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212 results on '"Sinhal, Ajay"'

1. Assessing the Impact of Colchicine on Coronary Plaque Phenotype After Myocardial Infarction with Optical Coherence Tomography: Rationale and Design of the COCOMO-ACS Study

Author

Montarello, Nicholas J., Singh, Kuljit, Sinhal, Ajay, Wong, Dennis T. L., Alcock, Richard, Rajendran, Sharmalar, Dautov, Rustem, Barlis, Peter, Patel, Sanjay, Nidorf, Stefan M., Thompson, Peter L., Salagaras, Thalia, Butters, Julie, Nerlekar, Nitesh, Di Giovanni, Giuseppe, Ottaway, Juanita L., Nicholls, Stephen J., and Psaltis, Peter J.

Published
2022
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6. Initial Feasibility Study of a New Transcatheter Mitral Prosthesis: The First 100 Patients

Author

Sorajja, Paul, Moat, Neil, Badhwar, Vinay, Walters, Darren, Paone, Gaetano, Bethea, Brian, Bae, Richard, Dahle, Gry, Mumtaz, Mubashir, Grayburn, Paul, Kapadia, Samir, Babaliaros, Vasilis, Guerrero, Mayra, Satler, Lowell, Thourani, Vinod, Bedogni, Francesco, Rizik, David, Denti, Paolo, Dumonteil, Nicolas, Modine, Thomas, Sinhal, Ajay, Chuang, Michael L., Popma, Jeffrey J., Blanke, Philipp, Leipsic, Jonathon, and Muller, David

Published
2019
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9. First-in-Human Evaluation of a Novel Polymer-Free Drug-Filled Stent: Angiographic, IVUS, OCT, and Clinical Outcomes From the RevElution Study

Author

Worthley, Stephen, Shetty, Sharad, Sinhal, Ajay, Meredith, Ian, Abizaid, Alexandre, Jepson, Nigel, Bhindi, Ravinay, Lim, Soo Teik, Stewart, Peter, Barlis, Peter, Walters, Darren, Muller, David, Cox, Stephen, Bhagwandeen, Rohan, Worthley, Stephen G., Kirtane, Ajay J., Simon, Daniel I., Windecker, Stephan, Brar, Sandeep, Meredith, Ian T., Almonacid, Alexandra Popma, Chamié, Daniel, Maehara, Akiko, and Stone, Gregg W.

Published
2017
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11. Catheter-based renal denervation for resistant hypertension: Twenty-four month results of the EnligHTN™ I first-in-human study using a multi-electrode ablation system

Author

Tsioufis, Costas P., Papademetriou, Vasilios, Dimitriadis, Kyriakos S., Kasiakogias, Alexandros, Tsiachris, Dimitrios, Worthley, Matthew I., Sinhal, Ajay R., Chew, Derek P., Meredith, Ian T., Malaiapan, Yuvi, Thomopoulos, Costas, Kallikazaros, Ioannis, Tousoulis, Dimitrios, and Worthley, Stephen G.

Published
2015
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12. Do Chest Pain Characteristics in Patients with Acute Myocardial Infarction Differ between Those with and without Obstructive Coronary Artery Disease?

Author

Pasupathy, Sivabaskari, La, Sarena, Tavella, Rosanna, Zeitz, Christopher, Worthley, Matthew, Sinhal, Ajay, Arstall, Margaret, and Beltrame, John F.

Subjects
MYOCARDIAL infarction, CHEST pain, CORONARY artery disease, MYOCARDIAL injury, MYOCARDIAL ischemia, CARDIOVASCULAR diseases risk factors
Abstract

The universal definition of acute myocardial infarction (MI) requires both evidence of myocardial injury and myocardial ischaemia. In MINOCA (MI with non-obstructive coronary arteries), patients must fulfil this MI criteria, but is their chest pain similar to those who have MI with obstructive CAD (MICAD)? This study compares prospectively collected chest pain features between patients with MINOCA and MICAD. Utilising the Coronary Angiogram Database of South Australia (CADOSA), consecutive MI patients were categorized as MINOCA or MICAD based on angiographic findings. Chest pain data were collected via direct patient interviews by trained staff members. Of 6811 consecutive patients fulfilling a clinical MI diagnosis, 411 (6.0%) were MINOCA, and 5948 MICAD. The MINOCA patients were younger, more often female and had less cardiovascular risk factors than those with MICAD. There were no significant differences in chest pain characteristics between the MINOCA and MICAD cohorts in relation to pain location, quality, associated symptoms, or duration. In conclusion, MINOCA patients have chest pain characteristics that are indistinguishable from MICAD patients, suggesting that their pain is ischaemic in nature. Thus, in the presence of positive myocardial injury markers, ischaemic chest pain fulfils the universal criteria for MI, despite the absence of obstructive coronary artery disease. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Obesity-induced vena cava compression syndrome: a case report of a rare precipitant of a type 2 myocardial infarction in a patient with critical aortic stenosis.

