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1. Accuracy of a new rapid diagnostic test for urinary antigen detection and assessment of drug treatment in opisthorchiasis

Author

Worasith, Chanika, Sithithaworn, Jiraporn, Wongphutorn, Phattharaphon, Homwong, Chutima, Khongsukwiwat, Kanoknan, Techasen, Anchalee, Kopolrat, Kulthida Y., Loilome, Watcharin, Namwat, Nisana, Thinkamrop, Bandit, Tawarungruang, Chaiwat, Titapun, Attapol, Laha, Thewarach, Andrews, Ross H., Taylor-Robinson, Simon D., and Sithithaworn, Paiboon

Published
2023
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3. Performance of Mini Parasep® SF stool concentrator kit, Kato-Katz, and formalin-ethyl acetate concentration methods for diagnosis of opisthorchiasis in Northeast Thailand

Author

Kopolrat, Kulthida Y., Singthong, Seri, Khuntikeo, Narong, Loilome, Watcharin, Worasith, Chanika, Homwong, Chutima, Wangboon, Chompunoot, Yasaka, Patiwat, Eamudomkarn, Chatanun, Pitaksakulrat, Opal, Tonkhamhak, Krisnakorn, Paeyo, Arunee, Crellen, Thomas, Sithithaworn, Jiraporn, and Sithithaworn, Paiboon

Published
2022
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4. Examination of Diagnostic Performance of New IgG4 Rapid Test Compared with IgG- and IgG4-ELISAs to Investigate Epidemiology of Strongyloidiasis in Northeast Thailand

Author

Wongphutorn, Phattharaphon, primary, Noordin, Rahmah, additional, Anuar, Nor Suhada, additional, Worasith, Chanika, additional, Kopolrat, Kulthida Y., additional, Homwong, Chutima, additional, Tippayawat, Patcharaporn, additional, Techasen, Anchalee, additional, Pitaksakurat, Opal, additional, Sithithaworn, Jiraporn, additional, Eamudomkarn, Chatanun, additional, and Sithithaworn, Paiboon, additional

Published
2024
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5. Accuracy of a new rapid diagnostic test for urinary antigen detection and assessment of drug treatment in opisthorchiasis

Author

Worasith, Chanika, primary, Sithithaworn, Jiraporn, additional, Wongphutorn, Phattharaphon, additional, Homwong, Chutima, additional, Khongsukwiwat, Kanoknan, additional, Techasen, Anchalee, additional, Kopolrat, Kulthida Y., additional, Loilome, Watcharin, additional, Namwat, Nisana, additional, Thinkamrop, Bandit, additional, Tawarungruang, Chaiwat, additional, Titapun, Attapol, additional, Laha, Thewarach, additional, Andrews, Ross H., additional, Taylor-Robinson, Simon, additional, and Sithithaworn, Paiboon, additional

Published
2023
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6. Comparison of a Urine Antigen Assay and Multiple Examinations with the Formalin-Ethyl Acetate Concentration Technique for Diagnosis of Opisthorchiasis

Author

Worasith, Chanika, primary, Techasen, Anchalee, additional, Duenngai, Kunyarat, additional, Intuyod, Kitti, additional, Kopolrat, Kulthida Y., additional, Sithithaworn, Jiraporn, additional, Loilome, Watcharin, additional, Crellen, Thomas, additional, Haswell, Melissa R., additional, and Sithithaworn, Paiboon, additional

Published
2023
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7. Epidemiology of strongyloidiasis determined by parasite-specific IgG detections by enzyme-linked immunosorbent assay on urine samples using Strongyloides stercoralis, S. ratti and recombinant protein (NIE) as antigens in Northeast Thailand

Author

Eamudomkarn, Chatanun, primary, Ruantip, Sirowan, additional, Sithithaworn, Jiraporn, additional, Techasen, Anchalee, additional, Kopoolrat, Kulthida Y., additional, Worasith, Chanika, additional, Wongphutorn, Phattharaphon, additional, Bethony, Jeffrey M., additional, Laha, Thewarach, additional, and Sithithaworn, Paiboon, additional

Published
2023
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8. Long-term Persistence of Opisthorchis viverrini Antigen in Urine: A Prospective Study in Northeast Thailand

