Search

Introduction:- One of the overlooked facilitating factors of recurrent shoulder pain due to tendon degeneration is the periarticular muscle latency (M1, M2, and M3). It leads to a lack of muscle protection against the external loads on the shoulder during the initiation of every shoulder movement. This creates multiple repetitive micro-traumas, gradually accumulating to tendon degeneration. The only way to overtake the periarticular muscle latency and its consequences is the preliminary biceps brachial muscle contraction. Aim:-To study the effect of the preliminary biceps brachial muscle contraction on the short-term rehabilitation and the long-term prophylaxis of recurrent shoulder pain due to tendon degeneration. Material and Methods:-For 10 years were followed 44 outpatients (age 50.1 ± 14.8 years) with recurrent shoulder pain due to tendon degeneration. They were randomized into two groups – standard (n=22) and maneuver (n=22). Both groups received prophylactic recommendations and were treated for two weeks with exercise, interferential current, and laser. The maneuver group received an additional recommendation to perform preliminary biceps brachial muscle contraction before every movement of the shoulder during the daily activities. Pain intensity, shoulder mobility, periarticular muscle strength, number of recurrences, number of rehabilitation courses, and success rate of the maneuver were followed-up for two weeks and ten consecutive years. For the statistical analysis, ANOVA with Bonferronis tests and Pearsons correlation with regression tests were used. Results:- The pain decreased significantly after the first day in the maneuver group (P Conclusion:-The preliminary biceps muscle contraction is appropriate an important additional recommendation in short-term treatment and long-term prophylaxis of recurrent shoulder pain due to tendon degeneration. It is simple, quick, effective, and without side effects or complications. It requires no allocation of space, time, or resources. This maneuver protects the shoulder before the initial external forces, avoiding the repetitive micro-traumas during the muscle latency, which is otherwise inevitable in daily activities. Another protecting factor is the increased muscle strength and co-contraction of all periarticular muscles, as a result of this bracing maneuver, leading to lesser pain with higher shoulder stability and mobility.&nbsp

Compound screening in biological assays and subsequent optimization of hits is indispensable for the development of new molecular research tools and drug candidates. To facilitate such discoveries, the European Research Infrastructure EU-OPENSCREEN was founded recently with the support of its member countries and the European Commission. Its distributed character harnesses complementary knowledge, expertise, and instrumentation in the discipline of chemical biology from 20 European partners, and its open working model ensures that academia and industry can readily access EU-OPENSCREEN’s compound collection, equipment, and generated data. To demonstrate the power of this collaborative approach, this perspective article highlights recent projects from EU-OPENSCREEN partner institutions. These studies yielded (1) 2-aminoquinazolin-4(3H)-ones as potential lead structures for new antimalarial drugs, (2) a novel lipodepsipeptide specifically inducing apoptosis in cells deficient for the pVHL tumor suppressor, (3) small-molecule-based ROCK inhibitors that induce definitive endoderm formation and can potentially be used for regenerative medicine, (4) potential pharmacological chaperones for inborn errors of metabolism and a familiar form of acute myeloid leukemia (AML), and (5) novel tankyrase inhibitors that entered a lead-to-candidate program. Collectively, these findings highlight the benefits of small-molecule screening, the plethora of assay designs, and the close connection between screening and medicinal chemistry within EU-OPENSCREEN.

International audience

International audience

Journal URL: http://www.jbc.org/

(1-Hydroxyalkyl)- and (1-hydroxy-1-methylalkyl) ferrocenes (α-ferrocenyl carbinols) have been synthesized and their high resolution 1H-NMR spectra studied as a function of the stereochemistry of the substituted connected to the cyclopentadienyl ring. It was found that when α-ferrocenyl carbinol contains a chiral center in the substituent, the 2,5- and 3,4-positions in the cyclopentadienyl ring become pairwise diastereotopic and magnetically unequivalent.