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Your search keyword '"Simpson, Nigel A.B."' showing total 23 results
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23 results on '"Simpson, Nigel A.B."'

7. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Author

Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, MariaCarolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun, Johannsdottir, Hrefna, Jonsdottir, Ingileif, Juliusdottir, Thorhildur, Kalsheker, Noor, Kasimov, Abdumadjit, Kemp, John P., Kivinen, Katja, Lee, Wai K., Melbye, Mads, Miedzybrodska, Zosia, Moffett, Ashley, Najmutdinova, Dilbar, Nishanova, Firuza, Olafsdottir, Thorunn, Perola, Markus, Broughton Pipkin, Fiona, Poston, Lucilla, Prescott, Gordon, Saevarsdottir, Saedis, Salimbayeva, Damilya, Juliet Scaife, Paula, Skotte, Line, Staines-Urias, Eleonora, Stefansson, Olafur A., Cecilie Vestrheim Thomsen, Liv, Tragante, Vinicius, Trogstad, Lill, Simpson, Nigel A.B., FINNPEC Consortium, GOPEC Consortium, Aripova, Tamara, Casas, Juan P., Dominiczak, Anna F., Walker, James J., Thorsteinsdottir, Unnur, Iversen, Ann-Charlotte, Feenstra, Bjarke, Lawlor, Deborah A., Boyd, Heather Allison, Magnus, Per, Laivuori, Hannele, Zakhidova, Nodira, Svyatova, Gulnara, Stefansson, Kari, and Morgan, Linda

Subjects
General Physics and Astronomy, General Chemistry, General Biochemistry, Genetics and Molecular Biology
Published
2020

9. Prenatal and Postpartum Maternal Iodide Intake from Diet and Supplements, Urinary Iodine and Thyroid Hormone Concentrations in a Region of the United Kingdom with Mild-to-Moderate Iodine Deficiency

Author

Threapleton, Diane E., primary, Waiblinger, Dagmar, additional, Snart, Charles J.P., additional, Taylor, Elizabeth, additional, Keeble, Claire, additional, Ashraf, Samina, additional, Bi, Shazia, additional, Ajjan, Ramzi, additional, Azad, Rafaq, additional, Hancock, Neil, additional, Mason, Dan, additional, Reid, Stephen, additional, Cromie, Kirsten J., additional, Alwan, Nisreen A., additional, Zimmermann, Michael, additional, Stewart, Paul M., additional, Simpson, Nigel A.B., additional, Wright, John, additional, Cade, Janet E., additional, Hardie, Laura J., additional, and Greenwood, Darren C., additional

Published
2021
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11. Folic acid supplementation is associated with size at birth in the Screening for Pregnancy Endpoints (SCOPE) international prospective cohort study

Author

Bulloch, Rhodi E., primary, Wall, Clare R., additional, Thompson, John M.D., additional, Taylor, Rennae S., additional, Poston, Lucilla, additional, Roberts, Claire T., additional, Dekker, Gustaaf A., additional, Kenny, Louise C., additional, Simpson, Nigel A.B., additional, Myers, Jenny E., additional, and McCowan, Lesley M.E., additional

Published
2020
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13. Maternal iron status in early pregnancy and birth outcomes: insights from the Baby's Vascular health and Iron in Pregnancy study

Author

Alwan, Nisreen A., Cade, Janet E., McArdle, Harry J., Greenwood, Darren C., Hayes, Helen E., and Simpson, Nigel A.B.

Subjects
Adult, Iron, Nutritional Status, Gestational Age, Cohort Studies, Hemoglobins, Birth weight, Pregnancy, Risk Factors, Receptors, Transferrin, Humans, Maternal Welfare, Anemia, Iron-Deficiency, Dietary Surveys and Nutritional Epidemiology, Infant, Newborn, Pregnancy Outcome, Preterm birth, Iron Deficiencies, Full Papers, United Kingdom, Pregnancy Complications, Pregnancy Trimester, First, Ferritins, Infant, Small for Gestational Age, Blood Vessels, Premature Birth, Female, Biomarkers
Abstract

Fe deficiency anaemia during early pregnancy has been linked with low birth weight and preterm birth. However, this evidence comes mostly from studies measuring Hb levels rather than specific measures of Fe deficiency. The present study aimed to examine the association between maternal Fe status during the first trimester of pregnancy, as assessed by serum ferritin, transferrin receptor and their ratio, with size at birth and preterm birth. In the Baby VIP (Baby's Vascular health and Iron in Pregnancy) study, we recruited 362 infants and their mothers after delivery in Leeds, UK. Biomarkers were measured in maternal serum samples previously obtained in the first trimester of pregnancy. The cohort included sixty-four (18 %) small for gestational age (SGA) babies. Thirty-three babies were born preterm (9 %; between 34 and 37 weeks). First trimester maternal Fe depletion was associated with a higher risk of SGA (adjusted OR 2·2, 95 % CI 1·1, 4·1). This relationship was attenuated when including early pregnancy Hb in the model, suggesting it as a mediator (adjusted OR 1·6, 95 % CI 0·8, 3·2). For every 10 g/l increase in maternal Hb level in the first half of pregnancy the risk of SGA was reduced by 30 % (adjusted 95 % CI 0, 40 %); levels below 110 g/l were associated with a 3-fold increase in the risk of SGA (95 % CI 1·0, 9·0). There was no evidence of association between maternal Fe depletion and preterm birth (adjusted OR 1·5, 95 % 0·6, 3·8). The present study shows that depleted Fe stores in early pregnancy are associated with higher risk of SGA.

