. J., van der Valk, M., Goorhuis, A., Hovius, J. W., van Eden, J., Henderiks, A., van Hes, A. M. H., Mutschelknauss, M., Nobel, H. E., Pijnappel, F. J. J., Westerman, A. M., Jurriaans, S., Back, N. K. T., Zaaijer, H. L., Berkhout, B., Cornelissen, M. T. E., Schinkel, C. J., Thomas, X. V., van den Berge, M., Stegeman, A., Baas, S., Hage de Looff, L., Versteeg, D., Pronk, M. J. H., Ammerlaan, H. S. M., Korsten-Vorstermans, E. M. H. M., de Munnik, E. S., Jansz, A. R., Tjhie, J., Wegdam, M. C. A., Deiman, B., Scharnhorst, V., van der Plas, A., Weijsenfeld, A. M., van der Ende, M. E., de Vries-Sluijs, T. E. M. S., C. M. van Gorp, E., Schurink, C. A. M., Nouwen, J. L., Verbon, A., Rijnders, B. J. A., Bax, H. I., Hassing, R. J., van der Feltz, M., Bassant, N., van Beek, J. E. A., Vriesde, M., van Zonneveld, L. M., de Oude-Lubbers, A., van den Berg-Cameron, H. J., Bruinsma-Broekman, F. B., de Groot, J., de Zeeuw- de Man, M., Broekhoven-Kruijne, M. J., Schutten, M., Osterhaus, A. D. M. E., Boucher, C. A. B., Driessen, G. J. A., van Rossum, A. M. C., van der Knaap, L. C., Visser, E., Branger, J., H. M. Duijf-van de Ven C., J., Schippers, E. F., van Nieuwkoop, C., Brimicombe, R. W., van IJperen, J. M., van der Hut, G., Franck, P. F. H., van Eeden, A., Brokking, W., Groot, M., Damen, M., Kwa, I. S., Groeneveld, P. H. P., Bouwhuis, J. W., van den Berg, J. F., van Hulzen, A. G. W., van der Bliek, G. L., Bor, P. C. J., Bloembergen, P., Wolfhagen, M. J. H. M., Ruijs, G. J. H. M., van Lelyveld, S. F. L., Soetekouw, R., Hulshoff, N., van der Prijt, L. M. M., Schoemaker, M., Bermon, N., van der Reijden, W. A., Jansen, R., Herpers, B. L., Veenendaal, D., Kroon, F. P., Arend, S. M., de Boer, M. G. J., Bauer, M. P., Jolink, H., Vollaard, A. M., Dorama, W., Moons, C., Claas, E. C. J., Kroes, A. C. M., den Hollander, J. G., Pogany, K., Kastelijns, M., Smit, J. V., Smit, E., Bezemer, M., van Niekerk, T., Pontesilli, O., Lowe, S. H., Oude Lashof, A., Posthouwer, D., Ackens, R. P., Schippers, J., Vergoossen, R., Weijenberg Maes, B., Savelkoul, P. H. M., Loo, I. H., Weijer, S., El Moussaoui, R., Heitmuller, M., Kortmann, W., van Twillert, G., Cohen Stuart, J. W. T., Diederen, B. M. W., Pronk, D., van Truijen-Oud, F. A., Leyten, E. M. S., Gelinck, L. B. S., van Hartingsveld, A., Meerkerk, C., Wildenbeest, G. S., Mutsaers, J. A. E. M., Jansen, C. L., van Vonderen, M. G. A., van Houte, D. P. F., Dijkstra, K., Faber, S., Weel, J., Kootstra, G. J., Delsing, C. E., van der Burg-van de Plas, M., Heins, H., Lucas, E., Brinkman, K., Frissen, P. H. J., Blok, W. L., Schouten, W. E. M., Bosma, A. S., Brouwer, C. J., Geerders, G. F., Hoeksema, K., Kleene, M. J., van der Meche, I. B., Toonen, A. J. M., Wijnands, S., van Ogtrop, M. L., Koopmans, P. P., Keuter, M., van der Ven, A. J. A. M., ter Hofstede, H. J. M., Dofferhoff, A. S. M., van Crevel, R., Albers, M., Bosch, M. E. W., Grintjes-Huisman, K. J. T., Zomer, B. J., Stelma, F. F., Burger, D., Richter, C., van der Berg, J. P., Gisolf, E. H., ter Beest, G., van Bentum, P. H. M., Langebeek, N., Tiemessen, R., Swanink, C. M. A., Veenstra, J., Lettinga, K. D., Spelbrink, M., Sulman, H., Witte, E., Peerbooms, P. G. H., Mulder, J. W., Vrouenraets, S. M. E., Lauw, F. N., van Broekhuizen, M. C., Paap, H., Vlasblom, D. J., Oudmaijer Sanders, E., Smits, P. H. M., Rosingh, A. W., Verhagen, D. W. M., Geilings, J., van Kasteren, M. E. E., Brouwer, A. E., de Kruijf-van de Wiel, B. A. F. M., Kuipers, M., Santegoets, R. M. W. J., van der Ven, B., Marcelis, J. H., G. M. Buiting, A., Kabel, P. J., Bierman, W. F. W., Sprenger, H. G., Scholvinck, E. H., van Assen, S., Wilting, K. R., Stienstra, Y., de Groot-de Jonge, H., van der Meulen, P. A., de Weerd, D. A., Niesters, H. G. M., Riezebos-Brilman, A., van Leer-Buter, C. C., Hoepelman, A. I. M., Schneider, M. M. E., Mudrikova, T., Ellerbroek, P. M., Oosterheert, J. J., Arends, J. E., Barth, R. E., Wassenberg, M. W. M., van Elst-Laurijssen, D. H. M., Laan, L. M., van Oers-Hazelzet, E. E. B., Patist, J., Vervoort, S., Nieuwenhuis, H. E., Frauenfelder, R., Schuurman, R., Verduyn-Lunel, F., Wensing, A. M. J., Peters, E. J. G., van Agtmael, M. A., Perenboom, R. M., Bomers, M., de Vocht, J., Elsenburg, L. J. M., Pettersson, A. M., Vandenbroucke-Grauls, C. M. J. E., Ang, C. W., Geelen, S. P. M., Wolfs, T. F. W., Bont, L. J., Nauta, N., Bezemer, D. O., Gras, L., van Sighem, A. I., Smit, C., Zaheri, S., Kimmel, V., Tong, Y., Lascaris, B., van den Boogaard, R., Hoekstra, P., de Lang, A., Berkhout, M., Grivell, S., Jansen, A., de Groot, L., van den Akker, M., Bergsma, D., Lodewijk, C., Meijering, R., Peeck, B., Raethke, M., Ree, C., Regtop, R., Ruijs, Y., Schoorl, M., Tuijn, E., Veenenberg, L., Woudstra, T., Bakker, Y., de Jong, A., Broekhoven, M., Claessen, E., Rademaker, M. J., Munjishvili, L., Kruijne, E., Tuk, B., Bonnet, F., Dupon, M., Chene, G., Breilh, D., Fleury, H., Malvy, D., Mercie, P., Pellegrin, I., Neau, D., Bouchet, S., Gaborieau, V., Lacoste, D., Tchamgoue, S., Thiebaut, R., Lawson-Ayayi, S., Wittkop, L., Bernard, N., Hessamfar, M., Vandenhende, M. A., Dauchy, F. A., Dutronc, H., Longy-Boursier, M., Duffau, P., Roger Schmeltz, J., Pistone, T., Receveur, M. C., Cazanave, C., Ochoa, A., Vareil, M. O., Pellegrin, J. L., Viallard, J. F., Greib, C., Lazaro, E., Lafon, M. E., Reigadas, S., Trimoulet, P., Molimard, M., Titier, K., Moreau, J. F., Haramburu, F., Miremont-Salame, G., Dupont, A., Gerard, Y., Caunegre, L., Andre, K., Bonnal, F., Farbos, S., Gemain, M. C., Ceccaldi, J., De Witte, S., Courtault, C., Monlun, E., Lataste, P., Meraud, J. P., Chossat, I., Blaizeau, M. 