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205 results on '"Sinha, Tushar"'

1. Incidence of post vitrectomy endophthalmitis in India – A multicentric study by VRSI study Group

Author

Shah, Payal Naresh, Mishra, Divyansh K., Shanmugam, Mahesh P., Agarwal, Manisha, Susvar, Pradeep, Sen, Alok C., Ramanjulu, Rajesh, Dave, Vivek, Saravanan, Veerapan, Kannan, Naresh, Sinha, Tushar, Sindal, Manavi D., Singh, Simar Rajan, Rajanna, Madhu Kumar, Ayachit, Apoorva G., Maitray, Aditya, Yadav, Naresh Kumar, Balakrishnan, Divya, Nigam, Eesh, Narula, Ritesh, Khadar, Syed M. A., Atri, Neelam, Mittal, Sangeet, Murthy, Hemanth, Mahalingam, Prabhu Shanker, Pillai, Gopal S., Nagpal, Manish, Walinjkar, Jaydeep, Gupta, Vishali, and Kothari, Abhishek

Published
2023
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9. Transitioning from Aflibercept to Biosimilar Ranibizumab in Neovascular AMD (The TRANSFORM Trial): A Multicenter Observational Study.

Author

Chakraborty, Debdulal, Boral, Subhendu, Sinha, Tushar Kanti, Das, Arnab, Mukherjee, Angshuman, Majumdar, Saptorshi, Bhattacharya, Ranabir, and Maitra, Ritobroto

Subjects
MACULAR degeneration, WILCOXON signed-rank test, FLUID injection, AFLIBERCEPT, VISUAL acuity
Abstract

Purpose: This study investigates the efficacy of transitioning patients with neovascular age-related macular degeneration (nAMD) from aflibercept (T1) to biosimilar ranibizumab (T2), an approach not previously documented in literature. Methods: In this multicenter observational study, patients over 50 years of age with nAMD were shifted from intravitreal aflibercept (IVI AFL) to biosimilar ranibizumab (B-RBZ) due to financial constraints. This study employed standardized ophthalmological methods to assess visual acuity (VA), central macular thickness (CMT), and subretinal and intraretinal fluid. Statistical analyses included paired t-tests, Wilcoxon signed-rank tests, and linear regression. Results: A total of 29 eyes (12 males and 17 females) were analyzed. Mean age was 72.55 ± 6.43 years. VA improved significantly during T1, with a mean increase from 55.0 ± 10.2 to 70.0 ± 8.5 ETDRS letters at the switch time point (p < 0.01), then a slight decrease to 62.3 ± 8.9 at 12 months (p < 0.05) was noted during T2. The mean CMT decreased notably from 400 ± 50 to 290 ± 45 μm at the switch. The final CMT at 12 months after switching to B-RBZ was 280 ± 40 μm (p < 0.01). There was a significant decrease in the retinal and intra retinal fluid during T1, followed by a gradual increase during T2. A significant correlation (p < 0.05) was noted between the presence of intraretinal fluid and increased injection frequency of B-RBZ. Conclusion: The switch from IVI AFL to IVI B-RBZ in patients with nAMD demonstrated efficacy in maintaining the VA and macular anatomy, with some challenges in fluid management. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Efficacy and safety of large-scale use of vancomycin injection in infusion bottle during vitreoretinal procedures.

Author

Boral, Subhendu Kumar, Agarwal, Deepak, Das, Arnab, Chakraborty, Debdulal, Mandal, Santanu, and Sinha, Tushar Kanti

Subjects
VITRECTOMY, VANCOMYCIN, BACTERIAL diseases, BOTTLES, ENDOPHTHALMITIS, VASCULITIS
Abstract

