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213 results on '"Sixt, S"'

1. Atherektomie

Author

Sixt, S., Teichgräber, Ulf, editor, Aschenbach, René, editor, Scheinert, Dierk, editor, and Schmidt, Andrej, editor

Published
2018
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5. Percutaneous endovascular treatment of infrainguinal PAOD: Results of the PSI register study in 74 German vascular centers

Author

Behrendt, C.-A., Heidemann, F., Haustein, K., Grundmann, R. T., Debus, E. S., Balzer, K. M., Banafsche, R., Barbera, L., Baumhäkel, M., Blajan, E., Böhner, H., Breuer, P., Brune, U., Brunkwall, J., Bürger, T., Classen, S., Cöster, A., Dahl, P., Dus, E. S., Delgado, J. P., Dill, H., Eder, S., Fährenkemper, T., Feidicker, B., Forkel, J., Gahlen, J., Geier, B., Ghoi, R., Görtz, H., Gräbedünkel, J., Gunkel, W., Hader, O., Hammermüller, T., Hatzl, J., Hoffmann, J., Hofmann, M., Huberts, U., Jacobs, M., Kiechle, V., Kindermann, M., Kleemann, M., Kolka, P., Krahl, M., Krönert, T., Krupski-Berdien, G., Kuffner, H., Kuhnert, M., Lange, T., Lauff, V. K., Lesser, T., Liewald, F., Lommel, D., Naundorf, M., Nitschmann, K., Nöldeke, S., Noppeney, T., Oberhuber, A., Ockert, D. M., Orend, K.-H., Ossig, U., Petridis, C., Pflugradt, A., Quellmalz, U., Reimer, P., Remig, J., Richter, P., Riepe, G., Rümenapf, G., Schaefer, T., Schelzig, H., Schmidt, G., Schneider, M., Schofer, J., Seifert, S., Siggelkow, M., Sixt, S., Stautner, E., Stehr, A., Storck, M., Teßarek, J., Teebken, O. E., Thom, K.-D., Tigges, W. P., Voshage, G., Wagenbreth, K.-D., Walluscheck, K. P., Walter, D., Weidenhagen, R., Weis-Müller, B., Wenk, H., Wenk, M., Wiedner, M., Wilde, J., Wittstock, F. T., and PSI Collaborators

Published
2017
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11. The IN.PACT DEEP Clinical Drug-Coated Balloon Trial: 5-Year Outcomes

Author

Zeller, T., Micari, A., Scheinert, D., Baumgartner, I., Bosiers, M., Vermassen, F. E. G., Banyai, M., Shishehbor, M. H., Wang, H., Brodmann, M., Diehm, N., Krankenberg, H., Sixt, S., Peeters, P., Vermassen, F., Lansink, W., de Vries, J. -P., and Blessing, E.

Subjects
Male, Biocompatible, Time Factors, infrapopliteal, Paclitaxel, Critical Illness, amputation, CD-TLR, drug-coated balloon, IN.PACT DEEP, mortality, paclitaxel, Aged, Aged, 80 and over, Amputation, Angioplasty, Balloon, Cardiovascular Agents, Equipment Design, Europe, Female, Humans, Ischemia, Limb Salvage, Middle Aged, Peripheral Arterial Disease, Prospective Studies, Recurrence, Risk Factors, Treatment Outcome, Vascular Patency, Coated Materials, Biocompatible, 80 and over, Angioplasty, Coated Materials, Balloon
Published
2020

12. Prospective observational study for perioperative volume replacement with 6% HES 130/0,42, 4% gelatin and 6% HES 200/0,5 in cardiac surgery

Author

Winterhalter M, Malinski P, Danzeisen O, Sixt S, Monaca E, Jüttner T, Peiper M, Kienbaum P, Koester A, and Rahe-Meyer N

