Search

Your search keyword '"Sjögren, K."' showing total 248 results
Start Over Author "Sjögren, K."
248 results on '"Sjögren, K."'

1. List of contributors

Author

Abrahamsen, Bo, primary, Adler, Robert A., additional, Ajjour, Sara, additional, Alemi, Mohammad Mehdi, additional, Anderson, Dennis E., additional, Arnett, Timothy R., additional, Assaad, Mariam A., additional, Ballane, Ghada T., additional, Baron, Roland, additional, Bassett, J.H. Duncan, additional, Bauer, Douglas C., additional, Bauman, William A., additional, Beavers, Kristen M., additional, Berry, Sarah D., additional, Bilezikian, John P., additional, Biver, Emmanuel, additional, Bliuc, Dana, additional, Bonewald, Lynda F., additional, Boskey, Adele L., additional, Bouxsein, Mary L., additional, Bravenboer, Nathalie, additional, Brown, Todd T., additional, Bukata, Susan V., additional, Burkhart, Katelyn, additional, Canalis, Ernesto, additional, Cardozo, Christopher, additional, Castillo, Alesha B., additional, Cauley, Jane A., additional, Center, Jacqueline R., additional, Chen, Julia C., additional, Civitelli, Roberto, additional, Cohen, Adi, additional, Cosman, Felicia, additional, Crandall, Carolyn J., additional, Crawford, Brooke M., additional, Cusano, Natalie E., additional, de Paula, Francisco J.A., additional, Delbaere, Kim, additional, Dempster, David W., additional, Diab, Dima L., additional, Dick-de-Paula, Ingrid, additional, DiMeglio, Linda A., additional, Drake, Matthew T., additional, Dubrovsky, Alanna M.K., additional, D’Onofrio, Luca, additional, Eastell, Richard, additional, Elder, Grahame J., additional, El-Hajj Fuleihan, Ghada A., additional, Ensrud, Kristine E., additional, Ferrari, Serge, additional, Freudenthal, Bernard, additional, Genant, Harry K., additional, Gerstenfeld, Louis C., additional, Giangregorio, Lora, additional, Gielen, Evelien, additional, Gold, Deborah T., additional, Goldring, Steven R., additional, Gordon, Catherine M., additional, Gori, Francesca, additional, Greendale, Gail A., additional, Griffith, James F., additional, Hadji, Peyman, additional, Hernandez, Christopher J., additional, Hoggatt, Jonathan, additional, Houston, Denise K., additional, Hussein, Amira I., additional, Jacobs, Christopher R., additional, Jiang, Xuezhi, additional, Johnston, James D., additional, Kagan, Risa, additional, Karim, Lamya, additional, Karvonen-Gutierrez, Carrie, additional, Katzman, Wendy B., additional, Kawai, Masanobu, additional, Khosla, Sundeep, additional, Kiel, Douglas P., additional, Kontulainen, Saija A., additional, Kostenuik, Paul, additional, Krez, Alexandra, additional, Kronenberg, Henry, additional, Kumar, Rajiv, additional, Lane, Nancy E., additional, Langsetmo, Lisa, additional, Laurent, Michaël R., additional, Lawenius, L., additional, Leikin, Sergey, additional, Leslie, William D., additional, Lewiecki, E. Michael, additional, Liu, Minghao, additional, Liu, Yi, additional, Lord, Stephen R., additional, Lorenzo, Joseph, additional, Ma, Nina S., additional, Maalouf, Naim M., additional, Marcus, Robert, additional, McClung, Michael R., additional, Mendes, Marcela Moraes, additional, Miller, Paul D., additional, Misra, Madhusmita, additional, Mohseni, Mahshid, additional, Morgan, Elise F., additional, Morin, Suzanne N., additional, Mukaddam, Mona Al, additional, Mulder, Chris J.J., additional, Nair, Nandini, additional, Napoli, Nicola, additional, Nasomyont, Nat, additional, Nelson, Dorothy A., additional, Nieves, Jeri W., additional, Nissenson, Robert, additional, Ohlsson, Claes, additional, Oleson, Christina V., additional, Ortinau, Laura, additional, Orwoll, Eric, additional, Ott, Susan M., additional, Pacifici, Roberto, additional, Palermo, Andrea, additional, Parfitt, A.M., additional, Park, Dongsu, additional, Provot, Sylvain, additional, Randhawa, Sonia Bhandari, additional, Randolph, John F., additional, Rivadeneira, Fernando, additional, Robey, Pamela Gehron, additional, Robinson, Lauren, additional, Rogers-Soeder, Tara, additional, Roodman, G. David, additional, Rosen, Clifford J., additional, Saag, Kenneth G., additional, Sahni, Shivani, additional, Sakhaee, Khashayar, additional, Scadden, David T., additional, Schafer, Anne L., additional, Schipani, Ernestina, additional, Serra, Monica C., additional, Shapiro, Jay R., additional, Sherrington, Catherine, additional, Shikany, James M., additional, Silverberg, Shonni J., additional, Singer, Andrea J., additional, Sjögren, K., additional, Snyder, Peter J., additional, Stein, Emily M., additional, Swanson, Christine M., additional, Szulc, Pawel, additional, Taxel, Pamela, additional, Tebben, Peter J., additional, Twardowski, Sarah E., additional, Uitterlinden, André G., additional, Vaidya, Rachana, additional, Vallera, Cristianna, additional, van Bodegraven, Adriaan A., additional, van der Eerden, Bram C.J., additional, van der Meulen, Marjolein C.H., additional, van Wijnen, André J., additional, Vanderschueren, Dirk, additional, Wactawski-Wende, Jean, additional, Watts, Laura, additional, Watts, Nelson B., additional, Weaver, Ashley A., additional, Weinstein, Robert S., additional, Williams, Graham R., additional, Wu, Joy, additional, Wu, Karin C., additional, Yin, Michael T., additional, Yu, Elaine W., additional, and Zhou, Hua, additional

Published
2021
Full Text
View/download PDF

3. Transgressive femininity : gender in the Scandinavian Modern Breakthrough

Author

Sjögren, K.

