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3. Anticoagulatory treatment and clinical outcomes after transcatheter aortic valve implantation: results from 45,598 patients of the German Aortic Valve Registry (GARY)

Author

Hohmann, C, primary, Pfister, R, additional, Frerker, C, additional, Beckmann, A, additional, Walther, T, additional, Bleiziffer, S, additional, Ensminger, S, additional, Bekeredjian, R, additional, Seiffert, M, additional, Sinning, J M, additional, Moellmann, H, additional, Beyersdorf, F, additional, Herrmann, E, additional, Balaban, Ü, additional, and Kuhn, E W, additional

Published
2023
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5. The association of CT-assessed fat-free muscle fraction with frailty and malnutrition and the predictive value of their combination in patients undergoing TAVR

Author

Al-Kassou, B, primary, Shamekhi, J, additional, Aksoy, A D E M, additional, Sprinkart, A, additional, Nowak, S, additional, Weber, M, additional, Zietzer, A, additional, Niepmann, S T, additional, Sinning, J M, additional, Grube, E, additional, Nickenig, G, additional, Luetkens, J, additional, and Zimmer, S, additional

Published
2023
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9. Optimal protamine-to-heparin dosing ratio for the prevention of bleeding complications in patients undergoing TAVR – a multicentre experience

Author

Al-Kassou, B, primary, Veulemans, V, additional, Shamekhi, J, additional, Maier, O, additional, Aksoy, A, additional, Zietzer, A, additional, Meertens, M, additional, Weber, M, additional, Sinning, J M, additional, Adam, M, additional, Zimmer, S, additional, Baldus, S, additional, Kelm, M, additional, Nickenig, G, additional, and Sedaghat, A, additional

Published
2022
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11. Transcatheter Aortic Valve Replacement in Patients at High Risk of Coronary Obstruction

Author

Ahmad, Y., Oakley, L., Yoon, S., Kaewkes, D., Chakravarty, T., Patel, C., Palmerini, Tullio, Bruno, A. G., Saia, Francesco, Testa, L., Bedogni, Francesco, Chieffo, Alaide, Montorfano, M., Bartorelli, A. L., Porto, Italo, Grube, E., Nickenig, G., Sinning, J. -M., De Carlo, M., Petronio, A. S., Barbanti, M., Tamburino, C., Iadanza, A., Burzotta, Francesco, Trani, Carlo, Fraccaro, C., Tarantini, G., Aranzulla, T. C., Musumeci, Giampaolo, Stefanini, G. G., Taramasso, M., Kim, H. -S., Codner, P., Kornowski, R., Pelliccia, F., Vignali, L., Makkar, R. R., Palmerini T., Saia F., Bedogni F., Chieffo A., Porto I. (ORCID:0000-0002-9854-5046), Burzotta F. (ORCID:0000-0002-6569-9401), Trani C. (ORCID:0000-0001-9777-013X), Musumeci G., Ahmad, Y., Oakley, L., Yoon, S., Kaewkes, D., Chakravarty, T., Patel, C., Palmerini, Tullio, Bruno, A. G., Saia, Francesco, Testa, L., Bedogni, Francesco, Chieffo, Alaide, Montorfano, M., Bartorelli, A. L., Porto, Italo, Grube, E., Nickenig, G., Sinning, J. -M., De Carlo, M., Petronio, A. S., Barbanti, M., Tamburino, C., Iadanza, A., Burzotta, Francesco, Trani, Carlo, Fraccaro, C., Tarantini, G., Aranzulla, T. C., Musumeci, Giampaolo, Stefanini, G. G., Taramasso, M., Kim, H. -S., Codner, P., Kornowski, R., Pelliccia, F., Vignali, L., Makkar, R. R., Palmerini T., Saia F., Bedogni F., Chieffo A., Porto I. (ORCID:0000-0002-9854-5046), Burzotta F. (ORCID:0000-0002-6569-9401), Trani C. (ORCID:0000-0001-9777-013X), and Musumeci G.

