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152 results on '"Sisani, Michele"'

2. PERSIAN trial (NCT05717660): an ongoing randomized trial testing androgen deprivation therapy, apalutamide and stereotactic body radiotherapy. An alternative “triplet” for oligometastatic hormone sensitive prostate cancer patients

Author

Francolini, Giulio, Porreca, Angelo, Facchini, Gaetano, Santini, Daniele, Bruni, Alessio, Simoni, Nicola, Trovò, Marco, Osti, Mattia Falchetto, Fornarini, Giuseppe, Sisani, Michele, Di Cataldo, Vanessa, Detti, Beatrice, Garlatti, Pietro, Bertini, Niccolò, Serni, Sergio, Minervini, Andrea, and Livi, Lorenzo

Published
2024
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6. Polyvinyl Alcohol Coatings Containing Lamellar Solids with Antimicrobial Activity.

Author

Bastianini, Maria, Sisani, Michele, Escudero García, Raúl, Di Guida, Irene, Russo, Carla, Pietrella, Donatella, and Narducci, Riccardo

Subjects
POLYETHYLENE films, LAYERED double hydroxides, POLYVINYL alcohol, INFECTION prevention, POLYETHYLENE terephthalate, SALICYLATES
Abstract

The design of an antimicrobial coating material has become important in the prevention of infections caused by the transmission of pathogens coming from human contact with contaminated surfaces. With that aim, layered single hydroxides (LSHs) and layered double hydroxides (LDHs) containing Zn and Cu intercalated with antimicrobial molecules were synthesized and characterized. Cinnamate and salicylate anions were chosen because of their well-known antimicrobial activity. Several coatings based on polyvinyl alcohol (PVA) and LDHs or LSHs with increasing amounts of filler were prepared and filmed on a polyethylene terephthalate (PET) substrate. The coatings were characterized, and their antimicrobial activity was evaluated against several pathogens that are critical in nosocomial infections, showing a synergistic effect between metal ions and active molecules and the ability to inhibit their growth. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Results of the observational prospective RealFLOT study

Author

Giommoni, Elisa, Lavacchi, Daniele, Tirino, Giuseppe, Fornaro, Lorenzo, Iachetta, Francesco, Pozzo, Carmelo, Satolli, Maria Antonietta, Spallanzani, Andrea, Puzzoni, Marco, Stragliotto, Silvia, Sisani, Michele, Formica, Vincenzo, Giovanardi, Filippo, Strippoli, Antonia, Prisciandaro, Michele, Di Donato, Samantha, Pompella, Luca, Pecora, Irene, Romagnani, Alessandra, Fancelli, Sara, Brugia, Marco, Pillozzi, Serena, De Vita, Ferdinando, and Antonuzzo, Lorenzo

Published
2021
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12. Assessing the effectiveness and safety of lenvatinib and everolimus in advanced renal cell carcinoma: insights from the RELIEVE study’s analysis of heavily pretreated patients

Author

Buti, Sebastiano, primary, Olivari, Alessandro, additional, Masini, Cristina, additional, Bimbatti, Davide, additional, Sartori, Donata, additional, Ermacora, Paola, additional, Cattrini, Carlo, additional, Vitale, Maria Giuseppa, additional, Rossi, Ernesto, additional, Mucciarini, Claudia, additional, Rizzo, Mimma, additional, Sisani, Michele, additional, Santoni, Matteo, additional, Roviello, Giandomenico, additional, Mollica, Veronica, additional, Conteduca, Vincenza, additional, Grillone, Francesco, additional, Cinausero, Marika, additional, Prati, Giuseppe, additional, Atzori, Francesco, additional, Stellato, Marco, additional, Massari, Francesco, additional, and Bersanelli, Melissa, additional

Published
2024
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13. First-Line Treatments and Management of Metastatic Renal Cell Carcinoma Patients: An Italian Interdisciplinary Uro-Oncologic Group Algorithm.