Author

Worasith, Chanika, primary, Wongphutorn, Phattharaphon, additional, Kopolrat, Kulthida Y., additional, Homwong, Chutima, additional, Techasen, Anchalee, additional, Thanan, Raynoo, additional, Wangboon, Chompunoot, additional, Eamudomkarn, Chatanun, additional, Sithithaworn, Jiraporn, additional, Crellen, Thomas, additional, and Sithithaworn, Paiboon, additional

Published
2023
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9. Effects of day-to-day variation of Opisthorchis viverrini antigen in urine on the accuracy of diagnosing opisthorchiasis in Northeast Thailand

Author

Worasith, Chanika, primary, Wongphutorn, Phattharaphon, additional, Homwong, Chutima, additional, Kopolrat, Kulthida Y., additional, Techasen, Anchalee, additional, Thanan, Raynoo, additional, Eamudomkarn, Chatanun, additional, Wangboon, Chompunoot, additional, Khuntikeo, Narong, additional, Loilome, Watcharin, additional, Sithithaworn, Jiraporn, additional, Crellen, Thomas, additional, and Sithithaworn, Paiboon, additional

Published
2022
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12. Performances of Mini Parasep SF stool concentrator kit , Kato-Katz and formalin-ethyl acetate concentration methods for diagnosis of opisthorchiasis among residents in an endemic community in northeast Thailand

Author

Kopolrat, Kulthida Y., primary, Singthong, Seri, additional, Khuntikeo, Narong, additional, Loilome, Watcharin, additional, Worasith, Chanika, additional, Homwong, Chutima, additional, Wangboon, Chompunoot, additional, Yasaka, Patiwat, additional, Eamudomkarn, Chatanun, additional, Pitaksakulrat, Opal, additional, Tonkhamhak, Krisnakorn, additional, Paeyo, Arunee, additional, Crellen, Thomas, additional, Sithithaworn, Jiraporn, additional, and Sithithaworn, Paiboon, additional

Published
2022
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13. Concentration of Urine Samples Improves Sensitivity in Detection of Strongyloides -Specific IgG Antibody in Urine for Diagnosis of Strongyloidiasis

Author

Chungkanchana, Natchita, primary, Sithithaworn, Paiboon, additional, Worasith, Chanika, additional, Wongphutorn, Phattharaphon, additional, Ruantip, Sirowan, additional, Kopolrat, Kulthida Y., additional, Jusakul, Apinya, additional, Thanan, Raynoo, additional, Duenngai, Kunyarat, additional, Sithithaworn, Jiraporn, additional, and Techasen, Anchalee, additional

Published
2022
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14. Development and Efficacy of Droplet Digital PCR for Detection of Strongyloides stercoralis in Stool

Author

Iamrod, Kantapong, primary, Chaidee, Apisit, additional, Rucksaken, Rucksak, additional, Kopolrat, Kulthida Y., additional, Worasith, Chanika, additional, Wongphutorn, Phattharaphon, additional, Intuyod, Kitti, additional, Pinlaor, Somchai, additional, Sithithaworn, Jiraporn, additional, Sithithaworn, Paiboon, additional, and Hongsrichan, Nuttanan, additional

Published
2022
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19. Performance of Mini Parasep® SF stool concentrator kit, Kato-Katz, and formalin-ethyl acetate concentration methods for diagnosis of opisthorchiasis in Northeast Thailand.

Author

Kopolrat, Kulthida Y., Singthong, Seri, Khuntikeo, Narong, Loilome, Watcharin, Worasith, Chanika, Homwong, Chutima, Wangboon, Chompunoot, Yasaka, Patiwat, Eamudomkarn, Chatanun, Pitaksakulrat, Opal, Tonkhamhak, Krisnakorn, Paeyo, Arunee, Crellen, Thomas, Sithithaworn, Jiraporn, and Sithithaworn, Paiboon

Subjects
PARASITIC diseases, ETHYL acetate, OPISTHORCHIS viverrini, DIAGNOSIS methods, LIVER flukes, ACETATES, DEFECATION, FECES
Abstract