Subjects
839
Abstract

This PhD thesis deals with how new discourses on femininity and gender developed in Scandinavian literature during the Modern Breakthrough, 1880-1909. Political, economic and demographic changes in the Scandinavian societies put pressures on the existing, conventional gender roles, which literature reflects; however, literature also created and introduced new discourses on gender. The main focus has been on transgressive female characters in Danish, Swedish and Norwegian novels, which I have seen as indicators of emerging new forms of femininity. The study shows how the transgression of gender boundaries is used in the novels, when presenting their views on what femininity is, should be or could be. In addition to analysing the textual strategies in the representation of these ‘deviant’ literary characters, I have examined how the relevant texts were received by critics and reviewers at the time, as reviews are in themselves discursive constructs. The theoretical basis of this study has mainly been Michel Foucault’s discourse theory, Judith Butler’s theory of performativity and Yvonne Hirdman’s theory of gender binarism. I have also used concepts from several (mainly Anglo-American and Scandinavian) literary gender theorists and historians in the analyses. The four novels analysed in this study are as follows: 1) Danish author Herman Bang’s early decadence novel Haabløse Slægter (1880), where I use a queer theory perspective. 2) Norwegian author Ragnhild Jølsen’s Rikka Gan (1904), where the strong elements of pre-psychoanalysis are analysed. 3) Swedish author August Strindberg’s Le Plaidoyer d’un fou (1887-88), where I make a narratological examination of the narrative voice from a gender perspective. 4) Swedish author Annie Quiding’s Fru Fanny (1904), analysed as an example of ‘negative’ New Woman literature. The thesis shows how literature of the time represented and introduced new forms of femininity, often in the form of ambiguous female characters, and often to the disapproval of the critics. It also shows that gender discourses were much alike within Scandinavia. Furthermore, my study lays bare the skeleton of normative Breakthrough femininity, what can be called the dominant discourse on femininity at the time: a nonexisting sexual desire, feminine immobility/containment in the home and an imperative, self-sacrificing motherliness.

Published
2010

6. Bone-derived IGF-I regulates radial bone growth in adult male mice

Author

Svensson, J. (Johan), Sjögren, K. (Klara), Lawenius, L. (Lina), Koskela, A. (Antti), Tuukkanen, J. (Juha), Nilsson, K. H. (Karin H), Movérare-Skrtic, S. (Sofia), Ohlsson, C. (Claes), Svensson, J. (Johan), Sjögren, K. (Klara), Lawenius, L. (Lina), Koskela, A. (Antti), Tuukkanen, J. (Juha), Nilsson, K. H. (Karin H), Movérare-Skrtic, S. (Sofia), and Ohlsson, C. (Claes)

Abstract

Insulin-like growth factor-I (IGF-I) levels, which are reduced by age, and cortical bone dimensions are major determinants of fracture risk in elderly subjects. Inactivation of liver-derived circulating IGF-I results in reduced periosteal bone expansion in young and older mice. In mice with lifelong depletion of IGF-I in osteoblast lineage cells, the long bones display reduced cortical bone width. However, it has not previously been investigated whether inducible inactivation of IGF-I locally in bone in adult/old mice affects the bone phenotype. Adult tamoxifen-inducible inactivation of IGF-I using a CAGG-CreER mouse model (inducible IGF-IKO mice) substantially reduced IGF-I expression in bone (−55%) but not in liver. Serum IGF-I and body weight were unchanged. We used this inducible mouse model to assess the effect of local IGF-I on the skeleton in adult male mice, avoiding confounding developmental effects. After tamoxifen-induced inactivation of the IGF-I gene at 9 months of age, the skeletal phenotype was determined at 14 months of age. Computed tomography analyses of tibia revealed that the mid-diaphyseal cortical periosteal and endosteal circumferences and calculated bone strength parameters were decreased in inducible IGF-IKO mice compared with controls. Furthermore, 3-point bending showed reduced tibia cortical bone stiffness in inducible IGF-IKO mice. In contrast, the tibia and vertebral trabecular bone volume fraction was unchanged. In conclusion, inactivation of IGF-I in cortical bone with unchanged liver-derived IGF-I in older male mice resulted in reduced radial growth of cortical bone. This suggests that not only circulating IGF-I but also locally derived IGF-I regulates the cortical bone phenotype in older mice.