Abstract

Background: Coronary obstruction following transcatheter aortic valve replacement (TAVR) is a life-threatening complication. For patients at elevated risk, it is not known how valve choice is influenced by clinical and anatomic factors and how outcomes differ between valve platforms. For patients at high risk of coronary obstruction, we sought to describe the anatomical and clinical characteristics of patients treated with both balloon-expandable (BE) and self-expanding (SE) valves. Methods: This was a multicenter international registry of patients undergoing TAVR who are considered to be at high risk of coronary obstruction and receiving pre-emptive coronary protection. Results: A total of 236 patients were included. Patients receiving SE valves were more likely to undergo valve-in-valve procedures and also had smaller sinuses of Valsalva and valve-to-coronary distance. Three-year cardiac mortality was 21.6% with SE vs 3.7% with BE valves. This was primarily driven by increased rates of definite or probable coronary occlusion, which occurred in 12.1% of patients with SE valves vs 2.1% in patients with BE valves. Conclusions: In patients undergoing TAVR with coronary protection, those treated with SE valves had increased rates of clinical and anatomic features that increase the risk of coronary obstruction. These include an increased frequency of valve-in-valve procedures, smaller sinuses of Valsalva, and smaller valve-to-coronary distances. These patients were observed to have increased cardiac mortality compared with patients treated with BE valves, but this is likely due to their higher risk clinical and anatomic phenotypes rather than as a function of the valve type itself.

Published
2022

14. Risk prediction in patients with classical Low-flow, low-gradient aortic stenosis undergoing TAVI

Author

Ludwig, S, primary, Gruhl, L, additional, Gossling, A, additional, Seiffert, M, additional, Westermann, D, additional, Sinning, J M, additional, Sugiura, A, additional, Adam, M, additional, Mauri, V, additional, Frank, D, additional, Seoudy, H, additional, Rudolph, T K, additional, Potratz, M, additional, Conradi, L, additional, and Schofer, N, additional

Published
2021
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15. Circulating microRNA-122-5p correlates with improvement in left-ventricular function after transcatheter aortic valve replacement and regulates viability of cardiomyocytes via extracellular vesicles

Author

Hosen, M R, primary, Xiang, X U, additional, Goody, P R, additional, Zietzer, A, additional, Niepmann, S T, additional, Zimmer, S, additional, Sinning, J M, additional, Sadeghat, A, additional, Tiyerili, V, additional, Latz, E, additional, Werner, N, additional, Nickenig, G, additional, and Jansen, F, additional

Published
2021
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17. Transcatheter Aortic Valve Replacement With the LOTUS Edge System: Early European Experience

Author

Armario, X., Rosseel, L., Kharbanda, R., Khogali, S., Abdel-Wahab, M., Van Mieghem, N. M., Tchetche, D., Dumonteil, N., De Backer, O., Cotton, J., Mcgrath, B., Balakrishnan, D., Ali, N., Farhan, S., Joseph, J., Charbonnier, G., Okuno, T., Mchugh, F., Hildick-Smith, D., Gilgen, N., Hokken, T., Spence, M. S., Frerker, C., Angelillis, M., Grygier, M., Cockburn, J., Bjursten, H., Jeger, R. V., Teles, R., Petronio, A. S., Pilgrim, T., Sinning, J. -M., Nickenig, G., Sondergaard, L., Blackman, D. J., Mylotte, D., and Cardiology

Subjects
Europe, Transcatheter Aortic Valve Replacement, Treatment Outcome, aortic valve stenosis, transcatheter aortic valve replacement, transcatheter heart valve, Aortic Valve, Humans, Prosthesis Design, Retrospective Studies, Risk Factors, Aortic Valve Stenosis, Heart Valve Prosthesis, 610 Medicine & health
Abstract

OBJECTIVES The aim of this study was to evaluate the short-term safety and efficacy of transcatheter aortic valve replacement (TAVR) with the LOTUS Edge system. BACKGROUND The LOTUS Edge system was commercially re-released in April 2019. The authors report the first European experience with this device. METHODS A multicenter, single-arm, retrospective registry was initiated to evaluate short-term clinical outcomes. Included cases are the first experience with this device and new implantation technique in Europe. Clinical, echocardiographic, and computed tomographic data were analyzed. Endpoints were defined according to Valve Academic Research Consortium-2 and were site reported. RESULTS Between April and November 2019, 286 consecutive patients undergoing TAVR with the LOTUS Edge system at 18 European centers were included. The mean age and Society of Thoracic Surgeons score were 81.2 �� 6.9 years and 5.2 �� 5.4%, respectively. Nearly one-half of all patients (47.9%) were considered to have complex anatomy. Thirty-day major adverse events included death (2.4% [n��=��7]) and stroke (3.5% [n��=��10]). After TAVR, the mean aortic valve area was 1.9 �� 0.9��cm2, and the mean transvalvular gradient was 11.9 �� 5.7��mm��Hg. None or trace paravalvular leak (PVL) occurred in 84.4% and moderate PVL in 2.0%. There were no cases of severe PVL. New permanent pacemaker (PPM) implantation was required in 25.9% among all patients and 30.8% among PPM-naive patients. CONCLUSIONS Early experience with the LOTUS Edge system demonstrated satisfactory short-term safety and efficacy, favorable hemodynamic data, and very low rates of PVL in an anatomically complex cohort. New PPM implantation remained high. Further study will evaluate if increasing operator experience with the device and new implantation technique can reduce the incidence of PPM implantation.