Background: Control and elimination of the liver fluke (Opisthorchis viverrini) is a primary preventive strategy against cholangiocarcinoma in Southeast Asia. A sensitive parasitological diagnostic method is required to facilitate a surveillance and control program. In this study, we evaluated the performance of Mini Parasep® SF stool concentrator kit (stool kit) compared with Kato-Katz (KK) and the quantitative formalin-ethyl acetate concentration technique (FECT) for detection of O. viverrini and co-endemic parasitic infections. Methods: A cross-sectional survey for parasitic infection in residents aged > 15 years in a community in Kalasin province, Northeast Thailand, was conducted in 2018. Fecal samples were collected and screened by KK method, and a subset of samples was further examined by the stool kit and FECT methods. The results were analyzed for prevalence of parasitic infections in addition to the diagnostic performance of the methods for qualitative and quantitative detection of helminthiases. Results: The initial survey of parasitic infection determined by the KK method (n = 567) showed the prevalence of O. viverrini was 32.63%, followed by Taenia 2.65%, echinostomes 1.76%, hookworms 1.41%, Trichuris trichiura 0.53% and Strongyloides stercoralis 0.53%. Within a subset of samples tested with multiple diagnostics (n = 150), the detection rates of O. viverrini by the stool kit, FECT and KK methods were 27.3%, 30.7% and 28.7%, respectively. The diagnostic sensitivity for opisthorchiasis was similar for FECT (75.5%), KK(66.0%) and the stool kit (67.3%). For other parasitic infections, FECT and stool kit methods performed better than KK, particularly in detecting minute intestinal flukes (MIF), S. stercoralis and coinfections. When measuring the intensity of O. viverrini infection (fecal egg counts), the stool kit results showed a significant positive correlation with KK and FECT (P < 0.05). Conclusions: As the stool kit is simple to use and shows a comparable performance to FECT, it may serve as an alternative method of fecal examination for screening of helminthiasis including opisthorchiasis. [ABSTRACT FROM AUTHOR]

Published
2022
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24. Comparing the performance of urine and copro-antigen detection in evaluating Opisthorchis viverrini infection in communities with different transmission levels in Northeast Thailand

Author

Worasith, Chanika, primary, Wangboon, Chompunoot, additional, Duenngai, Kunyarat, additional, Kiatsopit, Nadda, additional, Kopolrat, Kulthida, additional, Techasen, Anchalee, additional, Sithithaworn, Jiraporn, additional, Khuntikeo, Narong, additional, Loilome, Watcharin, additional, Namwat, Nisana, additional, Yongvanit, Puangrat, additional, Carlton, Elizabeth J., additional, and Sithithaworn, Paiboon, additional

Published
2019
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26. Evaluation of a short term effect of praziquantel treatment in opisthorchiasis-induced hepatobiliary inflammation by urinary 8-oxodG

Author

Wangboon, Chompunoot, primary, Worasith, Chanika, additional, Thanan, Raynoo, additional, Eamudomkarn, Chatanun, additional, Techasen, Anchalee, additional, Sithithaworn, Jiraporn, additional, Loilome, Watcharin, additional, Chamadol, Nittaya, additional, Pinlaor, Somchai, additional, Jumnainsong, Amonrat, additional, Yongvanit, Puangrat, additional, Khuntikeo, Narong, additional, Bethony, Jeffrey M., additional, and Sithithaworn, Paiboon, additional

Published
2019
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27. Diagnostic performance of urinary IgG antibody detection: A novel approach for population screening of strongyloidiasis

Author

Eamudomkarn, Chatanun, primary, Sithithaworn, Paiboon, additional, Kamamia, Christine, additional, Yakovleva, Anna, additional, Sithithaworn, Jiraporn, additional, Kaewkes, Sasithorn, additional, Techasen, Anchalee, additional, Loilome, Watcharin, additional, Yongvanit, Puangrat, additional, Wangboon, Chompunoot, additional, Saichua, Prasert, additional, Itoh, Makoto, additional, and M. Bethony, Jeffrey, additional

Published
2018
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28. Elevated Levels of Urinary 8-oxodG Correlate with Persistent Periductal Fibrosis after Praziquantel Treatment in Chronic Opisthorchiasis

