Search

Your search keyword '"Simpson, John M."' showing total 583 results
Start Over Author "Simpson, John M."
583 results on '"Simpson, John M."'

4. Shape-Guided In-Silico Characterization of 3D Fetal Arch Hemodynamics in Suspected Coarctation of the Aorta

Author

Hermida, Uxio, van Poppel, Milou P. M., Sabry, Malak, Keramati, Hamed, Lloyd, David F. A., Steinweg, Johannes K., Vigneswaran, Trisha V., Simpson, John M., Razavi, Reza, Pushparajah, Kuberan, Lamata, Pablo, De Vecchi, Adelaide, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Bernard, Olivier, editor, Clarysse, Patrick, editor, Duchateau, Nicolas, editor, Ohayon, Jacques, editor, and Viallon, Magalie, editor

Published
2023
Full Text
View/download PDF

6. Prevalence of cardiac valvar abnormalities in children and young people with autosomal dominant polycystic kidney disease

Author

Savis, Alexandra, Simpson, John M., Kabir, Saleha, Peacock, Kelly, Beardsley, Hayley, and Sinha, Manish D.

Subjects
Gene mutations -- Health aspects, Polycystic kidney disease -- Complications and side effects -- Care and treatment -- Genetic aspects, Heart valve diseases -- Risk factors -- Prevention, Health
Abstract

Background Valvar abnormalities in children and adults with autosomal dominant polycystic kidney disease (ADPKD) have previously been reported as a frequent occurrence. Mitral valve prolapse (MVP), in particular, has been reported in almost one-third of adult patients and nearly 12% of children with ADPKD. Our objective in this study was to establish the prevalence of valvar abnormalities in a large, contemporary series of children and young people (CYP) with ADPKD. Methods A retrospective, single centre, cross-sectional analysis of the echocardiograms performed on all consecutive children seen in a dedicated paediatric ADPKD clinic. Full anatomical and functional echocardiograms were performed and analysed for valvar abnormalities. Results The echocardiograms of 102 CYP with ADPKD (range 0.25-18 years, mean age 10.3 years, SD ± 5.3 years) were analysed. One (0.98%), 3-year-old boy, had MVP. There was no associated mitral regurgitation. Evaluating variations in normal valvar anatomy, 9 (8.8%) patients, aged 7.1 to 18 years, had minor bowing ± visual elongation of either the anterior or posterior leaflet of the mitral valve, none of which fell within the criteria of true MVP. Three (1.9%) patients, 2 boys and 1 girl aged between 7 and 14 years, had trivial or mild aortic regurgitation. No patients had echocardiographic evidence of tricuspid valve prolapse (TVP). Conclusion In this contemporary cohort of CYP with ADPKD, the incidence of MVP and other valvar lesions is significantly lower than previously reported. Graphical abstract A higher resolution version of the Graphical abstract is available as Supplementary information., Author(s): Alexandra Savis [sup.1] , John M. Simpson [sup.1] , Saleha Kabir [sup.1] , Kelly Peacock [sup.1] , Hayley Beardsley [sup.1] , Manish D. Sinha [sup.2] [sup.3] Author Affiliations: (1) [...]

Published
2023
Full Text
View/download PDF

8. D.C. Circuit Bounces Animal Rights Case On Standing Grounds

Author

Simpson, John M.

Subjects
Animal rights -- Cases, Standing (Law) -- Cases, Company legal issue, Business, international
Abstract

Animal rights groups often pursue consumer-type cases against food producers and argue that packaging claims and images supposedly mislead buyers into thinking that the animals turned into food were humanely [...]

Published
2024

11. Simplifying Disease Staging Models into a Single Anatomical Axis - A Case Study of Aortic Coarctation In-utero

Author

Hermida, Uxio, Poppel, Milou P. M. van, Stojanovski, David, Lloyd, David F. A., Steinweg, Johannes K., Vigneswaran, Trisha V., Simpson, John M., Razavi, Reza, Vecchi, Adelaide De, Pushparajah, Kuberan, Lamata, Pablo, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Camara, Oscar, editor, Puyol-Antón, Esther, editor, Qin, Chen, editor, Sermesant, Maxime, editor, Suinesiaputra, Avan, editor, Wang, Shuo, editor, and Young, Alistair, editor