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G., Benfield, T. L., Darbyshire, J. H., Babiker, A. G., Fleck, S. L., Collaco-Moraes, Y., Wyzydrag, L., Drummond, F. M., Connor, S. A., Satchell, C. S., Gunn, S., Delfino, M. A., Merlin, K., Mcginley, C., Neaton, J. D., George, M., Grund, B., Hogan, C., Miller, C., Roediger, M. P., Thackeray, L., Campbell, C., Lahart, C., Perlman, D., Rein, M., Dersimonian, R., Brody, B. A., Daar, E. S., Dubler, N. N., Fleming, T. R., Freeman, D. J., Kahn, J. P., Kim, K. M., Medoff, G., Modlin, J. F., Moellering, R., Murray, B. E., Robb, M. L., Scharfstein, D. O., Sugarman, J., Tsiatis, A., Tuazon, C., Zoloth, L., Belloso, W. H., Losso, M. H., Benetucci, J. A., Bogdanowicz, E. P., Cahn, P. E., Casiro, A. D., Cassetti, I., Contarelli, J. M., Corral, J. A., Crinejo, A., David, D. O., Ishida, M. T., Laplume, H. E., Lasala, M. B., Lupo, S. H., Masciottra, F., Michaan, M., Ruggieri, L., Salazar, E., Allworth, A. M., Anderson, J. S. C., Armishaw, J., Barnes, K., Chiam, A., Chuah, J. C. P., Curry, M. C., Dever, R. L., Donohue, W. A., Doong, N. C., Dwyer, D. E., Dyer, J., Eu, B., Ferguson, V. W., French, M. A. H., Garsia, R. J., Hudson, J. H., Jeganathan, S., Konecny, P., Mccormack, C. L., Mcmurchie, M., Moore, R. J., Moussa, M. B., Piper, M., Read, T., Roney, J. J., Shaw, D. R., Silvers, J., Smith, D. J., Street, A. C., Vale, R. J., Wendt, N. A., Wood, H., Youds, D. W., Zillman, J., Tozeau, V., de Roo, A., Leonard, P., Lynen, L., Moutschen, M., Pereira, L. C., Souza, T. N. L., Schechter, M., Zajdenverg, R., Almeida, M. M. T. B., Araujo, F., Bahia, F., Brites, C., Caseiro, M. M., Casseb, J., Etzel, A., Falco, G. G., Filho, E. C. J., Flint, S. R., Gonzales, C. R., Madruga, J. V. R., Passos, L. N., Reuter, T., Sidi, L. C., Toscano, A. L. C., Cherban, E., Conway, B., Dufour, C., Foster, A., Haase, D., Haldane, H., Klein, M., Lessard, B., Martel, A., Martel, C., Paradis, E., Schlech, W., Schmidt, S., Thompson, B., Vezina, S., Wolff Reyes, M. J., Northland, R., Hergens, L., Loftheim, I. R., Raukas, M., Justinen, J., Landman, R., Abel, S., Abgrall, S., Amat, K., Auperin, L., Barruet, R., Benalycherif, A., Benammar, N., Bentata, M., Besnier, J. M., Blanc, M., Cabie, A., Chavannet, P., Dargere, S., de la Tribonniere, X., Debord, T., Decaux, N., Delgado, J., Frixon-Marin, V., Genet, C., Gerard, L., Gilquin, J., Jeantils, V., Kouadio, H., Leclercq, P., Lelievre, J. -D., Michon, C. P., Nau, P., Pacanowski, J., Piketty, C., Salmon, D., Schmit, J. L., Serini, M. A., Tassi, S., Touam, F., Verdon, R., Weinbreck, P., Yazdanpanah, Y., Yeni, P., Bitsch, S., Bogner, J. R., Goebel, F. D., Lehmann, C., Lennemann, T., Potthof, A., Wasmuth, J. C., Wiedemeyer, K., Hatzakis, A., Touloumi, G., Antoniadou, A., Daikos, G. L., Dimitrakaki, A., Gargalianos-Kakolyris, P., Giannaris, M., Karafoulidou, A., Katsambas, A., Katsarou, O., Kontos, A. N., Kordossis, T., Lazanas, M. K., Panagopoulos, P., Paparizos, V., Papastamopoulos, V., Petrikkos, G., Skoutelis, A., Tsogas, N., Bergin, C. J., Mooka, B., Mamorksy, M. G., Agmon-Levin, N., Karplus, R., Shahar, E., Biglino, A., De Gioanni, M., Montroni, M., Raise, E., Honda, M., Ishisaka, M., Caplinskas, S., Uzdaviniene, V., Schmit, J. C., Mills, G. D., Blackmore, T., Masters, J. A., Morgan, J., Pithie, A., Brunn, J., Ormasssen, V., La Rosa, A., Guerra, O., Espichan, M., Gutierrez, L., Mendo, F., Salazar, R., Knytz, B., Kwiatkowski, J., Castro, R. S., Horta, A., Miranda, A. C., Pinto, I. V., Vera, J., Vinogradova, E., Yakovlev, A., Wood, R., Orrel, C., Arnaiz, J. A., Carrillo, R., Dalmau, D., Jordano, Q., Knobel, H., Larrousse, M., Moreno, J. S., Oretaga, E., Pena, J. N., Spycher, R., Bottone, S., Christen, A., Franc, C., Furrer, H. J., Gayet-Ageron, A., Genne, D., Hochstrasser, S., Moens, C., Nuesch, R., Ruxrungtham, K., Pumpradit, W., Dangthongdee, S., Kiertiburanakul, S., Klinbuayaem, V., Mootsikapun, P., Nonenoy, S., Piyavong, B., Prasithsirikul, W., Raksakulkarn, P., Gazzard, B. G., Ainsworth, J. G., Angus, B. J., Barber, T. J., Brook, M. G., Care, C. D., Chadwick, D. R., Chikohora, M., Churchill, D. R., Cornforth, D., Dockrell, D. H., Easterbrook, P. J., Fox, P. A., Gomez, P. A., Gompels, M. M., Harris, G. M., Herman, S., Jackson, A. G. A., Jebakumar, S. P. R., Kinghorn, G. R., Kuldanek, K. A., Larbalestier, N., Lumsden, M., Maher, T., Mantell, J., Muromba, L., Orkin, C. M., Palfreeman, A. J., Peters, B. S., Peto, T. E. A., Portsmouth, S. D., Rajamanoharan, S., Ronan, A., Schwenk, A., Slinn, M. A., Stroud, C. J., Thomas, R. C., Wansbrough-Jones, M. H., Whiles, H. J., White, D. J., Williams, E., Williams, I. G., Acosta, E. A., Adamski, A., Antoniskis, D., Aragon, D. R., Barnett, B. J., Baroni, C., Barron, M., Baxter, J. D., Beers, D., Beilke, M., Bemenderfer, D., Bernard, A., Besch, C. L., Bessesen, M. T., Bethel, J. T., Blue, S., Blum, J. D., Boarden, S., Bolan, R. K., Borgman, J. B., Brar, I., Braxton, B. K., Bredeek, U. F., Brennan, R., Britt, D. E., Bulgin-Coleman, D., Bullock, D. E., Campbell, B., Caras, S., Carroll, J., Casey, K. K., Chiang, F., Cindrich, R. B., Clark, C., Cohen, C., Coley, J., Condoluci, D. V., Contreras, R., Corser, J., Cozzolino, J., Daley, L., Dandridge, D., D'Antuono, V., Darcourt Rizo