Published
2015

17. Early Pregnancy Prediction of Preeclampsia in Nulliparous Women, Combining Clinical Risk and Biomarkers

Author

Kenny, Louise C., primary, Black, Michael A., additional, Poston, Lucilla, additional, Taylor, Rennae, additional, Myers, Jenny E., additional, Baker, Philip N., additional, McCowan, Lesley M., additional, Simpson, Nigel A.B., additional, Dekker, Gus A., additional, Roberts, Claire T., additional, Rodems, Kelline, additional, Noland, Brian, additional, Raymundo, Michael, additional, Walker, James J., additional, and North, Robyn A., additional

Published
2014
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22. Maternal Fatty Fish Intake Prior to and during Pregnancy and Risks of Adverse Birth Outcomes: Findings from a British Cohort.

Author

Cade, Janet E., Nykjaer, Camilla, Higgs, Charlotte, Simpson, Nigel A.B., Greenwood, Darren C., and Alwan, Nisreen A.

Abstract

Fish is an important source of the essential fatty acids contributing to foetal growth and development, but the evidence linking maternal fatty fish consumption with birth outcomes is inconsistent. In the UK, pregnant women are recommended to consume no more than two 140 g portions of fatty fish per week. This study aimed to investigate the association between fatty fish consumption before and during pregnancy with preterm birth and size at birth in a prospective birth cohort. Dietary intake data were acquired from a cohort of 1208 pregnant women in Leeds, UK (CARE Study) to assess preconception and trimester-specific fatty fish consumption using questionnaires. Multiple 24-h recalls during pregnancy were used to estimate an average fatty fish portion size. Intake was classified as ≤2, >2 portions/week and no fish categories. Following the exclusion of women taking cod liver oil and/or omega-3 supplements, the associations between fatty fish intake with size at birth and preterm delivery (<37 weeks gestation) were examined in multivariable regression models adjusting for confounders including salivary cotinine as a biomarker of smoking status.. The proportion of women reporting any fatty fish intake decreased throughout pregnancy, with the lowest proportion observed in trimester 3 (43%). Mean intakes amongst consumers were considerably lower than that recommended, with the lowest intake amongst consumers observed in the 1st trimester (106 g/week, 95% CI: 99, 113). This was partly due to small portion sizes when consumed, with the mean portion size of fatty fish being 101 g. After adjusting for confounders, no association was observed between fatty fish intake before or during pregnancy with size at birth and preterm delivery. [ABSTRACT FROM AUTHOR]

Published
2019
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23. Variants in the fetal genome near FLT1 are associated with risk of preeclampsia

Author

Williams, Nicholas O., Hildyard, Lucy, Casas, Juan P., McGinnis, Ralph, Lee, Wai Kwong, Pipkin, Fiona Broughton, Hjartardottir, Sigrun, Simpson, Nigel A.B., Kemp, John P., Silva, Gabriela B., Kalsheker, Noor, Zakhidova, Nodira, Chappell, Sally, Staines-Urias, Eleonora, Bumpstead, Suzannah, Stefansdottir, Lilja, Thorleifsson, Gudmar, Walker, James J., Moffett, Ashley, Padmanabhan, Sandosh, Lawlor, Debbie A., Morgan, Linda, Trogstad, Lill, Gjessing, Håkon K., Thomsen, Liv Cecilie V., Iversen, Ann-Charlotte, Geirsson, Reynir T., Kajantie, Eero, Laivuori, Hannele, Steinthorsdottir, Valgerdur, Magnus, Per, Svyatova, Gulnara, Stefansson, Kari, Jääskeläinen, Tiina, Engel, Stephanie M., Dudbridge, Frank, Najmutdinova, Dilbar, Sigurdsson, Jon K., Haugan, Anita, Dominiczak, Anna F., Thorsteinsdottir, Unnur, Dolby, Vivien A., Hiby, Susan, and Shooter, Scott

Subjects
embryonic structures, female genital diseases and pregnancy complications, reproductive and urinary physiology, 3. Good health
Abstract

Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) have not identified maternal sequence variants of genome-wide significance that replicate in independent data sets. We report the first GWAS of offspring from preeclamptic pregnancies and discovery of the first genome-wide significant susceptibility locus (rs4769613; P = 5.4 × 10(-11)) in 4,380 cases and 310,238 controls. This locus is near the FLT1 gene encoding Fms-like tyrosine kinase 1, providing biological support, as a placental isoform of this protein (sFlt-1) is implicated in the pathology of preeclampsia. The association was strongest in offspring from pregnancies in which preeclampsia developed during late gestation and offspring birth weights exceeded the tenth centile. An additional nearby variant, rs12050029, associated with preeclampsia independently of rs4769613. The newly discovered locus may enhance understanding of the pathophysiology of preeclampsia and its subtypes.

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