Published
2022
Full Text
View/download PDF

12. Artificial Intelligence to Assist in the Screening Fetal Anomaly Ultrasound Scan (PROMETHEUS): A Randomised Controlled Trial

Author

Day, Thomas George, primary, Matthew, Jacqueline, additional, Budd, Samuel F, additional, Farruggia, Alfonso, additional, Venturini, Lorenzo, additional, Wright, Robert, additional, Jamshidi, Babak, additional, To, Meekai, additional, Ling, Huazen, additional, Lai, Jonathon, additional, Tan, Min Yi, additional, Brown, Matthew, additional, Guy, Gavin, additional, Casagrandi, Davide, additional, Arechvo, Anastasija, additional, Syngelaki, Argyro, additional, Lloyd, David, additional, Zidere, Vita, additional, Vigneswaran, Trisha, additional, Miller, Owen, additional, Akolekar, Ranjit, additional, Nanda, Surabhi, additional, Nicolaides, Kypros, additional, Kainz, Bernhard, additional, Simpson, John M, additional, Hajnal, Jo V, additional, and Razavi, Reza, additional

Published
2024
Full Text
View/download PDF

13. Supreme Court Guts USDA's Power To Assess Civil Penalties Under The Animal Welfare Act

Author

Simpson, John M.

Subjects
United States. Department of Agriculture -- Powers and duties, United States. Supreme Court -- Powers and duties, Animal welfare -- Laws, regulations and rules, Fines (Penalties) -- Evaluation -- Laws, regulations and rules, Government regulation, Business, international, Animal Welfare Act
Abstract

Somewhat overshadowed by Chevron's spectacular crash and burn last week was the Supreme Court's decision the day before in SEC v. Jarkesy, No. 22-859 (U.S. June 27, 2024), holding that [...]

Published
2024

14. Supreme Court Puts An End To 'Resource Drain' Standing

Author

Simpson, John M.

Subjects
United States. Food and Drug Administration -- Cases, United States. Supreme Court -- Cases, Mifepristone -- Cases -- Marketing, Judicial opinions -- Cases, Drug approval -- Cases, Company legal issue, Company marketing practices, Business, international
Abstract

To paraphrase the line from 'Forrest Gump,' Supreme Court opinions are like 'a box of chocolates; you never know what you are going to get.' For standing nerds, there was [...]

Published
2024

17. Prenatal vs postnatal diagnosis of 22q11.2 deletion syndrome: cardiac and noncardiac outcomes through 1 year of age

Author

Freud, Lindsay R., Galloway, Stephanie, Crowley, T. Blaine, Moldenhauer, Julie, Swillen, Ann, Breckpot, Jeroen, Borrell, Antoni, Vora, Neeta L., Cuneo, Bettina, Hoffman, Hilary, Gilbert, Lisa, Nowakowska, Beata, Geremek, Maciej, Kutkowska-Kaźmierczak, Anna, Vermeesch, Joris R., Devriendt, Koen, Busa, Tiffany, Sigaudy, Sabine, Vigneswaran, Trisha, Simpson, John M., Dungan, Jeffrey, Gotteiner, Nina, Gloning, Karl-Philipp, Digilio, Maria Cristina, Unolt, Marta, Putotto, Carolina, Marino, Bruno, Repetto, Gabriela, Fadic, Magdalena, Garcia-Minaur, Sixto, Achón Buil, Ana, Thomas, Mary Ann, Fruitman, Deborah, Beecroft, Taylor, Hui, Pui Wah, Oskarsdottir, Solveig, Bradshaw, Rachael, Criebaum, Amanda, Norton, Mary E., Lee, Tiffany, Geiger, Miwa, Dunnington, Leslie, Isaac, Jacqueline, Wilkins-Haug, Louise, Hunter, Lindsey, Izzi, Claudia, Toscano, Marika, Ghi, Tullio, McGlynn, Julie, Romana Grati, Francesca, Emanuel, Beverly S., Gaiser, Kimberly, Gaynor, J. William, Goldmuntz, Elizabeth, McGinn, Daniel E., Schindewolf, Erica, Tran, Oanh, Zackai, Elaine H., Yan, Qi, Bassett, Anne S., Wapner, Ronald, and McDonald-McGinn, Donna M.

