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Intercostal stretch is a neuro physiological facilitation technique which has been proved to be effective on the ventilator parameters. Smoking is a worldwide problem which causes major health risks that are related to respiratory and cardiovascular diseases. Cigerrete smoking causes the alteration in lung function, increase the air way resistance and also irritates the airways. 30 subjects were taken for the study those who met with inclusion and exclusion criteria. Intercostal stretch was given to the subjects from 3rd to 8th rib. Chest expansion and 6 minute walk distance was calculated pre and post intervention immediately. Paired t test was calculated. The results of the study suggest that there is no significant difference in six minute walk distance (p>0.05) and there is a significant improvement in the chest expansion (p

Dance is the good form of exercise, the movement of the body in a rhythmic way to music and within a given space, for the purpose of expressing an idea or emotion, releasing energy, or simply taking delight in the movement itself which the body is capable. Though Bharatanatyam and Kuchipudi may look similar to the untrained eye, there are many differences which affect the mechanics of movement among practitioners of both art forms. The purpose of this study is to assess the vo2 max of Bharatanatyam and kuchipudi dancers and to find out whether there is any difference in the vo2 max between both the dancers. Total of 30 subjects who met the inclusion criteria were taken for study; Group A (n=15) Bharatanatyam dancers. Group B (n=15) kuchipudi dancers. Queen’s college step test was used to assess the vo2 max. Pre and post-test heart rate was measured and vo2 max calculated. Statistical analysis was tested with t test at 95% level of significance (p

A simple, rapid and robust reverse phase HPLC method was developed and validated for the determination of impurities in Dolutegravir drug substance. The main aim of this study is to reduce the time consumption and to develop and validate a less expensive method by using HPLC. The chromatographic separation of Dolutegravir and its related impurities is carried out by using C8 column (150 × 4.6 mm), 5µm with 0.1% trifluoroacetic acid in water as mobile phase A, methanol as mobile phase B. The flow rate is 1.0 mL/min with gradient elution mode and the wave length for detection is 240 nm (UV detector). The developed method was validated and proved that the method was specific, accurate and precise as per ICH. The system suitability criteria found to be within the limits. The limit of detection and limit of quantification demonstrate that the method is sensitive. The linearity curve was found to be linear and the correlation coefficient obtained is not less than 0.998. The average percentage recoveries of impurities were in the range of 97 to 101%. The proposed method was found to be suitable and accurate for quantitative determination of impurities in Dolutegravir drug substance.