1. Clinical and functional assessment of SARS-CoV-2 sequelae among young marines – a panel studyResearch in context
- Author
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Chad K. Porter, Charmagne G. Beckett, Elizabeth Cooper, Lindsey White, David Wallace, Silvia Jakubski, David Boulifard, Megan Schilling, Peifang Sun, Jan Marayag, Amethyst Marrone, Edgar O. Nunez-Hernandez, Sindhu Vangeti, Clare Miller, Yongchao Ge, Irene Ramos, Carl Goforth, Stuart C. Sealfon, and Andrew G. Letizia
- Subjects
COVID-19 ,SARS-CoV-2 ,Long COVID ,PASC ,Post-acute sequelae of COVID-19 ,Public aspects of medicine ,RA1-1270 - Abstract
Summary: Background: Long-term SARS-CoV-2 adverse health outcomes are of significant concern, especially among young adults with the potential for the greatest long-term morbidity. We sought to assess and characterize these outcomes in a cohort of Marines. Methods: We used a cohort of US Marines from a previous longitudinal, prospective observational study of acute SARS-CoV-2, most of whom were enrolled prior to infection. A panel study was established to assess for post-acute sequelae of COVID-19 (PASC), defined as symptoms at least 4 weeks after symptom onset or diagnosis. Symptoms were assessed through questionnaires and validated quality of health metrics. Periodic US Marine Corps fitness testing metrics provided an additional standardized functional assessment and were compared to a pre-pandemic cohort. Findings: Globally dispersed Marine participants (n = 899) seen an average of 330 days following initial enrollment were predominately male (n = 825, 91.7%), White (n = 613, 71.6%) or Black (n = 149, 17.4%) with a median age of 18 years (interquartile range: 18–19). Among 798 SARS-CoV-2 infected participants, 197 (24.7%) developed PASC. The most prevalent symptoms were loss of taste and/or smell (n = 82; 41.6%), shortness of breath (n = 74; 37.6%), and cough (n = 45; 22.8%). Those with PASC had higher rates and severity of somatic (p
- Published
- 2024
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