Published
2024
Full Text
View/download PDF

18. PETA's Animal 'Shelter' Continues As A Leader In Animal Death

Author

Simpson, John M.

Subjects
Animal shelters -- Laws, regulations and rules, Animal rights -- Laws, regulations and rules, Animal experimentation -- Laws, regulations and rules, Government regulation, Business, international
Abstract

Animal rights group People for the Ethical Treatment of Animals (PETA) recently posted the 'news' that it had 'newly obtained public records' showing that certain research universities had euthanized laboratory [...]

Published
2024

20. Simplifying Disease Staging Models into a Single Anatomical Axis - A Case Study of Aortic Coarctation In-utero

Author

Hermida, Uxio, primary, Poppel, Milou P. M. van, additional, Stojanovski, David, additional, Lloyd, David F. A., additional, Steinweg, Johannes K., additional, Vigneswaran, Trisha V., additional, Simpson, John M., additional, Razavi, Reza, additional, Vecchi, Adelaide De, additional, Pushparajah, Kuberan, additional, and Lamata, Pablo, additional

Published
2022
Full Text
View/download PDF

21. Prenatal diagnosis of hypoplastic left heart syndrome on ultrasound using artificial intelligence: How does performance compare to a current screening programme?

Author

Day, Thomas G., Budd, Samuel, Tan, Jeremy, Matthew, Jacqueline, Skelton, Emily, Jowett, Victoria, Lloyd, David, Gomez, Alberto, Hajnal, Jo V., Razavi, Reza, Kainz, Bernhard, and Simpson, John M.

Abstract

Background: Artificial intelligence (AI) has the potential to improve prenatal detection of congenital heart disease. We analysed the performance of the current national screening programme in detecting hypoplastic left heart syndrome (HLHS) to compare with our own AI model. Methods: Current screening programme performance was calculated from local and national sources. AI models were trained using four‐chamber ultrasound views of the fetal heart, using a ResNet classifier. Results: Estimated current fetal screening programme sensitivity and specificity for HLHS were 94.3% and 99.985%, respectively. Depending on calibration, AI models to detect HLHS were either highly sensitive (sensitivity 100%, specificity 94.0%) or highly specific (sensitivity 93.3%, specificity 100%). Our analysis suggests that our highly sensitive model would generate 45,134 screen positive results for a gain of 14 additional HLHS cases. Our highly specific model would be associated with two fewer detected HLHS cases, and 118 fewer false positives. Conclusion: If used independently, our AI model performance is slightly worse than the performance level of the current screening programme in detecting HLHS, and this performance is likely to deteriorate further when used prospectively. This demonstrates that collaboration between humans and AI will be key for effective future clinical use. Key points: What is already known on this topic? Artificial intelligence (AI) can be used to interpret medical images and make diagnoses, including detecting fetal congenital heart disease (CHD) by ultrasound.The sensitivity of the current English screening programme for fetal cardiac malformations is publicly available, but specificity is not reported. What this study adds? The current screening programme in our region is operating at a very high specificity for fetal hypoplastic left heart syndrome (HLHS).Using a curated retrospective dataset, it is possible to train AI models to detect HLHS with a performance approaching that of the current screening programme.Current AI models do not have high enough specificity to be used independently for screening for fetal CHD, meaning that human‐AI interaction when performing or interpreting ultrasound will be important to select cases for specialist referral. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

25. Prenatal diagnosis of hypoplastic left heart syndrome on ultrasound using artificial intelligence: How does performance compare to a current screening programme?

Author

Day, Thomas G., primary, Budd, Samuel, additional, Tan, Jeremy, additional, Matthew, Jacqueline, additional, Skelton, Emily, additional, Jowett, Victoria, additional, Lloyd, David, additional, Gomez, Alberto, additional, Hajnal, Jo V., additional, Razavi, Reza, additional, Kainz, Bernhard, additional, and Simpson, John M., additional

Published
2023
Full Text
View/download PDF

26. Prenatal versus Postnatal Diagnosis of 22q11.2 Deletion Syndrome: Cardiac and Non-Cardiac Outcomes through 1 Year of Age

