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AimsWe examined associations between lipoprotein subfractions and prevalent and incident T2D in two race/ethnically diverse cohort studies.MethodsAdults self-identifying as White, Black, Chinese, Hispanic and South Asian-American without cardiovascular disease, with fasting serum, demographic, and clinical data at enrollment and after 5 years of follow-up were included. Lipoprotein subfractions were measured at enrollment using NMR spectrometry. LASSO regularized logistic regression models adjusted for age, sex, race/ethnicity, lipid-lowering agent use, and waist circumference assessed odds of incident T2D in pooled analyses.ResultsThere were 4474 participants with lipoprotein subfraction data at enrollment and 3839 participants without prevalent diabetes, mean age 62 years, 51 % women, with 234 incident T2D cases at 5 years. Triglycerides in small, dense LDL-5 [OR 1.26 (95 % CI 1.11,1.43)], VLDL triglycerides 1.30** [1.16,1.46] and phospholipids in VLDL-1 [OR 1.31 (1.17,1.47)] were associated with higher odds of incident T2D, while free cholesterol in large HDL-1 [OR 0.75 (95 % CI 0.63,0.89)] was inversely associated. The results were similar for prevalent diabetes and did not vary by race/ethnic group.ConclusionsComposition of lipoprotein subfractions is differentially associated with prevalent and incident T2D without difference by race/ethnic group. Assessment of lipoprotein composition may enhance targeted risk reduction for T2D.

BackgroundFibrodysplasia ossificans progressiva (FOP) is an ultra-rare disorder marked by painful, recurrent flare-ups and heterotopic ossification (HO) in soft and connective tissues, which can be idiopathic or provoked by trauma, illness, inflammation, or surgery. There are currently no effective treatments for FOP, or for patients with FOP who must undergo surgery. Palovarotene, an investigational retinoic acid receptor-γ agonist, offers a potential avenue to prevent HO formation.Case presentationThe patient is a 32 year-old male, who at age 29 enrolled in a study evaluating palovarotene to prevent HO formation in FOP. One year after starting palovarotene, he fell resulting in a left intertrochanteric fracture. He underwent intramedullary nailing of the femur shaft with screw placement at the distal femur. After surgery, he received palovarotene at 20 mg/day for 4 weeks, then 10 mg/day for 8 weeks. Imaging 12 weeks after surgery showed new bridging HO at the site of intramedullary rod insertion and distal screw. Nine months after the left hip fracture, the patient had a second fall resulting in a subdural hematoma, left parietal bone fracture, and right intertrochanteric fracture. He underwent intramedullary nailing of the right hip, in a modified procedure which did not require distal screw placement. Palovarotene 20 mg/day was started at fracture occurrence and continued for 4 weeks, then reduced to 10 mg/day for 8 weeks. HO also formed near the insertion site of the intramedullary rod. No HO developed at the right distal intramedullary rod. After each fracture, the patient had prolonged recurrent flare-ups around the hips.ConclusionSurgery is only rarely considered in FOP due to the high risks of procedural complications and potential for inducing HO. This case emphasizes the risks of increased flare activity and HO formation from injury and surgery in patients with FOP. The efficacy of HO prevention by palovarotene could not be assessed; however, our observation that palovarotene can be administered in an individual with FOP following surgery with no negative impact on clinical fracture healing, osteointegration, or skin healing will help facilitate future trials testing the role of palovarotene as a therapy for HO.

Extant research on juvenile legal system (JLS) involved girls generally focuses on individual and proximal environmental levels that bring girls into contact with the JLS. There is less research on how the JLS responds to girls in case dispositions (e.g., sanction-based responses, treatment-focused services), and how combinations of dispositions relate to girls' further system involvement. In this study, we apply latent class analysis (LCA) to the juvenile legal context to categorize system responses in a sample of 1,133 adjudicated girls. We identify four distinct classes, comprising different types and combinations of dispositions. We then further analyzed the classes using individual characteristics and risk factors of girls to understand precursors to the system's response and further JLS involvement. Our findings offer insight into how packages of court dispositions are correlated with increased recidivism. We consider implications for JLS intervention with girls and provide suggestions for further research. [ABSTRACT FROM AUTHOR]

In an era of climate change and increasing power outages, microgrids have the potential to significantly improve grid resilience and reliability. Because they can operate separately from larger electric grids, microgrids can often continue providing electricity service during broader grid outages caused by severe weather events. To the extent that solar- or wind-powered microgrids displace fossil fuel electricity generation, they also help to decarbonize energy systems. Unfortunately, electric utilities often view privately-owned community microgrids as competitive threats and have reasons to obstruct them within their exclusive service areas. Utility opposition and other factors have heretofore hindered community microgrid development in much of the country. This Article highlights the scope of community microgrids' many benefits and advocates for statutory and regulatory changes capable of accelerating the deployment of community microgrid technologies across the United States. [ABSTRACT FROM AUTHOR]