Subjects
Medicine
Abstract

Abstract Background The constantly growing amount of different kinds of colloid fluids necessitates comparative investigations with regards to the safety and effectivity in clinical use of these preparations. Hence we compared three colloid fluids in an observational study. The objective was the exploration of the influence of these three colloids on blood coagulation, hemodynamics and renal function of the cardiac surgical patient. Methods We included 90 patients undergoing an elective open-heart surgery with the use of the heart-lung machine and observed them consecutively. Group 1 [gelatin 4% (n = 30)], Group 2 [HES 200/0,5 (n = 30)] and Group 3 [HES 130/0,42 (n = 30)]. We measured the perioperative volume replacement, the administration of blood- and coagulation-products, the application of catecholamines, the renal function, blood gas and the platelet aggregation using multiplate electrode analyzer (Multiplate®, Dynabyte medical, Munich, Germany). Results The gelatin-group needed significantly more norepinephrine than the HES 130/0.42 group. The responsible surgeon considered the blood coagulation in the HES 200/0.5 group most frequently as impaired. Furthermore we saw a significant decrease in platelet function in the HES 200/0.5 group when performing the multiplate®-analysis (ADP-and COL-test). HES 130/0.4 as well as gelatin 4% showed no significant change in platelet function. The gelatin-group and the HES 200/0.5 needed significantly more aprotinine than the HES 130/0.4 group. We saw no significant difference with regards to administration of blood and coagulation products between the three groups. The urinary excretion during the intervention was significantly higher in the HES 200/0.5 group and in the gelatin group than in the HES 130/0.4 group. Conclusions Our results confirm the lower stabilizing effect of gelatin on circulation during fluid resuscitation. The blood coagulation was mostly impaired due to HES 200/0.5 confirmed by the multiplate®-analysis as well as by different clinical findings.

Published
2010
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14. P4189Effects of coagulase reaction on aggregation in patients with endocarditis

Author

Polzin, A, primary, Dannenberg, L, additional, Naguib, D, additional, Achilles, A, additional, Mourikis, P, additional, Zako, S, additional, Helten, C, additional, Konsek, D, additional, M'pembele, R, additional, Hohlfeld, T, additional, Kelm, M, additional, Zeus, T, additional, Sixt, S, additional, Albert, A, additional, and Hoffmann, T, additional

Published
2018
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19. Erratum to: The effectiveness of the paclitaxel-coated Luminor® balloon catheter versus an uncoated balloon catheter in superficial femoral and popliteal arteries in preventing vessel restenosis or reocclusion: study protocol for a randomized controlled trial

Author

Teichgräber, U., primary, Aschenbach, R., additional, Scheinert, D., additional, Zeller, T., additional, Brechtel, K., additional, Thieme, M., additional, Blessing, E., additional, Treitl, M., additional, Lichtenberg, M., additional, von Flotow, P., additional, Vogel, B., additional, Werk, M., additional, Riambau, V., additional, Wienke, A., additional, Lehmann, T., additional, and Sixt, S., additional

Published
2017
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23. The effectiveness of the paclitaxel-coated Luminor® balloon catheter versus an uncoated balloon catheter in superficial femoral and popliteal arteries in preventing vessel restenosis or reocclusion: study protocol for a randomized controlled trial

Author

Teichgräber, U., primary, Aschenbach, R., additional, Scheinert, D., additional, Zeller, T., additional, Brechtel, K., additional, Thieme, M., additional, Blessing, E., additional, Treitl, M., additional, Lichtenberg, M., additional, von Flowtow, P., additional, Vogel, B., additional, Werk, M., additional, Riambau, V., additional, Wienke, A., additional, Lehmann, T., additional, and Sixt, S., additional

Published
2016
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25. Gewebespende in NRW und Reduzierung der Wartezeit auf ein Hornhauttransplantat im Netzwerk der DGFG

Author

Sixt, S., Tietz, S., Napieralski, B., and Lochmann, D.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Die Deutsche Gesellschaft für Gewebetransplantation (DGFG) ist ein gemeinnütziges Netzwerk der Gewebemedizin in Deutschland. Im Netzwerk sind zahlreiche Spendekliniken, Gewebebanken und Transplantationszentren organisiert. Durch die gemeinsamen Aktivitäten hat sich insbesondere die[for full text, please go to the a.m. URL], 174. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte

Published
2012

26. Distinct Proteasome Subpopulations in the Alveolar Space of Patients with the Acute Respiratory Distress Syndrome

Author

Sixt, S., Alami, R., Hakenbeck, J., Adamzik, M., Kloss, A., Costabel, U., Jungblut, P., Dahlmann, B., and Peters, J.