PURPOSE: The purpose of this study was to assess the safety and efficacy of large-scale use of vancomycin injection in an infusion bottle during vitreoretinal procedures. MATERIALS AND METHODS: This was a retrospective evaluation of all vitreoretinal procedures done in the last 70 months, where intraoperatively vancomycin injection (0.2 mg/mL) was used in an infusion bottle prophylactically as standard care. Vitreoretinal procedures were categorized as major (duration >30 min), minor (duration <30 min), and silicone oil removal. Postoperatively, a detailed ocular examination was done to rule out hemorrhagic occlusive retinal vasculitis (HORV) or signs of postoperative bacterial endophthalmitis. RESULTS: Over the last 70 months, a total of 31,720 vitreoretinal procedures were performed, which included 24,371 major vitreoretinal procedures, 1401 minor vitreoretinal procedures, and 5948 silicone oil removal cases. None of these cases developed HORV or bacterial endophthalmitis. CONCLUSION: Vancomycin (0.2 mg/mL) in infusion fluid during vitreoretinal procedures is safe and can be advocated as a prophylactic measure against postvitrectomy bacterial infections. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Optical coherence tomography angiography in type III retinal astrocytic hamartoma

Author

Kumar, Kshitiz, Sinha, Tushar, and Bhattacharya, Debashish

Subjects
Angiography -- Case studies, Hamartoma -- Case studies -- Diagnosis, CT imaging -- Case studies, Retinal diseases -- Case studies -- Diagnosis, Health
Abstract

Byline: Kshitiz. Kumar, Tushar. Sinha, Debashish. Bhattacharya A 26-year-old male had BCVA of plano 20/20 in the right eye (RE) and -2.75 Dsph/-2.0 Dcyl × 20° 20/20 in the left [...]

Published
2022

18. A rare finding of lamellar macular hole with lamellar hole-associated epiretinal proliferation in retinal vein occlusion

Author

Kumar, Kshitiz, Sinha, Tushar, and Bhattacharya, Debashish

Subjects
Retinal diseases -- Case studies -- Diagnosis, Health
Abstract

Byline: Kshitiz. Kumar, Tushar. Sinha, Debashish. Bhattacharya A 69-year-old female presented with right eye vision of 20/120 Snellens. Ultrawide-field fundus imaging showed old vitreous hemorrhage with superotemporal sclerosed vessels post [...]

Published
2022

21. Biosimilar versus InnovAtor MoLecule of RAnibizumab in Neovascular Age-Related MaCular DEgeneration (The BALANCE Trial): Real-World Evidence

Author

Chakraborty,Debdulal, Mondal,Soumen, Boral,Subhendu, Das,Arnab, Sinha,Tushar Kanti, Majumdar,Saptorshi, Bhattacharya,Ranabir, Maitra,Ritobroto, Chakraborty,Debdulal, Mondal,Soumen, Boral,Subhendu, Das,Arnab, Sinha,Tushar Kanti, Majumdar,Saptorshi, Bhattacharya,Ranabir, and Maitra,Ritobroto

Abstract

Debdulal Chakraborty,1 Soumen Mondal,1 Subhendu Boral,1 Arnab Das,1 Tushar Kanti Sinha,1 Saptorshi Majumdar,1 Ranabir Bhattacharya,2 Ritobroto Maitra3 1Department of Vitreoretinal Services, Disha Eye Hospitals, Kolkata, West Bengal, India; 2Department of MIS, Disha Eye Hospitals, Kolkata, West Bengal, India; 3Radical Health Tech, New Delhi, IndiaCorrespondence: Debdulal Chakraborty, Department of Vitreoretinal services, Disha Eye Hospitals, Kolkata, West Bengal, India, Tel +91 33 66360000, Email devdc@rediffmail.comPurpose: To analyse outcomes of innovator ranibizumab (IRM) (Lucentis) and biosimilar ranibizumab (BRM) (Razumab) in Indian eyes with neovascular age-related macular degeneration (nAMD).Methods: Retrospective observational study in nAMD patients, who were treated with IRM or BRM (3 loading doses followed by pro re nata (PRN). Primary outcome measures were change in best corrected visual acuity (BCVA) and central macular thickness (CMT) along with safety analysis. Secondary outcomes measures were changes in the subretinal fluid (SRF) and intraretinal fluid (IRF).Results: Inclusion criteria were satisfied in 164 eyes (60.74%). A total of 87 eyes were treated with IRM, and 77 eyes received BRM. Baseline BCVA was 0.57± 0.27 logMAR in IRM group and 0.61± 0.25 in the BRM group. At 3, 6, 9, and 12 months BCVA was 0.27± 0.22 (p< 0.0001), 0.34± 0.23 (p< 0.0001), 0.39± 0.25 (p< 0.0001), and 12 months 0.41± 0.23 (p< 0.0001) in the IRM group and 0.24± 0.16 (p< 0.0001), 0.27± 0.16 (p< 0.0001), 0.34± 0.17 (p< 0.0001), 0.38± 0.18 (p< 0.0001) in the BRM group. Baseline CMT was 420.39± 54.45 μm in IRM group and 407.82± 53.07 μm in BRM group. At 3, 6, 9, and 12 months, CMT decreased to 258.28± 20.4 μm (p< 0.0001), 268.38± 19.5 μm (p< 0.0001), 269.51± 32.41 μm (p< 0.0001), and 278.28± 16.56 μm (p< 0.0001) in the IRM group and 258.84± 17.47 μm (p< 0.0001), 265.69± 17.29 μm (p< 0.0001), 273.64± 23.13 μm (p&