Published
2021

18. Correction to: Predictors of high residual gradient after transcatheter aortic valve replacement in bicuspid aortic valve stenosis (Clinical Research in Cardiology, (2021), 10.1007/s00392-020-01793-9)

Author

Bugani, G., Pagnesi, M., Tchetche, D., Kim, W. -K., Khokhar, A., Sinning, J. -M., Landes, U., Kornowski, R., Codner, P., De Backer, O., Nickenig, G., Ielasi, A., De Biase, C., Sondergaard, L., De Marco, F., Ancona, M., Montorfano, M., Regazzoli, D., Stefanini, G., Toggweiler, S., Tamburino, C., Imme, S., Tarantini, G., Sievert, H., Schafer, U., Kempfert, J., Woehrle, J., Tespili, M., Laricchia, A., Latib, A., Giannini, F., Colombo, A., and Mangieri, A.

Published
2021

23. Coronary Protection to Prevent Coronary Obstruction During TAVR: A Multicenter International Registry

Author

Palmerini, T., Chakravarty, T., Saia, F., Bruno, A. G., Bacchi-Reggiani, M. -L., Marrozzini, C., Patel, C., Patel, V., Testa, L., Bedogni, F., Ancona, M., Montorfano, M., Chieffo, A., Olivares, P., Bartorelli, A. L., Buscaglia, A., Porto, I., Nickenig, G., Grube, E., Sinning, J. -M., De Carlo, M., Petronio, A. S., Barbanti, M., Tamburino, C., Iadanza, A., Burzotta, F., Trani, C., Fraccaro, C., Tarantini, G., Aranzulla, T. C., De Benedictis, M., Pagnotta, P., Stefanini, G. G., Miura, M., Taramasso, M., Kang, J. -H., Kim, H. -S., Codner, P., Kornowski, R., Pelliccia, F., Vignali, L., Taglieri, N., Ghetti, G., Leone, A., Galie, N., and Makkar, R.

Subjects
Male, Time Factors, Computed Tomography Angiography, Coronary Angiography, Prosthesis Design, Transcatheter Aortic Valve Replacement, Percutaneous Coronary Intervention, Risk Factors, coronary obstruction, stent thrombosis, transcatheter aortic valve replacement, 80 and over, Humans, Registries, Aged, Retrospective Studies, Aged, 80 and over, Aortic Valve, Coronary Stenosis, Female, Stents, Treatment Outcome, Coronary Vessels, Heart Valve Prosthesis, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE
Abstract

The aim of this study was to investigate the safety and efficacy of coronary protection by preventive coronary wiring and stenting across the coronary ostia in patients at high risk for coronary obstruction after transcatheter aortic valve replacement (TAVR).Coronary obstruction following TAVR is a life-threatening complication with high procedural and short-term mortality.Data were collected retrospectively from a multicenter international registry between April 2011 and February 2019.Among 236 patients undergoing coronary protection with preventive coronary wiring, 143 had eventually stents implanted across the coronary ostia after valve deployment. At 3-year follow-up, rates of cardiac death were 7.8% in patients receiving stents and 15.7% in those not receiving stents (adjusted hazard ratio: 0.42; 95% confidence interval: 0.14 to 1.28; p = 0.13). There were 2 definite stent thromboses (0.9%) in patients receiving stents, both occurring after TAVR in "valve-in-valve" procedures. In patients not receiving stents, there were 4 delayed coronary occlusions (DCOs) (4.3%), occurring from 5 min to 6 h after wire removal. Three cases occurred in valve-in-valve procedures and 1 in a native aortic valve procedure. Distance between the virtual transcatheter valve and the protected coronary ostia 4 mm was present in 75.0% of patients with DCO compared with 30.4% of patients without DCO (p = 0.19).In patients undergoing TAVR at high risk for coronary obstruction, preventive stent implantation across the coronary ostia is associated with good mid-term survival rates and low rates of stent thrombosis. Patients undergoing coronary protection with wire only have a considerable risk for DCO.

