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Acute ultraviolet (UV)-B irradiation causes skin wrinkle formation associated with hyperplasia of cutaneous blood vessels. This study reports that increased dermal oxygen tension attenuates acute UVB-induced angiogenesis and wrinkle formation. Twenty-four hairless mice (HOS: HR-1) were assigned to 3 groups: 1) control group, 2) UVB-irradiated (UVB) group, and 3) UVB-irradiated and hyperoxia-exposed (UVB+HO) group. The backs of the mice were exposed to UVB irradiation 3 times per week for a 5-wk period. To increase dermal oxygen tension, the mice were exposed to hyperoxia (90% oxygen) for 2 h immediately after each UVB irradiation. Hyperoxic exposure increased dermal oxygen tension by about 10 times compared with the control level. Degree of wrinkle formation and epidermal thickness increased significantly after a 5-wk UVB-irradiation period, whereas hyperoxic exposure attenuated these increases. Tissue adenosine triphosphate concentration and angiogenesis increased significantly only in the UVB group compared with the control group. Although the expression of hypoxia inducible factor-1 a mRNA, a key molecule for angiogenesis, increased significantly in the UVB and UVB+HO groups compared with the control group, the protein level increased significantly only in the UVB group. The activity of matrix metalloproteinase-2 and -9, critical molecules for angiogenesis, did not increase in the UVB and UVB + HO groups compared with the control group. Active type 1 collagenase activity and soluble collagen content in all of the groups were roughly similar. These results suggest that increased dermal oxygen tension attenuates angiogenesis and wrinkle formation following acute UVB irradiation. hypoxia inducible factor-[alpha]; matrix metalloproteinase; dermal P[O.sub.2] doi: 10.1152/ajpregu.00199.2010.

ABSTRACT It is believed that oxidative stress is caused by an imbalance between the production of reactive oxygen and a biological system's ability to neutralize the reactive intermediates. Oxidative damage [...]

A case where a 29-year-old woman experienced an outbreak of numerous superficial, nonfollicular pustule accompanied by subjective fever is described. The woman took amoxicillin two days before as a dental prophylaxis for endocarditis. The eruption resolved within four days after discontinuing the drug therapy.

Buruli/Bairnsdale ulcer (BU) is a severe skin and soft tissue disease caused by Mycobacterium ulcerans. To better understand how BU is acquired, we conducted a case--control study during a sustained [...]

Buruli ulcer (BU) occurs in >30 countries. The causative organism, Mycobacterium ulcerans, is acquired from the environment, but the exact mode of transmission is unknown. We investigated an outbreak of [...]

Mycobacterium ulcerans causes Buruli ulcer, an ulcerative skin disease in tropical and subtropical areas. Despite restricted genetic diversity, mycobacterial interspersed repetitive unit-variable-number tandem repeat analysis on M. ulcerans revealed 3 [...]

ABSTRACT Background: Lower leg edema is a common side effect of amlodipine therapy, but is often unrecognized as a contributor to stasis dermatitis. Objective: To determine whether amlodipine therapy is [...]

We investigated 42 patients who had unusual pruritic dermatitis associated with a specific clinical sign (comet sign) in 23 houses in southeastern France from May through September 2007. Pyemotes ventricosus, [...]

Nontuberculous mycobacteria, which are widespread in the environment, frequently cause opportunistic infections in immunocompromised patients. We report the first case of a patient with chronic granulomatous dermatitis caused by a [...]

Byline: Hemanta. Kar, Sonali. Langar, Tarlok. Arora, Pankaj. Sharma, Alok. Raina, Meenakshi. Bhardwaj Background: Photodermatitis is an abnormal response to ultraviolet radiation (UVR). The photoallergic contact dermatitis caused by plant [...]

Byline: Pallavi. Chauhan, Madhvi. Shakya Background: In the present scenario, wrinkle formation, prominent sign of skin ageing, is one of the most demanding areas of research. This burgeoning research demand [...]

Byline: Gurcharan. Singh The desire to look young and in turn vital has been a lure to man since ancient times, though aging as a rule remains a fact of [...]

Byline: Asok. Gangopadhyay, Jayanta. Das, Sujata. Sengupta Sir, Schamberg's disease (SD), (progressive pigmentary dermatosis), is of uncertain etiology.[sup] [1] Irregular patches of brown pigmentation due to hemosiderin deposits, with characteristic [...]

Byline: S. Murthy, Karjigi. Siddalingappa, T. Suresh Sir, Nicolau's syndrome (NS) is a rare injection site reaction, following intramuscular administration of drugs, with varying degrees of tissue damage. It is [...]

Byline: Amiya. Nath, Devinder. Thappa Sir, Cosmetics are defined as "articles intended to be rubbed, poured, sprayed on or sprinkled, introduced into or otherwise applied to the human body or [...]

Byline: Chembolli. Lakshmi, C. Srinivas Background: Parthenium dermatitis is a major problem in urban and rural India. Patients with severe allergic rhinitis due to exposure to pollens of parthenium are [...]

Byline: Gurcharan. Singh, Syed. Yousuf Ali Introduction Paederus dermatitis, also known as dermatitis linearis[1] or blister beetle dermatitis[2] is a peculiar irritant contact dermatitis characterized by erythematous and bullous lesions [...]

The purpose of the study was to develop, implement and evaluate a multicomponent psychosocial model-based intervention to reduce sun exposure and increase sun protection among young women and to characterize the intervention's mechanisms of action. The combination of general health models relevant to individual health behaviors forms the basis of an effective intervention and the interplay of broad literature with specific psychosocial studies is required to inform intervention design.

INTRODUCTION There are two types of photo recall phenomena: ultraviolet recall and radiation recall. Ultraviolet recall (UVR), also known as sunburn reactivation phenomenon, is characterized by an erythematous eruption in [...]

To the Editor: Bedbugs (Cimex lectularius) are hematophagous insects. Adults are 4-6 mm long, flattened, oval and wingless, and brown to brownish-red (Figure, panel A) (1). They may feed in [...]

Another study from the database explored generalized dermatitis in adults. This often frustrating condition can be caused by atopic dermatitis, allergic contact dermatitis, or a combination of causes. Unlike more [...]