Patron, J. G., Dehovitz, J. A., Dejesus, E., Desjardin, J., Dietrich, C., Dolce, E., Erickson, D., Faber, L. L., Falbo, J., Farrough, M. J., Farthing, C. F., Ferrell-Gonzalez, P., Flynn, H., Frank, M., Freeman, K. F., French, N., Fujita, N., Gahagan, L., Gilson, I., Goetz, M. B., Goodwin, E., Guity, C. K., Gulick, P., Gunderson, E. R., Hale, C. M., Hannah, K., Henderson, H., Hennessey, K., Henry, W. K., Higgins, D. T., Hodder, S. L., Horowitz, H. W., Howe-Pittman, M., Hubbard, J., Hudson, R., Hunter, H., Hutelmyer, C., Insignares, M. T., Jackson, L., Jenny, L., Johnson, D. L., Johnson, G., Johnson, J., Kaatz, J., Kaczmarski, J., Kagan, S., Kantor, C., Kempner, T., Kieckhaus, K., Kimmel, N., Klaus, B. M., Koeppe, J. R., Koirala, J., Kopka, J., Kostman, J. R., Kozal, M. J., Kumar, A., Lampiris, H., Lamprecht, C., Lattanzi, K. M., Lee, J., Leggett, J., Long, C., Loquere, A., Loveless, K., Lucasti, C. J., Macveigh, M., Makohon, L. H., Markowitz, N. P., Marks, C., Martorell, C., Mcfeaters, E., Mcgee, B., Mcintyre, D. M., Mcmanus, E., Melecio, L. G., Melton, D., Mercado, S., Merrifield, E., Mieras, J. A., Mogyoros, M., Moran, F. M., Murphy, K., Mutic, S., Nadeem, I., Nadler, J. P., Ognjan, A., O'Hearn, M., O'Keefe, K., Okhuysen, P. C., Oldfield, E., Olson, D., Orenstein, R., Ortiz, R., Parpart, F., Pastore-Lange, V., Paul, S., Pavlatos, A., Pearce, D. D., Pelz, R., Peterson, S., Pitrak, D., Powers, S. L., Pujet, H. C., Raaum, J. W., Ravishankar, J., Reeder, J., Reilly, N. A., Reyelt, C., Riddell, J., Rimland, D., Robinson, M. L., Rodriguez, A. E., Rodriguez-Barradas, M. C., Rodriguez Derouen, V., Rosmarin, C., Rossen, W. L., Rouff, J. R., Sampson, J. H., Sands, M., Savini, C., Schrader, S., Schulte, M. M., Scott, R., Seedhom, H., Sension, M., Sheble-Hall, A., Shuter, J., Slater, L. N., Slotten, R., Smith, M., Snap, S., States, D. M., Stringer, G., Summers, K. K., Swanson, K., Sweeton, I. B., Szabo, S., Telzak, E. E., Thompson, M. A., Thompson, S., Ting Hong Bong, C., Vaccaro, A., Vasco, L. M., Vecino, I., Verlinghieri, G. K., Visnegarwala, F., Wade, B. H., Weis, S. E., Weise, J. A., Weissman, S., Wilkin, A. M., Witter, J. H., Wojtusic, L., Wright, T. J., Yeh, V., Young, B., Zeana, C., Zeh, J., Savio, E., Vacarezza, M., and Cauda R. (ORCID:0000-0002-1498-4229)
- Abstract
Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with ≥3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR ≤ 60 ml/min/1.73 m2. Poisson regression was used to develop a risk score, externally validated on two independent cohorts. In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7–6.7; median follow-up 6.1 y, range 0.3–9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was −2 (interquartile range –4 to 2). There was a 1:393 chance of developing CKD in the next 5 y in the low risk group (risk score < 0, 33 events), rising to 1:47 and 1:6 in the medium (risk score 0–4, 103 events) and high risk groups (risk score ≥ 5, 505 events)
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- 2015
14. A standardized algorithm for determining the underlying cause of death in HIV infection as AIDS or non-AIDS related: results from the EuroSIDA study
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Jd1, Kowalska, Mocroft, A., Ledergerber, B., Florence, E., Ristola, M., Begovac, J., Sambatakou, H., Pedersen, C., Lundgren, J. d., Kirk, O., Group Collaborators Losso, Eurosida Study M., Elias, C., Vetter, N., Zangerle, R., Karpov, I., Vassilenko, A., Mitsura, V. m., Suetnov, O., Clumeck, N., De Wit, S., Poll, B., Colebunders, R., Vandekerckhove, L., Hadziosmanovic, V., Kostov, K., Machala, L., Rozsypal, H., Sedlacek, D., Nielsen, J., Kronborg, G., Benfield, T., Larsen, M., Gerstoft, J., Katzenstein, T., Hansen, A. b., Skinhoj, P., Oestergaard, L., Zilmer, K., Katlama, C., Viard, J. p., Girard, P. m., Livrozet, J. m., Vanhems, P., Pradier, C., Dabis, F., Neau, D., Rockstroh, J., Schmidt, R., Van Lunzen, J., Degen, O., Stellbrink, H. j., Staszewski, S., Bogner, J., Fiitkenheuer, G., Kosmidis, J., Gargalianos, P., Xylomenos, G., Perdios, J., Panos, G., Filandras, A., Karabatsaki, E., Banhegyi, D., Mulcahy, F., Yust, I., Turner, D., Burke, M., Pollack, S., Hassoun, G., Maayan, S., Chiesi, A., Esposito, R., Mazeu, I., Mussini, C., Arici, C., Pristera, R., Mazzotta, F., Gabbuti, A., Vullo, Vincenzo, Lichtner, Miriam, Chirianni, A., Montesarchio, E., Gargiulo, M., Anto Nucci, G., Iacomi, F., Narciso, P., Vlassi, C., Zaccarelli, M., Lazzarin, A., Finazzi, R., Galli, M., Ridolfo, A., Sacco, L., D'Arminio Monforte, A., Rozentale, B., Aldins, P., Chaplinskas, S., Hemmer, R., Staub, T., Reiss, P., Bruun, J., Maeland, A., Ormaasen, V., Knysz, B., Gasi, J., Hor Ban, A., Bakowska, E., Prokopowicz, D., Flisiak, R., Boron Kaczmarska, A., Pynka, M., Beniowski, M., Mularska, E., Trocha, H., Jablonowska, E., Malolepsza, E., Wojcik, K., Antunes, F., Valadas, E., Mansinho, K., Maltez, F., Duiculescu, D., Rakhmanova, A., Vinogradova, E., Buzunova, S., Jevtovic, D., Mokrb, M., Stanekovi, D., Tomazic, J., Gonzalez Lahoz, J., Soriano, V., Martin Carbonero, L., Labarga, P., Moreno, S., Clotet, B., Jou, A., Paredes, R., Tural, C., Puig, J., Bravo, I., Gatell, J. m., Mir, J. m., Domingo, P., Gutierrez, M., Mateo, G., Sambeat, M. a., Karlsson, A., Persson, P. o., Flamholc, L., Weber, R., Francioli, P., Cavassini, M., Hirschel, B., Boffi, E., Furrer, H., Battegay, M., Elzi, L., Kravchenko, E., Chentsova, N., Kutsyna, G., Servitskiy, S., Antoniak, S., Krasnov, M., Barton, S., Johnson, A. m., Mercey, D., Phillips, A., Johnson, M. a., Murphy, M., Weber, J., Scullard, G., Fisher, M., Leen, C., Gatell, J., Gazzard, B., Horban, A., D'Arminio Montforte, A., Lundgren, J., Friis Meller, N., Cozzi Lepri, A., Bannister, W., Ellefson, M., Borch, A., Podlekareva, D., Kjer, J., Peters, L., Reekie, J., Kowalska, Justyna D., University of Zurich, Colebunders, R., and EuroSIDA Study Group
- Subjects
