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243 results on '"Singh, Mansher"'

22. The effect of intraoperative specimen inking on lumpectomy re-excision rates

Author

Hogan Kevin T, Singh Gayatri, Singh Mansher, Atkins Kristen A, and Schroen Anneke T

Subjects
Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Lumpectomy re-excision to obtain negative margins is common. We compare the effect of two specimen orientation approaches on lumpectomy re-excision rates. Methods All women undergoing lumpectomy for breast cancer by a single surgeon between 03/2007 - 02/2009 were included. Lumpectomies underwent standard inking (SI) after surgery by a pathologist from 03/2007-02/2008 while intraoperative inking (II) with direct surgeon input was done from 03/2008-02/2009. Rates of margin positivity and re-excision were compared between these methods. Results 65 patients were evaluated, reflecting SI in 39 and II in 26 cases. Margin positivity rates of 46% [SI] vs. 23% [II] (p = 0.06) and re-excision rates of 38% [SI] vs. 19% [II] were observed. Residual disease at re-excision was found in 27% [SI] vs. 67% [II] of cases. Conclusions Intraoperative inking in this practice offered a simple way to reduce re-excision rates after lumpectomy and affect an improvement in quality of patient care.

Published
2010
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23. The effect of pH on cell viability, cell migration, cell proliferation, wound closure, and wound reepithelialization:In vitro and in vivo study

Author

Kruse, Carla R, Singh, Mansher, Targosinski, Stefan, Sinha, Indranil, Sørensen, Jens A, Eriksson, Elof, and Nuutila, Kristo

Subjects
integumentary system, Journal Article
Abstract

Wound microenvironment plays a major role in the process of wound healing. It contains various external and internal factors that participate in wound pathophysiology. The pH is an important factor that influences wound healing by changing throughout the healing process. Several previous studies have investigated the role of pH in relation to pathogens but studies concentrating on the effects of pH on wound healing itself are inconclusive. The purpose of this study was to comprehensively and in a controlled fashion investigate the effect of pH on wound healing by studying its effect on human primary keratinocyte and fibroblast function in vitro and on wound healing in vivo. In vitro, primary human keratinocytes and fibroblasts were cultured in different levels of pH (5.5-12.5) and the effect on cell viability, proliferation, and migration was studied. A rat full-thickness wound model was used to investigate the effect of pH (5.5-9.5) on wound healing in vivo. The effect of pH on inflammation was monitored by measuring IL-1 α concentrations from wounds and cell cultures exposed to different pH environments. Our results showed that both skin cell types tolerated wide range of pH very well. They further demonstrated that both acidic and alkaline environments decelerated cell migration in comparison to neutral environments and interestingly alkaline conditions significantly enhanced cell proliferation. Results from the in vivo experiments indicated that a prolonged, strongly acidic wound environment prevents both wound closure and reepithelialization while a prolonged alkaline environment did not have any negative impact on wound closure or reepithelialization. Separately, both in vitro and in vivo studies showed that prolonged acidic conditions significantly increased the expression of IL-1 α in fibroblast cultures and in wound fluid, whereas prolonged alkaline conditions did not result in elevated amounts of IL-1 α.

Published
2017

24. Geographic Distribution of Trauma Burden, Mortality, and Services in the United States: Does Availability Correspond to Patient Need?

Author

Rios-Diaz, Arturo J., Metcalfe, David, Olufajo, Olubode A., Zogg, Cheryl K., Yorkgitis, Brian, Singh, Mansher, Haider, Adil H., and Salim, Ali

Abstract

The association between the need for trauma care and trauma services has not been characterized previously. We compared the distribution of trauma admissions with state-level availability of trauma centers (TCs), surgical critical care (SCC) providers, and SCC fellowships, and assessed the association between trauma care provision and state-level trauma mortality.

Published
2024
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30. Abstract P3

Author

Tran, Bao Ngoc, primary, Singh, Mansher, additional, and Lee, Bernard, additional

Published
2017
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31. Innovative Techniques for Maximizing Limb Salvage and Function

Author

Singh, Mansher, primary, Li, Hehuan, additional, Nuutila, Kristo, additional, Collins, K. C., additional, Wall, Jennifer, additional, Riviello, Robert, additional, Weaver, Michael J., additional, Carty, Matthew J., additional, Pribaz, Julian, additional, and Talbot, Simon G., additional

Published
2017
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32. Use of Tumescence for Outpatient Abdominoplasty and Other Concurrent Body Contouring Procedures: A Review of 65 Consecutive Patients