Author

Wangboon, Chompunoot, primary, Yongvanit, Puangrat, additional, Loilome, Watcharin, additional, Thanan, Raynoo, additional, Worasith, Chanika, additional, Eamudomkarn, Chatanun, additional, Chamadol, Nittaya, additional, Mairiang, Eimorn, additional, Sithithaworn, Jiraporn, additional, Saichua, Prasert, additional, Sripa, Banchob, additional, Khuntikeo, Narong, additional, Bethony, Jeffrey M., additional, and Sithithaworn, Paiboon, additional

Published
2018
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29. Advances in the Diagnosis of Human Opisthorchiasis: Development of Opisthorchis viverrini Antigen Detection in Urine

Author

Worasith, Chanika, primary, Kamamia, Christine, additional, Yakovleva, Anna, additional, Duenngai, Kunyarat, additional, Wangboon, Chompunoot, additional, Sithithaworn, Jiraporn, additional, Watwiengkam, Nattaya, additional, Namwat, Nisana, additional, Techasen, Anchalee, additional, Loilome, Watcharin, additional, Yongvanit, Puangrat, additional, Loukas, Alex, additional, Sithithaworn, Paiboon, additional, and Bethony, Jeffrey M., additional

Published
2015
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30. Levels of 8-OxodG Predict Hepatobiliary Pathology in Opisthorchis viverrini Endemic Settings in Thailand

Author

Saichua, Prasert, primary, Yakovleva, Anna, additional, Kamamia, Christine, additional, Jariwala, Amar R., additional, Sithithaworn, Jiraporn, additional, Sripa, Banchob, additional, Brindley, Paul J., additional, Laha, Thewarach, additional, Mairiang, Eimorn, additional, Pairojkul, Chawalit, additional, Khuntikeo, Narong, additional, Mulvenna, Jason, additional, Sithithaworn, Paiboon, additional, and Bethony, Jeffrey M., additional

Published
2015
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33. Correction: Microproteinuria during Opisthorchis viverrini Infection: A Biomarker for Advanced Renal and Hepatobiliary Pathologies from Chronic Opisthorchiasis

Author

Saichua, Prasert, primary, Sithithaworn, Paiboon, additional, Jariwala, Amar R., additional, Diemert, David J., additional, Sithithaworn, Jiraporn, additional, Sripa, Banchob, additional, Laha, Thewarach, additional, Mairiang, Eimorn, additional, Pairojkul, Chawalit, additional, Periago, Maria Victoria, additional, Khuntikeo, Narong, additional, Mulvenna, Jason, additional, and Bethony, Jeffrey M., additional

Published
2013
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34. Microproteinuria during Opisthorchis viverrini Infection: A Biomarker for Advanced Renal and Hepatobiliary Pathologies from Chronic Opisthorchiasis

Author

Saichua, Prasert, primary, Sithithaworn, Paiboon, additional, Jariwala, Amar R., additional, Deimert, David J., additional, Sithithaworn, Jiraporn, additional, Sripa, Banchob, additional, Laha, Thewarach, additional, Mairiang, Eimorn, additional, Pairojkul, Chawalit, additional, Periago, Maria Victoria, additional, Khuntikeo, Narong, additional, Mulvenna, Jason, additional, and Bethony, Jeffrey M., additional

Published
2013
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39. Genetic relationships within the Opisthorchis viverrini species complex with specific analysis of O. viverrini from Savannakhet, Lao PDR by multilocus enzyme electrophoresis

Author

Kiatsopit, Nadda, primary, Sithithaworn, Paiboon, additional, Sithithaworn, Jiraporn, additional, Boonmars, Thidarut, additional, Tesana, Smarn, additional, Pitaksakulrat, Opal, additional, Saijuntha, Weerachai, additional, Petney, Trevor N., additional, and Andrews, Ross H., additional

Published
2010
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41. Microproteinuria during Opisthorchis viverrini Infection: A Biomarker for Advanced Renal and Hepatobiliary Pathologies from Chronic Opisthorchiasis

Author

Saichua, Prasert, Sithithaworn, Paiboon, Jariwala, Amar R., Deimert, David J., Sithithaworn, Jiraporn, Sripa, Banchob, Laha, Thewarach, Mairiang, Eimorn, Pairojkul, Chawalit, Periago, Maria Victoria, Khuntikeo, Narong, Mulvenna, Jason, and Bethony, Jeffrey M.

