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256 results on '"Sire, Olivier"'

3. Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer

Author

Guéguinou, Maxime, Ibrahim, Sajida, Bourgeais, Jérôme, Robert, Alison, Pathak, Trayambak, Zhang, Xuexin, Crottès, David, Dupuy, Jacques, Ternant, David, Monbet, Valérie, Guibon, Roseline, Flores-Romero, Hector, Lefèvre, Antoine, Lerondel, Stéphanie, Le Pape, Alain, Dumas, Jean-François, Frank, Philippe G., Girault, Alban, Chautard, Romain, Guéraud, Françoise, García-Sáez, Ana J., Ouaissi, Mehdi, Emond, Patrick, Sire, Olivier, Hérault, Olivier, Fromont-Hankard, Gaëlle, Vandier, Christophe, Tougeron, David, Trebak, Mohamed, Raoul, William, and Lecomte, Thierry

Published
2022
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5. Challenging the Microplastic Extraction from Sandy Sediments

Author

Kedzierski, Mikaël, Le Tilly, Véronique, Bourseau, Patrick, Bellegou, Hervé, César, Guy, Sire, Olivier, Bruzaud, Stéphane, Cocca, Mariacristina, editor, Di Pace, Emilia, editor, Errico, Maria Emanuela, editor, Gentile, Gennaro, editor, Montarsolo, Alessio, editor, and Mossotti, Raffaella, editor

Published
2018
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7. An explanatory model to validate the way water activity rules periodic terrace generation in Proteus mirabilis swarm

Author

Frenod, Emmanuel and Sire, Olivier

Subjects
Mathematics - Analysis of PDEs, Quantitative Biology - Populations and Evolution, Quantitative Biology - Quantitative Methods
Abstract

In this paper we explain the biophysical principles which, according to us, govern the Proteus mirabilis swarm phenomenon. Then, we translate this explanation into a mathematical model, essentially based on partial differential equations. This model is then implemented using numerical methods of the finite volume type in order to make simulations. The simulations show most of the characteristics which are observed in situ and in particular the terrace generation.

Published
2007

15. Identification of Novel Compounds Inhibiting the Kinase Activity of the CDK5/p25 Complex via Direct Binding to p25

Author

Jabeur, Riheb, primary, Corbel, Caroline, additional, Loyer, Pascal, additional, Le Parc, Annabelle, additional, Le Grand, Adélaide, additional, Comte, Arnaud, additional, Bach, Stéphane, additional, André-Leroux, Gwenaëlle, additional, Sire, Olivier, additional, Ben Mansour, Hedi, additional, and Le Tilly, Véronique, additional

Published
2023
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22. Mid-Infrared Spectroscopy as a New Tool for Ruling Out Spontaneous Bacterial Peritonitis: A Proof-of-Concept Study

Author

Farrugia, Marwin A, Le Corvec, Maëna, Renou, Christophe, Nousbaum, Jean-Baptiste, Ouizeman, Dann J, Sire, Olivier, Loréal, Olivier, Tariel, Hugues, Bernard, Jérôme, Piche, Thierry, Tran, Albert, Ait-Oufella, Hafid, Landraud, Luce, Gual, Philippe, Anty, Rodolphe, Centre Hospitalier Universitaire de Nice (CHU Nice), DIAFIR, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Institut de Recherche Dupuy de Lôme (IRDL), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Centre National de la Recherche Scientifique (CNRS), Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Pontchaillou [Rennes], Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, This research was funded by the 'Investments for the Future' LABEX SIGNALIFE project (#ANR-11-LABX-0028-01) and the UCAJEDI project (#ANR-15-IDEX-0001), the National Research Agency (#ANR-18-CE14-0019-02, #ANR-19-CE14-0044-01), the Association Française pour l’Etude du Foie (AFEF) to P.G, the PHRC and clinical research department (Centre Hospitalier Universitaire de Nice), the University of Nice, the INSERM, and the Société Nationale Française de Gastro-Entérologie (SNFGE-FARE) to R.A., ANR-11-LABX-0028,SIGNALIFE,Réseau d'Innovation sur les Voies de Signalisation en Sciences de la Vie(2011), ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), and ANR-18-CE14-0019,INFLAMMASYK,Etude de la signalisation SYK dans les maladies inflammatoires chroniques(2018)

