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3. The PSCA-rs2976395 functional variant is associated with pancreatic cancer development

Author

Corradi, Chiara, primary, Lencioni, Giulia, additional, Felici, Alessio, additional, Rizzato, Cosmeri, additional, Gentiluomo, Manuel, additional, Ermini, Stefano, additional, Archibugi, Livia, additional, Mickevicius, Antanas, additional, Lucchesi, Maurizio, additional, Malecka-Wojciesko, Ewa, additional, Basso, Daniela, additional, Arcidiacono, Paolo Giorgio, additional, Petrone, Maria Chiara, additional, Carrara, Silvia, additional, Götz, Mara, additional, Bunduc, Stefania, additional, Holleczek, Bernd, additional, Aoki, Mateus Nóbrega, additional, Uzunoglu, Faik G., additional, Zanette, Dalila Lucíola, additional, Mambrini, Andrea, additional, Jamroziak, Krzysztof, additional, Oliverius, Martin, additional, Lovecek, Martin, additional, Cavestro, Giulia Martina, additional, Milanetto, Anna Caterina, additional, Duchonova, Beatrice Mohelnikova, additional, Izbicki, Jacob R., additional, Zalinkevicius, Rimantas, additional, Hlavac, Viktor, additional, van Eijck, Casper H.J., additional, Brenner, Hermann, additional, Vanella, Giuseppe, additional, Cervena, Klara, additional, Soucek, Pavel, additional, Tavano, Francesca, additional, Perri, Francesco, additional, Capurso, Gabriele, additional, Hussein, Tamas, additional, Kiudelis, Mindaugas, additional, Kupcinskas, Juozas, additional, Busch, Olivier R., additional, Morelli, Luca, additional, Theodoropoulos, George E., additional, Testoni, Sabrina G.G., additional, Adamonis, Kestutis, additional, Neoptolemos, John P., additional, Gazouli, Maria, additional, Pasquali, Claudio, additional, Kormos, Zita, additional, Skalicky, Pavel, additional, Pezzilli, Raffaele, additional, Sperti, Cosimo, additional, Kauffmann, Emanuele, additional, Büchler, Markus W., additional, Schöttker, Ben, additional, Hegyi, Peter, additional, Capretti, Giovanni, additional, Lawlor, Rita T., additional, Canzian, Federico, additional, and Campa, Daniele, additional

Published
2023
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7. Possibilities of Modelling and Simulation in Military Engineering

Author

Skalický, Pavel, Palasiewicz, Tibor, Kyjovský, Jan, Zelený, Jaroslav, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, and Mazal, Jan, editor

Published
2018
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9. Morphine Analgesia, Cannabinoid Receptor 2, and Opioid Growth Factor Receptor Cancer Tissue Expression Improve Survival after Pancreatic Cancer Surgery

Author

Vecera, Lubomir, primary, Prasil, Petr, additional, Srovnal, Josef, additional, Berta, Emil, additional, Vidlarova, Monika, additional, Gabrhelik, Tomas, additional, Kourilova, Pavla, additional, Lovecek, Martin, additional, Skalicky, Pavel, additional, Skarda, Jozef, additional, Kala, Zdenek, additional, Michalek, Pavel, additional, and Hajduch, Marian, additional

Published
2023
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10. Fluorescence In Situ Hybridization in Primary Diagnosis of Biliary Strictures: A Single-Center Prospective Interventional Study

Author

Zoundjiekpon, Vincent Dansou, primary, Falt, Premysl, additional, Zapletalova, Jana, additional, Vanek, Petr, additional, Kurfurstova, Daniela, additional, Slobodova, Zuzana, additional, Skanderova, Daniela, additional, Korinkova, Gabriela, additional, Skalicky, Pavel, additional, Lovecek, Martin, additional, and Urban, Ondrej, additional

Published
2023
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15. Identification and Validation of Circulating Micrornas as Prognostic Biomarkers in Pancreatic Ductal Adenocarcinoma Patients Undergoing Surgical Resection

Author

Gablo, Natalia, primary, Trachtova, Karolina, additional, Prochazka, Vladimir, additional, Hlavsa, Jan, additional, Grolich, Tomas, additional, Kiss, Igor, additional, Srovnal, Josef, additional, Rehulkova, Alona, additional, Lovecek, Martin, additional, Skalicky, Pavel, additional, Berindan-Neagoe, Ioana, additional, Kala, Zdenek, additional, and Slaby, Ondrej, additional

Published
2020
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16. Germline DNA-repair genetic background in long-term survivors of pancreatic ductal adenocarcinoma

Author

Mohelnikova-Duchonova, Beatrice, primary, Janatova, Marketa, additional, Skalicky, Pavel, additional, Zemanek, Tomas, additional, Havlik, Roman, additional, Ehrmann, Jiri, additional, Strouhal, Ondrej, additional, Zemankova, Petra, additional, Lhotova, Klara, additional, Borecka, Marianna, additional, Soukupova, Jana, additional, Svebisova, Hana, additional, Soucek, Pavel, additional, Hlavac, Viktor, additional, Kleibl, Zdenek, additional, Neoral, Cestmir, additional, Melichar, Bohuslav, additional, and Lovecek, Martin, additional