Author

Bloise, Francesco, Manfredi, Fiorella, Zatteri, Luca, Dima, Giovanni, Carli, Chiara, Di Vita, Rosanna, Olivieri, Maria, Sammarco, Enrico, Ferrari, Marco, Salfi, Alessia, Bonato, Adele, Serafin, Debora, Coccia, Natalia, Doni, Laura, Galli, Luca, Sisani, Michele, Roviello, Giandomenico, Catalano, Martina, and Paolieri, Federico

Subjects
RENAL cell carcinoma, URODYNAMICS, IMMUNE checkpoint inhibitors, PROTEIN-tyrosine kinase inhibitors, METASTASIS, ALGORITHMS
Abstract

The treatment landscape for metastatic renal cell carcinoma (mRCC) has undergone significant transformations in recent years. The introduction of novel combination therapies involving tyrosine kinase inhibitors (TKI) and immune checkpoint inhibitors has resulted in improved oncological outcomes compared to traditional TKI monotherapy. In this evolving paradigm, the pivotal role of the multidisciplinary tumor board is underscored, particularly in shaping the therapeutic trajectory for patients eligible for locoregional interventions like cytoreductive nephrectomy and metastasectomy. In cases where systemic treatment is deemed appropriate, the absence of direct comparisons among the various combination therapies complicates the selection of a first-line approach. The clinician is faced with the challenge of making decisions based on patient-specific factors such as performance status, risk classification according to the International Metastatic Renal Cell Carcinoma Database Consortium, comorbidities, and disease characteristics, including the number and location of metastases and tumor histology. Considering these concerns, we propose, as a member of a Tuscany Interdisciplinary Uro-Oncologic Group, an algorithm to streamline the decision-making process for mRCC patients, offering guidance to clinicians in their day-to-day clinical practice. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Elongational flow‐induced microstructure evolutions in polypropylene/layered double hydroxides nanocomposites.

Author

Gnoffo, Chiara, Arrigo, Rossella, Sisani, Michele, and Frache, Alberto

Subjects
LAYERED double hydroxides, NANOCOMPOSITE materials, NANOSTRUCTURED materials, MICROSTRUCTURE, TENSILE strength
Abstract

In this work, the effect of the non‐isothermal elongational flow on the morphology and mechanical properties of polypropylene (PP)‐based nanocomposites containing Mg‐Al layered double hydroxides (LDHs) modified with stearate or oleate functional groups has been investigated. In particular, nanocomposites containing 5 and 10 wt% of LDHs prepared through melt compounding were subjected to uniaxial elongational flow at the exit of the extruder, leading to the formation of fibers characterized by different draw ratios (DRs). The mechanical characterization of the fibers demonstrated a progressive enhancement of the tensile strength as a function of the DR with increasing the content of nanofillers. Notably, for the fibers stretched at a DR of 200 and containing 10 wt% of LDHs modified with oleate groups, the tensile strength increased fourfold as compared to that of the unfilled matrix. These results have been attributed to a progressive enhancement of the extent of the dispersions of the embedded LDHs induced by the application of the elongational flow, as also confirmed by morphological analyses. In all, the obtained results demonstrated the beneficial effect of the elongational flow in promoting the achievement of superior mechanical properties in LDHs‐containing nanocomposites, hence widening the application field of these nanostructured materials. Highlights: PP/organomodified LDH nanocomposites were obtained through melt compounding.Nonisothermal elongational flow was applied to the extrudates at the die exit.Anisotropic fibers showed progressively enhanced tensile strength values.Elongational flow promoted a gradual evolution of the material microstructure.A gradual improvement of the nanofiller dispersion was observed upon elongation. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Apalutamide and stereotactic body radiation therapy for low-burden, metastatic, hormone-sensitive prostate cancer: A randomized trial (PERSIAN).

Author

Francolini, Giulio, Porreca, Angelo, Facchini, Gaetano, Santini, Daniele, Bruni, Alessio, Simoni, Nicola, Trovò, Marco, Osti, Mattia Falchetto, Fornarini, Giuseppe, Sisani, Michele, Di Cataldo, Vanessa, Detti, Beatrice, Garlatti, Pietro, Bertini, Niccolò, Burchini, Luca, Frosini, Giulio, Bonaparte, Ilaria, Serni, Sergio, Minervini, Andrea, and Livi, Lorenzo

Published
2024
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25. Additive Manufactured Scaffolds for Bone Tissue Engineering: Physical Characterization of Thermoplastic Composites with Functional Fillers