Subjects
spontaneous bacterial peritonitis, mid-infrared spectroscopy, cirrhosis, [SDV]Life Sciences [q-bio], Medicine (miscellaneous), ascites fluid, General Biochemistry, Genetics and Molecular Biology, infection
Abstract

International audience; BACKGROUND AND AIMS: A highly sensitive and specific point-of-care method for diagnosing spontaneous bacterial peritonitis (SBP) is currently lacking. The objective of the present study is to evaluate the diagnostic value of a rapid, easy-to-use, mid-infrared fiber evanescent wave spectroscopy (MIR-FEWS) method for ruling out SBP. PATIENTS AND METHODS: Cirrhotic patients (n = 256) at five centers in France were included for suspected SBP or for the scheduled evacuation of ascites fluid. The mid-infrared spectrum of 7 µL of an ascites fluid sample was recorded using a MIR-FEWS system. To define a model for the diagnosis of SBP, the patients were divided into a calibration group (n = 170) and a validation group (n = 86). RESULTS: Most of the patients were male (71%). The mean age was 60.25 years. Alcohol-related liver disease was the most common cause of cirrhosis. SBP was observed in 18% of the patients. For the diagnosis of SBP in the calibration and validation groups, respectively, the model gave areas under the receiver operating characteristic curves of 0.87 and 0.89, sensitivities of 90% and 87%, specificities of 78% and 80%, positive predictive values of 48% and 50%, negative predictive values of 97% and 96%, positive likelihood ratio of 4.09 and 4.35, negative likelihood ratio of 0.13 and 0.16, Youden index of 0.68 and 0.67, and correct classification rates of 80% and 81%. CONCLUSION: The results of this proof-of-concept study show that MIR-FEWS is a highly sensitive diagnostic method for ruling out SBP. The method warrants further investigation.

Published
2023
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25. Curcumin and NCLX Inhibitors Share Anti-Tumoral Mechanisms in Microsatellite-Instability-Driven Colorectal Cancer

Author

Guéguinou, Maxime, primary, Ibrahim, Sajida, additional, Bourgeais, Jérôme, additional, Robert, Alison, additional, Pathak, Trayambak, additional, Zhang, Xuexin, additional, Crottès, David, additional, Dupuy, Jacques, additional, Ternant, David, additional, Monbet, Valérie, additional, Guibon, Roseline, additional, Flores-Romero, Hector, additional, Lefèvre, Antoine, additional, Lerondel, Stéphanie, additional, Le Pape, Alain, additional, Dumas, Jean-François, additional, Frank, Philippe G., additional, Girault, Alban, additional, Chautard, Romain, additional, Guéraud, Françoise, additional, García-Sáez, Ana J., additional, Ouaissi, Mehdi, additional, Emond, Patrick, additional, Sire, Olivier, additional, Hérault, Olivier, additional, Fromont-Hankard, Gaëlle, additional, Vandier, Christophe, additional, Tougeron, David, additional, Trebak, Mohamed, additional, Raoul, William, additional, and Lecomte, Thierry, additional

Published
2022
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37. Bacterial swarming: a biochemical time-resolved FTIR-ATR study of Proteus mirabilis swarm-cell differentiation

Author

Gue, Michael, Dupont, Virginie, Dufour, Alain, and Sire, Olivier

Subjects
Biochemistry -- Research, Fourier transform infrared spectroscopy -- Usage, Cells -- Analysis, Bacteria -- Physiological aspects, Dimorphism (Plants) -- Analysis, Biological sciences, Chemistry
Abstract

Research has been conducted on the Proteus mirabilis which exhibits dimorphism. The in situ noninvasive analysis of the biochemical events occurring as the vegetative cells differentiate into the elongated swarm cells has been performed via the Fourier transform infrared spectroscopy and the results are discussed.