Published
2023

29. Long-term clinical outcomes of submacular blood removal with isolated autologous retinal pigment epithelium-choroid patch graft transplantation in long-standing large-sized submacular hematomas: An Indian experience

Author

Boral, Subhendu, Agarwal, Deepak, Das, Arnab, and Sinha, Tushar

Subjects
Ophthalmic research, Eye diseases -- Development and progression -- Care and treatment, Skin grafts -- Patient outcomes, Hematoma -- Development and progression -- Care and treatment, Health
Abstract

Byline: Subhendu. Boral, Deepak. Agarwal, Arnab. Das, Tushar. Sinha Purpose: To study the outcomes of submacular blood removal with isolated autologous full-thickness retinal pigment epithelial (RPE)-choroid patch graft transplantation in [...]

Published
2020

30. Brolucizumab in Neovascular Age-Related Macular Degeneration – Indian Real-World Experience: The BRAILLE Study – Fifty-Two-Week Outcomes

Author

Chakraborty,Debdulal, Maiti,Aniruddha, Sheth,Jay U, Mondal,Soumen, Boral,Subhendu, Nandi,Krishnendu, Sinha,Tushar Kanti, Das,Arnab, Chakraborty,Debdulal, Maiti,Aniruddha, Sheth,Jay U, Mondal,Soumen, Boral,Subhendu, Nandi,Krishnendu, Sinha,Tushar Kanti, and Das,Arnab

Abstract

Debdulal Chakraborty,1 Aniruddha Maiti,2 Jay U Sheth,3 Soumen Mondal,1 Subhendu Boral,1 Krishnendu Nandi,4 Tushar Kanti Sinha,1 Arnab Das1 1Department of Vitreoretinal Services, Disha Eye Hospitals, Kolkata, West Bengal, India; 2Department of Vitreoretinal Services, Global Eye Hospitals Eye, Kolkata, West Bengal, India; 3Department of Vitreoretinal Services, Shantilal Shanghvi Eye Institute, Mumbai, Maharashtra, India; 4Department of Vitreoretinal Services, Netralayam Super Speciality Eye Care Centre, Kolkata, West Bengal, IndiaCorrespondence: Debdulal Chakraborty, Department of Vitreoretinal services, Disha Eye Hospitals, Kolkata, West Bengal, India, Tel +91 9433059923, Email devdc@rediffmail.comPurpose: To report the 52-week real-world efficacy and safety outcomes of brolucizumab therapy for neovascular age-related macular degeneration (nAMD) in Indian eyes.Patients and Methods: A retrospective, multicentre chart analysis of 82 eyes of 82 patients with nAMD (switch therapy: 65 eyes; treatment-naïve: 17 eyes) with 52-week follow-up data was performed. Pro-re-nata re-treatment was offered based on visual and tomographic criteria. Changes in best-corrected visual acuity (BCVA), intraretinal fluid (IRF), subretinal fluid (SRF), central-subfield thickness (CST), and pigment epithelial detachment (PED) were the key outcome measures, coupled with the safety profile.Results: The mean age of the study population was 67.65 (± 10.67) years, with 57 male patients (69.5%). The study’s mean number of injections was 4.8 (± 0.77). After brolucizumab therapy, the BCVA improved significantly at weeks 4 (P< 0.001), and maintained up to week 52 (P< 0.001). The CST also reduced significantly at all the visits (Baseline: 413.6 ± 64.6 μm; 52-week: 292.37 ± 13.5 μm; P< 0.001). Significantly fewer eyes demonstrated residual SRF (P< 0.001) and IRF (P< 0.001) at all visits, starting with week 12 and continuing until week 52. The PED resolution was significant from w