Published
2020

24. Use of Pre- and Intensified Postprocedural Physiotherapy in Patients with Symptomatic Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement Study (the 4P-TAVR Study)

Author

Weber, M., primary, Klein, U., additional, Weigert, A., additional, Schiller, W., additional, Bayley-Ezziddin, V., additional, Wirtz, D. C., additional, Welz, A., additional, Werner, N., additional, Grube, E., additional, Nickenig, G., additional, Sinning, J.-M., additional, and Ghanem, A., additional

Published
2021
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26. Opportunistische CT-Bildgebung: Fettige Muskelfraktion zur Outcome-Prädiktion bei Patienten nach minimalinvasivem Aortenklappenersatz

Author

Luetkens, J, additional, Faron, A, additional, Geissler, H, additional, Al-Kassou, B, additional, Shamekh, J, additional, Stundl, A, additional, Sprinkart, A, additional, Meyer, C, additional, Fimmers, R, additional, Treede, H, additional, Grube, E, additional, Nickenig, G, additional, Attenberger, U, additional, Sinning, J, additional, and Thomas, D, additional

Published
2020
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34. P5738Multicenter analysis of left ventricular unloading on top of VA-ECMO for treatment of cardiogenic shock

Author

Schrage, B, primary, Dabboura, S, additional, Bezerra, H, additional, Sinning, J M, additional, Thiele, H, additional, Pauschinger, M, additional, Frank, D, additional, Schulze, P C, additional, Pappalardo, F, additional, Morrow, D, additional, Li, Y, additional, Eitel, I, additional, Nordbeck, P, additional, Skurk, C, additional, and Westermann, D, additional

Published
2019
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37. P3417Reclassification into moderate aortic valve stenosis after hybrid continuity equation by combination of CT and echocardiography and its clinical impact

Author

Weber, M, primary, Stundl, A, additional, Shamekhi, J, additional, Jaenisch, M, additional, Spilker, M, additional, Sedaghat, A, additional, Oeztuerk, C, additional, Schueler, R, additional, Pingel, S, additional, Mellert, F, additional, Welz, A, additional, Grube, E, additional, Nickenig, G, additional, Werner, N, additional, and Sinning, J.-M, additional

Published
2018
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38. P1643Indication and short-term clinical outcomes of high-risk percutaneous coronary intervention with microaxial Impella pump. Results from the German Impella registry

Author

Baumann, S, primary, Werner, N, additional, Ibrahim, K, additional, Westenfeld, R, additional, Al-Rashid, F, additional, Sinning, J.-M, additional, Westermann, D, additional, Schaefer, A, additional, Karatolios, K, additional, Bauer, T, additional, Becher, T, additional, and Akin, I, additional

Published
2018
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43. Correction: Expertenkonsensus zum praktischen Einsatz von Herzkreislaufunterstützungssystemen bei Hochrisiko-Koronarinterventionen

Author

Werner, N., primary, Akin, I., additional, Al-Rashid, F., additional, Bauer, T., additional, Ibrahim, K., additional, Karatolios, K., additional, Mellert, F., additional, Schäfer, A., additional, Sinning, J.-M., additional, Werner, G. S., additional, Westenfeld, R., additional, Westermann, D., additional, and Elsässer, A., additional

Published
2017
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46. P748Cardiac biomarkers and clinical scores for risk stratification in patients with severe symptomatic aortic stenosis undergoing TAVI. Which ranks first now?

Author

Stundl, A., primary, Shamekhi, J., additional, Weber, M., additional, Sedaghat, A., additional, Zur, B., additional, Holdenrieder, S., additional, Mellert, F., additional, Welz, A., additional, Grube, E., additional, Nickenig, G., additional, Werner, N., additional, and Sinning, J.-M., additional

Published
2017
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47. P1649Reclassification of aortic valve stenosis patients by integration of computed tomography parameters into the echocardiographically assessed continuity equation

Author

Weber, M., primary, Pingel, S., additional, Jaenisch, M., additional, Spilker, M., additional, Schueler, R., additional, Shamekhi, J., additional, Stundl, A., additional, Sedaghat, A., additional, Mellert, F., additional, Welz, A., additional, Werner, N., additional, Nickenig, G., additional, and Sinning, J.-M., additional

Published
2017
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