Survival ,Population ,Human immunodeficiency virus (HIV) ,610 Medicine & health ,Viral diseases ,030312 virology ,medicine.disease_cause ,10234 Clinic for Infectious Diseases ,03 medical and health sciences ,0302 clinical medicine ,Acquired immunodeficiency syndrome (AIDS) ,Cause of Death ,Methods ,Humans ,Medicine ,2736 Pharmacology (medical) ,Pharmacology (medical) ,Prospective Studies ,030212 general & internal medicine ,Mortality ,Prospective cohort study ,education ,Causes of death ,Cause of death ,Protocol (science) ,Acquired Immunodeficiency Syndrome ,0303 health sciences ,education.field_of_study ,Data collection ,business.industry ,HIV ,AIDS ,cause of death ,CoDe project ,mortality ,non-AIDS event ,Global ,2725 Infectious Diseases ,Classification ,medicine.disease ,CD4 Lymphocyte Count ,3. Good health ,Infectious Diseases ,Cohort ,HIV-1 ,sense organs ,business ,Algorithm ,Protocols ,Algorithms - Abstract
OBJECTIVES: Analyzing changes in causes of death over time is essential for understanding the emerging trends in HIV population mortality, yet data on cause of death are often missing. This poses analytic limitations, as does the changing approach in data collection by longitudinal studies, which are a natural consequence of an increased awareness and knowledge in the field. To monitor and analyze changes in mortality over time, we have explored this issue within the EuroSIDA study and propose a standardized protocol unifying data collected and allowing for classification of all deaths as AIDS or non-AIDS related, including events with missing cause of death.METHODS: Several classifications of the underlying cause of death as AIDS or non-AIDS related within the EuroSIDA study were compared: central classification (CC-reference group) based on an externally standardised method (the CoDe procedures), local cohort classification (LCC) as reported by the site investigator, and 4 algorithms (ALG) created based on survival times after specific AIDS events.RESULTS: A total of 2,783 deaths occurred, 540 CoDe forms were collected, and 488 were used to evaluate agreements. The agreement between CC and LCC was substantial (κ = 0.7) and the agreement between CC and ALG was moderate (κ < 0.6). Consequently, a stepwise algorithm was derived prioritizing CC over LCC and, in patients with no information available, best-fit ALG. Using this algorithm, 1,332 (47.9%) deaths were classified as AIDS and 1,451 (52.1%) as non-AIDS related.CONCLUSIONS: Our proposed stepwise algorithm for classifying deaths provides a valuable tool for future research, however validation in another setting is warranted.
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- 2011
15. Relationship between current level of immunodeficiency and non-acquired immunodeficiency syndrome-defining malignancies
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Reekie, J, Kosa, C, Engsig, F, Monforte, Ad, Wiercinska Drapalo, A, Domingo, P, Antunes, F, Clumeck, N, Kirk, O, Lundgren, Jd, Mocroft, A, Collaborators Losso M, EuroSIDA Study G. r. o. u. p., Elias, C, Vetter, N, Zangerle, R, Karpov, I, Vassilenko, A, Mitsura, Vm, Suetnov, O, De Wit, S, Delforge, M, Colebunders, R, Vanderkerckhove, L, Hadziosmanovic, V, Kostov, K, Begovac, J, Machala, L, Rozsypal, H, Sedlacek, D, Nielsen, J, Kronborg, G, Benfield, T, Larsen, M, Gerstoft, J, Katzenstein, T, Hansen, A., Skinhoj, P, Pedersen, C, Larsen, Od, Oestergaard, L, Zilmer, K, Smidt, J, Ristola, M, Katlama, C, Viard, J., Girard, P., Livrozet, Jm, Vanhems, P, Pradier, C, Dabis, F, Neau, D, Rockstroh, J, Schmidt, R, van Lunzen, J, Degen, O, Stellbrink, Hj, Staszewski, S, Bogner, J, Fatkenheuer, G, Kosmidis, J, Gargalianos, P, Xylomenos, G, Perdios, J, Panos, G, Filandras, A, Karabatsaki, E, Sambatakou, H, Banhegyi, D, Mulcahy, F, Yust, I, Turner, D, Burke, M, Pollack, S, Hassoun, G, Mayyan, S, Vella, S, Esposito, R, Mazeau, I, Mussini, C, Arici, C, Pristera, R, Mazzotta, F, Gabbuti, A, Vullo, Vincenzo, Lichtner, M, Chirianni, A, Montesarchio, E, Gargiulo, M, Antonucci, G, Iacomi, F, Narciso, P, Vlassi, C, Zacarelli, M, Lazzarin, A, Finazzi, R, Galli, M, Ridolfo, A, d'Arminio Monforte, A, Rozental, B, Zeltina, I, Chaplinskas, S, Hemmer, R, Staub, T, Reiss, P, Ormaasen, V, Maeland, A, Bruun, J, Knysz, B, Gasiorowski, J, Horban, A, Bakowska, E, Grzeszczuk, A, Flisiak, R, Boron Kaczmarska, A, Pynka, M, Parczewski, M, Beniowski, M, Mularska, E, Trocha, H, Jablonowska, E, Malolepsza, E, Wojcik, K, Valadas, E, Mansinho, K, Maltez, F, Duiculescu, D, Rakhmanova, A, Vinogradova, E, Buzunova, S, Jevtovic, D, Mokras, M, Stanekova, D, Tomazic, J, Gonzalez Lahoz, J, Soriano, V, Labarga, P, Medrano, J, Moreno, S, Clotet, B, Jou, A, Paredes, R, Tural, C, Puig, J, Bravo, I, Gatell, Jm, Miro, Jm, Gutierrez, M, Mateo, G, Sambeat, Ma, Karlsson, A, Flamholc, L, Ledergerber, B, Weber, R, Francioli, P, Cavassini, M, Hirschel, B, Boffi, E, Furrer, H, Battegay, M, Elzi, L, Kravchenko, E, Chentsova, N, Kutsyna, G, Servitskiy, S, Antoniak, S, Krasnov, M, Barton, S, Johnson, Am, Mercey, D, Phillips, A, Johnson, Ma, Murphy, M, Weber, J, Scullard, G, Fisher, M, and Leen, C.
- Published
- 2010
16. Isolation rooms for highly infectious diseases : an inventory of capabilities in European countries
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Fusco, F.M., Puro, V., Baka, A., Bannister, B., Brodt, H.-R., Brouqui, P., Follin, Per, Gjorup, I.E., Gottschalk, R., Hemmer, R., Hoepelman, I.M., Jarhall, Boo, Kutsar, K., Lanini, S., Lyytikainen, O., Maltezou, H.C., Mansinho, K., Marti, M.C., Ott, K., Peleman, R., Perronne, C., Sheehan, G., Siikamakii, H., Skinhoj, P., Trilla, A., Vetter, N., Ippolito, G., Fusco, F.M., Puro, V., Baka, A., Bannister, B., Brodt, H.-R., Brouqui, P., Follin, Per, Gjorup, I.E., Gottschalk, R., Hemmer, R., Hoepelman, I.M., Jarhall, Boo, Kutsar, K., Lanini, S., Lyytikainen, O., Maltezou, H.C., Mansinho, K., Marti, M.C., Ott, K., Peleman, R., Perronne, C., Sheehan, G., Siikamakii, H., Skinhoj, P., Trilla, A., Vetter, N., and Ippolito, G.
