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9. Child Health in the Faroe Islands: Medical examinations in regard to hematological, immunological, microbiological and lipid studies

Author

COHN, JØRGEN, Jordal, Robert, Elsborg, Lars, Gimsing, Peter, Hippe, Erik, Rønsted, Per, Jørgensen, Birgit Juul, Skinhøj, Peter, Vestergaard, Bent Faber, Grauballe, Per Christian, Larsen, Jørgen Hannover, Hornsleth, Allan, Hesse, Jette, Ibsen, Karsten Kaas, Meinertz, Hans, Schnohr, Peter, Jensen, Gorm, and Færgemann, Ole

Published
1982
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13. Vaccination i historisk perspektiv

Author

Skinhøj, Peter and Bygbjerg, Ib Christian

Abstract

This review is about the development and use of vaccines from the early smallpox vaccine in the 18th century to the forthcoming SARS-CoV 2 vaccines. Immunisations have been of paramount importance for childhood mortality and public health in general, but some obstacles have also been encountered such as vaccine failures and vaccine scepticism. This calls for continued emphasis on large phase three studies not only for demonstration of efficacy but also for safety and possible side effects. The rapid approval of SARS-CoV 2 vaccines requires special attention.

Published
2021

28. Natural immunity and HIV disease progression

Author

Ullum, Henrik, Lepri, Alessandro Cozzi, Aladdin, Hassan, Katzenstein, Terese, Victor, Jette, Phillips, Andrew N., Gerstoft, Jan, Skinhøj, Peter, and Pedersen, Bente Klarlund

Published
1999

43. Kompendium i mikrobiologi og infektionsmedicin

Author

Høiby, Niels, Skinhøj, Peter, Andersen, Åse Bengård, Andersen, Leif Percival, Arendrup, Maiken Cavling, Christiansen, Claus Bohn, Ciofu, Oana, Gerstoft, Jan, Johansen, Helle Krogh, Kemp, Michael, Kurtzhals, Jørgen Anders Lindholm, Nielsen, Lars Peter, Lyngsøe Svejgaard, Else, Theander, Thor Grundtvig, Thomsen, Allan Randrup, Høiby, Niels, Skinhøj, Peter, Andersen, Åse Bengård, Andersen, Leif Percival, Arendrup, Maiken Cavling, Christiansen, Claus Bohn, Ciofu, Oana, Gerstoft, Jan, Johansen, Helle Krogh, Kemp, Michael, Kurtzhals, Jørgen Anders Lindholm, Nielsen, Lars Peter, Lyngsøe Svejgaard, Else, Theander, Thor Grundtvig, and Thomsen, Allan Randrup

Published
2015

46. Long-term mortality after Staphylococcus aureus spondylodiscitis:A Danish nationwide population-based cohort study

Author

Aagaard, Theis, Roed, Casper, Larsen, Anders R, Petersen, Andreas, Dahl, Benny, Skinhøj, Peter, Obel, Niels, Aagaard, Theis, Roed, Casper, Larsen, Anders R, Petersen, Andreas, Dahl, Benny, Skinhøj, Peter, and Obel, Niels

Abstract

Patients diagnosed with Staphylococcus aureus spondylodiscitis have increased long-term mortality compared with the background population mainly due to infectious, endocrine, cardiovascular, gastrointestinal and alcohol and drug abuse-related diseases.

Published
2014

50. Hyaluronic Acid Levels Predict Risk of Hepatic Encephalopathy and Liver-Related Death in HIV/Viral Hepatitis Coinfected Patients

Author

Peters, Lars, Mocroft, Amanda, Soriano, Vincent, Rockstroh, Jürgen, Rauch, Andri, Karlsson, Anders, Knysz, Brygida, Pradier, Christian, Zilmer, Kai, Lundgren, Jens D, Losso, Marcello, Kundro, Mariana Angelica, Vetter, Norbert, Zangerle, Robert, Karpov, Igor, Vassilenko, A., Mitsura, Victor, Suetnov, Oleg, Clumeck, Nathan, De Wit, Stéphane, Delforge, Marc, Colebunders, Robert Leon, Vandekerckhove, Linos, Hadziosmanovic, Vesna, Kostov, Kostadin, Begovac, Josip, Machala, Ladislav, Jilich, David, Sedlacek, Dalibor, Nielsen, Jens Ole, Kronborg, Gitte, Benfield, Thomas, Larsen, Mette Vang, Gerstoft, Jan, Katzenstein, Terese Lea, Hansen, Annette Brit Eg, Skinhøj, Peter, Pedersen, Court, Peters, Lars, Mocroft, Amanda, Soriano, Vincent, Rockstroh, Jürgen, Rauch, Andri, Karlsson, Anders, Knysz, Brygida, Pradier, Christian, Zilmer, Kai, Lundgren, Jens D, Losso, Marcello, Kundro, Mariana Angelica, Vetter, Norbert, Zangerle, Robert, Karpov, Igor, Vassilenko, A., Mitsura, Victor, Suetnov, Oleg, Clumeck, Nathan, De Wit, Stéphane, Delforge, Marc, Colebunders, Robert Leon, Vandekerckhove, Linos, Hadziosmanovic, Vesna, Kostov, Kostadin, Begovac, Josip, Machala, Ladislav, Jilich, David, Sedlacek, Dalibor, Nielsen, Jens Ole, Kronborg, Gitte, Benfield, Thomas, Larsen, Mette Vang, Gerstoft, Jan, Katzenstein, Terese Lea, Hansen, Annette Brit Eg, Skinhøj, Peter, and Pedersen, Court

Abstract

Background:Whereas it is well established that various soluble biomarkers can predict level of liver fibrosis, their ability to predict liver-related clinical outcomes is less clearly established, in particular among HIV/viral hepatitis co-infected persons. We investigated plasma hyaluronic acid's (HA) ability to predict risk of liver-related events (LRE; hepatic coma or liver-related death) in the EuroSIDA study.Methods:Patients included were positive for anti-HCV and/or HBsAg with at least one available plasma sample. The earliest collected plasma sample was tested for HA (normal range 0-75 ng/mL) and levels were associated with risk of LRE. Change in HA per year of follow-up was estimated after measuring HA levels in latest sample before the LRE for those experiencing this outcome (cases) and in a random selection of one sixth of the remaining patients (controls).Results:During a median of 8.2 years of follow-up, 84/1252 (6.7%) patients developed a LRE. Baseline median (IQR) HA in those without and with a LRE was 31.8 (17.2-62.6) and 221.6 ng/mL (74.9-611.3), respectively (p<0.0001). After adjustment, HA levels predicted risk of contracting a LRE; incidence rate ratios for HA levels 75-250 or ≥250 vs. <75 ng/mL were 5.22 (95% CI 2.86-9.26, p<0.0007) and 28.22 (95% CI 14.95-46.00, p<0.0001), respectively. Median HA levels increased substantially prior to developing a LRE (107.6 ng/mL, IQR 0.8 to 251.1), but remained stable for controls (1.0 ng/mL, IQR -5.1 to 8.2), (p<0.0001 comparing cases and controls), and greater increases predicted risk of a LRE in adjusted models (p<0.001).Conclusions:An elevated level of plasma HA, particularly if the level further increases over time, substantially increases the risk of contracting LRE over the next five years. HA is an inexpensive, standardized and non-invasive supplement to other methods aimed at identifying HIV/viral hepatitis co-infected patients at risk of hepatic complications. © 2013 Peters et al., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2013

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