Author

Holzman, Nathaniel L., Singh, Mansher, Caterson, Stephanie A., Eriksson, Elof, and Pomahac, Bohdan

Subjects
tumescence, complications, Journal Article, abdominoplasty, pain, outpatient procedure
Abstract

Introduction: Abdominoplasty is being increasingly performed as an outpatient procedure. The role of tumescent technique in decreasing postoperative pain and hospital stay has not been extensively studied. Methods: We reviewed 65 consecutive patients who underwent tumescent abdominoplasty over 20 months by a single surgeon. All the patients were followed up for at least 1 year. The outcomes were evaluated in terms of systemic complications such as deep vein thrombosis and pulmonary embolism and local complications such as seroma, wound infection, and skin necrosis. Results: Of the 65 patient records analyzed, 61 were of females and 4 of males. Average age for the patient population was 45.2 years. Mean follow-up was at least 1 year for all the patients. Ninety-five percent of patients could be discharged the same day with tumescent abdominoplasty, whereas 71% of the patients who underwent concurrent procedures with abdominoplasty were also able to go home the same day. All the patients reported excellent postoperative pain control. There was no report of deep vein thrombosis or pulmonary embolism in any of these patients. Wound complications occurred in 14 patients (21.6%), of which 12 patients had seroma (18.5%) and 2 had wound infection (3.1%). The seromas were treated with repeated aspirations or Jackson-Pratt drain placement, whereas the wound infections resolved with outpatient antibiotics. Conclusions: The safety and efficiency of outpatient abdominoplasty can be further facilitated by utilizing tumescence. Tumescence helps the patients be discharged sooner, usually the same day, mobilize sooner, and rely less on oral narcotics at home.

Published
2015

35. Topical Minocycline Effectively Decontaminates and Reduces Inflammation in Infected Porcine Wounds

Author

Daly, Lauren Tracy, primary, Tsai, David M., additional, Singh, Mansher, additional, Nuutila, Kristo, additional, Minasian, Raquel A., additional, Lee, Cameron C. Y., additional, Kiwanuka, Elizabeth, additional, Hackl, Florian, additional, Onderdonk, Andrew B., additional, Junker, Johan P. E., additional, Eriksson, Elof, additional, and Caterson, Edward J., additional

Published
2016
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36. The external microenvironment of healing skin wounds

Author

Kruse, Carla R, Nuutila, Kristo, Lee, Cameron Cy, Kiwanuka, Elizabeth, Singh, Mansher, Caterson, Edward J, Eriksson, Elof, and Sørensen, Jens A

Subjects
wound pathophysiology, Atmospheric Pressure, integumentary system, wound microenvironment, Wound Healing/physiology, Temperature, Animals, Humans, Skin/injuries, wound healing, Cellular Microenvironment/physiology, Gases, Environmental Exposure
Abstract

The skin wound microenvironment can be divided into two main components that influence healing: the external wound microenvironment, which is outside the wound surface; and the internal wound microenvironment, underneath the surface, to which the cells within the wound are exposed. Treatment methods that directly alter the features of the external wound microenvironment indirectly affect the internal wound microenvironment due to the exchange between the two compartments. In this review, we focus on the effects of temperature, pressure (positive and negative), hydration, gases (oxygen and carbon dioxide), pH, and anti-microbial treatment on the wound. These factors are well described in the literature and can be modified with treatment methods available in the clinic. Understanding the roles of these factors in wound pathophysiology is of central importance in wound treatment.

Published
2015

46. Functional Outcomes after Bilateral Hand Transplantation

Author

Singh, Mansher, primary, Sisk, Geoffroy, additional, Carty, Matthew, additional, Sampson, Christian, additional, Blazar, Philip, additional, Dyer, George, additional, Earp, Brandon, additional, Pribaz, Julian, additional, Pomahac, Bohdan, additional, and Talbot, Simon G., additional

Published
2016
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47. Pixel Grafting

Author

Singh, Mansher, primary, Nuutila, Kristo, additional, Kruse, Carla, additional, Dermietzel, Alexander, additional, Caterson, E. J., additional, and Eriksson, Elof, additional

Published
2016
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50. Psychosocial Outcomes after Bilateral Hand Transplantation

Author

Singh, Mansher, primary, Oser, Megan, additional, Zinser, Jennifer, additional, Sisk, Geoffroy, additional, Carty, Matthew J, additional, Sampson, Christian, additional, Pribaz, Julian J, additional, Pomahac, Bohdan, additional, and Talbot, Simon G, additional

Published
2015
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