- Abstract
Isolation of patients with highly infectious diseases (HIDs) in hospital rooms with adequate technical facilities is essential to reduce the risk of spreading disease. The European Network for Infectious Diseases (EUNID), a project co-funded by European Commission and involving 16 European Union member states, performed an inventory of high level isolation rooms (HIRs, hospital rooms with negative pressure and anteroom). In participating countries, HIRs are available in at least 211 hospitals, with at least 1789 hospital beds. The adequacy of this number is not known and will depend on prevailing circumstances. Sporadic HID cases can be managed in the available HIRs. HIRs could also have a role in the initial phases of an influenza pandemic. However, large outbreaks due to natural or to bioterrorist events will need management strategies involving healthcare facilities other than HIRs.
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- 2009
- Full Text
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17. Infection control in the management of highly pathogenic infectious diseases : consensus of the European Network of Infectious Disease
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Brouqui, P., Puro, V., Fusco, F.M., Bannister, B., Schilling, S., Follin, Per, Gottschalk, R., Hemmer, R., Maltezou, H.C., Ott, K., Peleman, R., Perronne, C., Sheehan, G., Siikamaki, H., Skinhoj, P., Ippolito, G., Brouqui, P., Puro, V., Fusco, F.M., Bannister, B., Schilling, S., Follin, Per, Gottschalk, R., Hemmer, R., Maltezou, H.C., Ott, K., Peleman, R., Perronne, C., Sheehan, G., Siikamaki, H., Skinhoj, P., and Ippolito, G.
- Abstract
The European Network for Infectious Diseases (EUNID) is a network of clinicians, public health epidemiologists, microbiologists, infection control, and critical-care doctors from the European member states, who are experienced in the management of patients with highly infectious diseases. We aim to develop a consensus recommendation for infection control during clinical management and invasive procedures in such patients. After an extensive literature review, draft recommendations were amended jointly by 27 partners from 15 European countries. Recommendations include repetitive training of staff to ascertain infection control, systematic use of cough and respiratory etiquette at admission to the emergency department, fluid sampling in the isolation room, and analyses in biosafety level 3/4 laboratories, and preference for point-of-care bedside laboratory tests. Children should be cared for by paediatricians and intensive-care patients should be cared for by critical-care doctors in high-level isolation units (HLIU). Invasive procedures should be avoided if unnecessary or done in the HLIU, as should chest radiography, ultrasonography, and renal dialysis. Procedures that require transport of patients out of the HLIU should be done during designated sessions or hours in secure transport. Picture archiving and communication systems should be used. Post-mortem examination should be avoided; biopsy or blood collection is preferred.
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- 2009
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18. [Where is the HIV hiding--in the patient and in the population?]
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Gerstoft, J., Skinhoj, P., Gerstoft, J., and Skinhoj, P.
- Abstract
Udgivelsesdato: 2009/1/19
- Published
- 2009
19. Impact of hepatitis B virus co-infection on response to highly active antiretroviral treatment and outcome in HIV-infected individuals: a nationwide cohort study.
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Omland, L.H., Weis, Nina, Skinhoj, P., Laursen, A., Christensen, P.B., Nielsen, H.I., Moller, A., Engsig, F., Sorensen, H.T., Obel, N., Omland, L H, Weis, N, Skinhøj, P, Laursen, Al, Christensen, P B, Nielsen, H I, Møller, A, Engsig, F, Sørensen, H T, Obel, N, Omland, L.H., Weis, Nina, Skinhoj, P., Laursen, A., Christensen, P.B., Nielsen, H.I., Moller, A., Engsig, F., Sorensen, H.T., Obel, N., Omland, L H, Weis, N, Skinhøj, P, Laursen, Al, Christensen, P B, Nielsen, H I, Møller, A, Engsig, F, Sørensen, H T, and Obel, N
- Abstract
BACKGROUND: The impact of chronic hepatitis B virus (HBV) infection on viral suppression, immune recovery and mortality in HIV-1 infected patients on highly active antiretroviral treatment (HAART) is a matter of debate. The impact of HBeAg status is unknown. METHODS: This prospective cohort study included all adult Danish HIV-1 infected patients who started HAART between 1 January 1995 and 1 December 2006 (3180 patients). Patients were classified as chronic HBV-infected (6%), HBV-negative (87%) or HBV-unknown (7%). HBV-positive patients were divided into HBeAg-positive or -negative (3.0 vs. 2.6%). Study endpoints were viral load, CD4 cell count and mortality. RESULTS: HBV co-infection had no impact on response to HAART regarding viral suppression or immune recovery. HBV co-infection was associated with several outcomes: overall mortality [mortality rate ratio (MRR) 1.5; 95% confidence interval (CI) 1.1-2.1], liver-related mortality (MRR 4.0; 95% CI 1.6-9.9) and AIDS-related deaths (MRR 1.7; 95% CI 1.0-3.0). The presence of HBeAg did not influence patients' response to HAART. CONCLUSIONS: In HIV patients, chronic HBV infection has no impact on response to HAART concerning viral load and increase in CD4 cell count. However, co-infected patients have an increased mortality compared to HIV-monoinfected patients Udgivelsesdato: 2008/5
- Published
- 2008
20. Klinisk bakteriologi, infektionshygiejne og antibiotikabehandling
- Author
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Johansen, H.K., Andersen, L.P., Skinhoj, P., Høiby, Niels, Johansen, Helle Krogh, Johansen, H.K., Andersen, L.P., Skinhoj, P., Høiby, Niels, and Johansen, Helle Krogh
- Published
- 2008
21. Long-Term Mortality in Patients Diagnosed With Pneumococcal Meningitis: A Danish Nationwide Cohort Study
- Author
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Roed, C., primary, Engsig, F. N., additional, Omland, L. H., additional, Skinhoj, P., additional, and Obel, N., additional
- Published
- 2010
- Full Text
- View/download PDF
22. A 2-dose regimen of a recombinant hepatitis B vaccine with the immune stimulant AS04 compared with the standard 3-dose regimen of Engerix (TM)-B in healthy young adults
- Author
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UCL - MD/ESP - Ecole de santé publique, Levie, Karin, Gjorup, I, Skinhoj, P, Stoffel, M., UCL - MD/ESP - Ecole de santé publique, Levie, Karin, Gjorup, I, Skinhoj, P, and Stoffel, M.
- Abstract
An open-label randomized study was undertaken to compare a 2-dose regimen (Months 0 and 6) of hepatitis B surface antigen (HBsAg) vaccine formulated with a novel adjuvant (HBsAg/AS04) with a standard 3-dose regimen (Months 0, 1 and 6) of licensed recombinant HBsAg vaccine in terms of immunogenicity and reactogenicity when administered to healthy subjects aged between 15 and 40 y. At 1 and 6 months after the full vaccination course there was a 100% seroprotection rate (anti-HBs greater than or equal to 10 mIU/ml) with the HBsAg/AS04 vaccine, compared with a 99% response rate with the licensed vaccine. The corresponding geometric mean titres were significantly higher for the novel vaccine compared to the standard vaccine: 15, 468 and 2, 745 mIU/ml at Months 7 and 12 vs. 6,274 and 1, 883 mIU/ml, respectively. There was a higher prevalence of local symptoms with the adjuvant vaccine (90% of doses) than with the standard vaccine (48% of doses). However, these symptoms (pain, swelling and redness) were predominantly of mild-to-moderate intensity and resolved rapidly without treatment. A 2-dose regimen of the new HBsAg/AS04 adjuvant vaccine therefore compared favourably to the standard regimen in healthy young adults. It is anticipated that the simplified vaccination schedule may improve compliance and reduce costs.