Author

Sinha, Ravi, primary, Sanchez, Alberto, additional, Camara-Torres, Maria, additional, Uriszar-Aldaca, Iñigo Calderon, additional, Calore, Andrea Roberto, additional, Harings, Jules, additional, Gambardella, Ambra, additional, Ciccarelli, Lucia, additional, Vanzanella, Veronica, additional, Sisani, Michele, additional, Scatto, Marco, additional, Wendelbo, Rune, additional, Perez, Sergio, additional, Villanueva, Sara, additional, Matanza, Amaia, additional, Patelli, Alessandro, additional, Grizzuti, Nino, additional, Mota, Carlos, additional, and Moroni, Lorenzo, additional

Published
2021
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27. Additional file 1 of Results of the observational prospective RealFLOT study

Author

Giommoni, Elisa, Lavacchi, Daniele, Tirino, Giuseppe, Fornaro, Lorenzo, Iachetta, Francesco, Pozzo, Carmelo, Satolli, Maria Antonietta, Spallanzani, Andrea, Puzzoni, Marco, Stragliotto, Silvia, Sisani, Michele, Formica, Vincenzo, Giovanardi, Filippo, Strippoli, Antonia, Prisciandaro, Michele, Di Donato, Samantha, Pompella, Luca, Pecora, Irene, Romagnani, Alessandra, Fancelli, Sara, Brugia, Marco, Pillozzi, Serena, De Vita, Ferdinando, and Antonuzzo, Lorenzo

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2021
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28. Durvalumab with or without bevacizumab with transarterial chemoembolisation in hepatocellular carcinoma (EMERALD-1): a multiregional, randomised, double-blind, placebo-controlled, phase 3 study

Author

Sangro, Bruno, Kudo, Masatoshi, Erinjeri, Joseph P, Qin, Shukui, Ren, Zhenggang, Chan, Stephen L, Arai, Yasuaki, Heo, Jeong, Mai, Anh, Escobar, Jose, Lopez Chuken, Yamil Alonso, Yoon, Jung-Hwan, Tak, Won Young, Breder, Valeriy V, Suttichaimongkol, Tanita, Bouattour, Mohamed, Lin, Shi-Ming, Peron, Jean-Marie, Nguyen, Quang T, Yan, Lunan, Chiu, Chang-Fang, Santos, Florinda A, Veluvolu, Anil, Thungappa, Satheesh Chiradoni, Matos, Marco, Żotkiewicz, Magdalena, Udoye, Stephanie I, Kurland, John F, Cohen, Gordon J, Lencioni, Riccardo, Abdalla, Kathia, Allaire, Manon, Alves, Gustavo, Antunes, Luis, Assenat, Eric, Azevedo, Sergio, Barreto, Rafael, Beg, Muhammad, Bertollo, Glaucio, Blanc, Jean-Frederic, Bouattour, Mohamed, Boya, Rakesh Reddy, Breder, Valery, Bronowicki, Jean-Pierre, Buranachokphaisan, Manoch, Burgoyne, Adam, Chan, Stephen, Chang, Ting-Tsung, Chao, Yee, Chen, Eric, Chen, Xiaoming, Chiu, Chang-Fang, Choi, Minsig, Choi, Sunghee, Coburn, Natalie, Contreras, Luis, Dayyani, Farshid, Decaens, Thomas, Dechaphunkul, Arunee, del Consuelo Diaz, Maria, Dev, Anouk, Dutra, Jamille, Eastgate, Melissa, Escobar, Jose, Estfan, Bassam, Ferrari, Vittorio, Frin, Anne-Claire, Ganguly, Sandip, Ganta, Ranga Raman, Gu, Shanzhi, Guo, Yabing, Hagihara, Atsushi, Heo, Jeong, Hsu, Chih-Hung, Hwang, Jimmy, Inaba, Yoshitaka, Jain, Shikha, Jonker, Derek, K, Rajeev L, Kate, Shruti, Kato, Naoya, Kawaoka, Tomokazu, Kee, Kwong-Ming, Kim, Seung up, Kioka, Kiyohide, Koga, Hironori, Kudo, Masatoshi, Kuroda, Hidekatsu, Le, Phuong, Lee, Han-chu, Lee, Joon Hyeok, Lee, Teng-Yu, Li, Dongliang, Li, Hailiang, Li, Wei, Li, Xiao, Lin, Cheng-Yao, Lin, Shi-Ming, Lopez, Yamil, Lu, Ligong, Mai, Anh, Mamontov, Konstantin, Maneenil, Kunlatida, Manikhas, Aleksei, Masi, Gianluca, Matilla, Ana Maria, Matos, Marco, Mazzaferro, Vincenzo, Meng, Zhiqiang, Mohapatra, Prabrajya Narayan, Moiseyenko, Vladimir, Molina, Alejandro, Montero, Jose Luis, Morimoto, Manabu, Motola, Daniel, Mukhametshina, Guzel, Nakagawa, Hayato, Nault, Jean-Charles, Nguyen, Quang, Nicoll, Amanda, Noriega, Maria, Okusaka, Takuji, Onishi, Hideki, Ostwal, Vikas Sureshchand, Pan, Jie, Park, Joong-Won, Patel, Ankit, Perez, Rodrigo, Peron, Jean-Marie, Qin, Shukui, Ramirez, Francisco, Ren, Zhenggang, Roberts, Stuart, Rowe, Julie, Runglodvatana, Yotsawaj, Sangro, Bruno, Santos, Florinda, Saxena, Ravi Kumar, Shao, Guoliang, Shields, Anthony, Shirokova, Oksana, Shreenivas, Aditya, Sisani, Michele, Skoropad, Vitalii, Strasser, Simone, Suksombooncharoen, Thatthan, Suttichaimongkol, Tanita, Tai, Wai Meng, Tak, Won Young, Teng, Gaojun, Thungappa, Satheesh Chiradoni, Tran, Nguyen, Trinh, Son, Tsuchiya, Kaoru, Tsuji, Kunihiko, Ugarteburu, Idoia, Ungtrakul, Teerapat, Vaccaro, Gina, Veluvolu, Anil, Vo, Truc, Wada, Yoshiyuki, Weir, Alva, Xu, Aibing, Yan, Lvnan, Yoon, Jung-Hwan, Zarubenkov, Oleg, Zeng, Yongyi, Zhang, Yonghong, Zhao, Ming, Zheng, Xin, Zhu, Ling, and Zhu, Xu