Published
2022

31. Lenticular burns following PASCAL photocoagulation

Author

Kumar, Kshitiz, Ganguly, Ananya, Sinha, Tushar, and Bhattacharya, Debashish

Subjects
Laser photocoagulation -- Complications and side effects, Corneal injuries -- Diagnosis -- Care and treatment -- Complications and side effects, Vascular endothelial growth factor, Diabetic retinopathy, Medical examination, Edema, Diabetes mellitus, Endothelial growth factors, Operating systems (Software), Hemorrhage, Type 2 diabetes, Tomography, Ranibizumab, French writers, Health
Abstract

Byline: Kshitiz. Kumar, Ananya. Ganguly, Tushar. Sinha, Debashish. Bhattacharya A 64-year-old male with longstanding type-2 diabetes mellitus presented with progressive diminution of vision in both eyes for 2 months. Clinical [...]

Published
2020

32. Variable clinical profile of foveal hypoplasia in albinism

Author

Kumar, Kshitiz, Boral, Subhendu, Agarwal, Deepak, Goswami, Angshuman, Sinha, Tushar, and Bhattacharya, Debashish

Subjects
Retinal diseases -- Complications and side effects -- Care and treatment -- Development and progression, Albinism -- Development and progression -- Care and treatment -- Complications and side effects, Angiography, Epithelium, Diagnostic imaging, Health
Abstract

Byline: Kshitiz. Kumar, Subhendu. Boral, Deepak. Agarwal, Angshuman. Goswami, Tushar. Sinha, Debashish. Bhattacharya Clinical profiles of three patients are enumerated in [Table 1].{Table 1} Fundus examination of both eyes showed [...]

Published
2020

33. A novel standardized reproducible method to calculate the area of internal limiting membrane peeled intra-operatively in macular hole surgery by using a video overlay--A long-term study in cases of idiopathic macular holes

Author

Boral, Subhendu, Das, Arnab, and Sinha, Tushar

Subjects
Surgery -- Methods, Health
Abstract

Byline: Subhendu. Boral, Arnab. Das, Tushar. Sinha Purpose: To calculate AIP and to find correlation between hole closure pattern with AIP in idiopathic full thickness macular hole (FTMH) cases. Methods: [...]

Published
2020

35. Reclaiming freshwater sustainability in the Cadillac Desert

Author

Sabo, John L., Sinha, Tushar, Bowling, Laura C., Schoups, Gerrit H. W., Wallender, Wesley W., Campana, Michael E., Cherkauer, Keith A., Fuller, Pam L., Graf, William L., Hopmans, Jan W., Kominoski, John S., Taylor, Carissa, Trimble, Stanley W., Webb, Robert H., Wohl, Ellen E., and MacDonald, Glen M.