Author

Sellers, Alexander M, Alam, Ferdous, Bennetts, Jayme S, Lehman, Sam J, and Sinhal, Ajay R

Subjects
AORTIC stenosis, VENAE cavae, CRUSH syndrome, MORBID obesity, MYOCARDIAL infarction, VENA cava inferior, BUNDLE-branch block
Abstract

Background Obesity is a global health problem of increasing prevalence with a broad range of multisystem complications. An under-recognized complication of severe obesity is the potential haemodynamic compromise that may arise due to pathological external compression of the inferior vena cava whilst lying in the supine position, a phenomenon known as obesity-induced vena cava compression syndrome. Case summary A 56-year-old independent woman presented to a rural Australian hospital for routine dressing care for bilateral lymphoedema on a background of class III morbid obesity (weight 197 kg, body mass index 68.55 kg/m3) and aortic stenosis. Whilst laid in the supine position with both legs elevated to aid lower limb venous return, the patient developed angina with associated troponin rise (15 to 75 to 332 ng/L) and inferolateral territory ischaemic changes on electrocardiogram. The pain then resolved shortly after restoring the patient to the upright position. A transthoracic echocardiogram showed critical bicuspid aortic stenosis. Computerized tomography coronary angiogram showed no significant coronary artery disease. Following multidisciplinary discussions, a transcatheter aortic valve insertion was performed via a transfemoral approach. Post-procedure, she went into atrial fibrillation, she was cardioverted into a sinus rhythm with new left bundle branch block. There were no complications otherwise, and the patient was discharged home following a brief period of convalescence. Discussion We describe a case of suspected obesity-induced vena cava compression syndrome precipitating a type 2 myocardial infarction in a pre-load dependent patient with critical bicuspid valve aortic stenosis. This case highlights a potential haemodynamic consequence of morbid obesity in the supine position. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Assessing the Impact of Colchicine on Coronary Plaque Phenotype After Myocardial Infarction with Optical Coherence Tomography: Rationale and Design of the COCOMO-ACS Study

Author

Montarello, Nicholas J., primary, Singh, Kuljit, additional, Sinhal, Ajay, additional, Wong, Dennis T. L., additional, Alcock, Richard, additional, Rajendran, Sharmalar, additional, Dautov, Rustem, additional, Barlis, Peter, additional, Patel, Sanjay, additional, Nidorf, Stefan M., additional, Thompson, Peter L., additional, Salagaras, Thalia, additional, Butters, Julie, additional, Nerlekar, Nitesh, additional, Di Giovanni, Giuseppe, additional, Ottaway, Juanita L., additional, Nicholls, Stephen J., additional, and Psaltis, Peter J., additional

Published
2021
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23. Surgical and percutaneous management of Aboriginal Australians with rheumatic heart disease: Timeliness and concordance between practice and guidelines

Author

Roberts-Thomson, Ross L., primary, Baumann, Angus A.W., additional, Reade, Julie, additional, Culgan, Libby, additional, Kaethner, Alex, additional, Ilton, Marcus, additional, Kangaharan, Nadarajah, additional, Tayeb, Hussam M., additional, Sinhal, Ajay, additional, Chew, Derek P., additional, Bennetts, Jayme S., additional, Nicholls, Stephen J., additional, Psaltis, Peter J., additional, and Brown, Alex, additional

Published
2021
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29. Troponin elevation pattern and subsequent cardiac and non-cardiac outcomes: Implementing the Fourth Universal Definition of Myocardial Infarction and high-sensitivity troponin at a population level

Author

Chuang, Anthony (Ming-yu), primary, Nguyen, Mau T., additional, Khan, Ehsan, additional, Jones, Dylan, additional, Horsfall, Matthew, additional, Lehman, Sam, additional, Smilowitz, Nathaniel R., additional, Lambrakis, Kristina, additional, Than, Martin, additional, Vaile, Julian, additional, Sinhal, Ajay, additional, French, John K., additional, and Chew, Derek P., additional