Abstract

Transarterial chemoembolisation (TACE) is standard of care for patients with unresectable hepatocellular carcinoma that is amenable to embolisation; however, median progression-free survival is still approximately 7 months. We aimed to assess whether adding durvalumab, with or without bevacizumab, might improve progression-free survival.

Published
2025
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29. Additive manufactured scaffolds for bone tissue engineering: Physical characterization of thermoplastic composites with functional fillers

Author

European Commission, Sinha, Ravi, Sanchez, Alberto, Camara-Torres, Maria, Calderon Uriszar-Aldaca, Iñigo, Roberto Calore, Andrea, Harings, Jules, Gambardella, Ambra, Ciccarelli, Lucia, Vanzanella, Veronica, Sisani, Michele, Scatto, Marco, Wendelbo, Rune, Pérez, Sergio, Villanueva, Sara, Matanza, Amaia, Patelli, Alessandro, Grizzuti, Nino, Mota, Carlos, Moroni, Lorenzo, European Commission, Sinha, Ravi, Sanchez, Alberto, Camara-Torres, Maria, Calderon Uriszar-Aldaca, Iñigo, Roberto Calore, Andrea, Harings, Jules, Gambardella, Ambra, Ciccarelli, Lucia, Vanzanella, Veronica, Sisani, Michele, Scatto, Marco, Wendelbo, Rune, Pérez, Sergio, Villanueva, Sara, Matanza, Amaia, Patelli, Alessandro, Grizzuti, Nino, Mota, Carlos, and Moroni, Lorenzo