Author

Freud, Lindsay R., primary, Galloway, Stephanie, additional, Crowley, T. Blaine, additional, Moldenhauer, Julie, additional, Swillen, Ann, additional, Breckpot, Jeroen, additional, Borrell, Antoni, additional, Vora, Neeta L., additional, Cuneo, Bettina, additional, Hoffman, Hilary, additional, Gilbert, Lisa, additional, Nowakowska, Beata, additional, Geremek, Maciej, additional, Kutkowska-Kaźmierczak, Anna, additional, Vermeesch, Joris R., additional, Devriendt, Koen, additional, Busa, Tiffany, additional, Sigaudy, Sabine, additional, Vigneswaran, Trisha, additional, Simpson, John M., additional, Dungan, Jeffrey, additional, Gotteiner, Nina, additional, Gloning, Karl-Philipp, additional, Digilio, Maria Cristina, additional, Unolt, Marta, additional, Putotto, Carolina, additional, Marino, Bruno, additional, Repetto, Gabriela, additional, Fadic, Magdalena, additional, Garcia-Minaur, Sixto, additional, Buil, Ana Achón, additional, Thomas, Mary Ann, additional, Fruitman, Deborah, additional, Beecroft, Taylor, additional, Hui, Pui Wah, additional, Oskarsdottir, Solveig, additional, Bradshaw, Rachael, additional, Criebaum, Amanda, additional, Norton, Mary E., additional, Lee, Tiffany, additional, Geiger, Miwa, additional, Dunnington, Leslie, additional, Isaac, Jacqueline, additional, Wilkins-Haug, Louise, additional, Hunter, Lindsey, additional, Izzi, Claudia, additional, Toscano, Marika, additional, Ghi, Tullio, additional, McGlynn, Julie, additional, Grati, Francesca Romana, additional, Emanuel, Beverly S., additional, Gaiser, Kimberly, additional, Gaynor, J. William, additional, Goldmuntz, Elizabeth, additional, McGinn, Daniel E., additional, Schindewolf, Erica, additional, Tran, Oanh, additional, Zackai, Elaine H., additional, Yan, Qi, additional, Bassett, Anne, additional, Wapner, Ronald, additional, and McDonald-McGinn, Donna M., additional

Published
2023
Full Text
View/download PDF

30. COVID-19 in congenital heart disease (COaCHeD) study

Author

Chivers, Sian, primary, Cleary, Aoife, additional, Knowles, Rachel, additional, Babu-Narayan, Sonya V, additional, Simpson, John M, additional, Nashat, Heba, additional, Dimopoulos, Konstantinos, additional, Gatzoulis, Michael A, additional, Wilson, Dirk, additional, Prica, Milos, additional, Anthony, James, additional, Clift, Paul F, additional, Jowett, Victoria, additional, Jenkins, Petra, additional, Khodaghalian, Bernadette, additional, Jones, Caroline B, additional, Hardiman, Antonia, additional, Head, Catherine, additional, Miller, Owen, additional, Chung, Natali AY, additional, Mahmood, Umar, additional, Bu'Lock, Frances A, additional, Ramcharan, Tristan KW, additional, Chikermane, Ashish, additional, Shortland, Jennifer, additional, Tometzki, Andrew, additional, Crossland, David S, additional, Reinhardt, Zdenka, additional, Lewis, Clive, additional, Rittey, Leila, additional, Hares, Dominic, additional, Panagiotopoulou, Olga, additional, Smith, Benjamin, additional, Najih L, Muhammad, additional, Bharucha, Tara, additional, and Daubeney, Piers EF, additional

Published
2023
Full Text
View/download PDF

34. Ninth Circuit Tosses Grey Wolf Case On Standing Grounds

Author

Simpson, John M.

Subjects
Environmental permits -- Cases, Standing (Law) -- Cases, Company legal issue, Business, international
Abstract

On June 14, 2023, a panel of the U.S. Court of Appeals for the Ninth Circuit affirmed the dismissal of a lawsuit brought by Wildearth Guardians and other environment activist [...]

Published
2023

40. UK Gene Editing Law On Plants And Animals Takes Effect

Author

Simpson, John M.

Subjects
Genetically modified organisms -- Laws, regulations and rules, Government regulation, Business, international, United Kingdom. Genetic Technology (Precision Breeding) Act 2023 (Draft)
Abstract

On March 23, 2023, royal assent was given to a statute passed by the British Parliament entitled the Genetic Technology (Precision Breeding) Act 2023. The new law aims to facilitate [...]

