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299 results on '"Singh, Shilpa"'

4. Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer

Author

Duplaquet, Leslie, So, Kevin, Ying, Alexander W., Pal Choudhuri, Shreoshi, Li, Xinyue, Xu, Grace D., Li, Yixiang, Qiu, Xintao, Li, Rong, Singh, Shilpa, Wu, Xiaoli S., Hamilton, Seth, Chien, Victor D., Liu, Qi, Qi, Jun, Somerville, Tim D.D., Heiling, Hillary M., Mazzola, Emanuele, Lee, Yenarae, Zoller, Thomas, Vakoc, Christopher R., Doench, John G., Forrester, William C., Abrams, Tinya, Long, Henry W., Niederst, Matthew J., Drapkin, Benjamin J., Kadoch, Cigall, and Oser, Matthew G.

Published
2024
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9. A New Model SATV for Sentiment Analysis of Hinglish Sentences

Author

Singh, Shilpa, Pareek, Astha, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Rathore, Vijay Singh, editor, Sharma, Subhash Chander, editor, Tavares, Joao Manuel R.S., editor, Moreira, Catarina, editor, and Surendiran, B., editor

Published
2022
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10. Sentiment Analysis on Public Transportation Using Different Tools and Techniques: A Literature Review

Author

Singh, Shilpa, Pareek, Astha, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Balas, Valentina E., editor, Sinha, G. R., editor, Agarwal, Basant, editor, Sharma, Tarun Kumar, editor, Dadheech, Pankaj, editor, and Mahrishi, Mehul, editor

Published
2022
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19. Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer

Author

Duplaquet, Leslie, primary, So, Kevin, additional, Ying, Alexander W., additional, Li, Xinyue, additional, Li, Yixiang, additional, Qiu, Xintao, additional, Li, Rong, additional, Singh, Shilpa, additional, Wu, Xiaoli S., additional, Liu, Qi, additional, Qi, Jun, additional, Somerville, Tim D.D., additional, Heiling, Hillary, additional, Mazzola, Emanuele, additional, Lee, Yenarae, additional, Zoller, Thomas, additional, Vakoc, Christopher R., additional, Doench, John G, additional, Forrester, William C., additional, Abrams, Tinya, additional, Long, Henry W, additional, Niederst, Matthew J., additional, Kadoch, Cigall, additional, and Oser, Matthew G., additional

Published
2024
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38. Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication

Author

Singh, Shilpa, Vaughan, Catherine A., Frum, Rebecca A., Grossman, Steven R., Deb, Sumitra, and Deb, Swati Palit

Subjects
DNA replication -- Comparative analysis -- Research, Cancer -- Genetic aspects -- Development and progression -- Research, Gene mutation -- Research, RNA sequencing -- Comparative analysis -- Usage, Gene expression -- Research, Health care industry
Abstract

Gain-of-function (GOF) p53 mutations are observed frequently in most intractable human cancers and establish dependency for tumor maintenance and progression. While some of the genes induced by GOF p53 have been implicated in more rapid cell proliferation compared with p53-null cancer cells, the mechanism for dependency of tumor growth on mutant p53 is unknown. This report reveals a therapeutically targetable mechanism for GOF p53 dependency. We have shown that GOF p53 increases DNA replication origin firing, stabilizes replication forks, and promotes micronudei formation, thus facilitating the proliferation of cells with genomic abnormalities. In contrast, absence or depletion of GOF p53 leads to decreased origin firing and a higher frequency of fork collapse in isogenic cells, explaining their poorer proliferation rate. Following genomewide analyses utilizing ChIP-Seq and RNA-Seq, GOF p53-induced origin firing, micronudei formation, and fork protection were traced to the ability of GOF p53 to transactivate cydin A and CHK1. Highlighting the therapeutic potential of CHKTs role in GOF p53 dependency, experiments in cell culture and mouse xenografts demonstrated that inhibition of CHK1 selectively blocked proliferation of cells and tumors expressing GOF p53. Our data suggest the possibility that checkpoint inhibitors could efficiently and selectively target cancers expressing GOF p53 alleles., Introduction P53 is among the most commonly mutated genes in various cancers, but particularly in lung cancer (1, 2). The majority of p53 mutations found in human cancers, including lung [...]

Published
2017
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47. Demand-driven approach of vocational education and training (VET) and experiential learning: a thematic analysis through systematic literature review (SLR)

Author

Gupta, Shankar Lal, Mittal, Arun, Singh, Shilpa, and Dash, Debendra Nath

Abstract

Purpose: This study investigates the various themes around the demand-driven approach of vocational education and training (VET). The study focuses on investigating two major aspects of VET. Firstly, the extant literature has been systematically classified based on seven parameters: Geography, Focus on Vocational Education, Research Methods, Economic Sector, Origin of Study, Type of Training and Level of Skill. Secondly, this study has explored various themes around the VET implementation, performance gaps and road ahead. Design/methodology/approach: Thematic analysis with the systematic literature review (SLR) method is applied to 50 research papers on VET, published between 2011 and 2022. Findings: This systematic review has found that experiential compliments VET and VET is the medium of skill development. Further, it was extracted through themes that VET may help ensure alternate employment in rural areas and contribute to micro- and macro-level economic development. Also, there is a requirement to adopt a demand-driven approach to VET by localizing VT content and delivery. Research limitations/implications: The study's findings are directed towards the need for demand-driven and customized VET. This study also explores many potential areas for further empirical research through various themes. Originality/value: This study is a novel effort that extracts the themes constituting the effect of VETs along with the descriptive analysis of the extant literature using the SLR approach. The study has rationalized the findings by providing due coding to various parameters in the previous studies under investigation.

Published
2023
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