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140 results on '"Singhal, Dinesh"'

1. Evaluation of ACS-NSQIP and CR-POSSUM risk calculators for the prediction of mortality after colorectal surgery: A retrospective cohort study

Author

Vashistha, Nitin, Singhal, Siddharth, Budhiraja, Sandeep, and Singhal, Dinesh

Subjects
Mortality -- Taiwan, Metronidazole -- Health aspects, Health
Abstract

Byline: Nitin. Vashistha, Siddharth. Singhal, Sandeep. Budhiraja, Dinesh. Singhal Background: Several risk calculating tools have been introduced into clinical practice to provide patients and clinicians with objective, individualised estimates of [...]

Published
2024

4. Evaluation of Protective Capacity of Unconfined Aquifers Using Geoelectric Techniques: A Case Study from North India for Supporting Sound Geoethics

Author

Singhal, Dinesh Chandra, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Abrunhosa, Manuel, editor, Chambel, António, editor, Peppoloni, Silvia, editor, and Chaminé, Helder I., editor

Published
2021
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16. No mean feet

Author

Sethi, Pramod Karan, Singhal, Dinesh, and Nundy, Samiran

Published
2004

17. Diverse Clinical Isolates of Mycobacterium tuberculosis Develop Macrophage-Induced Rifampin Tolerance

Author

Adams, Kristin N, Verma, Amit Kumar, Gopalaswamy, Radha, Adikesavalu, Harresh, Singhal, Dinesh Kumar, Tripathy, Srikanth, Ranganathan, Uma Devi, Sherman, David R, Urdahl, Kevin B, Ramakrishnan, Lalita, Hernandez, Rafael E, Ramakrishnan, Lalita [0000-0003-0692-5533], and Apollo - University of Cambridge Repository

Subjects
Bacteria, Beijing lineage, THP-1 Cells, Rv1258c, Macrophages, Antitubercular Agents, antibiotic tolerance, Microbial Sensitivity Tests, Mycobacterium tuberculosis, drug efflux, Major Articles and Brief Reports, Bacterial Proteins, Loss of Function Mutation, Drug Resistance, Multiple, Bacterial, Tuberculosis, Multidrug-Resistant, Isoniazid, Humans, Tuberculosis, ATP-Binding Cassette Transporters, Rifampin
Abstract

The Mycobacterium tuberculosis lineage 4 strains CDC1551 and H37Rv develop tolerance to multiple antibiotics upon macrophage residence. To determine whether macrophage-induced tolerance is a general feature of clinical M. tuberculosis isolates, we assessed macrophage-induced drug tolerance in strains from lineages 1–3, representing the other predominant M. tuberculosis strains responsible for tuberculosis globally. All 3 lineages developed isoniazid tolerance. While lineage 1, 3, and 4 strains developed rifampin tolerance, lineage 2 Beijing strains did not. Their failure to develop tolerance may be explained by their harboring of a loss-of-function mutation in the Rv1258c efflux pump that is linked to macrophage-induced rifampicin tolerance., Mycobacterium tuberculosis develops tolerance to multiple antibiotics when residing in host macrophages. We demonstrate that macrophage-induced tolerance to rifampin is common across major lineages of M. tuberculosis, except for Beijing-family lineage 2 strains.

Published
2019

27. No mean feet

Author

Singhal, Dinesh and Nundy, Samiran

Published
2004

30. Macrophage-induced rifampin tolerance across Mycobacterium tuberculosis lineages is Rv1258c-dependent

Author

Adams, Kristin N., primary, Verma, Amit Kumar, additional, Gopalaswamy, Radha, additional, Adikesavalu, Harresh, additional, Singhal, Dinesh Kumar, additional, Tripathy, Srikanth, additional, Ranganathan, Uma Devi, additional, Sherman, David R., additional, Urdahl, Kevin B., additional, Ramakrishnan, Lalita, additional, and Hernandez, Rafael E., additional

Published
2018
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31. Management of Giant Gastric Ulcer Perforation: Report of a Case and Review of the Literature

Author

Vashistha, Nitin, Singhal, Dinesh, Makkar, Gurpreet, Chakravarty, Suneel, and Raj, Vivek