Published
2023

7. Transplantation of gut microbiota from old mice into young healthy mice reduces lean mass but not bone mass

Author

Lawenius, L. (Lina), Cowardin, C. (Carrie), Grahnemo, L. (Louise), Scheffler, J. M. (Julia M.), Horkeby, K. (Karin), Engdahl, C. (Cecilia), Wu, J. (Jianyao), Vandenput, L. (Liesbeth), Koskela, A. (Antti), Tuukkanen, J. (Juha), Coward, E. (Eivind), Hveem, K. (Kristian), Langhammer, A. (Arnulf), Abrahamsson, S. (Sanna), Gordon, J. I. (Jeffrey I.), Sjögren, K. (Klara), Ohlsson, C. (Claes), Lawenius, L. (Lina), Cowardin, C. (Carrie), Grahnemo, L. (Louise), Scheffler, J. M. (Julia M.), Horkeby, K. (Karin), Engdahl, C. (Cecilia), Wu, J. (Jianyao), Vandenput, L. (Liesbeth), Koskela, A. (Antti), Tuukkanen, J. (Juha), Coward, E. (Eivind), Hveem, K. (Kristian), Langhammer, A. (Arnulf), Abrahamsson, S. (Sanna), Gordon, J. I. (Jeffrey I.), Sjögren, K. (Klara), and Ohlsson, C. (Claes)

Abstract

Aging is associated with low bone and lean mass as well as alterations in the gut microbiota (GM). In this study, we determined whether the reduced bone mass and relative lean mass observed in old mice could be transferred to healthy young mice by GM transplantation (GMT). GM from old (21-month-old) and young adult (5-month-old) donors was used to colonize germ-free (GF) mice in three separate studies involving still growing 5- or 11-week-old recipients and 17-week-old recipients with minimal bone growth. The GM of the recipient mice was similar to that of the donors, demonstrating successful GMT. GM from old mice did not have statistically significant effects on bone mass or bone strength, but significantly reduced the lean mass percentage of still growing recipient mice when compared with recipients of GM from young adult mice. The levels of propionate in the cecum of mice receiving old donor GM were significantly lower than those in mice receiving young adult donor GM. Bacteroides ovatus was enriched in the microbiota of recipient mice harboring GM from young adult donors. The presence of B. ovatus was not only significantly associated with high lean mass percentage in mice, but also with lean mass adjusted for fat mass in the large human HUNT cohort. In conclusion, GM from old mice reduces lean mass percentage but not bone mass in young, healthy, still growing recipient mice. Future studies are warranted to determine whether GM from young mice improves the musculoskeletal phenotype of frail elderly recipient mice.

Published
2023

8. The significance of nursing home managers' leadership—longitudinal changes, characteristics and qualifications for perceived leadership, person-centredness and climate

Author

Backman, A, Lövheim, H, Lindkvist, M, Sjögren, K, and Edvardsson, David

Subjects
education, health care economics and organizations, Uncategorized
Abstract

Aims and objectives: The aim was to explore changes in nursing home managers’ leadership, person-centred care and psychosocial climate comparing matched units in a five-year follow-up and to explore the significance of managers’ educational qualifications and the ownership of nursing homes for perceived leadership, person-centred care and psychosocial climate in the follow-up data. Background: Leadership has been described as crucial for person-centred care and psychosocial climate even though longitudinal data are lacking. The significance of managerial leadership, its characteristics, managerial qualifications and ownership of nursing homes for perceived leadership, person-centred care and psychosocial climate also needs further exploration. Design: Repeated cross-sectional study. Methods: This study used valid and reliable measures of leadership, person-centred care, psychosocial climate and demographic variables collected from managers and staff n = 3605 in 2014 and n = 2985 in 2019. Descriptive and regression analyses were used. The STROBE checklist was used in reporting this study. Results: Leadership was still positively significantly associated to person-centred care in a five-year follow-up, but no changes in strength were seen. Leadership was still positively significantly associated with psychosocial climate, with stronger associations at follow-up. Six leadership characteristics increased over time. It was also shown that a targeted education for nursing home managers was positively associated with person-centred care. Conclusions: Leadership is still pivotal for person-centred care and psychosocial climate. Knowledge of nursing home managers’ leadership, characteristics and educational qualifications of significance for person-centred delivery provides important insights when striving to improve such services. Relevance to clinical practice: The findings can be used for management and clinical practice development initiatives because it was shown that nursing home managers’ leadership is vital to person-centred care practices and improves the climate for both staff and residents in these environments.

Published
2022
Full Text
View/download PDF

9. Acute fat loss does not affect bone mass

Author

Lagerquist, M. K. (Marie K.), Gustafsson, K. L. (Karin L.), Henning, P. (Petra), Farman, H. (Helen), Wu, J. (Jianyao), Sjögren, K. (Klara), Koskela, A. (Antti), Tuukkanen, J. (Juha), Ohlsson, C. (Claes), Wernstedt Asterholm, I. (Ingrid), Grahnemo, L. (Louise), Lagerquist, M. K. (Marie K.), Gustafsson, K. L. (Karin L.), Henning, P. (Petra), Farman, H. (Helen), Wu, J. (Jianyao), Sjögren, K. (Klara), Koskela, A. (Antti), Tuukkanen, J. (Juha), Ohlsson, C. (Claes), Wernstedt Asterholm, I. (Ingrid), and Grahnemo, L. (Louise)

Abstract

Obesity has previously been thought to protect bone since high body weight and body mass index are associated with high bone mass. However, some more recent studies suggest that increased adiposity negatively impacts bone mass. Here, we aimed to test whether acute loss of adipose tissue, via adipocyte apoptosis, alters bone mass in age-related obese mice. Adipocyte apoptosis was induced in obese male FAT-ATTAC mice through AP20187 dimerizer-mediated activation of caspase 8 selectively in adipocytes. In a short-term experiment, dimerizer was administered to 5.5 month-old mice that were terminated 2 weeks later. At termination, the total fat mass weighed 58% less in dimerizer-treated mice compared with vehicle-treated controls, but bone mass did not differ. To allow for the detection of long-term effects, we used 9-month-old mice that were terminated six weeks after dimerizer administration. In this experiment, the total fat mass weighed less (− 68%) in the dimerizer-treated mice than in the controls, yet neither bone mass nor biomechanical properties differed between groups. Our findings show that adipose tissue loss, despite the reduced mechanical loading, does not affect bone in age-related obese mice. Future studies are needed to test whether adipose tissue loss is beneficial during more severe obesity.