Published
2021
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32. Impact of increased augmentation index and valvuloarterial impedance on symptom recovery after aortic valve replacement for severe aortic stenosis

Author

Jones, Dylan R., primary, Chew, Derek P., additional, Horsfall, Matthew J., additional, Sinhal, Ajay R., additional, Joseph, Majo X., additional, Baker, Robert A., additional, Bennetts, Jayme S., additional, Selvanayagam, Joseph B., additional, Russell, Andrew E., additional, De Pasquale, Carmine G., additional, and Lehman, Sam J., additional

Published
2021
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33. Supplemental Material, Supplementary_files - Impact of Young Age and Gender on Outcomes of Transradial Versus Transfemoral Access Coronary Angiography

Author

Kuljit Singh, Tavella, Rosanna, Air, Tracy, Worthley, Matthew, Sinhal, Ajay, Arstall, Margaret, Zeitz, Christopher, and Beltrame, John

Subjects
Cardiology
Abstract

Supplemental Material, Supplementary_files for Impact of Young Age and Gender on Outcomes of Transradial Versus Transfemoral Access Coronary Angiography by Kuljit Singh, Rosanna Tavella, Tracy Air, Matthew Worthley, Ajay Sinhal, Margaret Arstall, Christopher Zeitz and John Beltrame in Angiology

Published
2020
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40. Effect of Balloon Aortic Valvuloplasty on Mortality in Patients With Severe Aortic Stenosis Prior to Conservative Treatment and Surgical or Transcatheter Aortic Valve Replacement

Author

Jones, Dylan R., primary, Chew, Derek P., additional, Horsfall, Matthew J., additional, Chuang, Anthony M., additional, Sinhal, Ajay R., additional, Joseph, Majo X., additional, Baker, Robert A., additional, Bennetts, Jayme S., additional, Selvanayagam, Joseph B, additional, and Lehman, Sam J., additional

Published
2020
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42. Clinical Outcomes With a Repositionable Self-Expanding Transcatheter Aortic Valve Prosthesis: The International FORWARD Study

Author

Grube, Eberhard, Van Mieghem, Nicolas M., Bleiziffer, Sabine, Modine, Thomas, Bosmans, Johan, Manoharan, Ganesh, Linke, Axel, Scholtz, Werner, Tchã©tchã©, Didier, Finkelstein, Ariel, Trillo, Ramiro, Fiorina, Claudia, Walton, Antony, Malkin, Christopher J., Oh, Jae K., Qiao, Hongyan, Windecker, Stephan, Van Mieghem, Nicolas, Sinhal, Ajay, Gooley, Robert, Walton, Tony, Yong, Gerald, Webb, John, Chu, Michael, Radhakrishnan, Sam, Dager, Antonio, Branny, Marian, Tchetche, Didier, Teiger, Emmanuel, Chevalier, Bernard, Himbert, Dominique, Schymik, Gerhard, Zeus, Tobias, Jensen, Christoph, Rassaf, Tienush, Fichtlscherer, Stephan, Nickenig, Georg, Kempfert, Jã¶rg, Harnath, Axel, Strasser, Ruth, Frerker, Christian, Spargias, Konstantinos, Merkely, Bã©la Peter, Tamburino, Corrado, Petronio, Anna Sonia, Bedogni, Francesco, Amoroso, Giovanni, Van Der Heijden, Jan, Tonino, Pim, Echeverria Beliz, Pedro, Witkowski, Adam, Gama Ribeiro, Vasco, Al Abdullah, Moheeb, Weich, Hellmuth, Hernã¡ndez Garcã­a, Josã© Maria, Moris, Cesar, Jã¶nsson, Anders Lars, Khogali, Saib, Hildick smith, David, COLOMBO, ANTONIO, Grube, Eberhard, Van Mieghem, Nicolas M., Bleiziffer, Sabine, Modine, Thoma, Bosmans, Johan, Manoharan, Ganesh, Linke, Axel, Scholtz, Werner, Tchã©tchã©, Didier, Finkelstein, Ariel, Trillo, Ramiro, Fiorina, Claudia, Walton, Antony, Malkin, Christopher J., Oh, Jae K., Qiao, Hongyan, Windecker, Stephan, Van Mieghem, Nicola, Sinhal, Ajay, Gooley, Robert, Walton, Tony, Yong, Gerald, Webb, John, Chu, Michael, Radhakrishnan, Sam, Dager, Antonio, Branny, Marian, Tchetche, Didier, Teiger, Emmanuel, Chevalier, Bernard, Himbert, Dominique, Schymik, Gerhard, Zeus, Tobia, Jensen, Christoph, Rassaf, Tienush, Fichtlscherer, Stephan, Nickenig, Georg, Kempfert, Jã¶rg, Harnath, Axel, Strasser, Ruth, Frerker, Christian, Spargias, Konstantino, Merkely, Bã©la Peter, Tamburino, Corrado, Colombo, Antonio, Petronio, Anna Sonia, Bedogni, Francesco, Amoroso, Giovanni, Van Der Heijden, Jan, Tonino, Pim, Echeverria Beliz, Pedro, Witkowski, Adam, Gama Ribeiro, Vasco, Al Abdullah, Moheeb, Weich, Hellmuth, Hernã¡ndez Garcã­a, Josã© Maria, Moris, Cesar, Jã¶nsson, Anders Lar, Khogali, Saib, and Hildick smith, David