Subjects
Article Subject
Abstract

Giant gastric ulcer (GGU) is defined as an ulcer more than 3 cm in diameter. Now infrequent in clinical practice, in the pre-H2 receptor antagonist (H2RA) era, the incidence of GGU varied between 12 and 24% of all gastric ulcers. Proton pump inhibitors reportedly achieve better healing rates and symptom relief in comparison to H2RA. The GGU is associated with high incidence of serious complications such as hemorrhage. A perforated GGU though rare (

Published
2016
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40. Generation of parthenogenetic goat blastocysts: effects of different activation methods and culture media

Author

Malik, Hruda Nanda, primary, Singhal, Dinesh Kumar, additional, Saugandhika, Shrabani, additional, Dubey, Amit, additional, Mukherjee, Ayan, additional, Singhal, Raxita, additional, Kumar, Sudarshan, additional, Kaushik, Jai Kumar, additional, Mohanty, Ashok Kumar, additional, Das, Bikash Chandra, additional, Bag, Sadhan, additional, Bhanja, Subrata Kumar, additional, and Malakar, Dhruba, additional

Published
2014
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41. Resveratrol treatment during goat oocytes maturation enhances developmental competence of parthenogenetic and hand-made cloned blastocysts by modulating intracellular glutathione level and embryonic gene expression

Author

Mukherjee, Ayan, primary, Malik, Hrudananda, additional, Saha, Ambika P., additional, Dubey, Amit, additional, Singhal, Dinesh Kumar, additional, Boateng, Samuel, additional, Saugandhika, Shrabani, additional, Kumar, Sudarshan, additional, De, Sachinandan, additional, Guha, Shyamal Kanti, additional, and Malakar, Dhruba, additional

Published
2013
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42. Derivation of goat embryonic stem cell-like cell lines from in vitro produced parthenogenetic blastocysts

Author

De, Arun Kumar, primary, Garg, Shweta, additional, Singhal, Dinesh Kumar, additional, Malik, Hrudananda, additional, Mukherjee, Ayan, additional, Jena, Manoj Kumar, additional, Kumar, Sudarshan, additional, Kaushik, Jai Kumar, additional, Mohanty, Ashok Kumar, additional, Das, Bikash Chandra, additional, Bag, Sadhan, additional, Bhanja, Subrata Kumar, additional, and Malakar, Dhruba, additional

Published
2013
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44. No mean feet: Pramod Karan Sethi, the inventor of a revolutionary artificial foot, regrets that he has not been able to pass his idealism on to young doctors. He talks to Dinesh Singhal and Samiran Nundy

Author

Singhal, Dinesh and Nundy, Samiran

Subjects
Orthopedists -- Portrayals, Health, Portrayals
Abstract

It was pure chance that led Pramod Karan Sethi to take up orthopaedics. 'In 1958 the Medical Council of India were to Inspect Jaipur Medical College to see whether it [...]

Published
2004

45. Editors

Author

Nundy, Samiran, Bains, Manjit Singh, Fong, Yuman, Gouma, Dirk, Humar, Abhinav, Obertop, Huug, Prasad, Raj, Rela, Mohamed, Williamson, Robin, Agarwal, Anil, Chaudhary, Adarsh, Chowbey, Pradeep, Gupta, Subash, Kapoor, V.K., Kumaran, Vinay, Mahajan, K.C., Nagral, Sanjay, Ramesh, H., Sahni, Peush, Singhal, Dinesh, Soin, A.S., and Wig, Jai Dev

Published
2011
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46. Diverse Clinical Isolates of Mycobacterium tuberculosis Develop Macrophage-Induced Rifampin Tolerance

Author

Adams, Kristin N, Verma, Amit Kumar, Gopalaswamy, Radha, Adikesavalu, Harresh, Singhal, Dinesh Kumar, Tripathy, Srikanth, Ranganathan, Uma Devi, Sherman, David R, Urdahl, Kevin B, Ramakrishnan, Lalita, and Hernandez, Rafael E