Published
2021

16. The androgen receptor is required for maintenance of bone mass in adult male mice

Author

Wu, J. (Jianyao), Henning, P. (Petra), Sjögren, K. (Klara), Koskela, A. (Antti), Tuukkanen, J. (Juha), Movérare-Skrtic, S. (Sofia), and Ohlsson, C. (Claes)

Subjects
Androgen receptor, Fat, Inducible, Bone
Abstract

Previous studies evaluating the role of the androgen receptor (AR) for bone mass have used mouse models with global or tissue-specific lifelong inactivation of the AR. However, these mouse models have the AR inactivated already early in life and the relative roles of the AR during development, sexual maturation and in adult mice cannot be evaluated separately. The aim of the present study was to determine the specific roles of the AR in bone during sexual maturation and in adult mice. The AR was conditionally ablated at four (pre-pubertal) or ten (post-pubertal) weeks of age in male mice using tamoxifen-inducible Cre-mediated recombination. Both the pre-pubertal and the post-pubertal AR inactivation were efficient demonstrated by substantially lower AR mRNA levels in seminal vesicle, bone and white adipose tissue as well as markedly reduced weights of reproductive tissues when comparing inducible ARKO mice and control mice at 14 weeks of age. Total body BMD, as analyzed by DXA, as well as tibia diaphyseal cortical bone thickness and proximal metaphyseal trabecular bone volume fraction, as analyzed by μCT, were significantly reduced by both pre-pubertal and post-pubertal AR inactivation. These bone effects were associated with an increased bone turnover, indicating a high bone turnover osteoporosis. Pre-pubertal but not post-pubertal AR inactivation resulted in substantially increased fat mass. In conclusion, the AR is required for maintenance of both trabecular and cortical bone in adult male mice while AR expression during puberty is crucial for normal fat mass homeostasis in adult male mice.

Published
2019

17. Inducible Wnt16 inactivation:WNT16 regulates cortical bone thickness in adult mice

Author

Ohlsson, C. (Claes), Henning, P. (Petra), Nilsson, K. H. (Karin H), Wu, J. (Jianyao), Gustafsson, K. L. (Karin L), Sjögren, K. (Klara), Törnqvist, A. (Anna), Koskela, A. (Antti), Zhang, F.-P. (Fu-Ping), Lagerquist, M. K. (Marie K), Poutanen, M. (Matti), Tuukkanen, J. (Juha), Lerner, U. H. (Ulf H), and Movérare-Skrtic, S. (Sofia)

Subjects
animal structures, tamoxifen, WNT16, cortical thickness, transgenic
Abstract

Substantial progress has been made in the therapeutic reduction of vertebral fracture risk in patients with osteoporosis, but non-vertebral fracture risk has been improved only marginally. Human genetic studies demonstrate that the WNT16 locus is a major determinant of cortical bone thickness and non-vertebral fracture risk and mouse models with life-long Wnt16 inactivation revealed that WNT16 is a key regulator of cortical thickness. These studies, however, could not exclude that the effect of Wnt16 inactivation on cortical thickness might be caused by early developmental and/or growth effects. To determine the effect of WNT16 specifically on adult cortical bone homeostasis, Wnt16 was conditionally ablated in young adult and old mice through tamoxifen-inducible Cre-mediated recombination using CAG-Cre-ER; Wnt16flox/flox (Cre-Wnt16flox/flox) mice. First, 10-week-old Cre-Wnt16flox/flox and Wnt16flox/flox littermate control mice were treated with tamoxifen. Four weeks later, Wnt16 mRNA levels in cortical bone were reduced and cortical thickness in femur was decreased in Cre-Wnt16flox/flox mice compared to Wnt16flox/flox mice. Then, inactivation of Wnt16 in 47-week-old mice (evaluated four weeks later) resulted in a reduction of Wnt16 mRNA levels, cortical thickness and cortical bone strength with no effect on trabecular bone volume fraction. Mechanistic studies demonstrated that the reduced cortical bone thickness was caused by a combination of increased bone resorption and reduced periosteal bone formation. In conclusion, WNT16 is a crucial regulator of cortical bone thickness in young adult and old mice. We propose that new treatment strategies targeting the adult regulation of WNT16 might be useful to reduce fracture risk at cortical bone sites.