Despite decades of research indicating classrooms shape student engagement, learning, and development, there is a dearth of empirically grounded research focusing specifically on observed classroom engagement as a predictor of student outcomes in community colleges. This article describes the development of a qualitatively grounded, quantitative classroom-level engagement measurement protocol designed for this purpose. We provide evidence for the measure's validity and reliability via confirmatory factor analyses and descriptive analyses that offer a snapshot of the information this measure can generate. Furthermore, we examine a two-level structural equation regression model that uses student survey data from students nested in observed classrooms. We then review our results in light of the relevance this measure has for researchers and educators in community colleges.

Scholarship on girlhood—especially for girls of Color—is often relegated to studying risk and emphasizing individual deficits over humanizing girls and centering their voices. This approach to generating scholarship renders oppressive systems and processes invisible from inquiry and unaddressed by practice, with particularly insidious consequences for youth in the legal system. Critical youth participatory action research (YPAR) is acknowledged as an antidote to these conceptualizations because it resists deficit‐oriented narratives circling systems‐impacted youth by inviting them to the knowledge‐generating table. In this paper, we present an empirical analysis of the promises and perils that emerged as we conducted a year‐long critical YPAR project alongside five system‐impacted girls of Color. Our thematic analysis of process notes (30 meetings, 120 h) documents the stories posited by girls, in a democratized space, about the injustices of interconnected institutions, and unearths a complicated tension for both youth and adult coresearchers around the promises and perils of engaging in YPAR within the academy. These findings underscore the importance of using intersectional, collaborative research to challenge perceptions around how we legitimize knowledge. We describe lessons learned in conducting YPAR in academic settings and highlight recommendations to grow youth–adult partnerships within oppressive systems to share power. Highlights: Critical YPAR is heralded as a liberatory epistemology for social justice committed research. We conducted critical YPAR with system‐impacted girls of Color. We synthesize the promises and perils of critical YPAR in a research‐intensive university setting. We name the limits inherent in imperial logics and structures between academia and legal systems. Recommendations focus on structural changes at the nexus of academia and other systems. [ABSTRACT FROM AUTHOR]

Immigrants are a fast-growing segment of the United States population. Presently, some 39.9 million immigrants call America home (Passel & Cohn, 2012; U.S. Census Bureau, 2011b). Today, immigrants come from all over the world, but most new Americans originate in Latin America, the Caribbean, and Asia. It is because of the mass migration of the two last generations that many states--including Hawaii (77.1% minority), the District of Columbia (64.7% minority), California (60.3% minority), New Mexico (59.8% minority), and Texas (55.2% minority)--are now "majority/minority" (U.S. Census, 2011a). The significant increase in the immigrant-origin population is a visible reality throughout schools, where 23.7% of all children are the children of immigrants (Migration Policy Institute, 2011). The data point to a future of growing diversity in the American classroom: As of July 1, 2011, 50.4% of the littlest Americans--those under age 1--were minorities. Immigration's echo, the children of immigrants, make the United States one of the few countries where immigration is both history and destiny. To be a teacher in 21st-century America means teaching immigrant students. In this article, the authors stress that if the heart of education is to develop an engaged, flourishing citizenry who is ready to partake in this globalized world, then teachers should first become aware of who their charges are. The children in today's schools originate from all over the world, from all socioeconomic strata of society, and contend with negotiating multiple cultural rules of engagement. Teachers today need to prepare all their students to function in a world that is evermore interconnected, miniaturized, and fragile. The rewards to teachers can be priceless.

System actors of color are considered a key intervention to reduce disparities in the juvenile legal system precisely because they share intersectional experiences of oppression similar to those experienced by system‐involved youth. In this study, we interrogate the assumption that diversifying the workforce can remedy intersectional disparities in youth outcomes. Grounded in intersectionality, we analyzed semi‐structured interviews with 17 (12 women, five men) actors of color—eight at the frontline, five at the mid‐level, and four at the top level. Specifically, we examined their narratives of lived oppressions, juxtaposed these narratives with their articulations of how well the system meets its welfare mandate, and examined actors' sense of their ability to contribute to girls' welfare, attending especially to how these experiences vary by their positions in the system's hierarchy. Our findings suggest that actors of color indeed share experiences of oppression as system‐involved youth, particularly along axes of race and gender. Further, across all levels of institutional positionality, actors articulate a disjunction, revealing the system's accountability to bureaucratic and funding structures rather than girls; they respond to this disjunction through resistant actions—with different degrees of effectiveness—anchored in accountability to girls, and by envisioning how, given their roles and relative power, the system can meet its social welfare mandate. Highlights: System actors of color invoke shared experiences of oppression as system‐involved youth.Actors articulate system disjunction—a disconnect between the welfare mandate and system praxis.Actors resist system disjunction through practice and policy—within the limits of their positions.Examining intersections between social and institutional positions is necessary for systems change. [ABSTRACT FROM AUTHOR]