Subjects
INFECTION, OPISTHORCHIS viverrini, BIOMARKERS, KIDNEY diseases, OPISTHORCHIASIS, CLONORCHIS sinensis
Abstract

Approximately 680 million people are at risk of infection with Opisthorchis viverrini (OV) and Clonorchis sinensis, with an estimated 10 million infected with OV in Southeast Asia alone. While opisthorchiasis is associated with hepatobiliary pathologies, such as advanced periductal fibrosis (APF) and cholangiocarcinoma (CCA), animal models of OV infection show that immune-complex glomerulonephritis is an important renal pathology that develops simultaneously with hepatobiliary pathologies. A cardinal sign of immune-complex glomerulonephritis is the urinary excretion of immunoglobulin G (IgG) (microproteinuria). In community-based studies in OV endemic areas along the Chi River in northeastern Thailand, we observed that over half of the participants had urine IgG against a crude OV antigen extract (OV antigen). We also observed that elevated levels of urine IgG to OV antigen were not associated with the intensity of OV infection, but were likely the result of immune-complex glomerulonephritis as seen in animal models of OV infection. Moreover, we observed that urine IgG to OV antigen was excreted at concentrations 21 times higher in individuals with APF and 158 times higher in individuals with CCA than controls. We also observed that elevated urine IgG to OV antigen could identify APF+ and CCA+ individuals from non-cases. Finally, individuals with urine IgG to OV antigen had a greater risk of APF as determined by Odds Ratios (OR = 6.69; 95%CI: 2.87, 15.58) and a greater risk of CCA (OR = 71.13; 95%CI: 15.13, 334.0) than individuals with no detectable level of urine IgG to OV antigen. Herein, we show for the first time the extensive burden of renal pathology in OV endemic areas and that a urine biomarker could serve to estimate risk for both renal and hepatobiliary pathologies during OV infection, i.e., serve as a “syndromic biomarker” of the advanced pathologies from opisthorchiasis. [ABSTRACT FROM AUTHOR]

Published
2013
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42. Long-term Persistence of Opisthorchis viverrini Antigen in Urine: A Prospective Study in Northeast Thailand.

Author

Worasith C, Wongphutorn P, Kopolrat KY, Homwong C, Techasen A, Thanan R, Wangboon C, Eamudomkarn C, Sithithaworn J, Crellen T, and Sithithaworn P

Subjects
Animals, Humans, Prospective Studies, Thailand epidemiology, Follow-Up Studies, Reproducibility of Results, Opisthorchis, Opisthorchiasis diagnosis, Opisthorchiasis epidemiology
Abstract

Antigen detected in urine for the diagnosis of opisthorchiasis has a low daily variation; however, the longer term variability in antigen concentrations is unknown. In this study, we prospectively monitored Opisthorchis viverrini antigen concentrations for 30 consecutive days and at subsequent monthly intervals in a cohort of opisthorchiasis-positive individuals. On the basis of the monoclonal antibody-based ELISA, the profiles of antigen-positive rate and antigen concentration exhibited no significant change over 30 days with a mean proportion positive of 87.1% (range 73.7%-100%), and the average antigen concentration was 29.7 ± 2.2 ng/mL (mean ± SE). The urine antigen concentration at baseline was similar to the subsequent measurements at 2, 4, 6, and 10 months in the follow-up study (P > 0.05). The consistency and low daily and long-term fluctuation of O. viverrini antigen in urine demonstrates the reliability of urine assay for diagnosis of opisthorchiasis.

Published
2022
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43. Development and Efficacy of Droplet Digital PCR for Detection of Strongyloides stercoralis in Stool.