Published
2018

19. The Beaker Phenomenon and the genomic transformation of Northwest Europe

Author

Olalde, I., Brace, S., Allentoft, M., Armit, I., Kristiansen, K., Rohland, N., Mallick, S., Booth, T., Szécsényi-Nagy, A., Mittnik, A., Altena, E., Lipson, M., Lazaridis, I., Patterson, N., Broomandkhoshbacht, N., Diekmann, Y., Faltyskova, Z., Fernandes, D., Ferry, M., Harney, E., de Knijff, P., Michel, M., Oppenheimer, J., Stewardson, K., Barclay, A., Alt, K., Fernández, A., Bánffy, E., Bernabò-Brea, M., Billoin, D., Blasco, C., Bonsall, C., Bonsall, L., Allen, T., Büster, L., Carver, S., Navarro, L., Craig, O., Cook, G., Cunliffe, B., Denaire, A., Dinwiddy, K., Dodwell, N., Ernée, M., Evans, C., Kuchařík, M., Farré, J., Fokkens, H., Fowler, C., Gazenbeek, M., Pena, R., Haber-Uriarte, M., Haduch, E., Hey, G., Jowett, N., Knowles, T., Massy, K., Pfrengle, S., Lefranc, P., Lemercier, O., Lefebvre, A., Maurandi, J., Majó, T., McKinley, J., McSweeney, K., Gusztáv, M., Modi, A., Kulcsár, G., Kiss, V., Czene, A., Patay, R., Endródi, A., Köhler, K., Hajdu, T., Cardoso, J., Liesau, C., Pearson, M., Włodarczak, P., Price, T., Prieto, P., Rey, P., Ríos, P., Risch, R., Guerra, M., Schmitt, A., Serralongue, J., Silva, A., Smrčka, V., Vergnaud, L., Zilhão, J., Caramelli, D., Higham, T., Heyd, V., Sheridan, A., Sjögren, K., Thomas, M., Stockhammer, P., Pinhasi, R., Krause, J., Haak, W., Barnes, I., Lalueza-Fox, C., and Reich, D.

Published
2017

20. Increased bone mass in a mouse model with low fat mass

Author

Grahnemo, L., primary, Gustafsson, K. L., additional, Sjögren, K., additional, Henning, P., additional, Lionikaite, V., additional, Koskela, A., additional, Tuukkanen, J., additional, Ohlsson, C., additional, Wernstedt Asterholm, I., additional, and Lagerquist, M. K., additional

Published
2018
Full Text
View/download PDF

26. ERα expression in T lymphocytes is dispensable for estrogenic effects in bone

Author

Gustafsson, K L, primary, Nilsson, K H, additional, Farman, H H, additional, Andersson, A, additional, Lionikaite, V, additional, Henning, P, additional, Wu, J, additional, Windahl, S H, additional, Islander, U, additional, Movérare-Skrtic, S, additional, Sjögren, K, additional, Carlsten, H, additional, Gustafsson, J-Å, additional, Ohlsson, C, additional, and Lagerquist, M K, additional

Published
2018
Full Text
View/download PDF

29. Erratum: Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits (vol 15, pg 811, 2016)

Author

Teumer, A., Qi, Q., Nethander, M., Aschard, H., Bandinelli, S., Beekman, M., Berndt, S.I., Bidlingmaier, M., Broer, L., Cappola, A., Ceda, G.P., Chanock, S., Chen, M.-H., Chen, T.C., Chen, Y.-D.I., Chung, J., Del Greco Miglianico, F., Eriksson, J., Ferrucci, L., Friedrich, N., Gnewuch, C., Goodarzi, M.O., Grarup, N., Guo, T., Hammer, E., Hayes, R.B., Hicks, A.A., Hofman, A., Houwing-Duistermaat, J.J., Hu, F., Hunter, D.J., Husemoen, L.L., Isaacs, A., Jacobs, K.B., Janssen, J.A.M.J.L., Jansson, J.-O., Jehmlich, Nico, Johnson, S., Juul, A., Karlsson, M., Kilpelainen, T.O., Kovacs, P., Kraft, P., Li, C., Linneberg, A., Liu, Y., Loos, R.J.F., Lorentzon, M., Lu, Y., Maggio, M., Magi, R., Meigs, J., Mellström, D., Nauck, M., Newman, A.B., Pollak, M.N., Pramstaller, P.P., Prokopenko, I., Psaty, B.M., Reincke, M., Rimm, R.B., Rotter, J.I., Saint Pierre, A., Schurmann, C., Seshadri, S., Sjögren, K., Slagboom, P.E., Strickler, H.D., Stumvoll, M., Suh, Y., Sun, Q., Zhang, C., Svensson, J., Tanaka, T., Tare, A., Tönjes, A., Uh, H.-W., van Duijn, C., van Heemst, D., Vandenput, L., Vasan, R.S., Völker, U., Willems, S.M., Ohlsson, C., Wallaschofski, H., Kaplan, R.C., Teumer, A., Qi, Q., Nethander, M., Aschard, H., Bandinelli, S., Beekman, M., Berndt, S.I., Bidlingmaier, M., Broer, L., Cappola, A., Ceda, G.P., Chanock, S., Chen, M.-H., Chen, T.C., Chen, Y.-D.I., Chung, J., Del Greco Miglianico, F., Eriksson, J., Ferrucci, L., Friedrich, N., Gnewuch, C., Goodarzi, M.O., Grarup, N., Guo, T., Hammer, E., Hayes, R.B., Hicks, A.A., Hofman, A., Houwing-Duistermaat, J.J., Hu, F., Hunter, D.J., Husemoen, L.L., Isaacs, A., Jacobs, K.B., Janssen, J.A.M.J.L., Jansson, J.-O., Jehmlich, Nico, Johnson, S., Juul, A., Karlsson, M., Kilpelainen, T.O., Kovacs, P., Kraft, P., Li, C., Linneberg, A., Liu, Y., Loos, R.J.F., Lorentzon, M., Lu, Y., Maggio, M., Magi, R., Meigs, J., Mellström, D., Nauck, M., Newman, A.B., Pollak, M.N., Pramstaller, P.P., Prokopenko, I., Psaty, B.M., Reincke, M., Rimm, R.B., Rotter, J.I., Saint Pierre, A., Schurmann, C., Seshadri, S., Sjögren, K., Slagboom, P.E., Strickler, H.D., Stumvoll, M., Suh, Y., Sun, Q., Zhang, C., Svensson, J., Tanaka, T., Tare, A., Tönjes, A., Uh, H.-W., van Duijn, C., van Heemst, D., Vandenput, L., Vasan, R.S., Völker, U., Willems, S.M., Ohlsson, C., Wallaschofski, H., and Kaplan, R.C.