- Published
- 2002
23. Isolation rooms for highly infectious diseases: an inventory of capabilities in European countries
- Author
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Fusco, F.M., primary, Puro, V., additional, Baka, A., additional, Bannister, B., additional, Brodt, H.-R., additional, Brouqui, P., additional, Follin, P., additional, Gjorup, I.E., additional, Gottschalk, R., additional, Hemmer, R., additional, Hoepelman, I.M., additional, Jarhall, B., additional, Kutsar, K., additional, Lanini, S., additional, Lyytikainen, O., additional, Maltezou, H.C., additional, Mansinho, K., additional, Marti, M.C., additional, Ott, K., additional, Peleman, R., additional, Perronne, C., additional, Sheehan, G., additional, Siikamakii, H., additional, Skinhoj, P., additional, Trilla, A., additional, Vetter, N., additional, and Ippolito, G., additional
- Published
- 2009
- Full Text
- View/download PDF
24. Granulocyte colony-stimulating factor increases CD4+ T cell counts of human immunodeficiency virus-infected patients receiving stable, highly active antiretroviral therapy:results from a randomized, placebo-controlled trial
- Author
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Aladdin, H, Ullum, H, Dam Nielsen, S., Espersen, C, Mathiesen, L, Katzenstein, T L, Gerstoft, J, Skinhoj, P, Pedersen, Bente Klarlund, Aladdin, H, Ullum, H, Dam Nielsen, S., Espersen, C, Mathiesen, L, Katzenstein, T L, Gerstoft, J, Skinhoj, P, and Pedersen, Bente Klarlund
- Abstract
Thirty human immunodeficiency virus (HIV)-infected patients with CD4+ T cell counts <350 cells/mm3 who had received stable, highly active antiretroviral therapy (HAART) for at least 24 weeks were randomized to receive either placebo or granulocyte colony-stimulating factor (G-CSF; 0.3 mg/mL 3 times a week) for 12 weeks. Blood samples were collected at specified time points. G-CSF treatment enhanced the total lymphocyte count (P=.002) and increased CD3+ (P=.005), CD4+ (P=.03), and CD8+ (P=.004) T cell counts as well as numbers of CD3-CD16+CD56+ NK cells (P=.001). The increases in CD4+ and CD8+ cell counts resulted from increases in CD45RO+ memory T cells and cells expressing the CD38 activation marker. Lymphocyte proliferative responses to phytohemagglutinin and Candida antigen decreased, whereas NK cell activity and plasma HIV RNA did not change during G-CSF treatment. After 24 weeks, all immune parameters had returned to baseline values. This study suggests that G-CSF treatment of HIV-infected patients receiving stable HAART increases the concentration of CD4+, CD8+, and NK cells without inducing changes in the virus load.
- Published
- 2000
25. Immunological changes in human immunodeficiency virus (HIV)-infected individuals during HIV-specific protease inhibitor treatment
- Author
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Ullum, H, Katzenstein, T, Aladdin, H, Nielsen, C, Sondergaard, S R, Gerstoft, J, Skinhoj, P, Pedersen, Bente Klarlund, Ullum, H, Katzenstein, T, Aladdin, H, Nielsen, C, Sondergaard, S R, Gerstoft, J, Skinhoj, P, and Pedersen, Bente Klarlund
- Abstract
The present study examines the influence of effective anti-retroviral treatment on immune function, evaluated by a broad array of immunological tests. We followed 12 individuals infected with human immunodeficiency virus (HIV) for 6 months after initiation of combination anti-retroviral treatment including a protease inhibitor. Unstimulated and pokeweed mitogen (PWM)-, interleukin (IL)-2- and phytohaemagglutinin (PHA)-stimulated lymphocyte proliferative responses increased during follow-up reaching average levels from 1.3-fold (PHA) to 3.7-fold (PWM) above baseline values. The total CD4+ lymphocyte count increased mainly due to increases in numbers of CD4+ CD28+ and CD4+ CD45RO+ cells, whereas increases in numbers of CD4+ CD45RA+ cells contributed little to the increase in CD4+ cell count. The total cytotoxic T-cell (CTL) killing of autologous B cells infected with HIV-encoding recombinant Vaccinia virus was increased after 3-6 months, whereas the specific HIV-directed CTL activity and the concentration and lytic activity of natural killer (NK) cells were unchanged during follow-up. These results demonstrate that the initiation of a treatment including an HIV protease inhibitor is followed by an increase in lymphocyte proliferation and lymphocyte-mediated cytotoxicity. However, unchanged levels of specific HIV CTL and NK cell activity warn us that not all measures of immune function may respond simultaneously to anti-retroviral treatment.
- Published
- 1999
26. Epinephrine-induced mobilization of natural killer (NK) cells and NK-like T cells in HIV-infected patients
- Author
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Sondergaard, S R, Ullum, H, Skinhoj, P, Pedersen, Bente Klarlund, Sondergaard, S R, Ullum, H, Skinhoj, P, and Pedersen, Bente Klarlund
- Abstract
HIV infection is known to cause changes in phenotype and function of natural killer (NK) cells. The aim of this study was to characterize the NK cells mobilized from peripheral reservoirs in human immunodeficiency virus (HIV)-infected patients and controls. Seventeen HIV-infected patients and eight age- and sex-matched controls received a 1-h epinephrine infusion. Epinephrine induced mobilization of high numbers of NK-like T cells with no difference between HIV-infected patients and controls. Interestingly, all subjects mobilized NK cells containing increased proportions of perforin, in particular the CD3(-)CD16(+)CD56(+) NK cell subset. The HIV-infected patients mobilized CD3(-)CD16(-)CD56(+) and CD3(-)CD16(+)CD56(+) NK cells to a lesser extent than did controls. In contrast, the HIV-infected patients mobilized relatively more CD3(-)CD16(+)CD56(-) NK cells independent of antiretroviral treatment. It is suggested that these cells represent an immature NK cell subpopulation possibly resulting from an impaired cytokine tissue environment in HIV-infected patients.
- Published
- 1999
27. Psychiatric Hospitalizations in a Cohort of Danish Polio Patients
- Author
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Nielsen, N. M., primary, Rostgaard, K., additional, Hjalgrim, H., additional, Askgaard, D., additional, Skinhoj, P., additional, and Aaby, P., additional
- Published
- 2006
- Full Text
- View/download PDF
28. T-Cell Receptor Excisional Circles, Telomere Length, Proliferation and Apoptosis in Peripheral Blood Mononuclear Cells of Human Immunodeficiency Virus-Infected Individuals after 18 Months of Treatment Induced Viral Suppression
- Author
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Aladdin, H., primary, Katzenstein, T., additional, Dreves, A.-M, additional, Ryder, L., additional, Gerstoft, J., additional, Skinhoj, P., additional, Pedersen, B. K., additional, and Ullum, H., additional
- Published
- 2003
- Full Text
- View/download PDF
29. Virological and immunological profiles among patients with undetectable viral load followed prospectively for 24 months
- Author
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Katzenstein, TL, primary, Ullum, H, additional, Roge, BT, additional, Wandall, J, additional, Dickmeiss, E, additional, Barrington, T, additional, Skinhoj, P, additional, and Gerstoft, J, additional
- Published
- 2003
- Full Text
- View/download PDF
30. Increased plasma HIV type 1 RNA levels are associated with low levels of non-MHC class I-restricted cytotoxicity
- Author
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Ullum, H., Katzenstein, T., Gerstoft, J., Skinhoj, P., Pedersen, B. K., Ullum, H., Katzenstein, T., Gerstoft, J., Skinhoj, P., and Pedersen, B. K.