Scholarship identifies critical consciousness as a key developmental asset in promoting the well‐being of adolescents experiencing multiple socio‐structural axes of oppression. Girls of color at acute risk for legal system involvement or re‐involvement are absent from this literature. They are a critical population in which to examine this construct given their experiences of oppression and the myriad benefits of critical consciousness. The current study addresses this gap by examining traumatic incidents and experiences of racism and sexism as correlates of critical reflection and action among a sample of girls (N = 220; Mean age = 14.5 years; SD = 1.3 years). Using path analysis and multigroup modeling, we examine direct associations between these three manifestations of structural oppression and critical consciousness and explore the interplay of traumatic incidents, and racism and sexism in girls' critical consciousness development. Findings suggest that experiences of sexism and racism, uniquely and positively predict critical action, but not critical reflection. Surprisingly, girls' experiences of traumatic incidents do not predict reflection or action. Finally, multigroup analyses show no evidence that these associations vary by the interplay of traumatic incidents, racism, and sexism. Implications for community psychology values and juvenile legal system practice and policy are discussed. Highlights: Experiences of sexism and racism uniquely predict critical action but not critical reflection.Traumatic incidents are not associated with critical reflection or critical action.System‐involved girls engage in multiple forms of critical action.Analyses show associations do not vary by the interplay of traumatic incidents, racism and sexism. [ABSTRACT FROM AUTHOR]

Friedman and Rosenman (1959) conceptualized Coronary Prone Behavior Pattern (also known as Type A Behavior Pattern). Type A individuals manifest intense striving for achievement, competitiveness, time urgency and hostility. Type A behavior pattern was exhibited by most of the patients suffering from Coronary Heart Disease (CHD). The present study was planned with the aim to study Type A Behavior in relation to Hostility, Stress and Optimism among Rural and Urban Male CHD Patients. The sample comprised of 100 Male CHD Patients (50 Rural Males and 50 Urban Males). They were in age range of 45-55 years. They were administered the test of Type A Behavior (Bortner, 1969), Hostility (Manifest Hostility Scale, MHS, Kool, 1980), Stress (Perceived Stress Scale, PSS, Cohen, Kamarck & Mermelstein, 1983) and Optimism (Life Orientation Test, LOT-R, Scheier, Carver & Bridges, 1994). t-test and Inter-correlational analysis was done. t-test revealed that urban patients scored higher on Hostility and Perceived Stress. Rural patients scored higher on Optimism. Inter-correlational analysis revealed that Type A behavior was positively related with Stress and Hostility among rural and urban patients. Type A Behavior was negatively related with Optimism among Urban Male CHD patients only. Present research has been supported by theoretical foundations, latest researches and implications have been further discussed. [ABSTRACT FROM AUTHOR]

The article informs the increase in immigration of students from Asia, Latin America and Mexico to the U.S. It informs that most of these students are from minority communities and speak different languages other than the official language. It highlight that due to this demographic shifts, several challenges are faced by teachers who are engaged for their education. Information on the relationship between immigrant families and education of their children is presented.

The role of integrins in regulating insulin signaling is incompletely understood. We have previously shown that binding of the integrin ligand milk fat globule epidermal growth factor like 8 (MFGE8) to the αvβ5 integrin promotes termination of insulin receptor signaling in mice. Upon ligation of MFGE8, β5 complexes with the insulin receptor beta (IRβ) in skeletal muscle resulting in dephosphorylation of IRβ and reduction of insulin-stimulated glucose uptake. Here we investigate the mechanism by which the interaction between β5 and IRβ impacts IRβ phosphorylation status. We show that β5 blockade inhibits and MFGE8 promotes PTP1B binding to and dephosphorylation of IRβ resulting in reduced or increased insulin-stimulated myotube glucose uptake respectively. The β5-PTP1B complex is recruited by MFGE8 to IRβ leading to termination of canonical insulin signaling. β5 blockade enhances insulin-stimulated glucose uptake in wild type but not Ptp1b KO mice indicating that PTP1B functions downstream of MFGE8 in modulating insulin receptor signaling. Furthermore, in a human cohort, we report serum MFGE8 levels correlate with indices of insulin resistance. These data provide mechanistic insights into the role of MFGE8 and β5 in regulating insulin signaling., Competing Interests: Conflict of interest None