Abstract

no abstract

Published
2017

30. The influence of rinsing routines on fluoride retention after toothbrushing

Author

Melin Nh and Sjögren K

Subjects
Adult, Toothbrushing, Time Factors, Statistics as Topic, Dental Plaque, Mouthwashes, Dentistry, Fluorides, chemistry.chemical_compound, Fluoride dentifrice, Dentifrice, Humans, Medicine, Whole saliva, Saliva, General Dentistry, Dentifrices, Analysis of Variance, Cross-Over Studies, business.industry, Water, Interdental consonant, Gingival Crevicular Fluid, Cariostatic Agents, chemistry, Geriatrics and Gerontology, business, Fluoride, Ion-Selective Electrodes
Abstract

Objective: An important determinant of the anticaries effect of brushing with a fluoride dentifrice is the retention of fluoride in the oral fluids. This study measured the influence of various post-brushing rinsing routines on fluoride retention. Setting: The Faculty of Odontology, Goteborg University, Sweden. Subjects: Twenty-one healthy dental students, aged 23±2 yr. Desing: A randomised, cross-over protocol, comparing various post-brushing rinsing procedures, with the following variables: volume of rinsing water (5 mL vs. 10×3mL) and duration of rinsing (10 vs. 60 s). Samples of whole saliva, interdental fluid and interdental plaque were analysed for fluoride content. Results: The duration of rinsing did not influence fluoride retention in whole saliva, interdental fluid or interdental plaque. Rinsing with a higher volume of water substantially decreased fluoride retention in all samples. Conclusion: Brushing with a fluoride dentifrice should be followed by rinsing procedures which enhance the retention of fluoride. Rinsing with large volumes of water decreases fluoride retention in the oral fluids, and should be discouraged.

Published
2001
Full Text
View/download PDF

31. Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits

Author

Teumer, A. (Alexander), Qi, Q., Nethander, M. (Maria), Aschard, H. (Hugues), Bandinelli, S. (Stefania), Beekman, M. (Marian), Berndt, S.I. (Sonja), Bidlingmaier, M. (Martin), Broer, L. (Linda), Cappola, A.R. (Anne), Ceda, G.P. (Gian Paolo), Chanock, S.J. (Stephen), Chen, M.-H. (Ming-Huei), Chen, T.C. (Tai C.), Chen, Y.D. (Y.), Chung, J. (Jonathan), Del Greco Miglianico, F. (Fabiola), Eriksson, J. (Joel), Ferrucci, L. (Luigi), Friedrich, N. (Nele), Gnewuch, C. (Carsten), Goodarzi, M. (Mark), Grarup, N. (Niels), Guo, T. (Tingwei), Hammer, E. (Elke), Hayes, R.B. (Richard), Hicks, A.A. (Andrew), Hofman, A. (Albert), Houwing-Duistermaat, J.J. (Jeanine), Hu, F. (Frank), Hunter, D. (David), Husemoen, L.L.N. (Lise Lotte), Isaacs, A.J. (Aaron), Jacobs, K.B. (Kevin), Janssen, J.A.M.J.L. (Joop), Jansson, J.-O. (John-Olov), Jehmlich, N. (Nico), Johnson, S. (Simon), Juul, A. (Anders), Karlsson, M. (Magnus), Kilpeläinen, T.O. (Tuomas), Kovacs, P. (Peter), Kraft, P. (Peter), Li, C. (Chao), Linneberg, A. (Allan), Liu, Y. (YongMei), Loos, R.J.F. (Ruth), Lorentzon, M. (Mattias), Lu, Y. (Yingchang), Maggio, M. (Marcello), Mägi, R. (Reedik), Meigs, J.B. (James), Mellström, D. (Dan), Nauck, M. (Matthias), Newman, A.B. (Anne B.), Pollak, M.N. (Michael), Pramstaller, P.P. (Peter Paul), Prokopenko, I. (Inga), Psaty, B.M. (Bruce), Reincke, M. (Martin), Rimm, E.B. (Eric B.), Rotter, J.I. (Jerome I.), Saint Pierre, A. (Aude), Schurmann, C. (Claudia), Seshadri, S. (Sudha), Sjögren, K. (Klara), Slagboom, P.E. (Eline), Strickler, H.D. (Howard D.), Stumvoll, M. (Michael), Suh, Y. (Yousin), Sun, Q. (Qi), Zhang, C. (Cuilin), Svensson, J. (Johan), Tanaka, T. (Toshiko), Tare, A. (Archana), Tönjes, A. (Anke), Uh, H.-W. (Hae-Won), Duijn, C.M. (Cornelia) van, Heemst, D. (Diana) van, Vandenput, L. (Liesbeth), Vasan, R.S. (Ramachandran Srini), Völker, U. (Uwe), Willems, S.M. (Sara), Ohlsson, C. (Claes), Wallaschofski, H. (Henri), Kaplan, R.C. (Robert), Teumer, A. (Alexander), Qi, Q., Nethander, M. (Maria), Aschard, H. (Hugues), Bandinelli, S. (Stefania), Beekman, M. (Marian), Berndt, S.I. (Sonja), Bidlingmaier, M. (Martin), Broer, L. (Linda), Cappola, A.R. (Anne), Ceda, G.P. (Gian Paolo), Chanock, S.J. (Stephen), Chen, M.-H. (Ming-Huei), Chen, T.C. (Tai C.), Chen, Y.D. (Y.), Chung, J. (Jonathan), Del Greco Miglianico, F. (Fabiola), Eriksson, J. (Joel), Ferrucci, L. (Luigi), Friedrich, N. (Nele), Gnewuch, C. (Carsten), Goodarzi, M. (Mark), Grarup, N. (Niels), Guo, T. (Tingwei), Hammer, E. (Elke), Hayes, R.B. (Richard), Hicks, A.A. (Andrew), Hofman, A. (Albert), Houwing-Duistermaat, J.J. (Jeanine), Hu, F. (Frank), Hunter, D. (David), Husemoen, L.L.N. (Lise Lotte), Isaacs, A.J. (Aaron), Jacobs, K.B. (Kevin), Janssen, J.A.M.J.L. (Joop), Jansson, J.-O. (John-Olov), Jehmlich, N. (Nico), Johnson, S. (Simon), Juul, A. (Anders), Karlsson, M. (Magnus), Kilpeläinen, T.O. (Tuomas), Kovacs, P. (Peter), Kraft, P. (Peter), Li, C. (Chao), Linneberg, A. (Allan), Liu, Y. (YongMei), Loos, R.J.F. (Ruth), Lorentzon, M. (Mattias), Lu, Y. (Yingchang), Maggio, M. (Marcello), Mägi, R. (Reedik), Meigs, J.B. (James), Mellström, D. (Dan), Nauck, M. (Matthias), Newman, A.B. (Anne B.), Pollak, M.N. (Michael), Pramstaller, P.P. (Peter Paul), Prokopenko, I. (Inga), Psaty, B.M. (Bruce), Reincke, M. (Martin), Rimm, E.B. (Eric B.), Rotter, J.I. (Jerome I.), Saint Pierre, A. (Aude), Schurmann, C. (Claudia), Seshadri, S. (Sudha), Sjögren, K. (Klara), Slagboom, P.E. (Eline), Strickler, H.D. (Howard D.), Stumvoll, M. (Michael), Suh, Y. (Yousin), Sun, Q. (Qi), Zhang, C. (Cuilin), Svensson, J. (Johan), Tanaka, T. (Toshiko), Tare, A. (Archana), Tönjes, A. (Anke), Uh, H.-W. (Hae-Won), Duijn, C.M. (Cornelia) van, Heemst, D. (Diana) van, Vandenput, L. (Liesbeth), Vasan, R.S. (Ramachandran Srini), Völker, U. (Uwe), Willems, S.M. (Sara), Ohlsson, C. (Claes), Wallaschofski, H. (Henri), and Kaplan, R.C. (Robert)