- Published
- 1997
31. Hypotension during endotoxemia in aged humans
- Author
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Krabbe, K. S., primary, Bruunsgaard, H., additional, Qvist, J., additional, Hansen, C. M., additional, Moller, K., additional, Fonsmark, L., additional, Madsen, P. L., additional, Kronborg, G., additional, Frandsen, U., additional, Andersen, H. O., additional, Skinhoj, P., additional, and Pedersen, B. K., additional
- Published
- 2001
- Full Text
- View/download PDF
32. A High Plasma Concentration of TNF- Is Associated With Dementia in Centenarians
- Author
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Bruunsgaard, H., primary, Andersen-Ranberg, K., additional, Jeune, B., additional, Pedersen, A. N., additional, Skinhoj, P., additional, and Pedersen, B. K., additional
- Published
- 1999
- Full Text
- View/download PDF
33. The effect of prophylaxis with chloroquine and proguanil on delayed-type hypersensitivity and antibody production following vaccination with diphtheria, tetanus, polio, and pneumococcal vaccines
- Author
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Gyhrs, A, Pedersen, B K, Bygbjerg, I, Henrichsen, J, Heron, I, Petersen, I, Skinhoj, P, Gyhrs, A, Pedersen, B K, Bygbjerg, I, Henrichsen, J, Heron, I, Petersen, I, and Skinhoj, P
- Abstract
Udgivelsesdato: 1991-Nov, In vitro studies have shown that anti-malarial drugs suppress immunity. In this study, the effects of chloroquine and proguanil (Paludrine) on the cellular and humoral immune system were measured by two in vivo methods: 1) cell-mediated immunity (delayed cutaneous hypersensitivity) i.e., skin tests with seven delayed-type common antigens (Multitest) and 2) humoral immunity by measurement of specific antibody response to vaccination. Sixty healthy young individuals were randomized into four groups and given 1) no treatment (controls), 2) chloroquine diphosphate (500 mg/week), 3) chloroquine diphosphate (1,000 mg/week), or 4) proguanil hydrochloride (200 mg/day) for six weeks. Skin testing was performed on days 0 and 28. Vaccinations with diphtheria, tetanus, polio, and pneumococcal polysaccharide antigen vaccines were performed on day 28, and the presence of specific antibodies was determined on days 0, 28, and 42. The skin tests induced a significant increase in skin reactive areas from day 0 to day 28 in all groups. Furthermore, the skin test induced an increase in the level of specific IgG for diphtheria and tetanus, but had no effect on antibodies to antigens not included in the skin test. The results showed that there were no significant differences among the four groups regarding skin test areas and increases in antibody titers following vaccination. Therefore, it is concluded that in healthy persons, six weeks intake of chloroquine, even in double doses, or proguanil in chemoprophylactic dosages, does not induce any detectable suppression of delayed-type hypersensitivity or vaccination responses to diphtheria, tetanus, polio, or pneumococcal polysaccharide antigens.
- Published
- 1991
34. The effect of fusidic acid on Tanzanian patients with AIDS
- Author
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Jorgensen, A. F., Mwakyusa, D., Cegielski, P., Gotzsche, P., Hording, M., Lallinger, G., Mbaga, I., Pallangyo, K., Richter, C., Shao, J., Bygbjerg, I., Skinhoj, P., Faber, V., Jorgensen, A. F., Mwakyusa, D., Cegielski, P., Gotzsche, P., Hording, M., Lallinger, G., Mbaga, I., Pallangyo, K., Richter, C., Shao, J., Bygbjerg, I., Skinhoj, P., and Faber, V.
- Published
- 1990
35. High prevalence of indeterminate Western blot tests for antibodies to HIV-1 in Tanzania
- Author
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Bohn Christiansen, C., Wantzin, P., Shao, J. F., Bakilana, P. B., Hiza, J. F R, Kilima, F., Bygbjerg, I., Skinhoj, P., Faber, V., Kvinesdal, B., Bohn Christiansen, C., Wantzin, P., Shao, J. F., Bakilana, P. B., Hiza, J. F R, Kilima, F., Bygbjerg, I., Skinhoj, P., Faber, V., and Kvinesdal, B.
- Published
- 1990
36. Beta2-microglobulin as a prognostic marker for patients with AIDS in Dar es Salaam, Tanzania
- Author
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Jorgensen, A. F., Jensen, V. G., Shao, J. F., Maselle, S., Mbaga, I. M., Mwakyusa, D. H., Gotzsche, P. C., Richter, C., Pallangyo, K., Cegielsky, P., Lallinger, G., Bygbjerg, I., Skinhoj, P., Faber, V., Jorgensen, A. F., Jensen, V. G., Shao, J. F., Maselle, S., Mbaga, I. M., Mwakyusa, D. H., Gotzsche, P. C., Richter, C., Pallangyo, K., Cegielsky, P., Lallinger, G., Bygbjerg, I., Skinhoj, P., and Faber, V.
- Published
- 1990
37. Tuberculous meningitis. 23 cases from a 12-year period (1976-1987)
- Author
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Jensen, T. H., Magnussen, P., Eriksen, N. H.R., Skinhoj, P., Jensen, T. H., Magnussen, P., Eriksen, N. H.R., and Skinhoj, P.
- Published
- 1990
38. Attachment of staphylococci to different plastic tubes in vitro
- Author
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Espersen, F., primary, Wurr, M., additional, Corneliussen, L., additional, HoG, A.-L., additional, Rosdahl, V. T., additional, Frimodt-MoLler, N., additional, and SkinhoJ, P., additional
- Published
- 1994
- Full Text
- View/download PDF
39. Long-term mortality in patients diagnosed with Listeria monocytogenes meningitis: A Danish nationwide cohort study.
- Author
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Roed, Casper, Engsig, Frederik Neess, Omland, Lars Haukali, Skinhoj, Peter, and Obel, Niels
- Subjects
LISTERIA monocytogenes ,LISTERIOSIS ,MENINGITIS ,COHORT analysis ,DANES ,FOLLOW-up studies (Medicine) ,MORTALITY ,DISEASES - Abstract
Summary: Objectives: To determine the long-term mortality, the causes of death and the incidence of cancer in listeria meningitis patients. Methods: Nationwide, population-based cohort study including all adult patients diagnosed with listeria meningitis from 1977 to 2006 and alive 1 year after diagnosis, and an age-and gender-matched, population control cohort. Kaplan–Meier tables, Cox regression analysis and cumulative incidence function were used as outcome analyses. Results: We identified 114 listeria meningitis patients and 1026 population controls. The adjusted mortality rate ratio (MRR) for listeria meningitis patients the first 5 years of follow-up was 2.35(95% confidence interval (CI) 1.60–3.45) thereafter the MRR was 0.93(95% CI: 0.56–1.55). Listeria meningitis patients had an increased risk of death due to cancer the first 5 years of follow-up, and in the same period patients above 50 years of age had a 2-fold increased risk of being diagnosed with cancer, thereafter the risks declined to that of the background population. Conclusions: The long-term mortality in adult patients diagnosed with listeria meningitis was increased the first 5 years of follow-up, mainly due to death from cancer, thereafter the mortality did not differ from the background population. To improve survival this patient population should be meticulously screened for predisposing conditions, mainly underlying malignant diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
40. Changing Pattern of Bone and Joint Infections Due to Staphylococcus aureus: Study of Cases of Bacteremia in Denmark, 1959-1988
- Author
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Espersen, F., primary, Frimodt-Moller, N., additional, Rosdahl, V. T., additional, Skinhoj, P., additional, and Bentzon, M. W., additional
- Published
- 1991
- Full Text
- View/download PDF
41. Effects of Isoprinosine Treatment of HIV-Positive Patients on Blood Mononuclear Cell Subsets, NK- and T-Cell Function, Tumour Necrosis Factor, and Interleukins 1, 2, and 6
- Author
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PEDERSEN, B. K., primary, TVEDE, N., additional, DIAMANT, M., additional, GERSTOFT, J., additional, HANSEN, M. BAGGE, additional, HAAHR, P. M., additional, HORDING, M., additional, KAPPEL, M., additional, KLOKKER, M., additional, SOEBERG, B., additional, and SKINHOJ, P., additional
- Published
- 1990
- Full Text
- View/download PDF
42. Proliferative responses of blood mononuclear cells (BMNC) in a cohort of elderly humans: role of lymphocyte phenotype and cytokine production.