The coronavirus disease 2019 (COVID-19) pandemic has caused significant morbidity and mortality worldwide. While patients with COVID-19 most frequently present with pneumonia, respiratory failure and acute respiratory distress syndrome, increasing cases of immune-mediated disorders such as autoimmune thrombocytopenia, haemolytic anaemia and antiphospholipid syndrome have been reported. In this article we describe a rare case of cold agglutinin syndrome (CAS) in a patient with COVID-19. The patient was a 77-year-old man with a history of glucose-6-phosphate dehydrogenase (G6PD) deficiency who presented with COVID-19 infection and acute respiratory failure. Initially he was started on intravenous steroids, antibiotics and hydroxychloroquine. Laboratory analysis revealed haemolytic anaemia with a positive direct anti-globulin test (DAT) and high titres of cold agglutinins. Hydroxychloroquine was stopped due to suspicion of haemolysis due to G6PD deficiency but the haemolysis persisted. Unfortunately, the respiratory failure progressed and the patient died. In summary, this article describes a rare case of CAS associated with COVID-19. CAS is a heterogenous group of cold autoimmune haemolytic anaemias occurring secondary to infections or malignancies. No definite treatment for CAS in COVID-19 patients has been approved so far., Learning Points: Autoimmune haemolytic anaemia has been reported in COVID-19 patients.Cold agglutinin syndrome (CAS) can occur in patients with COVID-19.Efforts to determine the optimal management of CAS in COVID-19 patients must continue., Competing Interests: Conflicts of Interests: The Authors declare that there are no competing interests., (© EFIM 2021.)

The VEGF pathway is critically required for vasculogenesis, the formation of the primary vascular network. It is also required for angiogenesis resulting in sprouting and pruning of vessels to generate mature arborizing structures. The Notch pathway is essential for arterial-venous specification and the maturation of nascent vessels. We have determined that Tspan18, a member of the Tetraspanin family, is expressed in developing vessels but not in mature vasculature in zebrafish and mouse wound healing. Moreover, reduction at Tspan18 level resulted in aberrant vascular patterning, impaired vessel stability and defective arterial-venous specification. Tspan18 deficiency reduced VEGF, VEGFR2, Notch3 and EphrinB2, and increased EphB4, VEGFR3, Semaphorin3, Neuropilin and PlexinD1 expression. Furthermore, vascular defects of Tspan18 deficiency could be rescued by ectopic expression of VEGFR2 and Notch, but not by knockdown of Semaphorin or Plexin. Functional studies showed that knockdown of Tspan18 led to reduced endothelial cell migration, invasion and tube formation. Tspan18 has dynamic expression, regulates vascular development and maturation in the embryo with re-expression in adult life in wound healing., (© 2021. Published by The Company of Biologists Ltd.)

Statement of Problem: Implant overdenture prostheses are prone to acrylic resin fracture because of space limitations around the implant overdenture components., Purpose: The purpose of this study was to evaluate the influence of E-glass fibers and acrylic resin thickness in resisting acrylic resin fracture around a simulated overdenture abutment., Material and Methods: A model was developed to simulate the clinical situation of an implant overdenture abutment with varying acrylic resin thickness (1.5 or 3.0 mm) with or without E-glass fiber reinforcement. Forty-eight specimens with an underlying simulated abutment were divided into 4 groups (n=12): 1.5 mm acrylic resin without E-glass fibers identified as thin with no E-glass fiber mesh (TN-N); 1.5 mm acrylic resin with E-glass fibers identified as thin with E-glass fiber mesh (TN-F); 3.0 mm acrylic resin without E-glass fibers identified as thick without E-glass fiber mesh (TK-N); and 3.0 mm acrylic resin with E-glass fibers identified as thick with E-glass fiber mesh (TK-F). All specimens were submitted to a 3-point bending test and fracture loads (N) were analyzed with a 2-way ANOVA and Tukey's post hoc test (α=.05)., Results: The results revealed significant differences in fracture load among the 4 groups, with significant effects from both thickness (P<.001) and inclusion of the mesh (P<.001). Results demonstrated no interaction between mesh and thickness (P=.690). The TN-N: 39 ±5 N; TN-F: 50 ±6.9 N; TK-N: 162 ±13 N; and TK-F: 193 ±21 N groups were all statistically different (P<.001)., Conclusions: The fracture load of a processed, acrylic resin implant-supported overdenture can be significantly increased by the addition of E-glass fibers even when using thin acrylic resin sections. On a relative basis, the increase in fracture load was similar when adding E-glass fibers or increasing acrylic resin thickness., (Copyright © 2011 The Editorial Council of the Journal of Prosthetic Dentistry. Published by Mosby, Inc. All rights reserved.)