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12 results on '"Siniscalchi, Chiara"'

1. A landscape of mouse mitochondrial small non-coding RNAs

Author

Siniscalchi, Chiara, primary, Di Palo, Armando, additional, Petito, Giuseppe, additional, Senese, Rosalba, additional, Manfrevola, Francesco, additional, Leo, Ilenia De, additional, Mosca, Nicola, additional, Chioccarelli, Teresa, additional, Porreca, Veronica, additional, Marchese, Giovanna, additional, Ravo, Maria, additional, Chianese, Rosanna, additional, Cobellis, Gilda, additional, Lanni, Antonia, additional, Russo, Aniello, additional, and Potenza, Nicoletta, additional

Published
2024
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7. Actin remodeling driven by circLIMA1: sperm cell as an intriguing cellular model

Author

Manfrevola, Francesco, primary, Potenza, Nicoletta, additional, Chioccarelli, Teresa, additional, Di Palo, Armando, additional, Siniscalchi, Chiara, additional, Porreca, Veronica, additional, Scialla, Arcangelo, additional, Mele, Vincenza Grazia, additional, Petito, Giuseppe, additional, Russo, Aniello, additional, Lanni, Antonia, additional, Senese, Rosalba, additional, Ricci, Giulia, additional, Pierantoni, Riccardo, additional, Chianese, Rosanna, additional, and Cobellis, Gilda, additional

Published
2022
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11. "Uocchie, maluocchie..." Il Malocchio nel Vallo di Lauro (AV).

Author

Siniscalchi, Chiara

Abstract

Il saggio che qui si va a presentare è stato redatto in seguito alla ricerca condotta nell'autunno 2012 nell'area del Vallo di Lauro (AV) avente come tema il fenomeno del malocchio e le pratiche curative ad esso legate presenti nella zona in questione. Il testo è suddiviso in quattro paragrafi che andranno via via a presentare la ricerca, la zona interessata dallo studio, le tipologie di pratiche rilevate ed i risultati ottenuti, infine verrà presentata una tabella riepilogativa delle persone incontrate. [ABSTRACT FROM AUTHOR]

Published
2013

12. Actin remodeling driven by circLIMA1: sperm cell as an intriguing cellular model

Author

Francesco Manfrevola, Nicoletta Potenza, Teresa Chioccarelli, Armando Di Palo, Chiara Siniscalchi, Veronica Porreca, Arcangelo Scialla, Vincenza Grazia Mele, Giuseppe Petito, Aniello Russo, Antonia Lanni, Rosalba Senese, Giulia Ricci, Riccardo Pierantoni, Rosanna Chianese, Gilda Cobellis, Manfrevola, Francesco, Potenza, Nicoletta, Chioccarelli, Teresa, DI PALO, Armando, Siniscalchi, Chiara, Porreca, Veronica, Scialla, Arcangelo, Grazia Mele, Vincenza, Petito, Giuseppe, Russo, Aniello, Lanni, Antonia, Senese, Rosalba, Ricci, Giulia, Pierantoni, Riccardo, Chianese, Rosanna, and Cobellis, Gilda

Subjects
Male, spermatozoa, QKI, RNA, Circular, Cell Biology, Spermatozoa, Applied Microbiology and Biotechnology, CB1, Actins, Mice, Semen, Animals, circRNA, Molecular Biology, actin, Ecology, Evolution, Behavior and Systematics, Gelsolin, Endocannabinoids, Developmental Biology
Abstract

CircRNA cargo in spermatozoa (SPZ) participates in setting cell quality, in terms of morphology and motility. Cannabinoid receptor CB1 activity is correlated with a proper spermatogenesis and epididymal sperm maturation. Despite CB1 promotes endogenous skill to circularize mRNAs in SPZ, few notions are reported regarding the functional link between endocannabinoids and spermatic circRNA cargo. In CB1 knock-out male mice, we performed a complete dataset of spermatic circRNA content by microarray strategy. Differentially expressed (DE)-circRNAs, as a function of genotype, were identified. Within DE-circRNAs, we focused the attention on circLIMA1, as putative actin-cytoskeleton architecture regulator. The validation of circLIMA1 dependent-competitive endogenous RNA (ceRNA) network (ceRNET) in in vitro cell line confirmed its activity in the regulation of the cytoskeletal actin. Interestingly, a dynamic actin regulation in SPZ nuclei was found during their epididymal maturation. In this scenario, we showed for the first time an intriguing sperm nuclear actin remodeling, regulated via a ceRNET-independent pathway, consisting in the nuclear shuttling of circLIMA1-QKI interactome and downstream in Gelsolin regulation. In particular, the increased levels of circLIMA1 in CB1 knock-out SPZ, associated with an inefficient depolymerization of nuclear actin, specifically illustrate how endocannabinoids, by regulating circRNA cargo, may contribute to sperm morpho-cellular maturation.

Published
2022

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