Author

Iamrod K, Chaidee A, Rucksaken R, Kopolrat KY, Worasith C, Wongphutorn P, Intuyod K, Pinlaor S, Sithithaworn J, Sithithaworn P, and Hongsrichan N

Subjects
Animals, Cross Reactions, Polymerase Chain Reaction methods, Strongyloides stercoralis genetics, Feces parasitology, Polymerase Chain Reaction standards, Strongyloides stercoralis isolation & purification, Strongyloidiasis diagnosis, Strongyloidiasis parasitology
Abstract

Human strongyloidiasis is one of the neglected tropical diseases caused by infection with soil-transmitted helminth Strongyloides stercoralis. Conventional stool examination, a method commonly used for diagnosis of S. stercoralis, has low sensitivity, especially in the case of light infections. Herein, we developed the droplet digital polymerase chain reaction (ddPCR) assay to detect S. stercoralis larvae in stool and compared its performance with real-time PCR and stool examination techniques (formalin ethyl-acetate concentration technique [FECT] and agar plate culture [APC]). The ddPCR results showed 98% sensitivity and 90% specificity, and real-time PCR showed 82% sensitivity and 76.7% specificity when compared with the microscopic methods. Moreover, ddPCR could detect a single S. stercoralis larva in feces, and cross-reactions with other parasites were not observed. In conclusion, a novel ddPCR method exhibited high sensitivity and specificity for detection of S. stercoralis in stool samples. This technique may help to improve diagnosis, particularly in cases with light infection. In addition, ddPCR technique might be useful for screening patients before starting immunosuppressive drug therapy, and follow-up after treatment of strongyloidiasis.

Published
2021
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44. Detection of Epidermal Growth Factor Receptor (EGFR) Gene Mutation in Formalin Fixed Paraffin Embedded Tissue by Polymerase Chain Reaction-Single Strand Conformational Polymorphism (PCR-SSCP) in Non-Small Cell Lung Cancer in the Northeastern Region of Thailand

Author

Saiyaros K, Kritpetcharat P, Pairojkul C, and Sithithaworn J

Subjects
Adenocarcinoma epidemiology, Adenocarcinoma genetics, Adenocarcinoma pathology, Adenocarcinoma, Bronchiolo-Alveolar epidemiology, Adenocarcinoma, Bronchiolo-Alveolar genetics, Adenocarcinoma, Bronchiolo-Alveolar pathology, Adult, Aged, Base Sequence, Carcinoma, Non-Small-Cell Lung epidemiology, Carcinoma, Non-Small-Cell Lung pathology, Carcinoma, Squamous Cell epidemiology, Carcinoma, Squamous Cell genetics, Carcinoma, Squamous Cell pathology, Case-Control Studies, ErbB Receptors genetics, Female, Follow-Up Studies, Formaldehyde chemistry, Humans, Lung Neoplasms epidemiology, Lung Neoplasms pathology, Male, Middle Aged, Paraffin Embedding methods, Prognosis, Sequence Homology, Thailand epidemiology, Biomarkers, Tumor genetics, Carcinoma, Non-Small-Cell Lung genetics, Lung Neoplasms genetics, Mutation, Polymerase Chain Reaction methods, Polymorphism, Single-Stranded Conformational
Abstract

Background: The use of targeted specific genes in therapeutic and treatment decisions has been considered for lung cancer. The epidermal growth factor receptor (EGFR) gene, which is over expressed in non-small cell lung cancer (NSCLC), was considered as one of the targeted specific genes. EGFR mutations in exons 18–21, which encode a portion of the EGFR kinase domain, were found in NSCLC patients and were associated with the response of EGFRtyrosine kinase inhibitors (EGFR-TKIs). Therefore, a molecular technique for EGFR mutation detection has important benefits for therapy in NSCLC patients. This study aims to determine the EGFR mutations in patients with NSCLC using polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) in exons 18-21. Methods: DNA samples were extracted from formalin fixed paraffin embedded tissues of NSCLC patients who attended hospital. The extracted DNA was used as a template for the EGFR gene amplification. Results: Occurrence of EGFR mutations were found in 29 out of 50 cases (58%).The frequency of EGFR mutations by first PCR at exon 18, 19, 20 and 21 were 6 (12%), 19 (38%) 20 (40%) and at 21 (42%), respectively. By PCR-SSCP, the frequencies of EGFR mutations at exon 18, 19, 20 and 21 were 3(6%), 18(36%), 23(46%) and 13(26%), respectively. All of the mutations found were in agreement with DNA sequencings. Conclusion: The high frequency of EGFR mutations in NSCLC suggests that PCR-SSCP is a efficient screening method and useful for treatment plan., (Creative Commons Attribution License)

Published
2019
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