Subjects
Beijing lineage, Rv1258c, THP-1 Cells, Macrophages, antibiotic tolerance, Antitubercular Agents, Microbial Sensitivity Tests, Mycobacterium tuberculosis, 3. Good health, drug efflux, Bacterial Proteins, Loss of Function Mutation, Drug Resistance, Multiple, Bacterial, Tuberculosis, Multidrug-Resistant, Isoniazid, Tuberculosis, Humans, ATP-Binding Cassette Transporters, Rifampin
Abstract

The Mycobacterium tuberculosis lineage 4 strains CDC1551 and H37Rv develop tolerance to multiple antibiotics upon macrophage residence. To determine whether macrophage-induced tolerance is a general feature of clinical M. tuberculosis isolates, we assessed macrophage-induced drug tolerance in strains from lineages 1-3, representing the other predominant M. tuberculosis strains responsible for tuberculosis globally. All 3 lineages developed isoniazid tolerance. While lineage 1, 3, and 4 strains developed rifampin tolerance, lineage 2 Beijing strains did not. Their failure to develop tolerance may be explained by their harboring of a loss-of-function mutation in the Rv1258c efflux pump that is linked to macrophage-induced rifampicin tolerance.

47. EDITORS

Author

Nundy, Samiran, Prasad, K. Raj, Bains, Manjit Singh, Fong, Yuman, Gouma, Dirk, Humar, Abhinav, Obertop, Huug, Rela, Mohamed, Williamson, Robin, Agarwal, Anil, Chaudhary, Adarsh, Chowbey, Pradeep, Gupta, Subash, Kapoor, V.K., Kumaran, Vinay, Mahajan, K.C., Nagral, Sanjay, Ramesh, H., Sahni, Peush, Singhal, Dinesh, Soin, A.S., and Wig, Jai Dev

Published
2012
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48. Papillary cystadenocarcinoma of extrahepatic left bile duct.

Author

Singh A, Singhal D, Bhalla S, and Chaudhary A

Subjects
Bile Duct Neoplasms pathology, Cystadenocarcinoma, Papillary pathology, Diagnosis, Differential, Humans, Male, Middle Aged, Bile Duct Neoplasms diagnosis, Bile Duct Neoplasms surgery, Bile Ducts, Extrahepatic pathology, Cystadenocarcinoma, Papillary diagnosis, Cystadenocarcinoma, Papillary surgery
Published
2009

49. Giant sigmoid diverticulum--report of two cases.

Author

Singh A, Perwaiz A, Singhal D, and Chaudhary A

Subjects
Aged, Humans, Male, Middle Aged, Tomography, X-Ray Computed, Diverticulum, Colon pathology, Sigmoid Diseases pathology
Published
2009

50. Isolated loop pancreatic remnant drainage following pancreaticoduodenal resection.

Author

Singhal D, Goyal N, Gupta S, Soin AS, and Nundy S

Subjects
Adult, Aged, Drainage, Female, Humans, Male, Middle Aged, Pancreaticoduodenectomy adverse effects, Postoperative Complications prevention & control, Prospective Studies, Pancreaticoduodenectomy methods
Abstract

Background/aims: Using technology-intensive postoperative critical care, interventional radiology and consequent better management of pancreaticojejunal anastomosis (PJA) leaks, the perioperative mortality of pancreaticoduodenal resection (PDR) at high volume Western centers ranges from 1-5%. Facilities for such sophisticated care are not available in most hospitals in the developing world. We hypothesized that by using an isolated Roux loop for the PJA to minimize the consequences of a leak, it might be feasible to perform PDR with comparable results., Methodology: From August 1996 to December 2002, 125 consecutive patients (98 males and 27 females with a mean age of 54 years) with peri-ampullary or pancreatic head carcinomas underwent PDR with the PJA made to an isolated Roux loop of jejunum. A prospectively maintained database was analyzed for perioperative mortality, morbidity, hospital stay and costs., Results: The perioperative mortality was 7 (5.6%) and morbidity 52 (42%). Pancreatic fistulae developed in 15 (12%) patients and biliary or intestinal fistulae developed in 1(0.8%) patient each. Five (4%) patients underwent relaparotomy. The median hospital stay was 13 days (6-46 days)., Conclusions: Using an isolated Roux loop for PJA, centers with limited resources can perform PDR to achieve perioperative outcomes comparable to those reported from more sophisticated centers.

Published
2008

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