Abstract

The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases including cardiovascular diseases, diabetes, and cancer. Through

Published
2016
Full Text
View/download PDF

32. Genomewide meta‐analysis identifies loci associated with IGF‐I and IGFBP‐3 levels with impact on age‐related traits

Author

Teumer, A., Qi, Q., Nethander, M., Aschard, H., Bandinelli, S., Beekman, M., Berndt, S.I., Bidlingmaier, M., Broer, L., Cappola, A., Ceda, G.P., Chanock, S., Chen, M.-H., Chen, T.C., Chen, Y.-D.I., Chung, J., Del Greco Miglianico, F., Eriksson, J., Ferrucci, L., Friedrich, N., Gnewuch, C., Goodarzi, M.O., Grarup, N., Guo, T., Hammer, E., Hayes, R.B., Hicks, A.A., Hofman, A., Houwing-Duistermaat, J.J., Hu, F., Hunter, D.J., Husemoen, L.L., Isaacs, A., Jacobs, K.B., Janssen, J.A.M.J.L., Jansson, J.-O., Jehmlich, Nico, Johnson, S., Juul, A., Karlsson, M., Kilpelainen, T.O., Kovacs, P., Kraft, P., Li, C., Linneberg, A., Liu, Y., Loos, R.J.F., Lorentzon, M., Lu, Y., Maggio, M., Magi, R., Meigs, J., Mellström, D., Nauck, M., Newman, A.B., Pollak, M.N., Pramstaller, P.P., Prokopenko, I., Psaty, B.M., Reincke, M., Rimm, R.B., Rotter, J.I., Saint Pierre, A., Schurmann, C., Seshadri, S., Sjögren, K., Slagboom, P.E., Strickler, H.D., Stumvoll, M., Suh, Y., Sun, Q., Zhang, C., Svensson, J., Tanaka, T., Tare, A., Tönjes, A., Uh, H.-W., van Duijn, C., van Heemst, D., Vandenput, L., Vasan, R.S., Völker, U., Willems, S.M., Ohlsson, C., Wallaschofski, H., Kaplan, R.C., Teumer, A., Qi, Q., Nethander, M., Aschard, H., Bandinelli, S., Beekman, M., Berndt, S.I., Bidlingmaier, M., Broer, L., Cappola, A., Ceda, G.P., Chanock, S., Chen, M.-H., Chen, T.C., Chen, Y.-D.I., Chung, J., Del Greco Miglianico, F., Eriksson, J., Ferrucci, L., Friedrich, N., Gnewuch, C., Goodarzi, M.O., Grarup, N., Guo, T., Hammer, E., Hayes, R.B., Hicks, A.A., Hofman, A., Houwing-Duistermaat, J.J., Hu, F., Hunter, D.J., Husemoen, L.L., Isaacs, A., Jacobs, K.B., Janssen, J.A.M.J.L., Jansson, J.-O., Jehmlich, Nico, Johnson, S., Juul, A., Karlsson, M., Kilpelainen, T.O., Kovacs, P., Kraft, P., Li, C., Linneberg, A., Liu, Y., Loos, R.J.F., Lorentzon, M., Lu, Y., Maggio, M., Magi, R., Meigs, J., Mellström, D., Nauck, M., Newman, A.B., Pollak, M.N., Pramstaller, P.P., Prokopenko, I., Psaty, B.M., Reincke, M., Rimm, R.B., Rotter, J.I., Saint Pierre, A., Schurmann, C., Seshadri, S., Sjögren, K., Slagboom, P.E., Strickler, H.D., Stumvoll, M., Suh, Y., Sun, Q., Zhang, C., Svensson, J., Tanaka, T., Tare, A., Tönjes, A., Uh, H.-W., van Duijn, C., van Heemst, D., Vandenput, L., Vasan, R.S., Völker, U., Willems, S.M., Ohlsson, C., Wallaschofski, H., and Kaplan, R.C.