Published
2001

38. Ruling out septic arthritis risk in a few minutes using mid-infrared spectroscopy in synovial fluids

Author

Albert, Jean-David, primary, Le Corvec, Maëna, additional, Berthoud, Olivia, additional, David, Claire, additional, Guennoc, Xavier, additional, Hoppe, Emmanuel, additional, Jousse-Joulin, Sandrine, additional, Le Goff, Benoît, additional, Tariel, Hugues, additional, Sire, Olivier, additional, Jolivet-Gougeon, Anne, additional, Coiffier, Guillaume, additional, and Loréal, Olivier, additional

Published
2020
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40. Estrogenic hazards of short chain phthalates and bisphenols found in cosmetic products.

Author

Chebbi, Manel, Beltifa, Asma, Alibi, Sana, Di Bella, Giuseppa, Loturco, Vincenzo, Sire, Olivier, Ben Mansour, Hedi, and Le Tilly, Véronique

Subjects
COSMETICS, IN vitro studies, PHENOLS, ESTROGEN, HAZARDOUS substance release, PLASTICIZERS, GAS chromatography, YEAST, MASS spectrometry, BIOLOGICAL assay
Abstract

For several years, environmental exogenous agents, called endocrine disruptors, are suspected to interfere with the essential functions of reproduction and development in many living organisms. In this study, endocrine disruptors including five phthalates and two bisphenols contents in finished products were assayed and their estrogenic activity were measured by using the Yeast Estrogen Screen system with respect to human and trout estrogen receptors hERα and rtERS. Independently of the estrogen receptor, only short-chain phthalates (DBP and BBP) and the two bisphenols exhibited an estrogenic activity. Besides, the risk of three end-products (agro-food, cosmetics, and pharmaceutical) was evaluated before and after forced aging. Only two cosmetics the face cream and the perfume presented a hazard which increases with aging. These results are consistent with the compounds identified by Gas chromatography-mass spectrometry. These findings confirmed that the YES system can be routinely used to evaluate the estrogenic hazards within finished products. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Apprendre la collaboration et apprendre par la collaboration dans un projet réel - à partir d'expériences en paysage et en architecture

Author

BLANCKAERT, Simon, STERNO, Jean-Marc, SIRE, Olivier, Possoz, Jean-Philippe, Université de Mons (UMons), Université libre de Bruxelles (ULB), Université de Liège, and ENSTA Bretagne, IMT-A, UBO

Subjects
Urbanisme, Paysage, [SHS.EDU]Humanities and Social Sciences/Education, Architecture, recherche, Coopération, Collaboration, transversalité, Enseignement du projet
Abstract

International audience; La communication s’attachera à présenter le projet pédagogique « Jardin d’Expériences » (« JExp’ ») qui s’appuie sur un principe d’apprentissage « design and build» Cette activité a été initiée en 2016 au sein de la FA+U (Faculté d’Architecture et d’Urbanisme de Mons). A travers un chantier d’aménagement, le « JExp’ » donne la liberté aux étudiants architectes de tester ensemble la matière et de confronter leurs concepts à la réalité du terrain. Echanges et partages in situ sont ainsi au cœur du système d’apprentissage dans l’objectif de développer une adaptabilité personnelle, gage d’un savoir-faire et savoir-être futur.