- Author
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Bruunsgaard, H., Pedersen, A.N., Schroll, M., Skinhoj, P., and Pedersen, B.K.
- Subjects
LYMPHOCYTES ,CYTOKINES ,IMMUNOLOGY - Abstract
Investigates the role of lymphocyte and cytokine production in the proliferative responses of blood mononuclear cells in a cohort of elderly humans. Identification of factors associated with the age-related decreased phytohaemagglutinin (PHA); Importance of T cell subsets and cytokine production for the proliferative response to PHA.
- Published
- 2000
- Full Text
- View/download PDF
43. Long-term Mortality in Children Diagnosed With Haemophilus influenzaeMeningitis
- Author
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Roed, Casper, Engsig, Frederik Neess, Omland, Lars Haukali, Skinhoj, Peter, and Obel, Niels
- Abstract
The long-term mortality in children diagnosed with Haemophilus influenzaemeningitis is poorly documented.
- Published
- 2011
- Full Text
- View/download PDF
44. Epidemiology of Hepatitis B Antigen and Antibody in Hospital Patients in Copenhagen
- Author
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Skinhoj P
- Subjects
Adult ,Male ,Microbiology (medical) ,medicine.medical_specialty ,Adolescent ,Denmark ,Population ,Antibodies, Viral ,medicine.disease_cause ,Gastroenterology ,Antibodies ,Hepatitis B Antigens ,Liver disease ,Antigen ,Internal medicine ,Humans ,Medicine ,Hepatitis B Antibodies ,education ,Hepatitis B virus ,Hepatitis ,education.field_of_study ,General Immunology and Microbiology ,biology ,business.industry ,Transmission (medicine) ,Age Factors ,General Medicine ,Middle Aged ,Hepatitis B ,medicine.disease ,Hospitalization ,Infectious Diseases ,Social Conditions ,Acute Disease ,Carrier State ,Chronic Disease ,Immunology ,biology.protein ,Female ,Antibody ,business - Abstract
A 4-year continuous screening for hepatitis B antigen (HBAg) in all patients admitted to a Copenhagen general hospital revealed 253 antigen-positive cases among 99000 patients (2.5%). 97 of the patients had acute or chronic hepatitis, while there were no signs of liver disease in 156. The "healthy" carriers showed a wavy age distribution, indicating an increased transmission of HBAg in age groups born 1920-30 and 1940-60. Hepatitis B antibody (HBAb), measured by a radioimmunoassay, occurred in 8.6% of 1000 patients. HBAb also showed an uneven age distribution with a peak prevalence of 17.5% in the age group born 1910-30. These figures indicate that the prevalence of HBAg and hence presumably also the hepatitis B virus has fluctuated within this homogeneous population, probably related to changes in the sociohygienic conditions. Determination of HBAg subtypes D and Y in 161 patients indicated that the Y-subtype is now being introduced into a formerly subtype D area by means of drug addiction, tourism or workers of East-Mediterranean origin.
- Published
- 1975
45. Decreased natural killer cell activity is associated with atherosclerosis in elderly humans
- Author
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Bruunsgaard, H., Pedersen, A. N., Schroll, M., Skinhoj, P., and Pedersen, B. K.
- Published
- 2001
- Full Text
- View/download PDF
46. TNF-a, leptin, and lymphocyte function in human aging
- Author
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Bruunsgaard, H., Pedersen, A. N., Schroll, M., Skinhoj, P., and Pedersen, B. K.
- Published
- 2000
- Full Text
- View/download PDF
47. Exercise Induces Recruitment of Lymphocytes with an Activated Phenotype and Short Telomeres in Young and Elderly Humans
- Author
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Bruunsgaard, H., Jensen, M.S., Schjerling, P., Halkjaer-Kristensen, J., Ogawa, K., Skinhoj, P., and Pedersen, B.K.
- Published
- 1999
- Full Text
- View/download PDF
48. Hepatitis and hepatitis B-antigen in Greenland.
- Author
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Skinhoj, P, McNair, A, and Andersen, S T
- Published
- 1974
- Full Text
- View/download PDF
49. Hepatitis Ain Greenland: importance of specific antibody testing in epidemiologic surveillance.
- Author
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Skinhoj, P, Mikkelsen, F, and Hollinger, F B
- Abstract
An epidemic of viral hepatitis type A in an arctic area is described. From 1970-1974, 4961 clinical cases of hepatitis were reported in Greenland, corresponding to 11 per cent of the total population. Epidemiologic surveillance indicated person-to-person transmission of the disease, apparently by the oralfecal route. The course of the disease was mild, and complications were rare with a case fatality rate of 0.3%. Ninety-three per cent of the cases occurred in individuals 1-25 years of age, suggesting widespread immunity in the adult population presumably due to infection with hepatitis A during a similar epidemic in 1947-1948. The occurrence of antibody to hepatitis A antigen (anti-HA) in healthy Greenlanders, as detected by radioimmunoassay, closely paralleled this observation. Anti-HA was present in 38 (93%) of 41 individuals born before 1948 and in one (3%) of 29 younger persons. Anti-HA also was detected during the epidemic in the sera of 25 randomly selected hepatitis cases. Immunoglobin analysis in three acute-phase sera showed anti-HA reactivity predominantly in the IgM fraction. The epidemic showed no relation to the hepatitis episodes occurring annually in the area, and seroepidemiologic data indicated that the endemic hepatitis may be caused by hepatitis B virus only.
- Published
- 1977
- Full Text
- View/download PDF
50. Hepatitis and hepatitis B-antigen in Greenland. II: Occurrence and interrelation of hepatitis B associated surface, core, and "e" antigen-antibody systems in a highly endemic area.
- Author
-
Skinhoj, P
- Abstract
The distribution of hepatitis B surface antigen and antibody (HBsAg and anti HBs), hepatitis B core antibody (anti-HBc), and the heaptitis B associated "e" antigen-antibody system (HBeAg and anti-HBe) were studied in three areas in Greenland previously shown to be endemic for hepatitis B. Overall prevalence of HBsAg and anti-HBs ranged from 47 - 81%, thus confirming the existence of a hyperendemicity of the hepatitis B agent in some polar areas. Anti-HBc occurred closely correlated to HBsAg and anti-HBs but appeared to be a less sensitive indicator of previous infection. HBeAg and anti-HBe were found in HBsAg-positive sera only. The presence of HBeAg correlated to a high titer of HBsAg and to young age and it occurred more frequently in east coast than in northwest coast Greenlanders. The "e"-antibody in contrast prevailed in old age groups and in sera with a low titer of HBsAg.
- Published
- 1977
- Full Text
- View/download PDF
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