Published
2010

43. Brolucizumab in Neovascular Age-Related Macular Degeneration – Indian Real-World Experience: The BRAILLE Study

Author

Chakraborty,Debdulal, Maiti,Aniruddha, Sheth,Jay U, Boral,Subhendu, Mondal,Soumen, Nandi,Krishnendu, Sinha,Tushar, Das,Arnab, Chakraborty,Debdulal, Maiti,Aniruddha, Sheth,Jay U, Boral,Subhendu, Mondal,Soumen, Nandi,Krishnendu, Sinha,Tushar, and Das,Arnab

Abstract

Debdulal Chakraborty,1 Aniruddha Maiti,2 Jay U Sheth,3 Subhendu Boral,1 Soumen Mondal,1 Krishnendu Nandi,2 Tushar Sinha,1 Arnab Das1 1Department of Vitreoretinal Services, Disha Eye Hospitals, Kolkata, West Bengal, India; 2Department of Vitreoretinal Services, Netralayam Super Speciality Eye Care Centre, Kolkata, West Bengal, India; 3Department of Vitreoretinal Services, Surya Eye Institute and Research Center, Mumbai, Maharashtra, IndiaCorrespondence: Debdulal ChakrabortyDepartment of Vitreoretinal Services, Disha Eye Hospitals, Kolkata, West Bengal, IndiaTel +91 9433059923Email devdc.dr@gmail.comPurpose: To assess the short-term efficacy and safety profile of intravitreal brolucizumab injection in Indian eyes with neovascular age-related macular degeneration (nAMD) under real-world conditions.Patients and Methods: This was a multicenter, retrospective chart review of 94 eyes of 94 patients with nAMD (treatment-naïve and switch-therapy) undergoing brolucizumab therapy. Re-treatment as per pro-re-nata protocol was performed based on fixed visual and tomographic criteria. The main outcome measures were changes in the best-corrected visual acuity (BCVA), intraretinal fluid (IRF), subretinal fluid (SRF), central subfield thickness (CST), and pigment epithelial detachment (PED) along with safety analysis.Results: Of the 94 eyes, 20 eyes (21.3%) were treatment-naïve, whereas the rest 74 eyes (78.7%) underwent switch therapy. One hundred and twenty-six injections were given over a mean follow-up of 7.3 ± 2.2 (range 5– 30) weeks. The BCVA improved significantly from 0.82 ± 0.5 LogMAR at baseline to 0.66 ± 0.5 LogMAR at the final visit (p < 0.0001). Significant reduction in CST was simultaneously noted (Baseline: 408.45 ± 65.63 μm; Final: 281.14 ± 37.74 μm; p < 0.0001). On qualitative analysis, resolution of subretinal fluid (SRF), intraretinal fluid (IRF), and pigment epithelial detachment (PED) was observed in 15.5%, 39.29%, and 23.81% of the eyes, respec

Published
2021

44. Piloting transdisciplinarity among faculty and students concerned with flood management on the South Texas Gulf Coast: A four-stage model for initial collaboration.

Author

Sherris, Ari, Hua Li, Ramirez, David, Sinha, Tushar, Fernandez, Francisco Haces Haces, Robbins, Christine Reiser, Pirozzolo, Marisol, Azayzeh, Mohammad Omar, Aguirre, Alberto Anthony, Maynard, Danielle, Green-Jordan, Yara, Jianhong Ren, and Mendoza, Mariee Fernanda Cruz

Subjects
FLOODS, SOCIAL advocacy, PROBLEM solving, ENGINEERING education
Abstract

The economic, social, environmental, and scientific interrelatedness of our ecological survival depend on shifts in how we educate the next generation of educators, engineers, scientists, and social activists. Education, both formal and informal, as well as social activism, have to find ways to cross borders, collaborating to find solutions to the pressing problems of our time. On the South Texas Gulf Coast, one of these pressing issues is stormwater management and policy, but it has been challenging to effectively engage local leaders, water professionals, researchers, and community stakeholders in the solution-seeking process. To overcome this challenge, the research team adopted a transdisciplinary methodology to pilot a four-stage model for initial collaboration activities in applied, convergent research. This paper reports on this pilot simulation to (1) test the effectiveness and (2) demonstrate the means on how to facilitate a transdisciplinary approach in engineering problem solving and education, targeting the case study of local flood management. This collaborative model for the identification, planning, and facilitation of convergent solution seeking processes is adaptable and scalable widely in addressing the five grand challenges identified by the National Academies of Sciences, Engineering, and Medicine (NASEM). [ABSTRACT FROM AUTHOR]

Published
2022

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