Subjects
respiratory system
Abstract

There is increasing evidence that proteasomes have a biological role in the extracellular alveolar space, but inflammation could change their composition. We tested whether immunoproteasome protein-containing subpopulations are present in the alveolar space of patients with lung inflammation evoking the acute respiratory distress syndrome (ARDS). Bronchoalveolar lavage (BAL) supernatants and cell pellet lysate from ARDS patients (n = 28) and healthy subjects (n = 10) were analyzed for the presence of immunoproteasome proteins (LMP2 and LMP7) and proteasome subtypes by western blot, chromatographic purification, and 2D-dimensional gelelectrophoresis. In all ARDS patients but not in healthy subjects LMP7 and LMP2 were observed in BAL supernatants. Proteasomes purified from pooled ARDS BAL supernatant showed an altered enzyme activity ratio. Chromatography revealed a distinct pattern with 7 proteasome subtype peaks in BAL supernatant of ARDS patients that differed from healthy subjects. Total proteasome concentration in BAL supernatant was increased in ARDS (971 ng/mL perpendicular to 1116 versus 59 perpendicular to 25; P < 0.001), and all fluorogenic substrates were hydrolyzed, albeit to a lesser extent, with inhibition by epoxomicin (P = 0.0001). Thus, we identified for the first time immunoproteasome proteins and a distinct proteasomal subtype pattern in the alveolar space of ARDS patients, presumably in response to inflammation.

Published
2012

27. Extracellular biologically active proteasome in cebrebrospinal fluid: a novel function for a well-known protein?

Author

Müller, OM, Wiedemann, J, Anlasik, T, Thomassen, J, Sixt, S, and Sure, U

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: To prove the existence and biological function of the free extracellular proteasome in the cerebrospinal fluid (CSF). The proteasome’s substrate ubiquitin has been proven to be biologically active in CSF. We hypothesized that the proteasome can also be found in the CSF, as in the e.g.[for full text, please go to the a.m. URL], 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH)

Published
2011
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28. Does exercise training impact clock genes in patients with coronary artery disease and type 2 diabetes mellitus?

Author

Sportbiologie, Steidle-Kloc E, Schoenfelder M, Mueller E, Sixt S, Schuler G, Patsch W, Niebauer J, Sportbiologie, and Steidle-Kloc E, Schoenfelder M, Mueller E, Sixt S, Schuler G, Patsch W, Niebauer J

Abstract

BACKGROUND: Recent findings revealed negative effects of deregulated molecular circadian rhythm in coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM). Physical exercise training (ET) has been shown to promote anti-diabetic and anti-atherogenic responses in skeletal muscle of these patients, but the role of the circadian clock-machinery remains unknown. This study investigated whether mRNA expression of clock genes in skeletal muscle of CAD and T2DM patients is influenced by physical ET intervention. METHODS: Nineteen patients with CAD and T2DM (age 64 ± 5 years) were randomised to either six months of ET (four weeks of in-hospital ET followed by a five-month ambulatory programme) or usual care. At the beginning of the study, after fourweeks and after six months parameters of metabolic and cardiovascular risk factors, and physical exercise capacity were assessed. Gene expression was measured in skeletal muscle biopsies by quantitative real-time polymerase chain reaction (PCR). RESULTS: A selection of clock genes and associated components (circadian locomoter output cycle kaput protein (CLOCK), period (PER) 1, cryptochrome (CRY) 2 and aminolevulinate-deltA-synthase-1 (ALAS1)) was reliably measured and used for further analysis. A time-dependent effect in gene expression was observed in CLOCK (p = 0.013) and a significant interaction between time and intervention was observed for ALAS1 (p = 0.032; p = 0.014) as a result of ET. CONCLUSION: This is the first study to analyse clock gene expression in skeletal muscles of patients with CAD and T2DM participating in a long-lasting exercise intervention. ET, as one of the cornerstones in prevention and rehabilitation of CAD and T2DM, exerts no effects on CLOCK genes but meaningful effects on the clock-associated gene ALAS1.

