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Aim: The threat of COVID-19 has been continuing as a recurring wave with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since its outbreak in December 2019 with the virus changing its variant form frequently. This study was conducted with the aim to study the clinical profile, laboratory parameters, complications, and other outcomes of patients who were hospitalized with COVID-19 infection during the third wave in a tertiary care hospital in Manipur, India. Materials and methods: This is a single-centre retrospective study. The data were collected from the medical record department of the Regional Institute of Medical Sciences (RIMS), Imphal. The case records of COVID-19 positive patients who were hospitalized in the RIMS Hospital from 1st January 2022 to 31st March 2022 have been collected. Corresponding data on demographic profile, clinical symptoms, laboratory findings, complications, and clinical outcome were also collected and were compared between patients classified as non-severe and severe cases. Results: The analysis included 275 confirmed COVID-19 patients. Median age was 37 years and IQR (Inter quartile range) was 27-62 years. Of the 275 cases, 41.5% (n = 114) were male and severity is more among the male patients with 58.1%. Old age, duration of hospitalization and d-dimer were independent factors increasing the risk of death due to COVID-19 (p<0.001). Nevertheless, vaccination was significantly associated with the severity of disease among the older population. Conclusion: In summary, vaccination and severity of disease were associated among the older population. Severity rate is more among the male patients. Old age, duration of hospitalization and d-dimer were independent factors increasing the risk of death due to COVID-19. [ABSTRACT FROM AUTHOR]

Background: The viability of any pedicled flap depends upon its vascularity. When a flap is dissected it becomes relatively ischaemic. Ultimately, the viability of the flap depends on the vessels incorporated in the pedicle and their perfusion capacity. There are different techniques to evaluate the blood supply of a flap. Aims: This study deals with experimental and clinical efficiency of fluorescein dye technique to evaluate the vascularity of flaps of various compositions. Materials and Methods: The experimental study was conducted on rats to standardize the technique. Thereafter clinical evaluation was conducted for different flaps namely fasciocutaneous, skeletonized perforator based fasciocutaneous, adipofascial, fasciocutaneous flap with adipofascial extension, fasciocutaneous flap with fascial extension and fasciocutaneous flap with split fascial extension. Conclusions: The paper deals in detail with the technique and method of documentation of a fluorescein study on flaps both experimentally and clinically. The appearance of fluorescein on both the surfaces and distal margin of the flap confirmed the adequacy of vascularity soon after dissection of the flaps. It was found to be an easy, safe and reliable objective method. [ABSTRACT FROM AUTHOR]