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4. Transcatheter Aortic Heart Valves:Histological Analysis Providing Insight to Leaflet Thickening and Structural Valve Degeneration

Author

Sellers, Stephanie L, Turner, Christopher T, Sathananthan, Janarthanan, Cartlidge, Timothy R G, Sin, Frances, Bouchareb, Rihab, Mooney, John, Nørgaard, Bjarne L, Bax, Jeroen J, Bernatchez, Pascal N, Dweck, Marc R, Granville, David J, Newby, David E, Lauck, Sandra, Webb, John G, Payne, Geoffrey W, Pibarot, Philippe, Blanke, Philipp, Seidman, Michael A, and Leipsic, Jonathon A

Subjects
cardiovascular system
Abstract

OBJECTIVES: This study investigated processes causing leaflet thickening and structural valve degeneration (SVD).BACKGROUND: Although transcatheter aortic valve replacement (TAVR) has changed the treatment of aortic stenosis, concerns remain regarding SVD, potentially related to valve thrombosis and thickening, based on studies using computed tomography (CT). Detailed histological analyses are provided to help attain insights into these processes.METHODS: Explanted transcatheter heart valves (THVs) were evaluated for thrombosis, fibrosis, and calcification for quantification of leaflet thickness. Immunohistochemical and microscopy approaches were used to investigate SVD-associated mechanisms.RESULTS: THVs (n = 23) were obtained from 22 patients (median 81 years of age; 50% male) from 0 to 2,583 days post TAVR. Maximal leaflet thickness increased relative to implant duration (ρ = 0.427; p = 0.027). THVs explanted after >2 years were thicker than those explanted after CONCLUSIONS: There is a time-dependent degeneration of THVs consisting of thrombus formation, endothelial hyperplasia, fibrosis, tissue remodeling, proteinase expression, and calcification. Future investigation is needed to further understand these mechanisms contributing to leaflet thickening and SVD.

Published
2018

5. Transcatheter Aortic Heart Valves

Author

Sellers, Stephanie L., primary, Turner, Christopher T., additional, Sathananthan, Janarthanan, additional, Cartlidge, Timothy R.G., additional, Sin, Frances, additional, Bouchareb, Rihab, additional, Mooney, John, additional, Nørgaard, Bjarne L., additional, Bax, Jeroen J., additional, Bernatchez, Pascal N., additional, Dweck, Marc R., additional, Granville, David J., additional, Newby, David E., additional, Lauck, Sandra, additional, Webb, John G., additional, Payne, Geoffrey W., additional, Pibarot, Philippe, additional, Blanke, Philipp, additional, Seidman, Michael A., additional, and Leipsic, Jonathon A., additional

Published
2019
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6. TCT-69 Transcatheter Aortic Heart Valves: Histological Analysis Providing Insight to Leaflet Thickening and Structural Valve Degeneration

Author

Sellers, Stephanie, primary, Turner, Christropher, additional, Cartlidge, Tim, additional, Sathananthan, Janarthanan, additional, Sin, Frances, additional, Bouchareb, Rihab, additional, Mooney, John, additional, Norgaard, Bjarne, additional, Bax, Jeroen, additional, Bernatchez, Pascal, additional, Dweck, Marc, additional, Granville, David, additional, Newby, David, additional, Lauck, Sandra, additional, Webb, John, additional, Payne, Geoffrey, additional, Pibarot, Philippe, additional, Blanke, Philipp, additional, Seidman, Michael, additional, and Leipsic, Jonathon, additional

Published
2018
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7. Non-Resident Corporations' GST/HST Registration Requirement in Canada

Author

Sin, Frances

Subjects
Canada. Revenue Agency -- Powers and duties, Goods and services tax -- Laws, regulations and rules, Residential construction -- Laws, regulations and rules, Government regulation, Business, international
Abstract

In general, a non-resident corporation is not required to register for GST/HST in Canada unless it makes taxable supplies of goods or services in the course of a business carried [...]

Published
2017

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