Abstract

The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases including cardiovascular diseases, diabetes, and cancer. Through genomewide association study of up to 30 884 adults of European ancestry from 21 studies, we confirmed and extended the list of previously identified loci associated with circulating IGF-I and IGFBP-3 concentrations (IGF1, IGFBP3, GCKR, TNS3, GHSR, FOXO3, ASXL2, NUBP2/IGFALS, SORCS2, and CELSR2). Significant sex interactions, which were characterized by different genotype–phenotype associations between men and women, were found only for associations of IGFBP-3 concentrations with SNPs at the loci IGFBP3 and SORCS2. Analyses of SNPs, gene expression, and protein levels suggested that interplay between IGFBP3 and genes within the NUBP2 locus (IGFALS and HAGH) may affect circulating IGF-I and IGFBP-3 concentrations. The IGF-I-decreasing allele of SNP rs934073, which is an eQTL of ASXL2, was associated with lower adiposity and higher likelihood of survival beyond 90 years. The known longevity-associated variant rs2153960 (FOXO3) was observed to be a genomewide significant SNP for IGF-I concentrations. Bioinformatics analysis suggested enrichment of putative regulatory elements among these IGF-I- and IGFBP-3-associated loci, particularly of rs646776 at CELSR2. In conclusion, this study identified several loci associated with circulating IGF-I and IGFBP-3 concentrations and provides clues to the potential role of the IGF axis in mediating effects of known (FOXO3) and novel (ASXL2) longevity-associated loci.

Published
2016

34. The influence of rinsing routines on fluoride retention after toothbrushing.

Author

Sjögren, K., Melin, N.-H., and Sjögren, K

Subjects
FLUORIDES, DENTAL caries, DENTIFRICES, ORAL hygiene products, ORAL hygiene, ANALYSIS of variance, CLINICAL trials, COMPARATIVE studies, CROSSOVER trials, DENTAL plaque, ELECTRODES, EXUDATES & transudates, RESEARCH methodology, MEDICAL cooperation, MOUTHWASHES, RESEARCH, SALIVA, STATISTICS, TOOTH care & hygiene, TIME, WATER, EVALUATION research, RANDOMIZED controlled trials, CARIOSTATIC agents
Abstract

Objective: An important determinant of the anticaries effect of brushing with a fluoride dentifrice is the retention of fluoride in the oral fluids. This study measured the influence of various post-brushing rinsing routines on fluoride retention.Setting: The Faculty of Odontology, Göteborg University, Sweden.Subjects: Twenty-one healthy dental students, aged 23 +/- 2 yr.Design: A randomised, cross-over protocol, comparing various post-brushing rinsing procedures, with the following variables: volume of rinsing water (5 mL vs. 10 x 3 mL) and duration of rinsing (10 vs. 60 s). Samples of whole saliva, interdental fluid and interdental plaque were analysed for fluoride content.Results: The duration of rinsing did not influence fluoride retention in whole saliva, interdental fluid or interdental plaque. Rinsing with a higher volume of water substantially decreased fluoride retention in all samples.Conclusion: Brushing with a fluoride dentifrice should be followed by rinsing procedures which enhance the retention of fluoride. Rinsing with large volumes of water decreases fluoride retention in the oral fluids, and should be discouraged. [ABSTRACT FROM AUTHOR]

Published
2001
Full Text
View/download PDF

36. Estrogen receptor alpha amplifies the osteogenic response to mechanical loading in a ligand-independent manner by its activation function 1 but not 2

Author

Windahl⁎, S.H., primary, Saxon, L., additional, Börjesson, A.E., additional, Lagerquist, M.K., additional, Engdahl, C., additional, Sjögren, K., additional, Antal, M.C., additional, Krust, A., additional, Chambon, P., additional, Lanyon, L.E., additional, Price, J.S., additional, and Ohlsson, C., additional

Published
2012
Full Text
View/download PDF

39. Roles of transactivating functions 1 and 2 of estrogen receptor-α in bone

Author

Börjesson, A. E., primary, Windahl, S. H., additional, Lagerquist, M. K., additional, Engdahl, C., additional, Frenkel, B., additional, Movérare-Skrtic, S., additional, Sjögren, K., additional, Kindblom, J. M., additional, Stubelius, A., additional, Islander, U., additional, Antal, M. C., additional, Krust, A., additional, Chambon, P., additional, and Ohlsson, C., additional

Published
2011
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results