Published
2019

42. Thèse par le projet et Transversalité – Évolution d'une (parenthèse) facultaire : 'l'Esquisse Commune'

Author

STERNO, Jean-Marc, SIRE, Olivier, Université libre de Bruxelles (ULB), ENSTA Bretagne, IMT-A, UBO, and Sciencesconf.org, CCSD

Subjects
[SHS.EDU]Humanities and Social Sciences/Education, [SHS.EDU] Humanities and Social Sciences/Education, Transversalité, Urbanisme et architecture (aspect sociologique), Conception & réalisation, Thèse par le projet, Enseignement du projet
Abstract

Dans cet article, les auteurs décrivent l’évolution d’un exercice facultaire nommé « Esquisse Commune ». A son origine, cet exercice proposait aux étudiants d’école d’architecture de concevoir et réaliser une construction de grande échelle. Aujourd’hui, cette semaine d’action est le terrain d’expérimentation d’une recherche par le projet. Cet ensemble permet la création d’un système transversal dans lequel concepteur, chercheur, politique et habitant coopèrent pour permettre la réalisation du projet. Cette coopération amène un apprentissage mutuel où chaque membre est autant enseignant qu’élève., info:eu-repo/semantics/published

Published
2019

43. Long-range effects in liganded hemoglobin investigated by neutron and UV Raman scattering, FTIR, and CT spectroscopies

Author

Sire, Olivier, Zentz, Christian, Pin, Serge, Chinsky, Laurent, Turpin, Pierre-Yves, Martel, Pierre, Wong, Patrick T.T., and Alpert, Bernard

Subjects
Raman effect -- Usage, Spectrum analysis -- Usage, Ligands -- Observations, Hemoglobin -- Observations, Chemistry
Abstract

Most investigations into the iron binding site have concentrated on the different affinity of hemoglobin for CO and Osub2, without success. The problem of nolocal effects, which have so far been disregarded, is reported, including investigation into the protein behaviour in relation to the iron-ligand nature. UV Raman scattering studies show that some protein parts not in contact with the heme pocket, can be affected by the nature of the iron-ligand bond.

Published
1997

46. Research by design - Evolution of a faculty course :'L'Esquisse Commune'

Author

Methods & topics in architecture, urbanism & landscape practices, theory & history (2019: Bruxelles), Sire, Olivier, Methods & topics in architecture, urbanism & landscape practices, theory & history (2019: Bruxelles), and Sire, Olivier

Abstract

info:eu-repo/semantics/nonPublished

Published
2019

50. extremefit: A Package for Extreme Quantiles

Author

Durrieu, Gilles, Pham, Quang-Khoai, Foltete, Anne-Sophie, Maxime, Valérie, Grama, Ion, Tilly, Véronique Le, Duval, Hélène, Tricot, Jean-Marie, Naceur, Chiraz Ben, Sire, Olivier, Jaunâtre, Kévin, SOLENN financial support, Laboratoire de Mathématiques de Bretagne Atlantique (LMBA), Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche Dupuy de Lôme (IRDL), Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Université de Brest (UBO)-Université de Bretagne Sud (UBS), Service d'anatomie et cytologie pathologiques [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Centre National de la Recherche Scientifique (CNRS), Service d'anatomie et cytologie pathologiques [Rennes] = Anatomy and Cytopathology [Rennes], and CHU Pontchaillou [Rennes]

Subjects
Statistics and Probability, QA76.75-76.765, QA273-280, tail conditional probabilities, adaptive estimation, 01 natural sciences, Data-driven, case study, 010104 statistics & probability, symbols.namesake, nonparametric estimation, extreme conditional quantile, application, Statistics, Rare events, Econometrics, 14. Life underwater, Pareto distribution, 0101 mathematics, lcsh:Statistics, lcsh:HA1-4737, ComputingMilieux_MISCELLANEOUS, Mathematics, Pointwise, [STAT.AP]Statistics [stat]/Applications [stat.AP], Distribution function, Simulated data, symbols, Statistics, Probability and Uncertainty, Software, Quantile
Abstract

extremefit is a package to estimate the extreme quantiles and probabilities of rare events. The idea of our approach is to adjust the tail of the distribution function over a threshold with a Pareto distribution. We propose a pointwise data driven procedure to choose the threshold. To illustrate the method, we use simulated data sets and three real-world data sets included in the package.

Published
2018
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