Subjects
Male, Time Factors, Time Factor, Global Health, Prosthesis Design, Severity of Illness Index, Follow-Up Studie, Transcatheter Aortic Valve Replacement, Risk Factors, Cause of Death, Multidetector Computed Tomography, 80 and over, Humans, aortic stenosis, degenerative valve, transcatheter aortic valve replacement, Aged, 80 and over, Aortic Valve Stenosis, Echocardiography, Female, Follow-Up Studies, Prospective Studies, Survival Rate, Treatment Outcome, Heart Valve Prosthesis, Cardiology and Cardiovascular Medicine, Aged, Risk Factor, aortic stenosi, Aortic Valve Stenosi, Prospective Studie, Heart Valve Prosthesi, Human
Abstract

Background Clinical outcomes in large patient populations from real-world clinical practice with a next-generation self-expanding transcatheter aortic valve are lacking. Objectives This study sought to document the clinical and device performance outcomes of transcatheter aortic valve replacement (TAVR) with a next-generation, self-expanding transcatheter heart valve (THV) system in patients with severe symptomatic aortic stenosis (AS) in routine clinical practice. Methods The FORWARD (CoreValve Evolut R FORWARD) study is a prospective, single-arm, multinational, multicenter, observational study. An independent clinical events committee adjudicated safety endpoints based on Valve Academic Research Consortium-2 definitions. An independent echocardiographic core laboratory evaluated all echocardiograms. From January 2016 to December 2016, TAVR with the next-generation self-expanding THV was attempted in 1,038 patients with symptomatic, severe AS at 53 centers on 4 continents. Results Mean age was 81.8 ± 6.2 years, 64.9% were women, the mean Society of Thoracic Surgeons Predicted Risk of Mortality was 5.5 ± 4.5%, and 33.9% of patients were deemed frail. The repositioning feature of the THV was applied in 25.8% of patients. A single valve was implanted in the proper anatomic location in 98.9% of patients. The mean aortic valve gradient was 8.5 ± 5.6 mm Hg, and moderate or severe aortic regurgitation was 1.9% at discharge. All-cause mortality was 1.9%, and disabling stroke occurred in 1.8% at 30 days. The expected-to-observed early surgical mortality ratio was 0.35. A pacemaker was implanted in 17.5% of patients. Conclusions TAVR using the next-generation THV is clinically safe and effective for treating older patients with severe AS at increased operative risk. (CoreValve Evolut R FORWARD Study [FORWARD]; NCT02592369)

Published
2017

44. Impact of Young Age and Gender on Outcomes of Transradial Versus Transfemoral Access Coronary Angiography.

Author

Singh, Kuljit, Tavella, Rosanna, Air, Tracy, Worthley, Matthew, Sinhal, Ajay, Arstall, Margaret, Zeitz, Christopher, and Beltrame, John

Subjects
AGE distribution, CONFIDENCE intervals, SCIENTIFIC observation, SEX distribution, MULTIPLE regression analysis, TREATMENT effectiveness, DESCRIPTIVE statistics, CORONARY angiography, ODDS ratio
Abstract