Published
2019
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17. Solitary needle tract seeding metastases following pancreatic cancer resections with previous EUS-FNA

Author

Skalicky, Pavel, primary, Tesaříková, Jana, additional, Urban, Ondrej, additional, Falt, Premysl, additional, Tozzi, Igor, additional, Zoundjiekpon, Vincent Dansou, additional, Kovar, Radim, additional, Ehrmann, Jiri, additional, Svebisova, Hana, additional, Mohelnikova-Duchonova, Beatrice, additional, Lemstrova, Radka, additional, Neoral, Cestmir, additional, and Lovecek, Martin, additional

Published
2019
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20. Genetic analysis of subsequent second primary malignant neoplasms in long-term pancreatic cancer survivors suggests new potential hereditary genetic alterations

Author

Lovecek, Martin, primary, Janatova, Marketa, additional, Skalicky, Pavel, additional, Zemanek, Tomas, additional, Havlik, Roman, additional, Ehrmann, Jiri, additional, Strouhal, Ondrej, additional, Zemankova, Petra, additional, Lhotova, Klara, additional, Borecka, Marianna, additional, Soukupova, Jana, additional, Svebisova, Hana, additional, Soucek, Pavel, additional, Hlavac, Viktor, additional, Kleibl, Zdenek, additional, Neoral, Cestmir, additional, Melichar, Bohuslav, additional, and Mohelnikova-Duchonova, Beatrice, additional

Published
2019
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21. Subsequent malignant neoplasms among pancreatic cancer long-term survivors; new potential hereditary genetic alterations

Author

Lovecek, Martin, primary, Janatova, Marketa, additional, Skalicky, Pavel, additional, Zemanek, Tomas, additional, Strouhal, Ondrej, additional, Zemankova, Petra, additional, Lhotova, Klara, additional, Borecka, Marianna, additional, Soukupova, Jana, additional, Svebisova, Hana, additional, Soucek, Pavel, additional, Hlavac, Viktor, additional, Kleibl, Zdenek, additional, and Mohelnikova-Duchonova, Beatrice, additional

Published
2018
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23. Different clinical presentations of metachronous pulmonary metastases after resection of pancreatic ductal adenocarcinoma: Retrospective study and review of the literature

Author

Lovecek, Martin, primary, Skalicky, Pavel, additional, Chudacek, Josef, additional, Szkorupa, Marek, additional, Svebisova, Hana, additional, Lemstrova, Radmila, additional, Ehrmann, Jiri, additional, Melichar, Bohuslav, additional, Yogeswara, Tharani, additional, Klos, Dusan, additional, Vrba, Radek, additional, Havlik, Roman, additional, and Mohelnikova-Duchonova, Beatrice, additional

Published
2017
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25. Metachronous pulmonary metastasis after resection of pancreatic ductal adenocarcinoma. Different clinical scenarios. Retrospective study. Supported by Ministry of Health CR (16-28375A)

Author

Lovecek, Martin, primary, Skalicky, Pavel, additional, Chudacek, Josef, additional, Szkorupa, Marek, additional, Svebisova, Hana, additional, Lemstrova, Radmila, additional, Ehrmann, Jiri, additional, Melichar, Bohuslav, additional, Yogeswara, Tharani, additional, and Mohelnikova-Duchonova, Beatrice, additional

Published
2017
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30. Are we any closer to screening for colorectal cancer using microbial markers? A critical review.

Author

Stary, Lubomir, Mezerova, Kristyna, Skalicky, Pavel, Zboril, Pavel, and Raclavsky, Vladislav

Abstract

The role of gut microbiota in the development of sporadic colorectal cancer (CRC) is supported by a number of studies, however, the conclusiveness of published metagenomic studies is questioned by technical pitfalls and limited by small cohort sizes. In this review, we evaluate the current knowledge critically and outline practical solutions. We also list candidate CRC risk markers that are - in our opinion - well supported by available data and thus deserve clinical validation. Last but not least, we summarise available knowledge useful for improving care for patients immediately. [ABSTRACT FROM AUTHOR]

Published
2017
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34. Detection of minimal residual disease in lung cancer

Author

Chudacek, Josef, primary, Bohanes, Tomas, additional, Klein, Jiri, additional, Benedikova, Andrea, additional, Srovnal, Josef, additional, Szkorupa, Marek, additional, Skalicky, Pavel, additional, Skarda, Jozef, additional, Hajduch, Marian, additional, and Neoral, Cestmir, additional

Published
2014
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38. Abstract 842: The detection of circulating tumor cells is a negative prognostic factor in colorectal cancer

Author

Srovnal, Josef, primary, Vyslouzil, Kamil, additional, Jancik, Sylwia, additional, Drabek, Jiri, additional, Radova, Lenka, additional, Duda, Miloslav, additional, Skalicky, Pavel, additional, Klementa, Ivo, additional, Stary, Lubomir, additional, Cwiertka, Karel, additional, Straznicka, Jana, additional, Sramek, Vlastimil, additional, Melichar, Bohuslav, additional, and Hajduch, Marian, additional

Published
2010
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39. DRAPA trial--closed-suction drains versus closed gravity drains in pancreatic surgery: study protocol for a randomized controlled trial.