Published
2023

41. PETA Open Records Case Takes An Interesting Turn

Author

Simpson, John M.

Subjects
Disclosure laws -- Cases, Personal information -- Access control -- Laws, regulations and rules, Company legal issue, Government regulation, Business, international
Abstract

On February 17, 2023, a panel of the U.S. Court of Appeals for the Ninth Circuit reversed a preliminary injunction that had restrained the University of Washington from releasing records [...]

Published
2023

42. PETA Hog-Catching Case Fails For Lack Of Standing

Author

Simpson, John M.

Subjects
Animal products industry -- Laws, regulations and rules, Cruelty to animals -- Cases, Animal rights -- Laws, regulations and rules, Company legal issue, Government regulation, Business, international
Abstract

On February 8, 2023, the Texas Fourth Court of Appeals affirmed a judgment dismissing a lawsuit that animal rights group, People for the Ethical Treatment of Animals (PETA), and a [...]

Published
2023

43. With The Death Rate In PETA's Animal Shelter, It Really Is Groundhog Day

Author

Simpson, John M.

Subjects
Euthanasia -- Statistics, Animal rights -- Laws, regulations and rules, Government regulation, Business, international, People for the Ethical Treatment of Animals -- Social aspects
Abstract

Annually, animal rights group People for the Ethical Treatment of Animals (PETA) condemns Groundhog Day. This year, PETA called the exhibition of Punxsutawney Phil 'a cruel form of speciesism, a [...]

Published
2023

45. Intensive compared with less intensive blood pressure control to prevent adverse cardiac remodelling in children with chronic kidney disease (HOT-KID): a parallel-group, open-label, multicentre, randomised, controlled trial

Author

Sinha, Manish D, primary, Gu, Haotian, additional, Douiri, Abdel, additional, Cansick, Janette, additional, Finlay, Eric, additional, Gilbert, Rodney, additional, Kerecuk, Larissa, additional, Lunn, Andrew, additional, Maxwell, Heather, additional, Morgan, Henry, additional, Shenoy, Mohan, additional, Shroff, Rukshana, additional, Subramaniam, Pushpa, additional, Tizard, Jane, additional, Tse, Yincent, additional, Rezavi, Reza, additional, Simpson, John M, additional, and Chowienczyk, Phil J, additional

Published
2023
Full Text
View/download PDF

46. Systematic review of long QT syndrome identified during fetal life

Author

Chivers, Sian, primary, Ovadia, Caroline, additional, Regan, William, additional, Zidere, Vita, additional, Vigneswaran, Trisha, additional, Sharland, Gurleen, additional, Rosenthal, Eric, additional, Seed, Paul T., additional, Simpson, John M., additional, and Williamson, Catherine, additional

Published
2022
Full Text
View/download PDF

48. Research priorities in children and adults with congenital heart disease: a James Lind Alliance Priority Setting Partnership

Author

Drury, Nigel E, primary, Herd, Clare P, additional, Biglino, Giovanni, additional, Brown, Katherine L, additional, Coats, Louise, additional, Cumper, Michael J, additional, Guerrero, Rafael R, additional, Miskin, Alex, additional, Murray, Sarah, additional, Pender, Fraser, additional, Rooprai, Sasha, additional, Simpson, John M, additional, Thomson, John D R, additional, Weinkauf, Jara, additional, Wootton, Julie, additional, Jones, Timothy J, additional, and Cowan, Katherine, additional

Published
2022
Full Text
View/download PDF

50. Fifth Circuit Declares Horseracing Integrity And Safety Act Unconstitutional

Author

Simpson, John M.

Subjects
United States. Federal Trade Commission -- Powers and duties, United States. Securities and Exchange Commission -- Powers and duties, Administrative procedure -- Laws, regulations and rules, Horse-racing -- Laws, regulations and rules, Government regulation, Business, international, Administrative Procedure Act, Consolidated Appropriations Act of 2021, Financial Industry Regulatory Authority Inc. -- Laws, regulations and rules
Abstract

In 2020, Congress passed, and President Trump signed, the Horseracing Integrity and Safety Act (HISA) which empowers a private entity - the Horseracing Integrity and Safety Authority (Authority) - to [...]

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results