The differential impact of young age and female gender on transradial access (TRA) outcomes remains to be confirmed. The primary objective was to assess the impact of young age and female gender on in-hospital net adverse cardiovascular events (NACE). Among 12 346 patients from the Coronary Angiogram Database of South Australia (CADOSA) Registry, the impact of gender; men (transfemoral access [TFA] 1995, TRA 6168) and women (TFA 1249, TRA 2934), and a median split of age, ≤63 years (TFA 1617, TRA 4727) and >63 years (TFA 1627, TRA 4375) were analyzed on in-hospital outcomes by creating 5 separate propensity-matched cohorts (entire cohort, men, women, ≤63 and > 63 years). Net adverse cardiovascular event reduction with TRA was limited to the >63 years old cohort (odds ratio [OR] = 0.56, 95% CI: 0.34-0.93, P =.02) and women (OR = 0.37, 95% CI: 0.18-0.76, P =.007). In both the age groups and genders, TRA was associated with a lower risk of bleeding and all-cause mortality. On multivariate logistic regression, TRA was associated with a significant reduction in NACE, major bleeding, and mortality in the overall cohort. In conclusion, a reduction in bleeding and mortality was noted with TRA in all the subgroups in this observational study. [ABSTRACT FROM AUTHOR]

Published
2021
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46. Clinical Outcomes With a Repositionable Self-Expanding Transcatheter Aortic Valve Prosthesis

Author

Grube, Eberhard, primary, Van Mieghem, Nicolas M., additional, Bleiziffer, Sabine, additional, Modine, Thomas, additional, Bosmans, Johan, additional, Manoharan, Ganesh, additional, Linke, Axel, additional, Scholtz, Werner, additional, Tchétché, Didier, additional, Finkelstein, Ariel, additional, Trillo, Ramiro, additional, Fiorina, Claudia, additional, Walton, Antony, additional, Malkin, Christopher J., additional, Oh, Jae K., additional, Qiao, Hongyan, additional, Windecker, Stephan, additional, Grube, Eberhard, additional, Van Mieghem, Nicolas, additional, Sinhal, Ajay, additional, Gooley, Robert, additional, Walton, Tony, additional, Yong, Gerald, additional, Webb, John, additional, Chu, Michael, additional, Radhakrishnan, Sam, additional, Dager, Antonio, additional, Branny, Marian, additional, Tchetche, Didier, additional, Teiger, Emmanuel, additional, Chevalier, Bernard, additional, Himbert, Dominique, additional, Schymik, Gerhard, additional, Zeus, Tobias, additional, Jensen, Christoph, additional, Rassaf, Tienush, additional, Fichtlscherer, Stephan, additional, Nickenig, Georg, additional, Kempfert, Jörg, additional, Harnath, Axel, additional, Strasser, Ruth, additional, Frerker, Christian, additional, Spargias, Konstantinos, additional, Merkely, Béla Peter, additional, Tamburino, Corrado, additional, Colombo, Antonio, additional, Petronio, Anna Sonia, additional, Bedogni, Francesco, additional, Amoroso, Giovanni, additional, van der Heijden, Jan, additional, Tonino, Pim, additional, Echeverria Beliz, Pedro, additional, Witkowski, Adam, additional, Gama Ribeiro, Vasco, additional, Al Abdullah, Moheeb, additional, Weich, Hellmuth, additional, Hernández García, José Maria, additional, Moris, Cesar, additional, Jönsson, Anders Lars, additional, Khogali, Saib, additional, and Hildick-Smith, David, additional

Published
2017
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47. TCT-443 First-in-Human Clinical Study with a Novel Drug-Filled Stent: 9-Month Clinical, Angiographic, IVUS, and OCT Outcomes from the RevElution Study

Author

Worthley, Stephen, primary, Brilakis, Nicole, additional, Abizaid, Alexandre, additional, Kirtane, Ajay, additional, Simon, Daniel, additional, Windecker, Stephan, additional, Brar, Sandeep, additional, Meredith, Ian, additional, shetty, sharad v, additional, Sinhal, Ajay, additional, Popma - Almonacid, Alexandra, additional, Chamie, Daniel, additional, Maehara, Akiko, additional, and Stone, Gregg, additional

Published
2016
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48. TCT-681 SOLACE AU Study: Interim results at one year of the Edwards SAPIEN XT TM Transcatheter Heart Valve in intermediate risk patients with severe aortic stenosis in Australia

Author

Walters, Darren, primary, Sinhal, Ajay, additional, Ng, Martin, additional, Yong, Gerald, additional, Jepson, Nigel, additional, Worthley, Stephen, additional, Gurvitch, Ronen, additional, Walton, Tony, additional, Bhindi, Ravinay, additional, and Whitbourn, Robert, additional

Published
2016
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