Search

Your search keyword '"Skeljo, Maryanne"' showing total 20 results
Start Over Author "Skeljo, Maryanne"
20 results on '"Skeljo, Maryanne"'

4. Immunogenicity of a monovalent 2009 influenza A (H1N1) vaccine in infants and children

Author

Nolan, Terry, McVernon, Jodie, Skeljo, Maryanne, Richmond, Peter, Wadia, Ushma, Lambert, Stephen, Nissen, Michael, Marshall, Helen, Booy, Robert, Heron, Leon, Hartel, Gunter, Lai, Michael, Basser, Russell, Gittleson, Charmaine, and Greenberg, Michael

Subjects
Swine influenza -- Drug therapy, Swine influenza -- Control, Immunology -- Analysis, Influenza vaccines -- Dosage and administration, Infants -- Care and treatment
Abstract

A study was conducted to evaluate the immunogenicity, efficacy and safety of the 2009 influenza A (H1N1) vaccine in infants and children. Results indicated that a dose of one 15 micor gram group was effective in children from the age of six months and also that there were mild to moderate side effects.

Published
2010

14. Absence of cross‐reactive antibodies to influenza A (H1N1) 2009 before and after vaccination with 2009 Southern Hemisphere seasonal trivalent influenza vaccine in children aged 6 months–9 years: a prospective study

Author

McVernon, Jodie, Laurie, Karen, Barr, Ian, Kelso, Anne, Skeljo, Maryanne, and Nolan, Terry

Subjects
Male, pandemic, Influenza A Virus, H3N2 Subtype, Vaccination, Australia, virus diseases, Infant, Original Articles, Cross Reactions, Hemagglutination Inhibition Tests, Antibodies, Viral, paediatrics, H1N1 subtype, Influenza A Virus, H1N1 Subtype, Influenza Vaccines, Child, Preschool, Influenza, Human, influenza A virus, Humans, human, Prospective Studies, Seasons, influenza, Child, Pandemics
Abstract

Please cite this paper as: McVernon et al. (2010) Absence of cross‐reactive antibodies to influenza A (H1N1) 2009 before and after vaccination with 2009 Southern Hemisphere seasonal trivalent influenza vaccine in children aged 6 months–9 years: a prospective study. Influenza and Other Respiratory Viruses 5(1), 7–11. Background Early outbreaks of the pandemic influenza A (H1N1) 2009 virus predominantly involved young children, who fuelled transmission through spread in homes and schools. Seroprevalence studies conducted on stored serum collections indicated low levels of antibody to the novel strain in this age group, leading many to recommend priority immunisation of paediatric populations. Objectives In a prospective study, we sought evidence of cross‐reactive antibodies to the pandemic virus in children who were naïve to seasonal influenza vaccines, at baseline and following two doses of the 2009 Southern Hemisphere trivalent influenza vaccine (TIV). Patients/Methods Twenty children were recruited, with a median age of 4 years (interquartile range 3–5 years); all received two age appropriate doses of TIV. Paired sera were collected pre‐ and post‐vaccination for the assessment of vaccine immunogenicity, using haemagglutination inhibition and microneutralisation assays against vaccine‐related viruses and influenza A (H1N1) 2009. Results Robust responses to H3N2 were observed regardless of age or pre‐vaccination titre, with 100% seroconversion. Fewer seroconverted to the seasonal H1N1 component. Only two children were weakly seropositive (HI titre 40) to the pandemic H1N1 strain at study entry, and none showed evidence of seroconversion by HI assay following TIV administration. Conclusions Administration of 2009 Southern Hemisphere TIV did little to elicit cross‐reactive antibodies to the pandemic H1N1 virus in children, in keeping with assay results on stored sera from studies of previous seasonal vaccines. Our findings support the recommendations for influenza A (H1N1) 2009 vaccination of children in preparation for the 2010 winter season.

Published
2010

18. Immunogenicity of a Monovalent 2009 Influenza A(H1 N1) Vaccine in Infants and Children.

Author

Nolan, Terry, McVernon, Jodie, Skeljo, Maryanne, Richmond, Peter, Wadia, Ushma, Lambert, Stephen, Nissen, Michael, Marshall, Helen, Booy, Robert, Heron, Leon, Hartel, Gunter, Lai, Michael, Basser, Russell, Gittleson, Charmaine, and Greenberg, Michael

Subjects
H1N1 influenza, VACCINES, VACCINATION, CHILDREN'S health, PEDIATRICS -- Immunological aspects
Abstract

The article focuses on a randomized, observer-blind, age-stratified, parallel group study which assessed the immunogenicity and safety of a 2009 influenza A (H1N1) vaccine in children. The study used 370 health infants and children aged 6 months to less than 9 years old living in Australia. Intramuscular injection of the vaccine was administered on the children in a 2 dose regimen, 21 days apart. A 1:40 or greater antibody titers were observed in all of the study participants after the second dose of the vaccine was given.

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results