Published
2015

33. Exercise training in chronic heart failure: Why, when and how

Author

Myers J, Dubach P, and Sixt S

Subjects
Heart Failure, medicine.medical_specialty, Time Factors, Chronic congestive heart failure, Ventricular Remodeling, Systole, business.industry, Hemodynamics, Training (meteorology), Cardiomyopathy, General Medicine, medicine.disease, Exercise Therapy, Quality of life, Diastole, Heart failure, Internal medicine, medicine, Cardiology, Etiology, Humans, business, Ventricular remodeling
Abstract

The management of patients with chronic congestive heart failure has changed considerably during the last decade. Until recently, restriction of physical activity was recommended for patients with chronic heart failure. However, the knowledge that training influences largely the periphery rather than the heart itself has led to a dramatic change in the approach toward training in patients with chronic heart failure. Why to train patients with chronic heart failure: Training increases exercise tolerance by an average of 20% in chronic heart failure regardless of etiology (ischemic or non-ischemic cardiomyopathy) or severity of left ventricular dysfunction. Available data, while limited, demonstrate that increases in exercise capacity are paralleled by an improvement in quality of life. Studies have consistently demonstrated that training has no deleterious effect on central haemodynamics, left ventricular remodeling, systolic or diastolic function, or myocardial metabolism. At present, there are insufficient data to determine the effect of training on prognosis, but trials are currently underway to address this. When to train patients with chronic heart failure: Exercise training should be performed only with the patients that have been in a stable clinical condition for a period of at least 3-4 weeks. Clinical stability is defined as no change in symptoms, weight, drug regimen, or NYHA class over this period. How to train patients with chronic heart failure: Initially, the program should be supervised for a period of 2 to 4 weeks; home-based programs are usually appropriate thereafter. Activities that can be maintained for a lifetime should be encouraged, and the focus should be on aerobic-type activities. The intensity level should be targeted to about 50%-70% of peak VO2 and/or Borg ratings of 12-14 ("walk and talk").

Published
2001
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39. Sirolimus-eluting stents vs. bare-metal stents for treatment of focal lesions in infrapopliteal arteries: a double-blind, multi-centre, randomized clinical trial

Author

Rastan, A., primary, Tepe, G., additional, Krankenberg, H., additional, Zahorsky, R., additional, Beschorner, U., additional, Noory, E., additional, Sixt, S., additional, Schwarz, T., additional, Brechtel, K., additional, Bohme, C., additional, Neumann, F.-J., additional, and Zeller, T., additional

Published
2011
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47. Long- but not short-term multifactorial intervention with focus on exercise training improves coronary endothelial dysfunction in diabetes mellitus type 2 and coronary artery disease

Author

Sixt, S., primary, Beer, S., additional, Bluher, M., additional, Korff, N., additional, Peschel, T., additional, Sonnabend, M., additional, Teupser, D., additional, Thiery, J., additional, Adams, V., additional, Schuler, G., additional, and Niebauer, J., additional

Published
2009
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48. Evaluation of Color Coded Ultrasound (CCU) for Quantitative Morphometry of Peripheral Arteries as Compared to Angiography: Results of the PeriQuant Registry Study

Author

Macharzina, RR, primary, Fan, N, additional, Charlotte, W, additional, Schwarzwälder, U, additional, Grabs, A, additional, Heykendorf, L, additional, Böhme, T, additional, Rastan, A, additional, Sixt, S, additional, Bürgelin, K, additional, Noory, E, additional, Beschorner, U, additional, Olschewski, M, additional, Neumann, F, additional, and Zeller, T, additional

Published
2009
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