Author

ecka, Filip, Lovecek, Martin, Jon, Bohumil, Skalicky, Pavel, Subrt, Zdenk, Ferko, Alexander, Čečka, Filip, Loveček, Martin, Skalický, Pavel, and Šubrt, Zdeněk

Abstract

Background: The morbidity of pancreatic resection remains high, with pancreatic fistula being the most common cause. The important question is whether any postoperative treatment adjustment may prevent the development of clinically significant postoperative pancreatic fistulae. Recent studies have shown that intraabdominal drains and manipulation using them are of great importance. Although authors of a few retrospective reports have described good results of pancreatic resection without the use of intraabdominal drains, a recent prospective randomized trial showed that routine elimination of drains in pancreaticoduodenectomy is associated with poor outcome. An important issue arises as to which type of drain is most suitable for pancreatic resection. Two types of surgical drains exist: open drains and closed drains. Open drains are considered obsolete nowadays because of frequent retrograde infection. Closed drains include two types: passive gravity drains and closed-suction drains. Closed-suction drains are more effective, as they remove fluid from the abdominal cavity under light pressure. However, some surgeons believe that closed-suction drains represent a potential hazard to patients and that negative pressure might increase the risk of pancreatic fistulae. Nobody has yet specifically dealt with the question of which kind of drainage is most appropriate in pancreatic surgery.Methods/design: The aim of the DRAins in PAncreatic surgery (DRAPA) trial is to compare the closed-suction drain versus the closed passive gravity drain in pancreatic resection. DRAPA is a dual-centre, prospective, randomized controlled trial. The primary endpoint is the rate of postoperative pancreatic fistula; the secondary endpoint is postoperative morbidity with follow-up of 3 months.Discussion: No study to date has compared different types of drains in pancreatic surgery. This study is designed to answer the question whether any particular type of drain might lower the rate of postoperative pancreatic fistula or other complications.Trial Registration: ClinicalTrials.gov Identifier: NCT01988519. Registered 13 November 2013. [ABSTRACT FROM AUTHOR]

Published
2015
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41. Potential association between PSCA rs2976395 functional variant and pancreatic cancer risk.

Author

Corradi C, Lencioni G, Felici A, Rizzato C, Gentiluomo M, Ermini S, Archibugi L, Mickevicius A, Lucchesi M, Malecka-Wojciesko E, Basso D, Arcidiacono PG, Petrone MC, Carrara S, Götz M, Bunduc S, Holleczek B, Aoki MN, Uzunoglu FG, Zanette DL, Mambrini A, Jamroziak K, Oliverius M, Lovecek M, Cavestro GM, Milanetto AC, Peduzzi G, Duchonova BM, Izbicki JR, Zalinkevicius R, Hlavac V, van Eijck CHJ, Brenner H, Vanella G, Vokacova K, Soucek P, Tavano F, Perri F, Capurso G, Hussein T, Kiudelis M, Kupcinskas J, Busch OR, Morelli L, Theodoropoulos GE, Testoni SGG, Adamonis K, Neoptolemos JP, Gazouli M, Pasquali C, Kormos Z, Skalicky P, Pezzilli R, Sperti C, Kauffmann E, Büchler MW, Schöttker B, Hegyi P, Capretti G, Lawlor RT, Canzian F, and Campa D

Subjects
Humans, Male, Case-Control Studies, White People genetics, Female, Quantitative Trait Loci, Alleles, Asian People genetics, Middle Aged, Polymorphism, Single Nucleotide, Pancreatic Neoplasms genetics, Genetic Predisposition to Disease, DNA Methylation, Carcinoma, Pancreatic Ductal genetics, GPI-Linked Proteins genetics, Linkage Disequilibrium, Antigens, Neoplasm genetics, Neoplasm Proteins genetics
Abstract

Correlated regions of systemic interindividual variation (CoRSIV) represent a small proportion of the human genome showing DNA methylation patterns that are the same in all human tissues, are different among individuals, and are partially regulated by genetic variants in cis. In this study we aimed at investigating single-nucleotide polymorphisms (SNPs) within CoRSIVs and their involvement with pancreatic ductal adenocarcinoma (PDAC) risk. We analyzed 29,099 CoRSIV-SNPs and 133,615 CoRSIV-mQTLs in 14,394 cases and 247,022 controls of European and Asian descent. We observed that the A allele of the rs2976395 SNP was associated with increased PDAC risk in Europeans (p = 2.81 × 10 -5 ). This SNP lies in the prostate stem cell antigen gene and is in perfect linkage disequilibrium with a variant (rs2294008) that has been reported to be associated with risk of many other cancer types. The A allele is associated with the DNA methylation level of the gene according to the PanCan-meQTL database and with overexpression according to QTLbase. The expression of the gene has been observed to be deregulated in many tumors of the gastrointestinal tract including pancreatic cancer; however, functional studies are needed to elucidate the function relevance of the association., (© 2024 UICC.)

Published
2024
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