Abstract

Thermoplastic polymer–filler composites are excellent materials for bone tissue engineering (TE) scaffolds, combining the functionality of fillers with suitable load-bearing ability, biodegradability, and additive manufacturing (AM) compatibility of the polymer. Two key determinants of their utility are their rheological behavior in the molten state, determining AM processability and their mechanical load-bearing properties. We report here the characterization of both these physical properties for four bone TE relevant composite formulations with poly(ethylene oxide terephthalate)/poly(butylene terephthalate (PEOT/PBT) as a base polymer, which is often used to fabricate TE scaffolds. The fillers used were reduced graphene oxide (rGO), hydroxyapatite (HA), gentamicin intercalated in zirconium phosphate (ZrP-GTM) and ciprofloxacin intercalated in MgAl layered double hydroxide (MgAl-CFX). The rheological assessment showed that generally the viscous behavior dominated the elastic behavior (G″ > G′) for the studied composites, at empirically determined extrusion temperatures. Coupled rheological–thermal characterization of ZrP-GTM and HA composites showed that the fillers increased the solidification temperatures of the polymer melts during cooling. Both these findings have implications for the required extrusion temperatures and bonding between layers. Mechanical tests showed that the fillers generally not only made the polymer stiffer but more brittle in proportion to the filler fractions. Furthermore, the elastic moduli of scaffolds did not directly correlate with the corresponding bulk material properties, implying composite-specific AM processing effects on the mechanical properties. Finally, we show computational models to predict multimaterial scaffold elastic moduli using measured single material scaffold and bulk moduli. The reported characterizations are essential for assessing the AM processability and ultimately the suitability of the manufactured scaffolds f

Published
2021

31. 3D Additive Manufactured Composite Scaffolds with Antibiotic-loaded Lamellar Fillers for Bone Infection Prevention and Tissue Regeneration

Author

Cámara-Torres, María, primary, Duarte, Stacy, additional, Sinha, Ravi, additional, Egizabal, Ainhoa, additional, Álvarez, Noelia, additional, Bastianini, Maria, additional, Sisani, Michele, additional, Scopece, Paolo, additional, Scatto, Marco, additional, Bonetto, Alessandro, additional, Marcomini, Antonio, additional, Sanchez, Alberto, additional, Patelli, Alessandro, additional, Mota, Carlos, additional, and Moroni, Lorenzo, additional

Published
2020
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37. biphasic creatine nutraceutic composition

Author

Spogli, Roberto, Sisani, Michele, Giuseppe, Salvadori, Perioli, Luana, and Pagano, Cinzia

Subjects
creatine, nutraceutical, creatine, solubility, dissolution, solubility, dissolution, nutraceutical
Published
2016

43. Maschere: innovazione e vantaggi

Author

Perioli, Luana, Pagano, Cinzia, Sisani, Michele, and Marco, Aitis

Subjects
idrotalcite, tricologia, prodotto cosmetico, reologia, texture, rilascio
Published
2013

48. Docetaxel rechallenge in metastatic castration-resistant prostate cancer: any place in the modern treatment scenario? An intention to treat evaluation

Author

Bracarda, Sergio, primary, Caserta, Claudia, additional, Galli, Luca, additional, Carlini, Paolo, additional, Pastina, Ilaria, additional, Sisani, Michele, additional, Scali, Simona, additional, Hamzaj, Alketa, additional, Derosa, Lisa, additional, Felici, Alessandra, additional, Rossi, Marta, additional, Altavilla, Amelia, additional, Chioni, Aldo, additional, and De Angelis, Verena, additional

Published
2015
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50. Active Polymer Nanocomposites: Application In Thermoplastic Polymers.

Author

Scatto, Marco and Sisani, Michele

Subjects
*POLYMERIC nanocomposites, *THERMOPLASTIC composites, *LAYERED double hydroxides, *SUPERIONIC conductors, *SCANNING electron microscopy
Abstract

Polymer nanocomposites are a new class of innovative materials in which well-dispersed fillers, having at least one dimension in the nanometric range, are incorporated into organic polymer matrix. Because of their nanometer-size dispersion, polymer nanocomposites exhibit improved mechanical, thermal and chemical properties in comparison with the pristine polymer or conventional composites. Layered inorganic nanostructures, which are fillers very used in polymer nanocomposite researches, can be intercalated or exfoliated into polymer matrix. Because of the larger surface area and high aspect ratio of the nanoclay layers, the exfoliated structures generally provide the best performances. In this study new Layered Double Hydroxide (LDH) nanocomposites able to provide an antimicrobial activity and barrier effect for food packaging application will be developed and their safety profile will be evaluated according to current EU regulation and EFSA recommendation. [ABSTRACT FROM AUTHOR]

Published
2016
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